{"id":6660,"date":"2017-12-13T10:00:54","date_gmt":"2017-12-13T01:00:54","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=6660"},"modified":"2017-12-11T15:51:09","modified_gmt":"2017-12-11T06:51:09","slug":"%e9%95%b7%e6%9c%9f%e8%a8%98%e6%86%b6%e3%81%ab%e4%b8%8d%e5%8f%af%e6%ac%a0%e3%81%aa%e5%88%86%e5%ad%90rng105-%e3%83%8b%e3%83%a5%e3%83%bc%e3%83%ad%e3%83%b3%e3%81%a7%e3%81%ae%e3%82%bf%e3%83%b3%e3%83%91","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=6660","title":{"rendered":"\u9577\u671f\u8a18\u61b6\u306b\u4e0d\u53ef\u6b20\u306a\u5206\u5b50RNG105 – \u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u3068\u9577\u671f\u8a18\u61b6\u5f62\u6210\u3092\u3064\u306a\u3050\u4ed5\u7d44\u307f"},"content":{"rendered":"

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\"\"
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RNG105\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u9577\u671f\u8a18\u61b6\u304c\u4f4e\u4e0b<\/h3>\n

RNG105\u304c\u9577\u671f\u8a18\u61b6\u306e\u5f62\u6210\u306b\u5fc5\u8981\u304b\u3069\u3046\u304b\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u3001\u907a\u4f1d\u5b50\u6539\u5909\u306b\u3088\u3063\u3066RNG105\u3092\u6b20\u640d\u3057\u305f\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u30015\u7a2e\u985e\u306e\u5b66\u7fd2\u30fb\u8a18\u61b6\u30c6\u30b9\u30c8\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u3059\u3079\u3066\u306e\u30c6\u30b9\u30c8\u3067RNG105\u6b20\u640d\u30de\u30a6\u30b9\u306e\u9577\u671f\u8a18\u61b6\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u7d50\u679c\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\n

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\"\"
RNG105\u6b20\u640d\u30de\u30a6\u30b9\u306e\u6697\u3044\u90e8\u5c4b\u3067\u306e\u6ede\u5728\u6642\u9593\u306f\u3001\u96fb\u6d41\u523a\u6fc05\u5206\u5f8c\u306f\u6b63\u5e38\u30de\u30a6\u30b9\u3068\u540c\u7b49\u306b\u4f4e\u4e0b\u3059\u308b\u3002\u3057\u304b\u3057\u30011\u65e5\u5f8c\u30011\u9031\u9593\u5f8c\u3067\u306f\u4e21\u30de\u30a6\u30b9\u306b\u5927\u304d\u306a\u5dee\u304c\u751f\u3058\u30011\u9031\u9593\u5f8c\u306b\u306fRNG105\u6b20\u640d\u30de\u30a6\u30b9\u306e\u6697\u3044\u90e8\u5c4b\u3067\u306e\u6ede\u5728\u6642\u9593\u306f\u3001\u307b\u307c\u3082\u3068\u306e\u30ec\u30d9\u30eb\u306b\u623b\u3063\u3066\u3057\u307e\u3046\u3002<\/figcaption><\/figure>\n

RNG105\u6b20\u640d\u30de\u30a6\u30b9\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u30b7\u30ca\u30d7\u30b9\u5f37\u5316\u304c\u4e0a\u624b\u304f\u3044\u304b\u306a\u3044<\/h3>\n

