{"id":7415,"date":"2018-05-07T10:00:22","date_gmt":"2018-05-07T01:00:22","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=7415"},"modified":"2019-04-04T17:37:43","modified_gmt":"2019-04-04T08:37:43","slug":"%e8%88%8c%e3%81%a0%e3%81%91%e3%81%a7%e3%81%af%e3%81%aa%e3%81%84%ef%bc%81-%e4%bd%93%e3%82%92%e5%ae%88%e3%82%8b%e5%91%b3%e7%b4%b0%e8%83%9e-%e7%94%9f%e4%bd%93%e9%98%b2%e5%be%a1%e3%81%ab%e9%96%a2","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=7415","title":{"rendered":"\u820c\u3060\u3051\u3067\u306f\u306a\u3044\uff01 \u4f53\u3092\u5b88\u308b\u5473\u7d30\u80de &#8211; \u751f\u4f53\u9632\u5fa1\u306b\u95a2\u308f\u308b\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u30de\u30b9\u30bf\u30fc\u56e0\u5b50\u3092\u767a\u898b"},"content":{"rendered":"<h3>\u820c\u3060\u3051\u3067\u306f\u306a\u3044\uff01 \u5168\u8eab\u306b\u5206\u5e03\u3059\u308b\u5473\uff08\u5316\u5b66\u7269\u8cea\uff09\u3092\u611f\u3058\u308b\u7d30\u80de<\/h3>\n<p>\u79c1\u305f\u3061\u306f\u98df\u3079\u7269\u3092\u53e3\u306b\u5165\u308c\u308b\u3068\u5473\u3092\u611f\u3058\u307e\u3059\u3002\u5473\u899a\u306f\u3001\u820c\u306e\u5473\u857e\u306b\u542b\u307e\u308c\u308b\u5473\u7d30\u80de\u304c\u5473\u3092\u5448\u3059\u308b\u7269\u8cea\u3092\u691c\u51fa\u3057\u3066\u3001\u305d\u306e\u60c5\u5831\u3092\u8133\u306e\u5927\u8133\u76ae\u8cea\u306e\u5473\u899a\u91ce\u306b\u9001\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u3058\u307e\u3059\u3002\u5473\u899a\u306f\u7518\u5473\u3001\u82e6\u5473\u3001\u65e8\u5473\u3001\u9178\u5473\u3001\u5869\u5473\u306e\u57fa\u672c\u4e94\u5473\u306b\u5206\u985e\u3067\u304d\u3001\u79c1\u305f\u3061\u306f\u7518\u5473\u30fb\u65e8\u5473\u30fb\u8584\u3044\u5869\u5473\u3092\u7f8e\u5473\u3057\u3044\u3068\u611f\u3058\u3001\u82e6\u5473\u30fb\u9178\u5473\u30fb\u6fc3\u3044\u5869\u5473\u3092\u4e0d\u5473\u3044\u3068\u611f\u3058\u307e\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u3001\u5473\u7d30\u80de\u306b\u826f\u304f\u4f3c\u305f\u7279\u5fb4\u3092\u6301\u3063\u305f\u7d30\u80de\u304c\u3001\u6c17\u9053\u3084\u6d88\u5316\u7ba1\u3092\u306f\u3058\u3081\u4f53\u306e\u3055\u307e\u3056\u307e\u306a\u5668\u5b98\u306b\u304a\u3044\u3066\u898b\u3064\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u306f\u3001\u7518\u5473\u30fb\u65e8\u5473\u30fb\u82e6\u5473\u306e\u77e5\u899a\u306b\u5fc5\u8981\u306a\u30a4\u30aa\u30f3\u30c1\u30e3\u30cd\u30ebTrpm5\u3092\u5171\u901a\u3057\u3066\u767a\u73fe\u3057\u3001\u5473\u53d7\u5bb9\u4f53\u3092\u6709\u3057\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3067\u306f\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306f\u3001\u3069\u3093\u306a\u5473\uff08\u5316\u5b66\u7269\u8cea\uff09\u3092\u611f\u3058\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<h3>\u6709\u5bb3\u7269\u8cea\u304b\u3089\u4f53\u3092\u5b88\u308b<\/h3>\n<p>\u4e00\u822c\u306b\u3001\u82e6\u5473\u3092\u5448\u3059\u308b\u7269\u8cea\u306f\u751f\u4f53\u306b\u3068\u3063\u3066\u6709\u5bb3\u306a\u6210\u5206\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u82e6\u3044\u3082\u306e\u3092\u53e3\u306b\u3059\u308b\u3068\u5410\u304d\u51fa\u3057\u3001\u5916\u306b\u51fa\u305d\u3046\u3068\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u4e00\u7a2e\u306e\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u3068\u3044\u3048\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u5168\u8eab\u306b\u5206\u5e03\u3059\u308bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u591a\u304f\u306f\u3001\u201d\u82e6\u5473\u201d\u306e\u53d7\u5bb9\u4f53\u3092\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