{"id":3406,"date":"2017-01-23T10:00:26","date_gmt":"2017-01-23T01:00:26","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=3406"},"modified":"2017-05-01T13:03:19","modified_gmt":"2017-05-01T04:03:19","slug":"%e7%b4%b0%e8%83%9e%e3%81%ae%e9%81%8b%e5%91%bd%e3%82%92%e5%b7%bb%e3%81%8d%e6%88%bb%e3%81%99%e9%81%ba%e4%bc%9d%e5%ad%90%e3%82%92%e7%99%ba%e8%a6%8b%ef%bc%81-%e7%94%9f%e5%91%bd%e3%81%a8%e7%94%9f","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=3406","title":{"rendered":"\u7d30\u80de\u306e\u904b\u547d\u3092\u5dfb\u304d\u623b\u3059\u907a\u4f1d\u5b50\u3092\u767a\u898b\uff01 – \u751f\u547d\u3068\u751f\u547d\u3092\u3064\u306a\u3050\u4ed5\u7d44\u307f\u306e\u4e00\u7aef\u304c\u660e\u3089\u304b\u306b"},"content":{"rendered":"

 <\/p>\n

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\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306b\u3088\u308b\u30a8\u30d4\u30b2\u30ce\u30e0\u60c5\u5831\u306e\u521d\u671f\u5316<\/figcaption><\/figure>\n

\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u5f62\u6210\u306b\u91cd\u8981\u306a\u56e0\u5b50\u3001PRDM14<\/h3>\n

\u3067\u306f\u3001\u306a\u305c\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u307f\u3067\u3053\u306e\u3088\u3046\u306a\u5927\u898f\u6a21\u306a\u30a8\u30d4\u30b2\u30ce\u30e0\u60c5\u5831\u306e\u518d\u7de8\u96c6\u304c\u8d77\u3053\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u79c1\u306f\u3001\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u307f\u3067\u767a\u73fe\u3059\u308b\u30a8\u30d4\u30b2\u30ce\u30e0\u5236\u5fa1\u56e0\u5b50\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3044\u3001PRDM14\u3068\u547c\u3070\u308c\u308b\u5206\u5b50\u304cES\u7d30\u80de\u306e\u8d77\u6e90\u3067\u3042\u308b\u5185\u90e8\u7d30\u80de\u584a\u3068\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u307f\u306b\u767a\u73fe\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u5f53\u521d\u3053\u306e\u5206\u5b50\u306f\u59cb\u539f\u751f\u6b96\u7d30\u80de\u3067\u8d77\u3053\u308bH3K27\u306e\u30c8\u30ea\u30e1\u30c1\u30eb\u5316\u306e\u4fc3\u9032\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306f\u5f62\u6210\u3055\u308c\u308b\u304c\u3001\u30a8\u30d4\u30b2\u30ce\u30e0\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u304c\u7834\u7dbb\u3057\u3001\u6e1b\u6570\u5206\u88c2\u306e\u958b\u59cb\u3084\u6b21\u4e16\u4ee3\u3067\u7570\u5e38\u304c\u8d77\u304d\u308b\u3068\u60f3\u5b9a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u3001\u84cb\u3092\u958b\u3051\u3066\u307f\u308b\u3068\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u521d\u671f\u5206\u5316\u306e\u7570\u5e38\u306b\u3088\u308a\u3001\u96cc\u96c4\u3068\u3082\u306b\u4e0d\u598a\u306b\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306f\u4f53\u306e\u306a\u304b\u3067\u306f\u5375\u3068\u7cbe\u5b50\u306e\u307f\u306b\u5206\u5316\u3067\u304d\u307e\u3059\u304c\u3001\u4f53\u5916\u306b\u53d6\u308a\u51fa\u3057\uff13\u7a2e\u985e\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08bFGF, LIF, SCF\uff09\u306e\u5b58\u5728\u4e0b\u3067\u57f9\u990a\u3059\u308b\u3068ES\u7d30\u80de\u3068\u307b\u307c\u540c\u3058\u6027\u8cea\u3092\u6301\u3064\u80da\u6027\u751f\u6b96\u7d30\u80de\uff08EG\u7d30\u80de\uff09\u3078\u8131\u5206\u5316\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002Prdm14\u3092\u6b20\u640d\u3057\u305f\u59cb\u539f\u751f\u6b96\u7d30\u80de\u3067\u306fiPS\u7d30\u80de\u306e\u4f5c\u88fd\u306b\u3082\u7528\u3044\u3089\u308c\u308bSox2\u53ca\u3073Klf2\u306e\u767a\u73fe\u304c\u4f4e\u3044\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u3066\u3044\u305f\u306e\u3067\u3001EG\u7d30\u80de\u3078\u306e\u8131\u5206\u5316\u80fd\u3092\u691c\u8a3c\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u91ce\u751f\u578b\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306fEG\u7d30\u80de\u3078\u3068\u8131\u5206\u5316\u3057\u307e\u3057\u305f\u304c\u3001Prdm14\u3092\u6b20\u640d\u3057\u305f\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306fEG\u7d30\u80de\u3078\u306e\u8131\u5206\u5316\u80fd\u3092\u6d88\u5931\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u4e88\u60f3\u5916\u306a\u3053\u3068\u306bPRDM14\u306f\u30a8\u30d4\u30b2\u30ce\u30e0\u306e\u521d\u671f\u5316\u306e\u76f4\u524d\u306b\u8d77\u3053\u308b\u6f5c\u5728\u7684\u591a\u80fd\u6027\u306e\u7372\u5f97\u306b\u6975\u3081\u3066\u91cd\u8981\u306a\u56e0\u5b50\u3068\u3044\u3046\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u308f\u3051\u3067\u3059\u3002<\/p>\n

