{"id":9212,"date":"2018-12-05T10:00:11","date_gmt":"2018-12-05T01:00:11","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=9212"},"modified":"2018-12-04T10:18:49","modified_gmt":"2018-12-04T01:18:49","slug":"%e6%b5%b7%e6%b0%b4%e9%ad%9a%e3%81%ae%e6%b5%b8%e9%80%8f%e5%9c%a7%e8%aa%bf%e6%95%b4%e7%89%a9%e8%b3%aa%e3%81%af%e6%b0%b4%e4%b8%ad%e3%81%a7%e6%b0%b4%e7%b4%a0%e7%b5%90%e5%90%88%e3%81%97%e3%81%aa%e3%81%84","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=9212","title":{"rendered":"\u6d77\u6c34\u9b5a\u306e\u6d78\u900f\u5727\u8abf\u6574\u7269\u8cea\u306f\u6c34\u4e2d\u3067\u6c34\u7d20\u7d50\u5408\u3057\u306a\u3044\uff1f &#8211; 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id=\"attachment_9213\" aria-describedby=\"caption-attachment-9213\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9213\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/001-7.jpg\" alt=\"\" width=\"600\" height=\"384\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/001-7.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/001-7-300x192.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/001-7-234x150.jpg 234w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9213\" class=\"wp-caption-text\">\u6d77\u6c34\u9b5a\u306e\u7d30\u80de\u5185\u306b\u542b\u307e\u308c\u308bTMAO\u3068\u5c3f\u7d20\uff08Y. Nagata \/ MPI-P (CC-BY-SA)\uff09<\/figcaption><\/figure>\n<h3>\u9ad8\u7cbe\u5ea6\u5206\u5b50\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3067\u8ffd\u3046\u5206\u5b50\u306e\u52d5\u304d\u3068\u5b89\u5b9a\u69cb\u9020<\/h3>\n<p>TMAO\u3068\u5c3f\u7d20\u306f\u6c34\u7d20\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u3053\u306e\u8b0e\u3092\u89e3\u304f\u305f\u3081\u3001\u6c34\u306b\u6eb6\u304b\u3057\u305fTMAO\u3068\u5c3f\u7d20\u306e\u5206\u5b50\u9593\u76f8\u4e92\u4f5c\u7528\u3092\u7406\u8ad6\u3068\u5b9f\u9a13\u306e\u4e21\u65b9\u3092\u7528\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u6c34\u4e2d\u306e\u5206\u5b50\u306f\u975e\u5e38\u306b\u65e9\u304f\u52d5\u304f\u305f\u3081\u3001\u305d\u306e\u7d50\u5408\u72b6\u614b\u3092\u8abf\u3079\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u56f0\u96e3\u3067\u3042\u308b\u3068\u3044\u3046\u554f\u984c\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u306f\u3058\u3081\u306b\u9ad8\u7cbe\u5ea6\u306e\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u30b7\u30df\u30e5\u30ec\u30fc\u30b7\u30e7\u30f3\u3092\u7528\u3044\u3066\u3001\u6c34\u4e2d\u306eTMAO\u3068\u5c3f\u7d20\u304c\u3069\u306e\u3088\u3046\u306b\u7d50\u5408\u3059\u308b\u304b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002<\/p>\n<p>\u7528\u3044\u305f\u624b\u6cd5\u306f\u5168\u539f\u5b50\u5206\u5b50\u52d5\u529b\u5b66\u6cd5\u3068\u547c\u3070\u308c\u3001\u30cb\u30e5\u30fc\u30c8\u30f3\u65b9\u7a0b\u5f0f\u306b\u5f93\u3063\u3066\u539f\u5b50\u306e\u4f4d\u7f6e\u3092\u6642\u9593\u767a\u5c55\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u5206\u5b50\u306e\u52d5\u304d\u3092\u8ffd\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u624b\u6cd5\u3067\u3059\u3002\u539f\u5b50\u306b\u50cd\u304f\u529b\u3092\u8a08\u7b97\u3059\u308b\u305f\u3081\u306b\u7d4c\u9a13\u7684\u30d1\u30e9\u30e1\u30fc\u30bf\u3092\u7528\u3044\u305f\u53e4\u5178\u5206\u5b50\u52d5\u529b\u5b66\u6cd5\uff08\u53e4\u5178MD\uff09\u304c\u5e83\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u4eca\u56de\u306f\u30b7\u30e5\u30ec\u30c7\u30a3\u30f3\u30ac\u30fc\u65b9\u7a0b\u5f0f\u3092\u89e3\u3044\u3066\u539f\u5b50\u306b\u50cd\u304f\u529b\u3092\u8a08\u7b97\u3059\u308b\u7b2c\u4e00\u539f\u7406\u5206\u5b50\u52d5\u529b\u5b66\u6cd5\uff08<em>ab initio<\/em> molecular