u304c\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u6700\u8fd1\u306e\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u304b\u3089\u3001\u9f3b\u3084\u53e3\u8154\u5185\u306e\u547c\u5438\u4e0a\u76ae\u306b\u7d30\u83cc\u304c\u4fb5\u5165\u3059\u308b\u3068\u3001\u7d30\u83cc\u304c\u5206\u6ccc\u3059\u308b\u82e6\u5473\u7269\u8cea\u3092Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u691c\u77e5\u3057\u3001\u4f53\u306e\u5965\u6df1\u304f\u306b\u6709\u5bb3\u7269\u8cea\u3092\u4fb5\u3055\u305b\u306a\u3044\u3088\u3046\u306b\u547c\u5438\u3092\u6291\u5236\u3057\u305f\u308a\u3001\u708e\u75c7\u53cd\u5fdc\u3092\u8a98\u5c0e\u3059\u308b\u3068\u3044\u3063\u305f\u3001\u521d\u671f\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_7412\" aria-describedby=\"caption-attachment-7412\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-7412\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/001-6.jpg\" alt=\"\" width=\"600\" height=\"464\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/001-6.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/001-6-300x232.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-7412\" class=\"wp-caption-text\">\u9f3b\u306e\u4e2d\u306b\u82e6\u5473\u7269\u8cea\u3084\u7d30\u83cc\u306a\u3069\u306e\u6709\u5bb3\u7269\u8cea\u304c\u5165\u308a\u8fbc\u3080\u3068\u3001\u9f3b\u8154\u4e0a\u76ae\u306b\u3042\u308bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u82e6\u5473\u53d7\u5bb9\u4f53\u3092\u7528\u3044\u3066\u305d\u308c\u3089\u3092\u691c\u51fa\u3057\u3001\u547c\u5438\u56de\u6570\u306e\u5236\u5fa1\u3084\u708e\u75c7\u53cd\u5fdc\u3068\u3044\u3063\u305f\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u3092\u8a98\u5c0e\u3059\u308b\u3002<\/figcaption><\/figure>\n<p>\u307e\u305f\u4eba\u9593\u3082\u9f3b\u8154\u5185\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u3092\u4f7f\u3063\u3066\u7d30\u83cc\u306e\u5897\u6b96\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u5168\u8eab\u306b\u5206\u5e03\u3059\u308bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u6b63\u5e38\u306b\u4f5c\u308a\u3060\u3055\u308c\u306a\u3051\u308c\u3070\u3001\u7d30\u83cc\u306e\u4f53\u3078\u306e\u4fb5\u5165\u3092\u8a31\u3057\u3001\u7d30\u83cc\u304c\u4f53\u306e\u4e2d\u3067\u5897\u6b96\u3059\u308b\u3053\u3068\u3067\u611f\u67d3\u75c7\u3084\u6162\u6027\u526f\u9f3b\u8154\u708e\u306a\u3069\u306e\u75c5\u6c17\u306b\u304b\u304b\u3063\u3066\u3057\u307e\u3046\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u4f5c\u308a\u51fa\u3055\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3057\u3001\u305d\u308c\u3089\u304c\u3069\u306e\u3088\u3046\u306a\u201d\u5473\uff08\u5316\u5b66\u7269\u8cea\uff09\u201d\u3092\u611f\u3058\u3068\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u306f\u3001\u7d30\u83cc\u3084\u5bc4\u751f\u866b\u3078\u306e\u611f\u67d3\u306b\u5bfe\u3059\u308b\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u8ab2\u984c\u3067\u3059\u3002<\/p>\n<h3>\u8ee2\u5199\u56e0\u5b50Skn-1a<\/h3>\n<p>\u820c\u3067\u306f\u57fa\u672c\u4e94\u5473\u3092\u611f\u3058\u308b\u7d30\u80de\u306e\u3046\u3061\u3001\u7518\u5473\u30fb\u65e8\u5473\u30fb\u82e6\u5473\u3092\u611f\u77e5\u3059\u308b\u7d30\u80de\u306e\u7523\u751f\u306b\u306f\u8ee2\u5199\u56e0\u5b50Skn-1a\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002Skn-1a\u306e\u6a5f\u80fd\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u7518\u5473\u30fb\u65e8\u5473\u30fb\u82e6\u5473\u7d30\u80de\u304c\u306a\u304f\u306a\u308a\u3001\u305d\u306e\u4ee3\u308f\u308a\u306b\u9178\u5473\u7d30\u80de\u306e\u6570\u304