{"id":4997,"date":"2017-06-20T10:00:36","date_gmt":"2017-06-20T01:00:36","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=4997"},"modified":"2018-12-21T08:53:19","modified_gmt":"2018-12-20T23:53:19","slug":"%e5%8f%97%e7%b2%be%e5%8d%b5%e3%81%ae%e3%82%a8%e3%83%94%e3%82%b2%e3%83%8e%e3%83%a0%e7%b7%a8%e9%9b%86%e3%81%ab%e6%88%90%e5%8a%9f-%e3%82%b2%e3%83%8e%e3%83%a0%e3%81%ab%e8%a8%98%e3%81%95%e3%82%8c","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=4997","title":{"rendered":"\u53d7\u7cbe\u5375\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u6210\u529f &#8211; \u30b2\u30ce\u30e0\u306b\u8a18\u3055\u308c\u305f\u300c\u4ed8\u7b8b\u300d\u3092\u66f8\u304d\u66ff\u3048\u308b\u65b0\u624b\u6cd5"},"content":{"rendered":"<h3>\u3072\u3068\u3064\u306e\u30b2\u30ce\u30e0\u304b\u3089\u591a\u5f69\u306a\u7d30\u80de\u304c\u3064\u304f\u3089\u308c\u308b\u3057\u304f\u307f<\/h3>\n<p>\u79c1\u305f\u3061\u306e\u8eab\u4f53\u306f\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u7d30\u80de\u3084\u7d44\u7e54\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u307b\u3068\u3093\u3069\u306e\u7d30\u80de\u304c\u540c\u3058\u907a\u4f1d\u60c5\u5831\uff08\u30b2\u30ce\u30e0\uff09\u3092\u6838\u5185\u306b\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u540c\u3058\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3064\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u3069\u306e\u3088\u3046\u306b\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u7d44\u7e54\u3084\u7d30\u80de\u304c\u3064\u304f\u3089\u308c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u3053\u308c\u306f\u7d30\u80de\u5185\u306b\u304a\u3044\u3066\u3001\u300c\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u304c\u8aad\u307f\u51fa\u3055\u308c\u308b\u3053\u3068\u300d\u300c\u4e0d\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u306e\u8aad\u307f\u51fa\u3057\u3092\u5236\u9650\u3059\u308b\u3053\u3068\u300d\u306b\u3088\u3063\u3066\u6210\u3057\u9042\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8a00\u3044\u63db\u3048\u308c\u3070\u4e00\u518a\u306e\u8a2d\u8a08\u56f3\uff08\u907a\u4f1d\u60c5\u5831\uff09\u3092\u8aad\u307f\u51fa\u3059\u4ed8\u7b8b\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u3063\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u304c\u3064\u304f\u3089\u308c\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<p>\u3053\u306e\u4ed8\u7b8b\u306e\u5f79\u5272\u3092\u679c\u305f\u3059\u306e\u304c\u30a8\u30d4\u30b2\u30ce\u30e0\u3068\u547c\u3070\u308c\u308bDNA\u3084\u30d2\u30b9\u30c8\u30f3\u306a\u3069\u306b\u751f\u3058\u308b\u5316\u5b66\u4fee\u98fe\u3067\u3059\u3002\u306a\u304b\u3067\u3082DNA\u30e1\u30c1\u30eb\u5316\u306f4\u3064\u306eDNA\u5869\u57fa\u3001\u30a2\u30c7\u30cb\u30f3\uff08A\uff09\u3001\u30c1\u30df\u30f3\uff08T\uff09\u3001\u30b0\u30a2\u30cb\u30f3\uff08G\uff09\u3001\u30b7\u30c8\u30b7\u30f3\uff08C\uff09\u306e\u3046\u3061\u3001\u30b7\u30c8\u30b7\u30f3\u304c\u53d7\u3051\u308b\u5316\u5b66\u4fee\u98fe\u3067\u3042\u308a\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6291\u5236\u3001\u5237\u308a\u8fbc\u307f\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5236\u5fa1\uff08\u30b2\u30ce\u30e0\u30a4\u30f3\u30d7\u30ea\u30f3\u30c6\u