{"id":6821,"date":"2018-01-11T10:00:28","date_gmt":"2018-01-11T01:00:28","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=6821"},"modified":"2018-01-11T12:30:56","modified_gmt":"2018-01-11T03:30:56","slug":"%e5%81%a5%e5%ba%b7%e3%81%a7%e9%95%b7%e7%94%9f%e3%81%8d%e3%81%97%e3%81%9f%e3%81%91%e3%82%8c%e3%81%b0%e3%82%b9%e3%83%88%e3%83%ac%e3%82%b9%e3%82%92%e6%ba%9c%e3%82%81%e3%81%aa%e3%81%84%e3%81%93%e3%81%a8","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=6821","title":{"rendered":"\u5065\u5eb7\u3067\u9577\u751f\u304d\u3057\u305f\u3051\u308c\u3070\u30b9\u30c8\u30ec\u30b9\u3092\u6e9c\u3081\u306a\u3044\u3053\u3068\u304c1\u756a – \u6606\u866b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7814\u7a76\u304b\u3089\u308f\u304b\u308b\u3053\u3068"},"content":{"rendered":"

\u6606\u866b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u7814\u7a76\u3067\u4f55\u304c\u308f\u304b\u308b\u304b\uff1f<\/h3>\n

\u3059\u3079\u3066\u306e\u751f\u7269\u306f\u591a\u69d8\u306a\u30b9\u30c8\u30ec\u30b9\u306b\u66dd\u3055\u308c\u306a\u304c\u3089\u751f\u547d\u6d3b\u52d5\u3092\u55b6\u3093\u3067\u3044\u307e\u3059\u3002\u3055\u307e\u3056\u307e\u306a\u5185\u56e0\u6027\u30fb\u5916\u56e0\u6027\u30b9\u30c8\u30ec\u30b9\u3078\u306e\u5bfe\u5fdc\u306b\u4e0d\u53ef\u6b20\u306a\u60c5\u5831\u4f1d\u9054\u56e0\u5b50\u306e\u3072\u3068\u3064\u304c\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3044\u3046\u751f\u4f53\u6210\u5206\u3067\u3059\u3002\u3082\u3068\u3082\u3068\u3001\u54fa\u4e73\u985e\u3067\u767a\u898b\u3055\u308c\u305f\u56e0\u5b50\u3067\u3059\u304c\u3001\u6606\u866b\u3067\u3082\u6570\u7a2e\u985e\u898b\u3064\u304b\u3063\u3066\u304a\u308a\u3001Growth-blocking peptide(GBP)\u3082\u305d\u306e\u306a\u304b\u306e1\u7a2e\u3067\u3059\u3002<\/p>\n

GBP\u306f\u300130\u5e74\u8fd1\u304f\u524d\u306b\u898b\u3064\u304b\u3063\u305f\u30da\u30d7\u30c1\u30c9\u3067\u3059\u304c\u3001\u305d\u306e\u53d7\u5bb9\u4f53\u306f\u540c\u5b9a\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u79c1\u305f\u3061\u306fGBP\u53d7\u5bb9\u4f53\u306e\u540c\u5b9a\u3092\u76ee\u6307\u3057\u3066\u304d\u307e\u3057\u305f\u3002GBP\u306e\u53d7\u5bb9\u4f53\u304c\u540c\u5b9a\u3067\u304d\u308c\u3070\u3001GBP-GBP\u53d7\u5bb9\u4f53\u306e\u60c5\u5831\u4f1d\u9054\u6d3b\u6027\u3092\u907a\u4f1d\u7684\u306b\u64cd\u4f5c\u3057\u305f\u5909\u7570\u4f53\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3092\u4f5c\u6210\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3068\u306a\u308a\u3001\u305d\u306e\u8868\u73fe\u578b\u306e\u89e3\u6790\u304b\u3089\u30b9\u30c8\u30ec\u30b9\u304c\u751f\u4f53\u306b\u53ca\u307c\u3059\u3055\u307e\u3056\u307e\u306a\u5f71\u97ff\u3092\u751f\u304d\u305f\u30cf\u30a8\u3067\u8abf\u3079\u308b\u3053\u3068\u3082\u53ef\u80fd\u3068\u306a\u308b\u304b\u3089\u3067\u3059\u3002<\/p>\n

