{"id":5728,"date":"2017-09-06T10:00:06","date_gmt":"2017-09-06T01:00:06","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=5728"},"modified":"2017-08-30T15:16:08","modified_gmt":"2017-08-30T06:16:08","slug":"%e5%93%ba%e4%b9%b3%e9%a1%9e%e3%81%ae%e7%b4%b0%e8%83%9e%e5%88%86%e8%a3%82%e3%82%92%e5%ae%88%e3%82%8b%e6%9f%93%e8%89%b2%e4%bd%93%e9%a0%98%e5%9f%9f%e3%81%a7rna%e3%81%8c%e6%9e%9c%e3%81%9f%e3%81%99","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=5728","title":{"rendered":"\u54fa\u4e73\u985e\u306e\u7d30\u80de\u5206\u88c2\u3092\u5b88\u308b\u67d3\u8272\u4f53\u9818\u57df\u3067RNA\u304c\u679c\u305f\u3059\u5f79\u5272\u3068\u306f\uff1f"},"content":{"rendered":"

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\"\"
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\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306e\u6a21\u5f0f\u56f3\u3002\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u9818\u57df\u304c\u52d5\u539f\u4f53\u8fd1\u508d\u306b\u5b58\u5728\u3057\u3001\u305d\u306e\u9818\u57df\u306b\u5178\u578b\u7684\u306a\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\uff08\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\uff09\u304c\u5f62\u6210\u3055\u308c\u308b<\/figcaption><\/figure>\n

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\u305d\u3053\u3067\u3001Suv39h1\u3082CD\u3092\u4ecb\u3057\u3066RNA\u306b\u7d50\u5408\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3001\u751f\u5316\u5b66\u7684\u306b\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001Suv39h1\u306eCD\u306fRNA\u3068\u7d50\u5408\u3057\u3001\u30d2\u30b9\u30c8\u30f3\u306e\u30e1\u30c1\u30eb\u5316\u306e\u7a0b\u5ea6\u306b\u5f71\u97ff\u3055\u308c\u306a\u3044\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u30de\u30a6\u30b9\u306e\u7d30\u80de\u5185\u306b\u304a\u3044\u3066\u3082\u3001Suv39h1\u306fCD\u306eRNA\u7d50\u5408\u6d3b\u6027\u4f9d\u5b58\u7684\u306b\u3001\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u9818\u57df\u304b\u3089\u8ee2\u5199\u3055\u308c\u305f\u300c\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8RNA\u300d\u3068\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

RNA\u3068\u7d50\u5408\u3067\u304d\u306a\u3044\u3068\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u304c\u9045\u308c\u308b<\/h3>\n

Suv39h1\u306eCD\u306fRNA\u3068\u7d50\u5408\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u304c\u3001CD\u306fH3K9me3\u3068\u3082\u7d50\u5408\u3067\u304d\u307e\u3059\u3002\u305d\u3053\u3067\u3001H3K9me3\u3068\u7d50\u5408\u3059\u308bSuv39h1\u306eCD\u3092\u89e3\u6790\u3057\u3001\u305d\u306e\u7d50\u5408\u306b\u95a2\u308f\u308b\u30a2\u30df\u30ce\u9178\u6b8b\u57fa\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u751f\u5316\u5b66\u7684\u306a\u89e3\u6790\u306b\u3088\u308a\u3001\u4e21\u8005\u306e\u7d50\u5408\u306f\u72ec\u7acb\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001Suv39h1\u304cCD\u3092\u4ecb\u3057\u3066\u3001H3K9me3\u3068RNA\u306e\u4e21\u65b9\u306b\u7d50\u5408\u3067\u304d\u3001\u4e21\u8005\u306e\u7d50\u5408\u306f\u305d\u308c\u305e\u308c\u72ec\u7acb\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u3067\u306f\u3001\u5b9f\u969b\u306b\u7d30\u80de\u5185\u3067\u306fSuv39h1\u306eRNA\u7d50\u5408\u304c\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u306b\u3069\u306e\u3088\u3046\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n