30a3\u30f3\u30b0\uff09\u3001X\u67d3\u8272\u4f53\u306e\u4e0d\u6d3b\u6027\u5316\u3001\u30ec\u30c8\u30ed\u30c8\u30e9\u30f3\u30b9\u30dd\u30be\u30f3\u306a\u3069\u52d5\u304f\u907a\u4f1d\u5b50\u306e\u8ee2\u79fb\u6291\u5236\u306a\u3069\u3001\u6b63\u5e38\u306a\u500b\u4f53\u767a\u751f\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u764c\u3084\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306b\u304a\u3044\u3066\u3082DNA\u30e1\u30c1\u30eb\u5316\u60c5\u5831\u306e\u4e71\u308c\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u7d30\u80de\u304c\u6b63\u5e38\u306a\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u305f\u3081\u306b\u306f\u6b63\u5e38\u306aDNA\u30e1\u30c1\u30eb\u5316\u30d1\u30bf\u30fc\u30f3\u306e\u5f62\u6210\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<h3>\u4ed8\u7b8b\u306e\u610f\u5473\u3092\u77e5\u308b<\/h3>\n<p>\u7d30\u80de\u5185\u3067\u30a8\u30d4\u30b2\u30ce\u30e0\u304c\u5f62\u6210\u30fb\u7dad\u6301\u3055\u308c\u308b\u904e\u7a0b\u306b\u304a\u3044\u3066\u306f\u3001\u5316\u5b66\u4fee\u98fe\u3092\u66f8\u304d\u8fbc\u3080\u5206\u5b50\u3001\u6d88\u53bb\u3059\u308b\u5206\u5b50\u3001\u8a8d\u8b58\u3059\u308b\u5206\u5b50\u304c\u5354\u8abf\u3057\u3066\u52d5\u304f\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u30a8\u30d4\u30b2\u30ce\u30e0\u306e\u5f62\u6210\u306b\u95a2\u308f\u308b\u5206\u5b50\u306f\u30b2\u30ce\u30e0\u306e\u5e83\u7bc4\u56f2\u306b\u6e21\u3063\u3066\u6a5f\u80fd\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u306e\u89e3\u6790\u624b\u6cd5\u3067\u306f\u7279\u5b9a\u30b2\u30ce\u30e0\u90e8\u4f4d\u306eDNA\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3092\u64cd\u4f5c\u3059\u308b\u3053\u3068\u3084\u3001\u305d\u306e\u90e8\u4f4d\u306b\u304a\u3051\u308bDNA\u30e1\u30c1\u30eb\u5316\u304c\u679c\u305f\u3059\u751f\u7269\u5b66\u7684\u306a\u5f79\u5272\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u3044\u3068\u3044\u3046\u554f\u984c\u3082\u62b1\u3048\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u5b9f\u969b\u3001\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u306fDnmt\u3068\u547c\u3070\u308c\u308bDNA\u30e1\u30c1\u30eb\u5316\u3092\u66f8\u304d\u8fbc\u3080\u5206\u5b50\u3001Tet\u3068\u547c\u3070\u308c\u308bDNA\u30e1\u30c1\u30eb\u5316\u3092\u6d88\u53bb\u3055\u305b\u308b\u5206\u5b50\u304c\u5b58\u5728\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3044\u305a\u308c\u306e\u5206\u5b50\u306e\u907a\u4f1d\u5b50\u7834\u58ca\u52d5\u7269\u306b\u304a\u3044\u3066\u3082\u80ce\u751f\u81f4\u6b7b\u3084\u51fa\u751f\u5f8c\u306e\u6b7b\u4ea1\u3042\u308b\u3044\u306f\u751f\u4f53\u306b\u4f55\u304b\u3057\u3089\u306e\u7570\u5e38\u3092\u3082\u3063\u3066\u751f\u307e\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u8ab2\u984c\u3092\u30af\u30ea\u30a2\u3059\u308b\u305f\u3081\u3001\u79c1\u305f\u3061\u306f\u307e\u305aDNA\u30e1\u30c1\u30eb\u5316\u3092\u30b2\u30ce\u30e0\u306e\u90e8\u4f4d\u7279\u7570\u7684\u306b\u66f8\u304d\u8fbc\u3080\u624b\u6cd5\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u3080\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<h3>\u53d7\u7cbe\u5375\u3067\u306eDNA\u30e1\u30c1\u30eb\u5316\u8a98\u5c0e<\/h3>\n<p>\u79c1\u305f\u3061\u306f\u3001\u4efb\u610f\u306e\u5869\u57fa