\u6606\u866b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3Growth-blocking peptide(GBP)\u3068\u306f\u4f55\u304b\uff1f<\/h3>\n

GBP\u306f\u30a2\u30ef\u30e8\u30c8\u30a6\u3068\u3044\u3046\u86fe\u306e\u5e7c\u866b\u306e\u4f53\u6db2\u3067\u898b\u3064\u304b\u3063\u305f\u30da\u30d7\u30c1\u30c9\u3067\u3059\u3002\u305d\u306e\u5e7c\u866b\u306f\u3001\u5bc4\u751f\u8702\u306b\u3088\u3063\u3066\u5bc4\u751f\u3055\u308c\u5e7c\u866b\u304b\u3089\u86f9\u3078\u306e\u767a\u80b2\u304c\u963b\u5bb3\u3055\u308c\u305f\u72b6\u614b\u3067\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001GBP\u306f\u3001\u5bc4\u751f\u3068\u3044\u3046\u30b9\u30c8\u30ec\u30b9\u72b6\u6cc1\u4e0b\u306b\u767a\u80b2\u3092\u6291\u5236\u3059\u3079\u304f\u3001\u30a2\u30ef\u30e8\u30c8\u30a6\u5e7c\u866b\u81ea\u8eab\u304c\u751f\u7523\u3057\u305f\u56e0\u5b50\u3060\u3063\u305f\u308f\u3051\u3067\u3059\u3002\u305d\u306e\u5f8c\u306e\u56fd\u5185\u5916\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001GBP\u306f\u591a\u6a5f\u80fd\u6027\u3092\u6301\u3064\u30da\u30d7\u30c1\u30c9\u3067\u3001\u69cb\u9020\u7684\u306b\u826f\u304f\u4f3c\u305f\u30da\u30d7\u30c1\u30c9\u304c\u591a\u304f\u306e\u86fe\u306e\u4ef2\u9593\u306b\u3082\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u305f\u3060\u3001GBP\u306e\u6700\u521d\u306e\u767a\u898b\u304b\u308920\u5e74\u4ee5\u4e0a\u7d4c\u3063\u3066\u3082\u3001\u7570\u76ee\u7a2e\u306e\u6606\u866bGBP\u306f\u5831\u544a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306eGBP\u306e\u540c\u5b9a\u3092\u76ee\u6307\u3057\u3001\u6700\u7d42\u7684\u306b\u3001\u86fe\u306eGBP\u3068\u6a5f\u80fd\u7684\u306b\u76f8\u540c\u306a\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8GBP\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n

GBP\u53d7\u5bb9\u4f53\u306f\u3069\u306e\u3088\u3046\u306a\u69cb\u9020\u304b\uff1f<\/h3>\n