\u305d\u306e\u7b54\u3048\u3092\u5c0e\u304f\u305f\u3081\u306b\u3001\u79c1\u305f\u3061\u306f\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u9818\u57df\u306eH3K9me3\u304c\u6d88\u5931\u3057\u3066\u3044\u308bSuv39h\u6b20\u640d\u7dda\u7dad\u82bd\u7d30\u80de\u306b\u3001\u5909\u7570\u578b\u306eSuv39h1\u3092\u5c0e\u5165\u3057\u3066\u6a5f\u80fd\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001H3K9me3\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001RNA\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u3067\u3082\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u304c\u9045\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u3053\u308c\u3089\u306e\u7d30\u80de\u682a\u306b\u304a\u3051\u308b\u6838\u306e\u72b6\u614b\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001Suv39h1\u306eH3K9me3\u7d50\u5408\u90e8\u4f4d\u3068RNA\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u3067\u306f\u3001\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u306bSuv39h1\u304c\u84c4\u7a4d\u3057\u3066\u3044\u308b\u7d30\u80de\u306e\u5272\u5408\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n

\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u304b\u3089\u306eRNA\u306e\u5f79\u5272\u306f\uff1f<\/h3>\n

\u3053\u308c\u3089\u306e\u7d50\u679c\u306f\u3001\u5909\u7570\u578b\u306eSuv39h1\u304c\u5b89\u5b9a\u7684\u306b\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u306b\u3064\u306a\u304e\u6b62\u3081\u3089\u308c\u3066\u3044\u306a\u3044\u304b\u3089\u3060\u3068\u8003\u3048\u3001Suv39h1\u306e\u52d5\u7684\u306a\u6319\u52d5\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001H3K9me3\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u3060\u3051\u3067\u306a\u304f\u3001RNA\u7d50\u5408\u90e8\u4f4d\u306b\u5909\u7570\u3092\u5c0e\u5165\u3057\u305f\u7d30\u80de\u3082\u3001\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u9818\u57df\u3067\u306eSuv39h1\u306e\u52d5\u304d\u304c\u901f\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3001\u3064\u307e\u308a\u53ef\u52d5\u6027\u304c\u5897\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
RNA\u7d50\u5408\u6b20\u640d\u578bSuv39h1\u3084H3K9me3\u7d50\u5408\u6b20\u640d\u578bSuv39h1\u306e\u52d5\u7684\u6319\u52d5\u3002\u3053\u308c\u3089\u306e\u7d30\u80de\u3067\u306fSuv39h1\u306e\u52d5\u304d\u304c\u901f\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308b<\/figcaption><\/figure>\n

\u3057\u304b\u3057\u3001\u3053\u308c\u3060\u3051\u3067\u306f\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8\u304b\u3089\u8ee2\u5199\u3055\u308c\u3066\u3044\u308bRNA\u304cSuv39h1\u306e\u52d5\u304d\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u3044\u308b\u76f4\u63a5\u7684\u306a\u7d50\u679c\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001\u6838\u5185\u306e\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8RNA\u3092\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3057\u305f\u7d30\u80de\u3067\u3001Suv39h1\u306e\u6319\u52d5\u3092\u9855\u5fae\u93e1\u3067\u89b3\u5bdf\u3057\u305f\u3068\u3053\u308d\u3001\u30ce\u30c3\u30af\u30c0\u30a6\u30f3\u3059\u308b\u3053\u3068\u3067\u3082Suv39h1\u306e\u52d5\u304d\u304c\u901f\u304f\u306a\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u3001Suv39h1\u304c\u5b89\u5b9a\u7684\u306b\u67d3\u8272\u4f53\u306b\u7d50\u5408\u3059\u308b\u305f\u3081\u306b\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8RNA\u304c\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3001\u305d\u308c\u304c\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u306b\u91cd\u8981\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"
RNA\u304c\u5a92\u4ecb\u3059\u308b\u54fa\u4e73\u985e\u306e\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u6a5f\u69cb<\/figcaption><\/figure>\n