\u914d\u5217\u306b\u5bfe\u3059\u308bDNA\u7d50\u5408\u30e2\u30b8\u30e5\u30fc\u30eb\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306a\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u547c\u3070\u308c\u308b\u6280\u8853\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u308bTALEN\u304a\u3088\u3073CRISPR\/Cas9\u306eDNA\u7d50\u5408\u30e2\u30b8\u30e5\u30fc\u30eb\u3068\u3001\u30b9\u30d4\u30ed\u30d7\u30e9\u30ba\u30de\u3068\u547c\u3070\u308c\u308b\u7d30\u83cc\u304c\u4fdd\u6709\u3059\u308bDNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u306e\u3072\u3068\u3064\u3067\u3042\u308bSssI\u3068\u306e\u878d\u5408\u907a\u4f1d\u5b50\u3092\u4f5c\u88fd\u3057\u3001\u3053\u306e\u4eba\u5de5\u907a\u4f1d\u5b50\u3092\u7d30\u80de\u5185\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u30de\u30a6\u30b9\u306e\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306b\u5b58\u5728\u3059\u308bDNA\u914d\u5217\u3067\u3042\u308b\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8\u306b\u5bfe\u3057\u3066DNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u304c\u53ef\u80fd\u304b\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_4998\" aria-describedby=\"caption-attachment-4998\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4998\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/001-2.jpg\" alt=\"\" width=\"600\" height=\"404\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/001-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/001-2-300x202.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-4998\" class=\"wp-caption-text\">\u672c\u7814\u7a76\u306b\u304a\u3051\u308b\u30a8\u30d4\u30b2\u30ce\u30e0\u7de8\u96c6\u306e\u6982\u8981<\/figcaption><\/figure>\n<p>\u305d\u306e\u7d50\u679c\u3001\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2DNA\u304c\u4f4e\u30e1\u30c1\u30eb\u5316\u3092\u793a\u3059\u30de\u30a6\u30b9\u53d7\u7cbe\u5375\u3084\u3001DNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u3092\u6b20\u640d\u3057\u305f\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u306bDNA\u4f4e\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3092\u793a\u3059ES\u7d30\u80de\u306e\u30e1\u30b8\u30e3\u30fc\u30b5\u30c6\u30e9\u30a4\u30c8\u306b\u3001DNA\u30e1\u30c1\u30eb\u5316\u3092\u52b9\u7387\u7684\u306b\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306eDNA\u30e1\u30c1\u30eb\u5316\u306e\u4ea2\u9032\u306f\u30d0\u30a4\u30b5\u30eb\u30d5\u30a1\u30a4\u30c8\u30b7\u30fc\u30b1\u30f3\u30b9\u306b\u3088\u308b1\u5869\u57fa\u30ec\u30d9\u30eb\u306e\u89e3\u50cf\u5ea6\u3060\u3051\u3067\u306a\u304f\u3001DNA\u30e1\u30c1\u30eb\u5316\u306e\u751f\u7d30\u80de\u30ec\u30dd\u30fc\u30bf\u30fc\u30d7\u30ed\u30fc\u30d6\uff08mCherry-MBD-NLS\uff09\u3092\u7528\u3044\u305f\u86cd\u5149\u9855\u5fae\u93e1\u30ec\u30d9\u30eb\u3067\u3082\u691c\u51fa\u53ef\u80fd\u306a\u3082\u306e\u3067\u3042\u308a\u3001\u5927\u898f\u6a21\u306bDNA\u30e1\u30c1\u30eb\u5316\u304c\u5c0e\u5165\u3055\u308c\u308b\u69d8\u5b50\u3092\u30e9\u30a4\u30d6\u30bb\u30eb\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306b\u3088\u3063\u3066\u8ffd\u8de1\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_4999\" aria-describedby=\"caption-attachment-4999\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-4999\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/002-2.jpg\" alt=\"\" width=\"600\" height=\"377\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/002-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/002-2-300x189.