GBP\u53d7\u5bb9\u4f53\u306e\u540c\u5b9a\u306f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u57f9\u990a\u7d30\u80deS3\u3092\u7528\u3044\u3066\u884c\u3044\u307e\u3057\u305f\u3002\u5148\u884c\u7814\u7a76\u306b\u3088\u308a\u3001GBP\u306b\u3088\u308bPhospholipase C\u4f9d\u5b58\u7684\u306a\u7d30\u80de\u8cea\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u4e0a\u6607\u4f5c\u7528\u3092\u78ba\u8a8d\u3057\u3066\u3044\u307e\u3057\u305f\u306e\u3067\u3001\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306edsRNA\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u3092\u7528\u3044\u3066\u7db2\u7f85\u7684\u306bRNA\u5e72\u6e09\uff08RNAi\uff09\u3092\u884c\u3044\u3001GBP\u4f9d\u5b58\u7684\u306a\u30ab\u30eb\u30b7\u30a6\u30e0\u6fc3\u5ea6\u4e0a\u6607\u306b\u95a2\u4e0e\u3059\u308b\u907a\u4f1d\u5b50\u306e\u540c\u5b9a\u3092\u8a66\u307f\u305f\u308f\u3051\u3067\u3059\u3002\u4e00\u9023\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001GBP\u53d7\u5bb9\u4f53\u907a\u4f1d\u5b50\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u305fMethuselah-like 10 (Mthl10)\u306f\u3001\u7d30\u80de\u5916\u30c9\u30e1\u30a4\u30f3\u3092\u6709\u3059\u308bclass B GPCR\u3092\u30b3\u30fc\u30c9\u3059\u308b\u907a\u4f1d\u5b50\u3067\u3057\u305f\u3002\u305d\u306e\u907a\u4f1d\u5b50\u540d\u304c\u793a\u3059\u3088\u3046\u306bMthl10\u306f\u4ed6\u306e15\u7a2e\u985e\u306e\u907a\u4f1d\u5b50\u3068\u5171\u306bMth\/Mthl\u30d5\u30a1\u30df\u30ea\u30fc\u3092\u5f62\u6210\u3057\u3001\u305d\u306e\u30ea\u30ac\u30f3\u30c9\u306f\u3082\u3061\u308d\u3093\u751f\u7406\u6a5f\u80fd\u3082\u307e\u3063\u305f\u304f\u4e0d\u660e\u306e\u907a\u4f1d\u5b50\u3067\u3057\u305f\u3002\u540c\u65cf\u907a\u4f1d\u5b50\u306e\u306a\u304b\u3067\u3001\u305d\u3046\u3057\u305f\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u3044\u305f\u907a\u4f1d\u5b50\u304c\u552f\u4e00Mth\u3067\u3057\u305f\u3002Mth\u5909\u7570\u4f53\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306f\u5bff\u547d\u304c\u5ef6\u3073\u308b\u3053\u3068\u304b\u3089\u3001\u300e\u65e7\u7d04\u8056\u66f8\u300f\u4e0a\u3067\u6700\u9577\u5bff\u3068\u3057\u3066\u63cf\u304b\u308c\u305f\u4eba\u7269\u306e\u540d\u524d’Methuselah’\u306b\u3061\u306a\u3093\u3067\u547d\u540d\u3055\u308c\u305f\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n

GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u7cfb\u306f\u3069\u306e\u3088\u3046\u306a\u751f\u7406\u6a5f\u80fd\u3092\u62c5\u3063\u3066\u3044\u308b\u304b\uff1f<\/h3>\n

