{"id":9486,"date":"2018-12-26T10:00:43","date_gmt":"2018-12-26T01:00:43","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=9486"},"modified":"2018-12-24T08:22:35","modified_gmt":"2018-12-23T23:22:35","slug":"%e7%b2%be%e5%ad%90%e3%81%af%e3%81%a9%e3%81%ae%e3%82%88%e3%81%86%e3%81%ab%e5%8d%b5%e3%82%92%e8%a6%8b%e3%81%a4%e3%81%91%e3%82%8b%e3%81%8b%ef%bc%9f-%e3%83%9b%e3%83%a4%e3%81%8c%e5%8f%97%e7%b2%be","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=9486","title":{"rendered":"\u7cbe\u5b50\u306f\u3069\u306e\u3088\u3046\u306b\u5375\u3092\u898b\u3064\u3051\u308b\u304b\uff1f &#8211; \u30db\u30e4\u304c\u53d7\u7cbe\u3059\u308b\u3068\u304d\u306e\u7e4a\u7d30\u306a\u8a8d\u8b58\u6a5f\u69cb"},"content":{"rendered":"<h3>\u7cbe\u5b50\u306e\u8d70\u5316\u6027<\/h3>\n<p>\u30d2\u30c8\u3092\u306f\u3058\u3081\u591a\u304f\u306e\u52d5\u7269\u306f\u6027\u3092\u6301\u3061\u3001\u96c4\u7531\u6765\u306e\u7cbe\u5b50\u3068\u96cc\u7531\u6765\u306e\u5375\u3068\u304c\u53d7\u7cbe\u3068\u3044\u3046\u878d\u5408\u3092\u304a\u3053\u3059\u3053\u3068\u306b\u3088\u3063\u3066\u65b0\u3057\u3044\u4e16\u4ee3\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u3002\u305d\u306e\u904e\u7a0b\u3067\u7cbe\u5b50\u306f\u5375\u3092\u63a2\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u7cbe\u5b50\u306f\u96c4\u306e\u4f53\u5916\u306b\u51fa\u308b\u3068\u308f\u305a\u304b\u306a\u6642\u9593\u3057\u304b\u904b\u52d5\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u305d\u3053\u3067\u7cbe\u5b50\u304c\u5375\u306b\u7121\u4e8b\u305f\u3069\u308a\u7740\u3051\u308b\u3088\u3046\u306b\u3001\u5375\u307e\u305f\u306f\u96cc\u6027\u5668\u5b98\u304c\u81ea\u8eab\u306e\u5834\u6240\u3092\u793a\u3059\u5316\u5b66\u7269\u8cea\u3092\u653e\u51fa\u3057\u3001\u305d\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u624b\u304c\u304b\u308a\u306b\u7cbe\u5b50\u304c\u5375\u307e\u3067\u8a98\u5c0e\u3055\u308c\u308b\u73fe\u8c61\u304c\u898b\u3089\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u7cbe\u5b50\u8d70\u5316\u6027\u3068\u547c\u3070\u308c\u3001\u690d\u7269\u304b\u3089\u52d5\u7269\u307e\u3067\u5e83\u304f\u898b\u3089\u308c\u308b\u73fe\u8c61\u3067\u3001\u7279\u306b\u6d77\u6c34\u4e2d\u306b\u653e\u5375\u30fb\u653e\u7cbe\u3092\u884c\u3063\u3066\u4f53\u5916\u53d7\u7cbe\u3092\u884c\u3046\u6d77\u7523\u52d5\u7269\u3067\u9855\u8457\u306b\u898b\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u591a\u304f\u306e\u52d5\u7269\u306b\u304a\u3044\u3066\u7cbe\u5b50\u306e\u8a98\u5f15\u4f5c\u7528\u306f\u7a2e\u7279\u7570\u7684\u3067\u3042\u308a\u3001\u7cbe\u5b50\u8d70\u5316\u6027\u306f\u3001\u7cbe\u5b50\u304c\u540c\u7a2e\u306e\u5375\u3068\u51fa\u4f1a\u3046\u78ba\u7387\u3092\u4e0a\u3052\u308b\u4ed5\u7d44\u307f\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u3068\u7cbe\u5b50\u306e\u904b\u52d5<\/h3>\n<p>\u8d70\u5316\u6027\u304c\u591a\u304f\u306e\u52d5\u7269\u3067\u77e5\u3089\u308c\u3066\u3044\u308b\u4e00\u65b9\u3001