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-4999\" class=\"wp-caption-text\">\u53d7\u7cbe\u5375\u306e\u5206\u5272\u671f\u306b\u304a\u3051\u308b\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3078\u306eDNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165<\/p>\n<p>\u53d7\u7cbe\u5375\u306b\u304a\u3051\u308b\u5206\u88c2\u5f8c\u671f\u306e\u67d3\u8272\u4f53\u306e\u30b9\u30ca\u30c3\u30d7\u30b7\u30e7\u30c3\u30c8\u3002\u300c\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u6709\u308a\u300d\u306e\u53d7\u7cbe\u5375\u306b\u304a\u3044\u3066\u5206\u914d\u65b9\u5411\u306e\u67d3\u8272\u4f53\u672b\u7aef\u8fd1\u304f\u306bDNA\u30e1\u30c1\u30eb\u5316\u306e\u4ea2\u9032\u304c\u8a8d\u3081\u3089\u308c\u308b\u3002\u300c\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u7121\u3057\u300d\u306e\u67d3\u8272\u4f53\u306b\u304a\u3044\u3066\u3082\u672b\u7aef\u90e8\u5206\u306b\u30e1\u30c1\u30eb\u5316DNA\u306e\u30b7\u30b0\u30ca\u30eb\u304c\u8a8d\u3081\u3089\u308c\u308b\u304c\u3001\u3053\u308c\u306f\u5143\u3005\u7d30\u80de\u304c\u6301\u3063\u3066\u3044\u308bDNA\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u77e2\u5370\uff1a\u67d3\u8272\u4f53\u5206\u914d\u65b9\u5411\u3001\u30b9\u30b1\u30fc\u30eb\u30d0\u30fc\uff1a20\u03bcm<\/figcaption><\/figure>\n<figure id=\"attachment_5000\" aria-describedby=\"caption-attachment-5000\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-5000\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/003-2.jpg\" alt=\"\" width=\"600\" height=\"371\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/003-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2017\/06\/003-2-300x186.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-5000\" class=\"wp-caption-text\">DNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u6b20\u640d\u30de\u30a6\u30b9ES\u7d30\u80de\u5185\u3067\u306e\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3078\u306eDNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165<\/p>\n<p>\u300c\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u6709\u308a\u300d\u306e\u7d30\u80de\u3067\u306f\u6838\u5185\u306e\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u8fd1\u508d\u306b\u304a\u3044\u3066\u30e1\u30c1\u30eb\u5316DNA\u306e\u30b7\u30b0\u30ca\u30eb\u306e\u4ea2\u9032\u304c\u8a8d\u3081\u3089\u308c\u308b\uff08\u77e2\u5370\uff09\u3002\u4e00\u65b9\u3067\u3001\u300c\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u7121\u3057\u300d\u306e\u7d30\u80de\u3067\u306f\u30e1\u30c1\u30eb\u5316DNA\u306e\u30b7\u30b0\u30ca\u30eb\u306f\u6838\u5185\u3067\u307b\u307c\u5747\u4e00\u306e\u30b7\u30b0\u30ca\u30eb\u3068\u306a\u308b\uff08\u6838\u5c0f\u4f53\u306b\u30b7\u30b0\u30ca\u30eb\u304c\u96c6\u7a4d\u3059\u308b\uff09\u3002\u30b9\u30b1\u30fc\u30eb\u30d0\u30fc\uff1a20\u03bcm<\/figcaption><\/figure>\n<p>\u3055\u3089\u306b\u3001\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306bDNA\u30e1\u30c1\u30eb\u5316\u3092\u5c0e