\u30b7\u30ca\u30d7\u30b9\u5f37\u5316\u3092\u8a55\u4fa1\u3059\u308b\u65b9\u6cd5\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001\u4eba\u70ba\u7684\u306a\u523a\u6fc0\u306b\u3088\u3063\u3066\u30b7\u30ca\u30d7\u30b9\u306e\u4fe1\u53f7\u4f1d\u9054\u3092\u8d77\u3053\u3057\u3001\u305d\u306e\u969b\u306b\u4fe1\u53f7\u306e\u53d7\u3051\u53d6\u308a\u5074\u306e\u30b7\u30ca\u30d7\u30b9\uff08\u5f8c\u30b7\u30ca\u30d7\u30b9\uff09\u304c\u80a5\u5927\u5316\u3059\u308b\u73fe\u8c61\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3059\u308b\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u65b9\u6cd5\u3092\u7528\u3044\u3066\u3001RNG105\u306e\u6b20\u640d\u304c\u30b7\u30ca\u30d7\u30b9\u5f37\u5316\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u3079\u307e\u3057\u305f\u3002\u6b63\u5e38\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u523a\u6fc0\u306b\u3088\u308a\u5f8c\u30b7\u30ca\u30d7\u30b9\u304c\u80a5\u5927\u3057\u3001\u305d\u306e\u30b5\u30a4\u30ba\u306f\u523a\u6fc0\u5f8c1\u6642\u9593\u7d4c\u3063\u3066\u3082\u7dad\u6301\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001RNG105\u6b20\u640d\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u523a\u6fc0\u306b\u3088\u308a\u5f8c\u30b7\u30ca\u30d7\u30b9\u306f\u4e00\u5ea6\u80a5\u5927\u3057\u305f\u3082\u306e\u306e\u3001\u6642\u9593\u7d4c\u904e\u3068\u3068\u3082\u306b\u6b21\u7b2c\u306b\u7e2e\u5c0f\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"
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\u5225\u306e\u8a55\u4fa1\u6cd5\u3068\u3057\u3066\u3001\u5f8c\u30b7\u30ca\u30d7\u30b9\u8868\u9762\u306eAMPA\u53d7\u5bb9\u4f53\u306e\u91cf\u3092\u6e2c\u5b9a\u3059\u308b\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\u3002AMPA\u53d7\u5bb9\u4f53\u3068\u306f\u3001\u30b7\u30ca\u30d7\u30b9\u4fe1\u53f7\u4f1d\u9054\u306b\u4e2d\u5fc3\u7684\u5f79\u5272\u3092\u679c\u305f\u3059\u5206\u5b50\u3067\u3059\u3002AMPA\u53d7\u5bb9\u4f53\u3092\u691c\u51fa\u3059\u308b\u6297\u4f53\u67d3\u8272\u6cd5\u3068\u3044\u3046\u624b\u6cd5\u3067\u305d\u306e\u91cf\u3092\u6e2c\u5b9a\u3057\u305f\u7d50\u679c\u3001\u6b63\u5e38\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u6bd4\u3079\u3066RNG105\u6b20\u640d\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u3001\u5f8c\u30b7\u30ca\u30d7\u30b9\u8868\u9762\u306eAMPA\u53d7\u5bb9\u4f53\u3092\u5897\u3084\u3059\u5236\u5fa1\u6a5f\u69cb\u304c\u4e0a\u624b\u304f\u50cd\u304b\u306a\u3044\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001RNG105\u306f\u3001\u9577\u671f\u7684\u306a\u30b7\u30ca\u30d7\u30b9\u5f37\u5316\u306b\u5fc5\u9808\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

RNG105\u6b20\u640d\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u30b7\u30ca\u30d7\u30b9\u4ed8\u8fd1\u3078\u306e\u4f1d\u4ee4RNA\u306e\u914d\u7f6e\u304c\u4f4e\u4e0b<\/h3>\n