\u5375\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306f\u3054\u304f\u5fae\u91cf\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u540c\u5b9a\u306f\u96e3\u3057\u304f\u3001\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u304c\u540c\u5b9a\u3055\u308c\u3066\u3044\u308b\u52d5\u7269\u306f\u3001\u30db\u30e4\u3001\u30a6\u30cb\u3001\u30b5\u30f3\u30b4\u3001\u30a2\u30ef\u30d3\u3001\u30d2\u30c8\u30c7\u306a\u3069\u3001\u307e\u306010\u7a2e\u7a0b\u5ea6\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u307e\u305f\u540c\u5b9a\u3055\u308c\u305f\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u6027\u306e\u5927\u304d\u306a\u5206\u5b50\u304b\u3089\u4f4e\u5206\u5b50\u6709\u6a5f\u5316\u5408\u7269\u307e\u3067\u591a\u69d8\u3067\u3042\u308b\u3053\u3068\u3082\u3042\u308a\u3001\u7cbe\u5b50\u8d70\u5316\u6027\u306e\u5206\u5b50\u6a5f\u69cb\u306f\u307e\u3060\u3042\u307e\u308a\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u306a\u304b\u3067\u3001\u7814\u7a76\u304c\u826f\u304f\u9032\u3093\u3067\u3044\u308b\u52d5\u7269\u304c\u3001\u68d8\u76ae\u52d5\u7269\u3067\u3042\u308b\u30a6\u30cb\u306e\u4e00\u7a2e \uff08<em>Arbacia puncturata<\/em>\uff09\uff08\u5927\u897f\u6d0b\u7523\u306e\u30a6\u30cb\uff09\u3068\u3001\u5c3e\u7d22\u52d5\u7269\u3067\u3042\u308b\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\uff08<em>Ciona intestinalis<\/em>\uff09\u3067\u3059\u3002<\/p>\n<p>\u8d70\u5316\u6027\u904b\u52d5\u6642\u306e\u7cbe\u5b50\u306f\u3089\u305b\u3093\u904b\u52d5\u3092\u3057\u306a\u304c\u3089\u6bb5\u3005\u3068\u5375\u3078\u8fd1\u3065\u3044\u3066\u3044\u304d\u307e\u3059\u304c\u3001\u305d\u306e\u969b\u3001\u8a98\u5f15\u6e90\u304b\u3089\u9060\u3056\u304b\u308b\u3068\u904a\u6cf3\u65b9\u5411\u304c\u6025\u6fc0\u306b\u5909\u5316\u3057\u3001\u5f15\u304d\u7d9a\u3044\u3066\u8a98\u5f15\u6e90\u65b9\u5411\u3078\u3068\u76f4\u9032\u3059\u308b\u3068\u3044\u3046\u7279\u5fb4\u7684\u306a\u65b9\u5411\u8ee2\u63db\uff08\u30bf\u30fc\u30f3\uff09\u3092\u884c\u3044\u307e\u3059\u3002\u3053\u306e\u300c\u30bf\u30fc\u30f3\u300d\u306e\u969b\u306b\u3001\u7cbe\u5b50\u97ad\u6bdb\u5185\u3067Ca<sup>2+<\/sup>\u306e\u4e00\u904e\u7684\u306a\u4e0a\u6607\uff08Ca<sup>2+<\/sup>\u30d0\u30fc\u30b9\u30c8\uff09\u304c\u304a\u3053\u308a\u3001\u305d\u308c\u304c\u97ad\u6bdb\u6ce2\u5f62\u3092\u77ac\u6642\u306b\u5909\u5316\u3055\u305b\u3001\u904a\u6cf3\u65b9\u5411\u306e\u8ee2\u63db\u3092\u884c\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u30a6\u30cb\u3084\u30db\u30e4\u3067\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u30a6\u30cb\u306b\u304a\u3051\u308b\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306f\u5375\u306e\u5468\u308a\u306b\u3042\u308b\u30bc\u30ea\u30fc\u5c64\u306b\u542b\u307e\u308c\u308b\u30da\u30d7\u30c1\u30c9\u3067\u3042\u308a\u3001\u3053\u308c\u306b\u3088\u3063\u3066\u7cbe\u5b50\u304c\u8a98\u5f15\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30da\u30d7\u30c1\u30