\u5165\u3057\u305f\u30de\u30a6\u30b9\u53d7\u7cbe\u5375\u306e\u7d30\u80de\u5206\u88c2\u671f\u306b\u304a\u3051\u308b\u67d3\u8272\u4f53\u5206\u914d\u7570\u5e38\u3092\u8abf\u3079\u305f\u3068\u3053\u308d\u3001DNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u3057\u305f\u53d7\u7cbe\u5375\u3068DNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u3057\u3066\u3044\u306a\u3044\u53d7\u7cbe\u5375\u306b\u304a\u3044\u3066\u5927\u304d\u306a\u9055\u3044\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u7740\u5e8a\u524d\u521d\u671f\u80da\u767a\u751f\u306e\u30ad\u30cd\u30c8\u30b3\u30a2\u6a5f\u80fd\u306bDNA\u30e1\u30c1\u30eb\u5316\u306f\u91cd\u8981\u3067\u306f\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u5f93\u6765\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u4f7f\u7528\u3055\u308c\u3066\u304d\u305f\u54fa\u4e73\u52d5\u7269\u7531\u6765\u306eDNA\u30e1\u30c1\u30eb\u5316\u9175\u7d20\u306f\u3001\u5354\u8abf\u3057\u3066\u50cd\u304f\u5206\u5b50\u3092\u5fc5\u8981\u3068\u3057\u307e\u3059\u304c\u3001\u672c\u7814\u7a76\u3067\u4f5c\u88fd\u3055\u308c\u305f\u7d30\u83cc\u7531\u6765\u306e\u4eba\u5de5\u9175\u7d20\u306f\u305d\u308c\u5358\u72ec\u3067\u6a5f\u80fd\u3059\u308b\u305f\u3081\u3001\u4ed6\u306e\u751f\u4f53\u4f5c\u7528\u306e\u5f71\u97ff\u3092\u53d7\u3051\u305a\u306b\u5b89\u5b9a\u3057\u305fDNA\u30e1\u30c1\u30eb\u5316\u5c0e\u5165\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<h3>\u4eca\u5f8c\u306e\u5c55\u958b<\/h3>\n<p>\u53d7\u7cbe\u5375\u3092\u542b\u3080\u30de\u30a6\u30b9\u751f\u6b96\u7d30\u80de\u306e\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\uff08\u7d30\u80de\u5206\u88c2\u306b\u5fc5\u9808\u306a\u67d3\u8272\u4f53\u914d\u5217\uff09\u304a\u3088\u3073\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u3067\u306f\u3001\u4f53\u7d30\u80de\u3068\u6bd4\u3079\u3066\u5927\u898f\u6a21\u306aDNA\u8131\u30e1\u30c1\u30eb\u5316\u304c\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u305d\u306e\u5177\u4f53\u7684\u306a\u610f\u7fa9\u306b\u3064\u3044\u3066\u306f\u660e\u3089\u304b\u306b\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u672c\u7814\u7a76\u3067\u958b\u767a\u3057\u305f\u624b\u6cd5\u306f\u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u624b\u6bb5\u306e\u3072\u3068\u3064\u306b\u306a\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8907\u6570\u306e\u304c\u3093\u7d30\u80de\u306b\u304a\u3044\u3066\u3082\u751f\u6b96\u7d30\u80de\u3068\u540c\u69d8\u306b\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u306eDNA\u8131\u30e1\u30c1\u30eb\u5316\u304c\u5927\u898f\u6a21\u306b\u751f\u3058\u3066\u3044\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u306b\u7279\u5fb4\u7684\u306a\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3068\u306e\u76f8\u95a2\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u672c\u7814\u7a76\u306b\u3088\u308bDNA\u30e1\u30c1\u30eb\u5316\u64cd\u4f5c\u306b\u3088\u3063\u3066\u3001\u304c\u3093\u7d30\u80de\u306b\u304a\u3051\u308b\u30b2\u30ce\u30e0\u4e0d\u5b89\u5b9a\u6027\u3068DNA\u8131\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3068\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3068\u306a\u308a\u3001\u65b0\u305f\u306a\u304c\u3093\u7814\u7a76\u306e\u89e3\