\u4eca\u56de\u79c1\u305f\u3061\u306f\u3001\u54fa\u4e73\u985e\u3067\u306f\u3001\u30af\u30ed\u30e2\u30c9\u30e1\u30a4\u30f3\uff08CD\uff09\u3068SET\u30c9\u30e1\u30a4\u30f3\uff08SET\uff09\u3092\u6301\u3064Suv39h1\u304c\u3001\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3068CD\u3092\u4ecb\u3057\u3066\u7d50\u5408\u3057\u3001\u307e\u305fH3K9me3\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u52b9\u7387\u7684\u306b\u30d2\u30b9\u30c8\u30f3H3K9\u3092\u30c8\u30ea\u30e1\u30c1\u30eb\u5316\u3057\u3001\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u3092\u5f62\u6210\u3059\u308b\u3068\u3044\u3046\u65b0\u3057\u3044\u6a5f\u69cb\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u8fd1\u5e74\u3001\u67d3\u8272\u4f53\u7570\u5e38\u304c\u539f\u56e0\u306e\u5148\u5929\u6027\u75be\u60a3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4ed5\u7d44\u307f\u3092\u5b8c\u5168\u306b\u7406\u89e3\u3059\u308b\u306b\u306f\u81f3\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u9032\u5316\u7684\u306b\u30ce\u30f3\u30b3\u30fc\u30c7\u30a3\u30f3\u30b0RNA\u3092\u4ecb\u3057\u305f\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u304c\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u306f\u3001\u4eca\u5f8c\u3001\u672a\u3060\u306b\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u306a\u3044\u521d\u671f\u306e\u30d8\u30c6\u30ed\u30af\u30ed\u30de\u30c1\u30f3\u5f62\u6210\u3092\u89e3\u660e\u3059\u308b\u7cf8\u53e3\u3068\u306a\u308a\u3001\u5148\u5929\u6027\u7570\u5e38\u3092\u5f15\u304d\u8d77\u3053\u3059\u67d3\u8272\u4f53\u4e0d\u5b89\u5b9a\u6027\u3092\u89e3\u660e\u3059\u308b\u91cd\u8981\u306a\u4e00\u6b69\u306b\u306a\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\nAtsuko Shirai, Takayuki Kawaguchi, Hideaki Shimojo, Daisuke Muramatsu, Mayumi, Ishida-Yonetani, Yoshifumi Nishimura, Hiroshi Kimura, Jun-ichi Nakayama and Yoichi Shinkai, “Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly”, eLife, doi:10.7554\/eLife.25317
\nIshida et.al. Molecular Cell, 47, 228-241 (2012)<\/p>\n","protected":false},"excerpt":{"rendered":"

\u7d30\u80de\u5206\u88c2\u3092\u5b88\u308b\u67d3\u8272\u4f53\u9818\u57df\uff1a\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2 \u3072\u3068\u3064\u306e\u7d30\u80de\u304c\u6301\u3063\u3066\u3044\u308b\u30b2\u30ce\u30e0\u60c5\u5831\u306f\u3001\u30de\u30a6\u30b9\u3067\u7d0425\u5104\u5869\u57fa\u5bfe\u3001\u30d2\u30c8\u3067\u7d0429\u5104\u5869\u57fa\u5bfe\u304b\u3089\u306a\u308a\u3001\u304a\u3088\u305d2\u30e1\u30fc\u30c8\u30eb\u304f\u3089\u3044\u306e\u9577\u5927\u306a\u4e8c\u91cd\u3089\u305b\u3093\u69cb\u9020\u3092\u3068\u3063\u3066\u3044\u307e\u3059\u3002\u3053\u306e […]<\/p>\n","protected":false},"author":196,"featured_media":5723,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[82,15,54],"class_list":["post-5728","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-82","tag-biology","tag-54","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/5728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/196"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5728"}],"version-history":[{"count":0,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/5728\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/5723"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}