c9\u306f\u3001\u7cbe\u5b50\u306e\u53d7\u5bb9\u4f53\u3067\u3042\u308b\u30b0\u30a2\u30cb\u30eb\u9178\u30b7\u30af\u30e9\u30fc\u30bc\uff08cGMP\u306e\u5408\u6210\u9175\u7d20\uff09\u3092\u6d3b\u6027\u5316\u3057\u3066cGMP\u3092\u4f5c\u308a\u51fa\u3057\u3001cGMP\u306f\u6700\u7d42\u7684\u306bCa<sup>2+<\/sup>\u30c1\u30e3\u30cd\u30eb\u306eCatSper\u3092\u958b\u53e3\u3055\u305b\u308b\u3053\u3068\u304c\u3053\u308c\u307e\u3067\u306b\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4e00\u65b9\u3001\u30db\u30e4\u306e\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306f\u3001\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\u304a\u3088\u3073\u30b9\u30b8\u30ad\u30ec\u30dc\u30e4\uff08<em>Ascidia sydneiensis<\/em>\uff09\u306b\u304a\u3044\u3066\u300cSAAF\uff08Sperm-Activating and -Attracting Factor\uff09\u300d\u3068\u547c\u3070\u308c\u308b\u30b9\u30c6\u30ed\u30a4\u30c9\u8a98\u5c0e\u4f53\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_9483\" aria-describedby=\"caption-attachment-9483\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9483\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/001-5.jpg\" alt=\"\" width=\"600\" height=\"376\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/001-5.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/001-5-300x188.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/001-5-239x150.jpg 239w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9483\" class=\"wp-caption-text\">\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\u304a\u3088\u3073\u30b9\u30b8\u30ad\u30ec\u30dc\u30e4\u306b\u304a\u3051\u308b\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u300cSAAF\u300d\u306e\u69cb\u9020<\/figcaption><\/figure>\n<p>\u30db\u30e4\u3067\u306f\u7cbe\u5b50\u306e\u53d7\u5bb9\u4f53\u306f\u4e0d\u660e\u3067\u3057\u305f\u304c\u3001\u30b0\u30a2\u30cb\u30eb\u9178\u30b7\u30af\u30e9\u30fc\u30bc\u304c\u7cbe\u5b50\u8d70\u5316\u6027\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u306f\u5426\u5b9a\u7684\u306b\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30db\u30e4\u3092\u542b\u3081\u3001\u30a6\u30cb\u4ee5\u5916\u306e\u52d5\u7269\u3067\u306f\u3069\u306e\u3088\u3046\u306b\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u304cCa<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u306e\u304b\u306f\u9577\u5e74\u306e\u8b0e\u3067\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u304cCa<sup>2+<\/sup>\u30c1\u30e3\u30cd\u30eb\u306e\u958b\u53e3\u306b\u3064\u306a\u304c\u308b\u3068\u3059\u308b\u3068\u3001\u306a\u305c\u7cbe\u5b50\u304c\u5375\u304b\u3089\u9060\u3056\u304b\u308b\u969b\u306bCa<sup>2+<\/sup>\u30d0\u30fc\u30b9\u30c8\u3092\u5f15\u304d\u8d77\u3053\u3059\u306e\u304b\u3001\u305d\u306e\u4ed5\u7d44\u307f\u3082\u8aac\u660e\u304c\u3064\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h3>\u30db\u30e4\u306e\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306fCa<sup>2+<\/sup>\u30dd\u30f3