{"id":6333,"date":"2017-10-31T10:00:52","date_gmt":"2017-10-31T01:00:52","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=6333"},"modified":"2018-10-03T19:26:01","modified_gmt":"2018-10-03T10:26:01","slug":"%e3%82%a4%e3%83%b3%e3%82%b9%e3%83%aa%e3%83%b3%e3%81%a8%e3%83%ac%e3%83%97%e3%83%81%e3%83%b3%e3%81%ae%e5%83%8d%e3%81%8d%e3%82%92%e6%8a%91%e5%88%b6%e3%81%97%e3%81%a6%e3%81%84%e3%82%8b%e8%84%b1%e3%83%aa","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=6333","title":{"rendered":"\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u30ec\u30d7\u30c1\u30f3\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u8131\u30ea\u30f3\u9178\u5316\u9175\u7d20 – PTPRJ\u306e\u5f79\u5272\u3068\u306f"},"content":{"rendered":"

\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u30ec\u30d7\u30c1\u30f3<\/h3>\n

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\"\"
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\"\"
\u9ad8\u8102\u80aa\u98df\u3067\u98fc\u80b2\u3057\u305f\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3068Ptprj\u6b20\u640d\u30de\u30a6\u30b9\u306e\u6bd4\u8f03\u3002\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306b\u6bd4\u3079\u3066Ptprj\u6b20\u640d\u30de\u30a6\u30b9\u306f\u4f4e\u4f53\u91cd\u3067\u3042\u308a\uff08\u5de6\u4e0a\uff09\u3001\u6442\u98df\u91cf\u3082\u5c11\u306a\u3044\uff08\u53f3\u4e0a\uff09\u3002CT\u753b\u50cf\u89e3\u6790\u304b\u3089\u3001Ptprj\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8102\u80aa\uff08\u9ec4\u8272\uff09\u306e\u91cf\u304c\u9855\u8457\u306b\u5c11\u306a\u3044\u3053\u3068\u308f\u304b\u308b\uff08\u4e0b\uff09\u3002<\/figcaption><\/figure>\n

PTPRJ\u306e\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u3078\u306e\u95a2\u4e0e<\/h3>\n

\u80a5\u6e80\u72b6\u614b\u306e\u4eba\u306f\u3001\u8102\u80aa\u7d44\u7e54\u304c\u591a\u3044\u305f\u3081\u306b\u30ec\u30d7\u30c1\u30f3\u306e\u30ec\u30d9\u30eb\u306f\u9ad8\u3044\u72b6\u614b\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u304c\u3001\u6442\u98df\u306f\u5fc5\u305a\u3057\u3082\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u305d\u306e\u7406\u7531\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u304c\u52b9\u304d\u306b\u304f\u304f\u306a\u308b\u3001\u300c\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u300d\u3068\u547c\u3070\u308c\u308b\u73fe\u8c61\u304c\u8d77\u3053\u308b\u304b\u3089\u3067\u3059\u3002\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u751f\u3058\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3088\u304f\u308f\u304b\u3063\u3066\u304a\u3089\u305a\u3001\u305d\u306e\u6cbb\u7642\u6cd5\u3082\u898b\u3064\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u305d\u3053\u3067\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u306e\u5f62\u6210\u306b\u304a\u3051\u308bPTPRJ\u306e\u95a2\u4e0e\u306b\u3064\u3044\u3066\u8abf\u3079\u307e\u3057\u305f\u3002\u30de\u30a6\u30b9\u3092\u9ad8\u8102\u80aa\u98df\u30672\u304b\u6708\u9593\u98fc\u80b2\u3059\u308b\u3068\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u5f62\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3068\u304d\u3001\u6442\u98df\u4e2d\u67a2\u3067PTPRJ\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u6b21\u306b\u3001\u9ad8\u8102\u80aa\u98df\u306714\u9031\u9593\u98fc\u80b2\u3057\u305f\u30de\u30a6\u30b9\u306b\u30ec\u30d7\u30c1\u30f3\u3092\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\u3067\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u3092\u767a\u75c7\u3057\u3066\u3044\u308b\u305f\u3081\u306b\u3001\u6442\u98df\u91cf\u3068\u4f53\u91cd\u306e\u6e1b\u5c11\u306f\u307b\u3068\u3093\u3069\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u4e00\u65b9\u3001Ptprj\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u6295\u4e0e\u306b\u5fdc\u7b54\u3057\u3066\u6442\u98df\u91cf\u304a\u3088\u3073\u4f53\u91cd\u306e\u9855\u8457\u306a\u6e1b\u5c11\u304c\u898b\u3089\u308c\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u751f\u3058\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u9006\u306b\u3001\u901a\u5e38\u72b6\u614b\u306e\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306e\u6442\u98df\u4e2d\u67a2\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u3066\u3001\u4eba\u70ba\u7684\u306bPTPRJ\u306e\u767a\u73fe\u3092\u5897\u52a0\u3055\u305b\u308b\u3068\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u8a98\u5c0e\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u80a5\u6e80\u306b\u3068\u3082\u306a\u3044\u5f13\u72b6\u6838\u3067PTPRJ\u306e\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u5f62\u6210\u306e\u8981\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u91ce\u751f\u578b\u30de\u30a6\u30b9\u306e\u6442\u98df\u4e2d\u67a2\u306b\u3001\u30a6\u30a4\u30eb\u30b9\u30d9\u30af\u30bf\u30fc\u3092\u7528\u3044\u3066\u4eba\u70ba\u7684\u306bPTPRJ\u3092\u904e\u5270\u767a\u73fe\u3055\u305b\u305f\u3002\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u306e\u30a6\u30a4\u30eb\u30b9\u3092\u611f\u67d3\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u30ec\u30d7\u30c1\u30f3\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u6442\u98df\u91cf\u3068\u4f53\u91cd\u306b\u9855\u8457\u306a\u6e1b\u5c11\u304c\u898b\u3089\u308c\u305f\u304c\uff08\u9ed2\u7dda\uff09\u3001PTPRJ\u30a6\u30a3\u30eb\u30b9\u3092\u611f\u67d3\u3055\u305b\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u5fdc\u7b54\u304c\u5931\u308f\u308c\uff08\u8d64\u7dda\uff09\u3001\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\u304c\u8a98\u5c0e\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308b\u3002<\/figcaption><\/figure>\n