Mth\u5909\u7570\u4f53\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u8868\u73fe\u7cfb\u304b\u3089\u3001Mthl10\u767a\u73fe\u6291\u5236\u3082\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u5bff\u547d\u3092\u5ef6\u3070\u3059\u53ef\u80fd\u6027\u5927\u3068\u4e88\u60f3\u3057\u307e\u3057\u305f\u3002\u305f\u3060\u3001\u4eee\u306b\u3001\u671f\u5f85\u3069\u304a\u308a\u306e\u8868\u73fe\u7cfb\u304c\u89b3\u5bdf\u3067\u304d\u305f\u3068\u3057\u3066\u3082\u3001\u305d\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u308f\u3051\u3067\u3059\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u3001GBP\u306e\u65e2\u77e5\u751f\u7406\u6d3b\u6027\u3067\u3042\u308b\u611f\u67d3\u30fb\u975e\u611f\u67d3\u3092\u554f\u308f\u306a\u3044\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u4e0b\u3067\u306e\u81ea\u7136\u514d\u75ab\u6d3b\u6027\u5316\u3068Mthl10\u306e\u95a2\u4fc2\u3092\u660e\u3089\u304b\u306b\u3059\u3079\u304f\u89e3\u6790\u3092\u958b\u59cb\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u57f9\u990a\u7d30\u80deS2\u3042\u308b\u3044\u306f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u5e7c\u866b\u30fb\u6210\u866b\u3067\u3082\u3001RNAi\u306b\u3088\u308bMthl10\u306e\u767a\u73fe\u6291\u5236\u306f\u3001GBP\u4f9d\u5b58\u7684\u306a\u7d30\u80de\u6027\u514d\u75ab\u3001\u3055\u3089\u306b\u3001\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u767a\u73fe\u306e\u3088\u3046\u306a\u6db2\u6027\u514d\u75ab\u6d3b\u6027\u3092\u9855\u8457\u306b\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u514d\u75ab\u6d3b\u6027\u306e\u6291\u5236\u306f\u3001\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u75c5\u539f\u83cc\u3078\u306e\u611f\u53d7\u6027\u3092\u6709\u610f\u306b\u9ad8\u3081\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u306f\u3001GBP\u4f9d\u5b58\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u6761\u4ef6\u4e0b\u3067\u306e\u81ea\u7136\u514d\u75ab\u6d3b\u6027\u306e\u6d3b\u6027\u5316\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u3067\u3042\u308b\u3053\u3068\u304c\u8a3c\u660e\u3067\u304d\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n

GBP\u306e\u3082\u3046\u3072\u3068\u3064\u306e\u91cd\u8981\u306a\u6a5f\u80fd\u304c\u4ee3\u8b1d\u8abf\u7bc0\u3067\u3059\u3002\u6700\u8fd1\u3001GBP\u306f\u4f53\u6db2\u4e2d\u306e\u30a2\u30df\u30ce\u9178\u6fc3\u5ea6\u306e\u4e0a\u6607\u306b\u547c\u5fdc\u3057\u3066\u8133\u5185\u304b\u3089\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u306e\u5206\u6ccc\u3092\u4fc3\u3059\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u79c1\u305f\u3061\u306f\u3001GBP\u306e\u5f37\u5236\u767a\u73fe\u3055\u3089\u306bMthl10\u306e\u767a\u73fe\u6291\u5236\u7cfb\u7d71\u306e\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3067\u8133\u795e\u7d4c\u7d30\u80de\u304b\u3089\u306e\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u306e\u5206\u6ccc\u6d3b\u6027\u3092\u6e2c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4e88\u60f3\u3069\u304a\u308a\u3001GBP\u306e\u5f37\u5236\u767a\u73fe\u3067\u306f\u5206\u6ccc\u304c\u4fc3\u9032\u3057\u3001Mthl10\u306e\u767a\u73fe\u6291\u5236\u3067\u306f\u5206\u6ccc\u304c\u6e1b\u5c11\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u3053\u306e\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u5206\u6ccc\u7d30\u80de\u306f\u3001Mthl10\u3092\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u306f\u3001\u4f53\u6db2\u4e2d\u306e\u30a2\u30df\u30ce\u9178\u6fc3\u5ea6\u4f9d\u5b58\u7684\u306a\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u5206\u6ccc\u306e\u8abf\u7bc0\u306b\u4e0d\u53ef\u6b20\u306a\u7cfb\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u3001\u6442\u98df\u304c\u4f4e\u4e0b\u3059\u308b\u3068GBP\u306e\u5206\u6ccc\u306f\u6e1b\u5c11\u3057\u3001Mthl10\u306f\u6d3b\u6027\u5316\u3057\u306a\u3044\u305f\u3081\u306b\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u5206\u6ccc\u3082\u6291\u3048\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\"\"
\u3055\u307e\u3056\u307e\u306a\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u3001\u3042\u308b\u3044\u306f\u3001\u4f53\u6db2\u4e2d\u306e\u6804\u990a\u5206\uff08\u7279\u306b\u3001\u30a2\u30df\u30ce\u9178\uff09\u6fc3\u5ea6\u4e0a\u6607\u306b\u53cd\u5fdc\u3057\u3066\u3001\u8102\u80aa\u4f53\uff08\u30d2\u30c8\u306e\u809d\u81d3\u306b\u76f8\u5f53\u3059\u308b\u5668\u5b98\uff09\u304b\u3089GBP\u306f\u5206\u6ccc\u3055\u308c\u3001\u8102\u80aa\u4f53\u81ea\u4f53\u304b\u3089\u306e\u6297\u83cc\u307a\u30d7\u30c1\u30c9\u306e\u7523\u751f\u30fb\u5206\u6ccc\u3092\u4fc3\u3059\u3002\u4e00\u65b9\u3001\u8133\u304b\u3089\u306e\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u69d8\u30da\u30d7\u30c1\u30c9\u306e\u5206\u6ccc\u3082\u4fc3\u3057\u3066\u4ee3\u8b1d\u30ec\u30d9\u30eb\u3082\u4e0a\u6607\u3055\u305b\u308b\u3002<\/figcaption><\/figure>\n

GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u7cfb\u306f\u5bff\u547d\u306b\u5f71\u97ff\u3059\u308b\u304b\uff1f<\/h3>\n

GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u7cfb\u306e\u6d3b\u6027\u4f4e\u4e0b\u306f\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u81ea\u7136\u514d\u75ab\u6d3b\u6027\u3092\u6291\u5236\u3057\u3001\u3055\u3089\u306b\u3001\u4ee3\u8b1d\u30ec\u30d9\u30eb\u3082\u4f4e\u4e0b\u3055\u305b\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u751f\u7406\u7684\u74b0\u5883\u306f\u30cf\u30a8\u306e\u5bff\u547d\u3092\u5ef6\u3070\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u306b\u9055\u3044\u306a\u3044\u3068\u601d\u3048\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001GBP\u5f37\u5236\u767a\u73fe\u7cfb\u7d71\u3001Mthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71\u3001\u305d\u3057\u3066\u3001GBP\u5f37\u5236\u767a\u73fe\uff0fMthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71\uff08\u5f37\u5236\u767a\u73fe\u3068\u767a\u73fe\u6291\u5236\u3092\u540c\u6642\u9032\u884c\u3059\u308b\u7cfb\u7d71\uff09\u306e3\u7a2e\u985e\u306e\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3068\u3053\u308c\u3089\u306e\u7cfb\u7d71\u3068\u4ea4\u914d\u3057\u305f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7cfb\u7d71\u306e\u30cf\u30a8\u306e\u5bff\u547d\u6e2c\u5b9a\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u671f\u5f85\u3069\u304a\u308a\u3001GBP\u5f37\u5236\u767a\u73fe\u7cfb\u7d71\u3067\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7cfb\u7d71\u306b\u6bd4\u3079\u7d0410%\u5bff\u547d\u306f\u7e2e\u307e\u308a\u3001Mthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71\u3067\u306f\u7d0425%\u5bff\u547d\u304c\u5ef6\u3073\u307e\u3057\u305f\u3002\u307e\u305f\u3001GBP\u5f37\u5236\u767a\u73fe\uff0fMthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71\u3067\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6709\u610f\u5dee\u306e\u306a\u3044\u5bff\u547d\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
GBP\u5f37\u5236\u767a\u73fe\u7cfb\u7d71(W1118<\/sup>;Actin-Gal4;UAS-GBP)\u3067\u306f\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7cfb\u7d71(W1118<\/sup>)\u306b\u6bd4\u3079\u7d0410%\u5bff\u547d\u306f\u7e2e\u307e\u308a\u3001Mthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71(W1118<\/sup>;Actin-Gal4;UAS-dsMthl10)\u3067\u306f\u7d0425%\u5bff\u547d\u304c\u5ef6\u3073\u305f\u3002\u307e\u305f\u3001GBP\u5f37\u5236\u767a\u73fe\uff0fMthl10\u767a\u73fe\u6291\u5236\u7cfb\u7d71(W1118<\/sup>;Actin-Gal4;UAS-GBP;Actin-Gal4;UAS-dsMthl10)\u3067\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6709\u610f\u5dee\u306e\u306a\u3044\u5bff\u547d\u3068\u306a\u308b\u3002\u56f3\u306f\u6587\u732e\u3088\u308a\u5f15\u7528\u3002<\/figcaption><\/figure>\n