\u30d7\u306b\u4f5c\u7528\u3059\u308b<\/h3>\n<p>\u3053\u306e\u7591\u554f\u3092\u89e3\u6d88\u3059\u308b\u305f\u3081\u3001\u6211\u3005\u306f\u3001\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\u306b\u304a\u3044\u3066\u7cbe\u5b50\u8a98\u5f15\u7269\u8ceaSAAF\u304c\u3069\u306e\u3088\u3046\u306b\u7cbe\u5b50\u306b\u50cd\u304d\u304b\u3051\u308b\u304b\u306e\u89e3\u660e\u3092\u9032\u3081\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\u3067\u306fSAAF\u306f\u7cbe\u5b50\u819c\u306b\u5b58\u5728\u3059\u308bCa<sup>2+<\/sup>\u30dd\u30f3\u30d7\u3067\u3042\u308b\u300cPMCA\uff08Plasma Membrane Ca<sup>2+<\/sup>-ATPase\uff09\u300d\u3068\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>PMCA\u306f\u7cbe\u5b50\u97ad\u6bdb\u306b\u591a\u91cf\u306b\u5b58\u5728\u3057\u3001SAAF\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u9175\u7d20\u6d3b\u6027\u304c\u4e0a\u6607\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001PMCA\u306e\u963b\u5bb3\u5264\u3092\u7cbe\u5b50\u306b\u4f5c\u7528\u3055\u305b\u308b\u3068\u3001SAAF\u306b\u5bfe\u3059\u308b\u8d70\u5316\u6027\u3092\u793a\u3055\u306a\u304f\u306a\u308b\u3053\u3068\u3001\u305d\u306e\u969b\u306b\u306f\u7cbe\u5b50\u5185\u306eCa<sup>2+<\/sup>\u6fc3\u5ea6\u304c\u9ad8\u3044\u307e\u307e\u306b\u4fdd\u305f\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u3001\u30ab\u30bf\u30e6\u30a6\u30ec\u30a4\u30dc\u30e4\u306e\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u306f\u3001\u7cbe\u5b50\u7d30\u80de\u819c\u306b\u3042\u308bCa<sup>2+<\/sup>\u30dd\u30f3\u30d7\uff08PMCA\uff09\u306b\u4f5c\u7528\u3057\u3001\u7cbe\u5b50\u5185\u306eCa<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u7cbe\u5b50\u8a98\u5f15\u7269\u8ceaSAAF\u306f\u3001\u7cbe\u5b50\u306b\u4f5c\u7528\u3057\u3066\u3044\u308b\u3042\u3044\u3060\u306fPMCA\u3092\u6d3b\u6027\u5316\u3057\u3066\u7cbe\u5b50\u5185\u306eCa<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u4e0b\u3052\u308b\u65b9\u5411\u306b\u50cd\u3044\u3066\u304a\u308a\u3001\u7cbe\u5b50\u304c\u8a98\u5f15\u6e90\u3088\u308a\u9060\u3056\u304b\u308a\u3001\u8a98\u5f15\u7269\u8cea\u306e\u6fc3\u5ea6\u304c\u6e1b\u5c11\u3059\u308b\u3068PMCA\u306e\u4e0d\u6d3b\u6027\u5316\u306b\u3088\u308aCa<sup>2+<\/sup>\u6392\u51fa\u304c\u6b62\u307e\u308a\u3001\u7d50\u679c\u7684\u306bCa<sup>2+<\/sup>\u30d0\u30fc\u30b9\u30c8\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7e4a\u7d30\u306a\u5236\u5fa1\u306f\u3001SAAF\u3068PMCA\u306e\u201c\u5f31\u3044\u201d\u7d50\u5408\u306b\u3088\u3063\u3066\u3082\u305f\u3089\u3055\u308c\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_9484\" aria-describedby=\"caption-attachment-9484\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9484\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/002-7.jpg\" alt=\"\" width=\"600\" height=\"426\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/002-7.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/002-7-300x213.