c\u5897\u3048\u307e\u3059\u3002Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u5473\u899a\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3001\u5f62\u614b\u7684\u306b\u3082\u7518\u5473\u30fb\u65e8\u5473\u30fb\u82e6\u5473\u7d30\u80de\u306b\u4f3c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u79c1\u305f\u3061\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u5168\u8eab\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306b\u3082Skn-1a\u304c\u767a\u73fe\u3057\u3001\u305d\u306e\u7523\u751f\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067in situ hybridization\u3068\u547c\u3070\u308c\u308b\u3001\u7d44\u7e54\u4e2d\u306emRNA\u3092\u691c\u51fa\u3059\u308b\u65b9\u6cd5\u3067Skn-1a\u907a\u4f1d\u5b50\u304c\u3069\u306e\u3088\u3046\u306a\u7d30\u80de\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u304b\u3092\u30de\u30a6\u30b9\u306e\u7d44\u7e54\u306b\u304a\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u89e3\u6790\u3057\u305f\u5168\u3066\u306e\u5668\u5b98\uff08\u55c5\u4e0a\u76ae\u3001\u6c17\u9053\u3001\u80c3\u3001\u5c0f\u8178\u3001\u5927\u8178\u3001\u8033\u7ba1\u3001\u5c3f\u9053\u3001\u80f8\u817a\u3001\u81b5\u7ba1\uff09\u306b\u304a\u3044\u3066\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306bSkn-1a\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306b\u304a\u3051\u308bSkn-1a\u306e\u6a5f\u80fd\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001Skn-1a\u306e\u907a\u4f1d\u5b50\u3092\u7834\u58ca\u3057\u305f\u3057\u305f\u30de\u30a6\u30b9\uff08Skn-1a\u6a5f\u80fd\u6b20\u640d\u30de\u30a6\u30b9\uff09\u306e\u8868\u73fe\u578b\u3092\u8abf\u3079\u307e\u3057\u305f\u3002Skn-1a\u6a5f\u80fd\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001\u89e3\u6790\u3057\u305f\u3059\u3079\u3066\u306e\u5668\u5b98\u306b\u304a\u3044\u3066Trpm5\u306e\u767a\u73fe\u304c\u6d88\u3048\u3001\u305d\u308c\u306b\u52a0\u3048\u3066Trpm5\u4ee5\u5916\u306e\u5473\u899a\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3082\u6d88\u5931\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001Skn-1a\u304c\u820c\u3060\u3051\u3067\u306a\u304f\u5168\u8eab\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u7523\u751f\u306b\u5fc5\u9808\u306a\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_7411\" aria-describedby=\"caption-attachment-7411\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-7411\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/002-5.jpg\" alt=\"\" width=\"600\" height=\"550\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/002-5.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/002-5-300x275.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-7411\" class=\"wp-caption-text\">(A) in situ hybridization\u306e\u7d50\u679c\u304b\u3089\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u6c17\u7ba1\u4e0a\u76ae\u306b\u304a\u3044\u3066Skn-1a\uff08\u7dd1\uff09\u3068Trpm5\uff08\u30de\u30bc\u30f3\u30bf\uff09\u306f\u5171\u767a\u73fe\u3057\u3066\u304a\u308a\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306bSkn-1a\u304c\u767a\u73fe\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002<br \/>(B) \u91ce\u751f\u578b\u30de\u30a6\u30b9\u6c17\u7ba1\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306b\u306f\u3001\u5473\u899a\u60c5\u5831\u306e\u4f1d\u9054\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\uff08Tas2r:\u82e6\u5473\u53d7\u5bb9\u4f53\u3001Gnat3, Plcb2, Trpm5: \u5473\u899a\u60c5\u5831\u4f1d\u9054\u5206\u5b50\uff09\u304c\u767a\u73fe\u3057\u3066\u3044\u305f\uff08\u4e0a\u6bb5\uff1a\u91ce\u751f\u578b\uff09\u3002\u4e00\u65b9\u3067\u3001Skn-1a\u6a5f\u80fd\u6b20\u640d\u578b\u30de\u30a6\u30b9\uff08\u4e0b\u6bb5\uff1a\u5909\u7570\u578b\uff09\u3067\u306f\u3001\u3053\u308c\u3089\u5473\u899a\u95a2\u9023\u5206\u5b50\u306e\u767a\u73fe\u304c\u6d88\u5931\u3057\u3066\u3044\u305f\u3002Yamashita et al. (2017)\u3092\u5143\u306b\u6539\u5909\u3002<\/figcaption><\/figure>\n<h3>\u4eca\u5f8c\u306e\u5c55\u671b\u306b\u3064\u3044\u3066<\/h3>\n<p>\u4eca\u56de\u306e\u767a\u898b\u306b\u3088\u3063\u3066Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u7523\u751f\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u98db\u8e8d\u7684\u306b\u9032\u5c55\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u5168\u8eab\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u6d88\u5931\u3059\u308bSkn-1a\u6a5f\u80fd\u6b20\u640d\u30de\u30a6\u30b9\u306f\u3001\u5404\u5668\u5b98\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u751f\u7406\u6a5f\u80fd\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306e\u6709\u7528\u306a\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001Skn-1a\u6a5f\u80fd\u6b20\u640d\u578b\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u7814\u7a76\u304b\u3089\u3001\u5c0f\u8178\u306b\u3042\u308bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\uff08tuft cells\u3068\u547c\u3070\u308c\u3066\u3044\u308b\uff09\u306e\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u91ce\u751f\u578b\u3068Skn-1a\u6a5f\u80fd\u6b20\u640d\u578b\u30de\u30a6\u30b9\u306b\u8815\u866b\u306a\u3069\u306e\u5c0f\u8178\u306e\u5bc4\u751f\u866b\u3092\u611f\u67d3\u3055\u305b\u308b\u3068\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306f\u6570\u65e5\u3067\u5bc4\u751f\u866b\u3092\u99c6\u9010\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001Trpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u306a\u3044Skn-1a\u6a5f\u80fd\u6b20\u640d\u578b\u30de\u30a6\u30b9\u3067\u306f\u5bc4\u751f\u866b\u3092\u99c6\u9664\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n<figure id=\"attachment_7410\" aria-describedby=\"caption-attachment-7410\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-7410\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/003-5.jpg\" alt=\"\" width=\"600\" height=\"438\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/003-5.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2018\/04\/003-5-300x219.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-7410\" class=\"wp-caption-text\">\u80f8\u817a\u9ac4\u8cea\u3084\u8033\u7ba1\u3001\u80c3\u3001\u5927\u8178\u3001\u81b5\u7ba1\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306f\u6a5f\u80fd\u304c\u672a\u89e3\u660e\u3067\u3042\u308b\u3002Skn-1a\u6a5f\u80fd\u6b20\u640d\u578b\u30de\u30a6\u30b9\u306f\u3001\u5316\u5b66\u611f\u899a\u7d30\u80de\u304c\u95a2\u308f\u308b\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u3092\u89e3\u660e\u3059\u308b\u4e0a\u3067\u826f\u3044\u30e2\u30c7\u30eb\u52d5\u7269\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3002<\/figcaption><\/figure>\n<p>\u3053\u306e\u3088\u3046\u306b\u3001\u5c0f\u8178\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306f\u5bc4\u751f\u866b\u3092\u99c6\u9664\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u5302\u3044\u3092\u691c\u51fa\u3059\u308b\u5316\u5b66\u611f\u899a\u5668\u5b98\u3067\u3042\u308b\u55c5\u4e0a\u76ae\u3067\u306f\u3001Trpm5\u967d\u6027\u5fae\u7d68\u6bdb\u7d30\u80de\u304c\u9ad8\u6fc3\u5ea6\u306e\u5302\u3044\u7269\u8cea\u306e\u3088\u3046\u306b\u904e\u5270\u3067\u6709\u5bb3\u306a\u5316\u5b66\u7269\u8cea\u304b\u3089\u55c5\u4e0a\u76ae\u3092\u4fdd\