\u6700\u5f8c\u306b<\/h3>\n

PTPRJ\u304c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u3068\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3053\u3068\u306b\u3088\u308a\u3001PTPRJ\u3092\u963b\u5bb3\u3059\u308b\u85ac\u5264\u306f\u3001\u7cd6\u5c3f\u75c5\uff08\u305d\u308c\u306b\u4f34\u3046\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\uff09\u3068\u3068\u3082\u306b\u80a5\u6e80\uff08\u305d\u308c\u306b\u4f34\u3046\u30ec\u30d7\u30c1\u30f3\u62b5\u6297\u6027\uff09\u3092\u6539\u5584\u3059\u308b\u6cbb\u7642\u85ac\u3068\u306a\u308a\u3046\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3059\u306a\u308f\u3061\u3001PTPRJ\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u5c11\u306a\u3044\u30a4\u30f3\u30b9\u30ea\u30f3\u3067\u3082\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u304c\u5145\u5206\u306b\u6d3b\u6027\u5316\u3057\u3001\u9ad8\u8840\u7cd6\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u307e\u305f\u3001\u540c\u6642\u306b\u3001\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\u306e\u6d3b\u6027\u5316\u3092\u4fc3\u9032\u3057\u3001\u80a5\u6e80\u3057\u305f\u4eba\u306e\u98df\u6b32\u306e\u4ea2\u9032\u3092\u6539\u5584\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4eca\u5f8c\u3001PTPRJ\u3092\u6a19\u7684\u3068\u3059\u308b\u85ac\u5264\u304c\u3001\u7cd6\u5c3f\u75c5\u3068\u3068\u3082\u306b\u80a5\u6e80\u3092\u6539\u5584\u3059\u308b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u958b\u767a\u3055\u308c\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\"\"
PTPRJ\u306f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u6a19\u7684\u5668\u5b98\u3067\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u53d7\u5bb9\u4f53\u3092\u8131\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u8996\u5e8a\u4e0b\u90e8\u306e\u795e\u7d4c\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u30ec\u30d7\u30c1\u30f3\u53d7\u5bb9\u4f53\u306eJAK2\u3092\u8131\u30ea\u30f3\u9178\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u30ec\u30d7\u30c1\u30f3\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3002PTPRJ\u306f\u3001\u3053\u308c\u3089\u306e\u5236\u5fa1\u3092\u901a\u3057\u3066\u3001\u7cd6\u4ee3\u8b1d\u3001\u4e26\u3073\u306b\u6442\u98df\u30fb\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u306e\u5236\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u304c\u3001\u80a5\u6e80\u7b49\u306e\u75c5\u614b\u306b\u304a\u3044\u3066\u306f\u3001PTPRJ\u306e\u50cd\u304d\u306f\u3080\u3057\u308d\u75c5\u72b6\u306e\u60aa\u5316\u306b\u8ca2\u732e\u3057\u3066\u3044\u308b\u3068\u3044\u3048\u308b\u3002<\/figcaption><\/figure>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\nShintani T, Higashi S, Suzuki R, Takeuchi Y, Ikaga R, Yamazaki T, Kobayashi K and Noda M. (2017) PTPRJ inhibits leptin signaling, and induction of PTPRJ in the hypothalamus is a cause of the development of leptin resistance. Sci. Reports, 7, 11627. doi: 10.1038\/s41598-017-12070-7.<\/p>\n

Shintani T, Higashi S, Takeuchi Y, Gaudio E, Trapasso F, Fusco A and Noda M. (2015) The R3 receptor-like protein-tyrosine phosphatase subfamily inhibits insulin signaling by dephosphorylating the insulin receptor at specific sites. J. Biochem. 158, 235-243. doi: 10.1093\/jb\/mvv045.<\/p>\n","protected":false},"excerpt":{"rendered":"

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