\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u308b\u5bff\u547d\u5ef6\u9577\u306f\u3001\u3055\u307e\u3056\u307e\u306a\u79d1\u5b66\u5831\u9053\u756a\u7d44\u3067\u3082\u53d6\u308a\u4e0a\u3052\u3089\u308c\u3066\u304d\u305f\u5468\u77e5\u306e\u4e8b\u5b9f\u3067\u3059\u3002\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3067\u3082\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u3063\u3066\u5bff\u547d\u306e\u5ef6\u9577\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3059\u3002\u305d\u3053\u3067\u6700\u5f8c\u306b\u3001GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u7cfb\u3068\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u307e\u305a\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3092\u3057\u305f\u30cf\u30a8\u3067\u306fGBP\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u3053\u3046\u3057\u305f\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u500b\u4f53\u3067\u306f\u3001\u3084\u306f\u308a\u6db2\u6027\u514d\u75ab\u306e\u30a8\u30d5\u30a7\u30af\u30bf\u30fc\u5206\u5b50\u3067\u3042\u308b\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u306e\u767a\u73fe\u304c\u660e\u3089\u304b\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001Mthl10\u306e\u767a\u73fe\u6291\u5236\u7cfb\u7d71\u3067\u306f\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3092\u3057\u3088\u3046\u304c\u3057\u307e\u3044\u304c\u3001\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u907a\u4f1d\u5b50\u767a\u73fe\u306f\u975e\u5e38\u306b\u4f4e\u3044\u72b6\u614b\u3067\u3042\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u5c11\u306a\u304f\u3068\u3082\u81ea\u7136\u514d\u75ab\u6d3b\u6027\u306e\u89b3\u70b9\u306b\u304a\u3044\u3066\u306f\u3001GBP-Mthl10\u60c5\u5831\u4f1d\u9054\u6d3b\u6027\u306e\u4f4e\u4e0b\u304c\u3001\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u3092\u3057\u3066\u3044\u308b\u30cf\u30a8\u3068\u4f3c\u305f\u751f\u7406\u7684\u74b0\u5883\u3092\u4f5c\u308a\u4e0a\u3052\u3066\u3044\u305f\u306e\u3067\u3059\u3002<\/p>\n

\"\"
\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7cfb\u7d71(y w)\u7cfb\u7d71\u3067\u306f\u3001\u7d0424\u6642\u9593\u306e\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306b\u3088\u3063\u3066\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u767a\u73fe\u306f\u6709\u610f\u306b\u6e1b\u5c11\u50be\u5411\u3092\u793a\u3059\u3002\u4e00\u65b9\u3001Mthl10\u306e\u767a\u73fe\u6291\u5236\u7cfb\u7d71(Actin-Gal4;UAS-dsMthl10)\u3067\u306f\u3001\u666e\u901a\u306e\u98df\u4e8b\u3067\u3082\u30ab\u30ed\u30ea\u30fc\u5236\u9650\u306e\u98df\u4e8b\u3067\u3082\u3001\u6297\u83cc\u30da\u30d7\u30c1\u30c9\u767a\u73fe\u306f\u4e00\u8cab\u3057\u3066\u4f4e\u3044\u30ec\u30d9\u30eb\u306b\u7559\u307e\u308b\u3002\u56f3\u306f\u6587\u732e\u3088\u308a\u5f15\u7528\u3002<\/figcaption><\/figure>\n