u8b77\u3059\u308b\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u80f8\u817a\u9ac4\u8cea\u3084\u8033\u7ba1\u3001\u80c3\u3001\u5927\u8178\u3001\u81b5\u7ba1\u306a\u3069\u3001\u591a\u304f\u306eTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u6a5f\u80fd\u306f\u672a\u89e3\u660e\u306e\u307e\u307e\u3067\u3059\u3002\u4eca\u5f8c\u3001Skn-1a\u6a5f\u80fd\u6b20\u640d\u30de\u30a6\u30b9\u3092\u7528\u3044\u308b\u3053\u3068\u3067\u3001\u3055\u3089\u306bTrpm5\u967d\u6027\u5316\u5b66\u611f\u899a\u7d30\u80de\u306e\u751f\u4f53\u5185\u3067\u306e\u6a5f\u80fd\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u307e\u305fTrpm5\u5316\u5b66\u611f\u899a\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u5473\u899a\u53d7\u5bb9\u4f53\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7d30\u83cc\u30fb\u5bc4\u751f\u866b\u611f\u67d3\u306b\u5bfe\u3059\u308b\u751f\u4f53\u9632\u5fa1\u53cd\u5fdc\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e\u3001\u305d\u3057\u3066\u611f\u67d3\u75c7\u3084\u5598\u606f\u306a\u3069\u306e\u75be\u75c5\u306e\u6cbb\u7642\u306b\u5411\u3051\u305f\u5275\u85ac\u7814\u7a76\u3078\u306e\u767a\u5c55\u304c\u898b\u8fbc\u307e\u308c\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ul>\n<li>Yamashita J, Ohmoto M, Yamaguchi T, Matsumoto I, Hirota J. \u201cSkn-1a\/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice\u201d, PLOS ONE, 12(12), 2017, doi: 10.1371\/journal.pone.0189340.<\/li>\n<li>Yamaguchi T, Yamashita J, Ohmoto M, Aoud\u00e9 I, Ogura T, Luo W, Bachmanov AA, Lin W, Matsumoto I, Hirota J. \u201cSkn-1a\/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium\u201d, BMC Neurosci, 2202-15-13, 2014, doi: 10.1186\/1471-2202-15-13.<\/li>\n<li>Ohmoto M, Yamaguchi T, Yamashita J, Bachmanov AA, Hirota J, Matsumoto I. \u201cPou2f3\/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity\u201d, Biosci Biotechnol Biochem, vol.10, pp2154-6, 2013, DOI: 10.1271\/bbb.130454.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u820c\u3060\u3051\u3067\u306f\u306a\u3044\uff01 \u5168\u8eab\u306b\u5206\u5e03\u3059\u308b\u5473\uff08\u5316\u5b66\u7269\u8cea\uff09\u3092\u611f\u3058\u308b\u7d30\u80de \u79c1\u305f\u3061\u306f\u98df\u3079\u7269\u3092\u53e3\u306b\u5165\u308c\u308b\u3068\u5473\u3092\u611f\u3058\u307e\u3059\u3002\u5473\u899a\u306f\u3001\u820c\u306e\u5473\u857e\u306b\u542b\u307e\u308c\u308b\u5473\u7d30\u80de\u304c\u5473\u3092\u5448\u3059\u308b\u7269\u8cea\u3092\u691c\u51fa\u3057\u3066\u3001\u305d\u306e\u60c5\u5831\u3092\u8133\u306e\u5927\u8133\u76ae\u8cea\u306e\u5473\u899a\u91ce\u306b\u9001\u308b\u3053 [&hellip;]<\/p>\n","protected":false},"author":291,"featured_media":7410,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[99,20,168,15,54,85],"class_list":["post-7415","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-99","tag-20","tag-168","tag-biology","tag-54","tag-85","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/7415","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/291"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=7415"}],"version-history":[{"count":5,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/7415\/revisions"}],"predecessor-version":[{"id":7444,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/7415\/revisions\/7444"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/7410"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=7415"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=7415"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=7415"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}