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\"\"
\u6b63\u5e38\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u3001\u7279\u5b9a\u306e\u7a2e\u985e\u306e\u4f1d\u4ee4RNA\uff08\u30b7\u30ca\u30d7\u30b9\u5f37\u5316\u306b\u50cd\u304f\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u8a2d\u8a08\u56f3\u3067\u3042\u308b\u4f1d\u4ee4RNA\u304c\u591a\u6570\u542b\u307e\u308c\u308b\uff09\u304c\u3001\u5f8c\u30b7\u30ca\u30d7\u30b9\u306e\u591a\u304f\u5b58\u5728\u3059\u308b\u6a39\u72b6\u7a81\u8d77\u306b\u504f\u3063\u3066\u914d\u7f6e\u3055\u308c\u308b\u3002\u4e00\u65b9\u3001RNG105\u6b20\u640d\u30cb\u30e5\u30fc\u30ed\u30f3\u3067\u306f\u3001\u305d\u308c\u3089\u7279\u5b9a\u306e\u4f1d\u4ee4RNA\u304c\u6a39\u72b6\u7a81\u8d77\u304b\u3089\u6e1b\u5c11\u3057\u3066\u3057\u307e\u3046\u3002<\/figcaption><\/figure>\n

\u304a\u308f\u308a\u306b<\/h3>\n

\u4eca\u56de\u306eRNG105\u304c\u9577\u671f\u8a18\u61b6\u5f62\u6210\u306b\u5fc5\u9808\u3068\u3044\u3046\u767a\u898b\u306b\u3088\u308a\u3001\u9577\u671f\u8a18\u61b6\u5f62\u6210\u306e\u969b\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u5408\u6210\u304c\u3069\u306e\u3088\u3046\u306b\u8d77\u3053\u308b\u306e\u304b\u3001\u307e\u305f\u3001\u3069\u306e\u3088\u3046\u306a\u7a2e\u985e\u306e\u4f1d\u4ee4RNA\u304b\u3089\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u5408\u6210\u3055\u308c\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u3001\u65b0\u305f\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u672c\u7a3f\u3067\u306f\u7d39\u4ecb\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001RNG105\u306f\u5de8\u5927\u306a\u8907\u5408\u4f53\u3067\u3042\u308b\u300cRNA\u9846\u7c92\u300d\u306e\u4e3b\u8981\u306a\u69cb\u6210\u56e0\u5b50\u3067\u3059\u3002RNA\u9846\u7c92\u306e\u7570\u5e38\u306f\u3001\u8a8d\u77e5\u75c7\u3001\u7b4b\u840e\u7e2e\u6027\u5074\u7d22\u786c\u5316\u75c7\uff08ALS\uff09\u3001\u81ea\u9589\u75c7\u30b9\u30da\u30af\u30c8\u30e9\u30e0\u969c\u5bb3\uff08ASD\uff09\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u795e\u7d4c\u7cbe\u795e\u75be\u60a3\u306e\u539f\u56e0\u306b\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u4eca\u56de\u306e\u767a\u898b\u3092\u8db3\u304c\u304b\u308a\u306b\u3057\u3066\u3001\u9577\u671f\u8a18\u61b6\u5f62\u6210\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u3055\u3089\u306b\u89e3\u660e\u3055\u308c\u308b\u3053\u3068\u306b\u52a0\u3048\u3001\u81e8\u5e8a\u30fb\u5275\u85ac\u5206\u91ce\u306e\u5fdc\u7528\u7814\u7a76\u306b\u3082\u9053\u3092\u958b\u304f\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

Nakayama K*, Ohashi R*, Shinoda Y, Yamazaki M, Abe M, Fujikawa A, Shigenobu S, Futatsugi A, Noda M, Mikoshiba K, Furuichi T, Sakimura K, Shiina N. (*equal contribution) (2017) RNG105\/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation. eLife 6, e29677.<\/p>\n

Ohashi R, Takao K, Miyakawa T, Shiina N. (2016) Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci. Rep. 6, 20775.<\/p>\n

Shiina N, Yamaguchi K, Tokunaga M. (2010) RNG105 deficiency impairs the dendritic localization of mRNAs for Na+<\/sup>\/K+<\/sup> ATPase subunit isoforms and leads to the degeneration of neuronal networks. J. Neurosci. 30, 12816-12830.<\/p>\n","protected":false},"excerpt":{"rendered":"

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