dynamics, AIMD\uff09\u3092\u6c34\u4e2d\u306eTMAO\u3068\u5c3f\u7d20\u306b\u521d\u3081\u3066\u9069\u7528\u3057\u307e\u3057\u305f\u3002\u8a08\u7b97\u30b3\u30b9\u30c8\u304c\u975e\u5e38\u306b\u5927\u304d\u3044\u305f\u3081\u3001\u30b9\u30fc\u30d1\u30fc\u30b3\u30f3\u30d4\u30e5\u30fc\u30bf\u30fc\u3092\u7528\u3044\u305f\u81a8\u5927\u306a\u91cf\u306e\u8a08\u7b97\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u8a08\u7b97\u306e\u7d50\u679c\u3001\u56f3\u306b\u793a\u3059\u3088\u3046\u306b\u3001AIMD\u3067\u306f\u3053\u308c\u307e\u3067\u306e\u7406\u89e3\u3068\u53cd\u3057\u3001TMAO\u3068\u5c3f\u7d20\u304c\u76f4\u63a5\u6c34\u7d20\u7d50\u5408\u3059\u308b\u69cb\u9020\u306f\u4e0d\u5b89\u5b9a\u3067\u3042\u308b\u3068\u3044\u3046\u7d50\u679c\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_9214\" aria-describedby=\"caption-attachment-9214\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-9214\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/002-7.jpg\" alt=\"\" width=\"600\" height=\"399\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/002-7.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/002-7-300x200.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/002-7-226x150.jpg 226w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/11\/002-7-480x320.jpg 480w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-9214\" class=\"wp-caption-text\">TMAO\u3068\u5c3f\u7d20\u306e\u81ea\u7531\u30a8\u30cd\u30eb\u30ae\u30fc\u30c0\u30a4\u30a2\u30b0\u30e9\u30e0<br 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Jun Xie, Seoncheol Cha, Tatsuhiko Ohto, Wataru Mizukami, Yuezhi Mao, Manfred Wagner, Mischa Bonn, Johannes Hunger, and Yuki Nagata, Large Hydrogen Bond Mismatch between TMAO and Urea Promotes Their Hydrophobic Association, <em>Chem<\/em> <strong>4<\/strong>, 2615 (2018)<\/li>\n<li>Tatsuhiko Ohto, Johannes Hunger, Ellen H. G. Backus, Wataru Mizukami, Mischa Bonn, and Yuki Nagata, Trimethylamin-N-oxide: Hydration structure, surface activity, and biological function viewed by vibrational spectroscopy and molecular dynamics simulations, <em>Phys. Chem. Chem. Phys<\/em>. <strong>19<\/strong>, 6909 (2017)<\/li>\n","protected":false},"excerpt":{"rendered":"<p>\u6d77\u6c34\u9b5a\u306e\u6d78\u900f\u5727\u8abf\u7bc0\u7269\u8cea\u3068\u306f\uff1f \u6d77\u6c34\u306f3.5%\u7a0b\u5ea6\u306e\u5869\u5206\u3092\u542b\u3093\u3067\u304a\u308a\u3001\u305d\u306e\u6fc3\u5ea6\u306f\u4e00\u822c\u7684\u306a\u751f\u7269\u306e\u4f53\u6db2\uff08\u305f\u3068\u3048\u3070\u4eba\u4f53\u3067\u306f0.9%\uff09\u3088\u308a\u3082\u9ad8\u3044\u305f\u3081\u3001\u6d77\u6c34\u4e2d\u306b\u751f\u7269\u306e\u7d30\u80de\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u305d\u306e\u307e\u307e\u3067\u306f\u5869\u304c\u91ce\u83dc\u306b\u6d78\u900f\u3057 [&hellip;]<\/p>\n","protected":false},"author":356,"featured_media":9213,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[98,20,14,15,63],"class_list":["post-9212","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-98","tag-20","tag-physics","tag-biology","tag-63","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9212","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/356"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=9212"}],"version-history":[{"count":10,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9212\/revisions"}],"predecessor-version":[{"id":9245,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/9212\/revisions\/9245"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/9213"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=9212"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=9212"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=9212"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}