{"id":4501,"date":"2017-05-02T10:00:07","date_gmt":"2017-05-02T01:00:07","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=4501"},"modified":"2017-04-30T16:19:18","modified_gmt":"2017-04-30T07:19:18","slug":"%e3%82%bb%e3%83%ac%e3%83%b3%e5%8e%9f%e5%ad%90%e3%81%8c%e5%88%87%e3%82%8a%e9%96%8b%e3%81%8f%e3%80%81%e3%82%a4%e3%83%b3%e3%82%b9%e3%83%aa%e3%83%b3%e5%8c%96%e5%ad%a6%e5%90%88%e6%88%90%e3%81%a8%e6%a9%9f","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=4501","title":{"rendered":"\u30bb\u30ec\u30f3\u539f\u5b50\u304c\u5207\u308a\u958b\u304f\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u5316\u5b66\u5408\u6210\u3068\u6a5f\u80fd\u306e\u5411\u4e0a\u3092\u76ee\u6307\u3057\u305f\u65b0\u3057\u3044\u9053\u7b4b"},"content":{"rendered":"

\u30a4\u30f3\u30b9\u30ea\u30f3\u88fd\u5264\u306e\u73fe\u72b6<\/h3>\n

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\u3053\u306e\u624b\u6cd5\u3067\u306f\u3001(1)Step 1\u304c\u751f\u7269\u306e\u529b\u306b\u4f9d\u5b58\u3059\u308b\u305f\u3081\u975e\u5929\u7136\u30a2\u30df\u30ce\u9178\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u304c\u56f0\u96e3\u3067\u3001\u65b0\u898f\u88fd\u5264\u306e\u5206\u5b50\u8a2d\u8a08\u3092\u5927\u304d\u304f\u5236\u7d04\u3059\u308b\u3001(2)Step 2\u306b\u304a\u3044\u3066\u3067\u305f\u3089\u3081\u306bS-S\u67b6\u6a4b\u3057\u305f\u7a2e\u304c\u751f\u3058\u308b\u3001(3)Step 3\u306b\u304a\u3044\u3066\u76ee\u7684\u90e8\u4f4d\u4ee5\u5916\u3067\u306e\u30da\u30d7\u30c1\u30c9\u306e\u5207\u65ad\u304c\u8d77\u3053\u308b\u3001\u306a\u3069\u591a\u304f\u306e\u554f\u984c\u3092\u5b55\u3093\u3067\u3044\u308b\u306e\u304c\u73fe\u72b6\u3067\u3059\u3002<\/p>\n

\u6e29\u6545\u77e5\u65b0 – \u6700\u53e4\u306e\u624b\u6cd5\u304b\u3089\u5b66\u3076\u30a4\u30f3\u30b9\u30ea\u30f3\u5408\u6210\u306e\u65b0\u624b\u6cd5<\/h3>\n

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\u5b9f\u969b\u3001Cys\u6b8b\u57fa\u306eS\u3092Se\u539f\u5b50\u306b\u7f6e\u63db\u3057\u305f\u30bb\u30ec\u30ce\u30b7\u30b9\u30c6\u30a4\u30f3\uff08Sec\uff1bU\uff09\u3092\u7d44\u307f\u8fbc\u3093\u3060A\u9396\u3068B\u9396\u3092\u5408\u6210\u3057\u3001\u5404\u30da\u30d7\u30c1\u30c9\u9396\u3092\u6700\u9069\u306a\u6761\u4ef6\u4e0b\u3067\u6df7\u5408\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u76ee\u7684\u306e\u30bb\u30ec\u30f3\u542b\u6709\u30a4\u30f3\u30b9\u30ea\u30f3\u3001\u540d\u4ed8\u3051\u3066\u300c\u30bb\u30ec\u30ce\u30a4\u30f3\u30b9\u30ea\u30f3\u300d\u304c\u6700\u592727\uff05\u306e\u5358\u96e2\u53ce\u7387\u3067\u5f97\u3089\u308c\u307e\u3057\u305f\u3002\u30bb\u30ec\u30f3\u3092\u5c0e\u5165\u3059\u308b\u6226\u7565\u306f\u3001\u4e88\u60f3\u3069\u304a\u308a\u3001\u4e8c\u672c\u9396\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u69cb\u6210\u9396\u3092\u7528\u3044\u305f\u53e4\u5178\u7684\u306a\u624b\u6cd5\u3092\u6539\u5584\u3057\u307e\u3057\u305f\u3002<\/p>\n

\"\"<\/p>\n

\u300c\u30bb\u30ec\u30ce\u30a4\u30f3\u30b9\u30ea\u30f3\u300d\u306e\u7279\u5fb4<\/h3>\n

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\"\"
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\"\"
in vitro\u306b\u304a\u3051\u308bIDE\u306b\u3088\u308b\u30a4\u30f3\u30b9\u30ea\u30f3\u3068\u30bb\u30ec\u30ce\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u5206\u89e3\u901f\u5ea6\u306e\u6bd4\u8f03<\/figcaption><\/figure>\n

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<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\nKjeldsen, T. Yeast secretory expression of insulin precursors. Appl. Microbiol. Biotechnol. 54, 277\u2013286 (2000)
\nE. Liu, et al., Chemical synthesis of peptides within the insulin superfamily. J. Pept. Sci. 22, 260\u2013270 (2016).
\nK. Arai, et al., Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue, Angew. Chem. Int. Ed., 56, (2017), in press.<\/p>\n","protected":false},"excerpt":{"rendered":"

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