u6790\u30c4\u30fc\u30eb\u3068\u306a\u308b\u3053\u3068\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u672c\u7814\u7a76\u3067\u4f7f\u7528\u3057\u305fDNA\u7d50\u5408\u30e2\u30b8\u30e5\u30fc\u30eb\u306f\u4efb\u610f\u306e\u30b2\u30ce\u30e0\u9818\u57df\u306b\u8a2d\u8a08\u3067\u304d\u308b\u3053\u3068\u304b\u3089\u3001\u30da\u30ea\u30bb\u30f3\u30c8\u30ed\u30e1\u30a2\u4ee5\u5916\u306e\u3055\u307e\u3056\u307e\u306a\u30b2\u30ce\u30e0\u90e8\u4f4d\u306b\u5bfe\u3057\u3066DNA\u30e1\u30c1\u30eb\u5316\u306e\u5c0e\u5165\u3092\u884c\u3046\u3053\u3068\u304c\u53ef\u80fd\u3060\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u907a\u4f1d\u5b50\u7834\u58ca\u3092\u4f34\u308f\u305a\u306b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u6291\u5236\u3092\u884c\u3046\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u304c\u3093\u907a\u4f1d\u5b50\u3092\u306f\u3058\u3081\u3068\u3059\u308b\u75be\u60a3\u539f\u56e0\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u6291\u5236\u306a\u3069\u3001\u30b2\u30ce\u30e0\u3092\u66f8\u304d\u63db\u3048\u306a\u3044\u907a\u4f1d\u5b50\u6cbb\u7642\u3078\u306e\u5c06\u6765\u7684\u306a\u5fdc\u7528\u5c55\u958b\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\nYamazaki T,\u00a0Yamagata\u00a0K,\u00a0Baba T. (2007). Time-lapse and retrospective analysis of DNA methylation in mouse preimplantation embryos by live cell imaging. Dev Biol. 304, 409-419.<br \/>\nYamagata\u00a0K,\u00a0Yamazaki T,\u00a0Miki H,\u00a0Ogonuki N,\u00a0Inoue K,\u00a0Ogura A,\u00a0Baba T. (2007). Centromeric DNA hypomethylation as an epigenetic signature discriminates between germ and somatic cell lineages. Dev Biol. 312, 419-426.<br \/>\nYamazaki T,\u00a0Hatano Y\u00a0Handa T,\u00a0Kato S,\u00a0Hoida K,\u00a0Yamamura R,\u00a0Fukuyama T,\u00a0Uematsu T,\u00a0Kobayashi N,\u00a0Kimura H,\u00a0Yamagata\u00a0K. (2017). Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase. PLoS One.\u00a012: e0177764.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3072\u3068\u3064\u306e\u30b2\u30ce\u30e0\u304b\u3089\u591a\u5f69\u306a\u7d30\u80de\u304c\u3064\u304f\u3089\u308c\u308b\u3057\u304f\u307f \u79c1\u305f\u3061\u306e\u8eab\u4f53\u306f\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u7d30\u80de\u3084\u7d44\u7e54\u304b\u3089\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u307b\u3068\u3093\u3069\u306e\u7d30\u80de\u304c\u540c\u3058\u907a\u4f1d\u60c5\u5831\uff08\u30b2\u30ce\u30e0\uff09\u3092\u6838\u5185\u306b\u3082\u3063\u3066\u3044\u307e\u3059\u3002\u540c\u3058\u907a\u4f1d\u60c5\u5831\u3092\u3082\u3064\u306b [&hellip;]<\/p>\n","protected":false},"author":152,"featured_media":5000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[52,16,69,15],"class_list":["post-4997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-52","tag-16","tag-69","tag-biology","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/4997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/152"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4997"}],"version-history":[{"count":0,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/4997\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/5000"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}