\u7d42\u308f\u308a\u306b<\/h3>\n

\u4ee5\u4e0a\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u52d5\u7269\u304c\u62b1\u3048\u308b\u5bbf\u547d\u7684\u30b8\u30ec\u30f3\u30de\u3092\u6d6e\u304d\u5f6b\u308a\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u3001\u79c1\u305f\u3061\u306f\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u3088\u3063\u3066\u3055\u307e\u3056\u307e\u306a\u74b0\u5883\u30b9\u30c8\u30ec\u30b9\u306b\u6297\u3057\u3066\u751f\u304d\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u76db\u3093\u306b\u5206\u6ccc\u3057\u3066\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\u6a5f\u80fd\u3092\u50cd\u304b\u305b\u308b\u3068\u81ea\u3089\u306e\u5bff\u547d\u3092\u7e2e\u3081\u3066\u3057\u307e\u3046\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u4e00\u65b9\u3067\u3001\u4eca\u56de\u306e\u7814\u7a76\u306f\u3001\u5065\u5eb7\u9577\u5bff\u3092\u5fd7\u5411\u3059\u308b\u4e88\u9632\u533b\u5b66\u306b\u3072\u3068\u3064\u306e\u57fa\u790e\u7684\u306a\u7814\u7a76\u77e5\u898b\u3092\u63d0\u4f9b\u3057\u305f\u3053\u3068\u306b\u3082\u306a\u308a\u307e\u3059\u3002\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5fc5\u8981\u4ee5\u4e0a\u306b\u5206\u6ccc\u3057\u306a\u3044\u3001\u3059\u306a\u308f\u3061\u3001\u30b9\u30c8\u30ec\u30b9\u3092\u611f\u77e5\u3057\u305f\u308a\u3001\u3042\u308b\u3044\u306f\u3001\u4e0b\u6d41\u306e\u60c5\u5831\u4f1d\u9054\u3092\u4f5c\u52d5\u3059\u308b\u30cf\u30fc\u30c9\u30eb\uff08\u95be\u5024\uff09\u3092\u9069\u5ea6\u306b\u4e0a\u3052\u308b\u6280\u8853\u306e\u9032\u6b69\u306f\u5065\u5eb7\u9577\u5bff\u306b\u7d50\u3073\u3064\u304f\u53ef\u80fd\u6027\u3092\u5f37\u304f\u793a\u5506\u3057\u3066\u3044\u308b\u304b\u3089\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u305d\u3046\u3057\u305f\u751f\u7406\u7684\u74b0\u5883\u3092\u4fdd\u3064\u98df\u54c1\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u958b\u767a\u306f\u3072\u3068\u3064\u306e\u6709\u529b\u306a\u7814\u7a76\u5206\u91ce\u3068\u8a00\u3048\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\nTsuzuki, S., Ochiai, M., Matsumoto, H., Kurata, S., Ohnishi, A. and Hayakawa, Y., 2012
\nDrosophila growth-blocking peptide-like factor mediates acute immune reactions durig
\ninfectious and non-infectious stress. Scientific Reports, 2. 210.<\/p>\n

Tsuzuki, S. Matsumoto, H., Furihata, S., Ryuda, M., Tanaka, H., Sung, E-J., Bird,
\nG.S., Zhou, Y., Shears, S.B., and Hayakawa, Y., 2014, Switching between
\nhumoral and cellular immune responses in Drosophila is guided by the cytokine
\nGBP. Nat. Commun., 5, 4628.<\/p>\n

Sung, E.J., Ryuda, M., Matsumoto, H., Uryu, O., Cook, M.E.,Yi, N.Y, Wang, H., Putney, J.W., Bird, G.S., Shears, S.B., Hayakawa, Y., 2017 Cytokine signaling through Drosophila Mthl10 ties lifespan to environmental stress. Proc. Nat. Acad. Sci. USA, 114, 13786-13791.<\/p>\n","protected":false},"excerpt":{"rendered":"

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