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/12\/002-7-211x150.jpg 211w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9484\" class=\"wp-caption-text\">\u7cbe\u5b50\u8d70\u5316\u6027\u306b\u304a\u3051\u308b\u7cbe\u5b50\u819c\u306eCa<sup>2+<\/sup>\u30dd\u30f3\u30d7\uff08PMCA\uff09\u306e\u50cd\u304d\u3068\u7cbe\u5b50\u5185\u306e\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u5909\u5316\u306e\u4eee\u8aac<\/figcaption><\/figure>\n<p>\u5f93\u6765\u3001\u7d30\u80de\u819c\u306eCa<sup>2+<\/sup>\u30dd\u30f3\u30d7\u306b\u306fCa<sup>2+<\/sup>\u6d41\u5165\u3067\u8d77\u3053\u3063\u305f\u60c5\u5831\u4f1d\u9054\u3092\u7d42\u4e86\u3055\u305b\u308b\u305f\u3081\u306b\u3001\u7d30\u80de\u5916\u3078Ca<sup>2+<\/sup>\u3092\u6392\u51fa\u3059\u308b\u5f79\u5272\u304c\u3042\u308b\u3053\u3068\u3057\u304b\u308f\u304b\u3063\u3066\u304a\u3089\u305a\u3001\u7a4d\u6975\u7684\u306b\u30b7\u30b0\u30ca\u30eb\u3092\u751f\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u306e\u306f\u521d\u3081\u3066\u3067\u3059\u3002<\/p>\n<p>\u4eca\u5f8c\u3001\u7cbe\u5b50\u8a98\u5f15\u7269\u8cea\u3068Ca<sup>2+<\/sup>\u30dd\u30f3\u30d7\u306e\u76f8\u4e92\u4f5c\u7528\u306e\u7a2e\u7279\u7570\u6027\u3084\u3001Ca<sup>2+<\/sup>\u306e\u8a73\u7d30\u306a\u8abf\u7bc0\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5375\u306b\u5bfe\u3059\u308b\u7cbe\u5b50\u8d70\u5316\u6027\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u8a73\u7d30\u3068\u305d\u306e\u9032\u5316\u306e\u7406\u89e3\u3092\u9032\u3081\u308b\u3068\u540c\u6642\u306b\u3001\u7d30\u80de\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u5916\u90e8\u304b\u3089\u5236\u5fa1\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u624b\u6cd5\u306e\u958b\u767a\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>\u53d7\u7cbe\u306b\u304a\u3051\u308b\u7a2e\u7279\u7570\u6027\u306e\u5206\u5b50\u6a5f\u69cb\u89e3\u660e\u306b\u5411\u3051\u3066<\/h3>\n<p>\u672c\u7814\u7a76\u306b\u3088\u308a\u3001\u7cbe\u5b50\u8d70\u5316\u6027\u306b\u304a\u3044\u3066\u8a98\u5f15\u7269\u8cea\u304c\u7cbe\u5b50\u5185Ca<sup>2+<\/sup>\u6fc3\u5ea6\u3092\u8abf\u7bc0\u3059\u308b\u3057\u304f\u307f\u306e\u4e00\u7aef\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u8a98\u5f15\u7269\u8cea\u304cCa<sup>2+<\/sup>\u6fc3\u5ea6\u306e\u6e1b\u5c11\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3067\u3001\u7cbe\u5b50\u304c\u8a98\u5f15\u7269\u8cea\u306e\u6e1b\u5c11\u3068\u3044\u3046\u8ca0\u306e\u6fc3\u5ea6\u5909\u5316\u306e\u611f\u77e5\u3092\u53ef\u80fd\u3068\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u3001\u3053\u308c\u307e\u3067\u306e\u5e38\u8b58\u3092\u8986\u3059\u8208\u5473\u6df1\u3044\u7d50\u679c\u3092\u5f97\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001Ca<sup>2+<\/sup>\u6fc3\u5ea6\u306e\u4e0a\u6607\u306b\u95a2\u4e0e\u3059\u308b\u30c1\u30e3\u30cd\u30eb\u306e\u540c\u5b9a\u3084\u3001Ca<sup>2+<\/sup>\u306b\u3088\u308b\u97ad\u6bdb\u6ce2\u5f62\u306e\u5236\u5fa1\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u3067\u3001\u9577\u5e74\u306e\u8b0e\u3067\u3042\u3063\u305f\u7cbe\u5b50\u904b\u52d5\u306e\u5236\u5fa1\u30b7\u30b9\u30c6\u30e0\u304c\u89e3\u660e\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u7cbe\u5b50\u8d70\u5316\u6027\u306b\u306f\u7a2e\u7279\u7570\u6027\u304c\u3042\u308a\u3001\u30db\u30e4\u306b\u304a\u3044\u3066\u3082\u7cbe\u5b50\u8a98\u5f15\u7269\u8ceaSAAF\u306e\u69cb\u9020\u306f\u7a2e\u306b\u3088\u3063\u3066\u5fae\u5999\u306b\u7570\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304a\u308a\u3001\u3055\u3089\u306b\u30a6\u30cb\u306e\u7cbe\u5b50\u8d70\u5316\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u306f\u5927\u304d\u304f\u7570\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u4eca\u5f8c\u306f\u3001\u53d7\u7cbe\u306e\u5206\u5b50\u6a5f\u69cb\u304c\u3069\u306e\u3088\u3046\u306b\u9032\u5316\u3057\u7a2e\u5206\u5316\u3057\u3066\u304d\u305f\u304b\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u3001SAAF\u3068PMCA\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u7a2e\u7279\u7570\u6027\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u3001\u3055\u3089\u306b\u306f\u4ed6\u306e\u52d5\u7269\u3068\u306e\u30b7\u30b0\u30ca\u30eb\u7cfb\u306e\u6bd4\u8f03\u3092\u9032\u3081\u3066\u884c\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u7cbe\u5b50\u306e\u8d70\u5316\u6027 \u30d2\u30c8\u3092\u306f\u3058\u3081\u591a\u304f\u306e\u52d5\u7269\u306f\u6027\u3092\u6301\u3061\u3001\u96c4\u7531\u6765\u306e\u7cbe\u5b50\u3068\u96cc\u7531\u6765\u306e\u5375\u3068\u304c\u53d7\u7cbe\u3068\u3044\u3046\u878d\u5408\u3092\u304a\u3053\u3059\u3053\u3068\u306b\u3088\u3063\u3066\u65b0\u3057\u3044\u4e16\u4ee3\u3092\u751f\u307f\u51fa\u3057\u307e\u3059\u3002\u305d\u306e\u904e\u7a0b\u3067\u7cbe\u5b50\u306f\u5375\u3092\u63a2\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u304c\u3001\u7cbe\u5b50\u306f\u96c4\u306e\u4f53\u5916\u306b\u51fa\u308b\u3068 [&hellip;]<\/p>\n","protected":false},"author":361,"featured_media":9492,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[22,69,101,15],"class_list":["post-9486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-22","tag-69","tag-101","tag-biology","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9486","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/361"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9486"}],"version-history":[{"count":11,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9486\/revisions"}],"predecessor-version":[{"id":9510,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9486\/revisions\/9510"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/9492"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9486"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9486"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9486"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}