PRDM14\u306b\u3088\u308b\u7d30\u80de\u904b\u547d\u306e\u5dfb\u304d\u623b\u3057<\/h3>\n

\u907a\u4f1d\u5b50\u6b20\u640d\u30de\u30a6\u30b9\u306e\u89e3\u6790\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u73fe\u8c61\u306b\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u306e\u304b\uff1f\u3000\u305d\u306e\u554f\u3044\u306b\u5bfe\u3057\u3066\u306f\u660e\u78ba\u306a\u7b54\u3048\u3092\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u76f4\u63a5\u7684\u306a\u95a2\u4e0e\u306a\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u9593\u63a5\u7684\u306a\u95a2\u4e0e\u306a\u306e\u304b\u3001\u307e\u305f\u3069\u306e\u3088\u3046\u306a\u52d5\u4f5c\u539f\u7406\u3067\u5236\u5fa1\u3057\u3066\u3044\u308b\u306e\u304b\u3001\u305d\u306e\u554f\u3044\u306b\u5bfe\u3057\u3066\u306f\u7b54\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u305b\u3093\u3002\u305d\u3053\u3067\u3001ES\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u3066\u4f5c\u88fd\u3057\u305f\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u69d8\u7d30\u80de\uff08Epilblast-like cell: EpiLC\uff09\u306bPRDM14\u3092\u8a98\u5c0e\u7684\u306b\u767a\u73fe\u3055\u305b\u308b\u3053\u3068\u3067in vivo\u306e\u72b6\u614b\u3092\u518d\u73fe\u3057\u3001PRDM14\u304c\u76f4\u63a5\u5236\u5fa1\u3059\u308b\u751f\u547d\u73fe\u8c61\u304a\u3088\u3073\u5206\u5b50\u57fa\u76e4\u306e\u89e3\u660e\u3092\u8a66\u307f\u307e\u3057\u305f\u3002\u3053\u306e\u5b9f\u9a13\u3067\u306f\u3001PRDM14\u306e\u300c\u76f4\u63a5\u7684\u300d\u306a\u4e0b\u6d41\u3092\u63a2\u7d22\u3059\u308b\u3053\u3068\u304c\u76ee\u7684\u3067\u3057\u305f\u306e\u3067\u3001\u7d30\u80de\u9593\u76f8\u4e92\u4f5c\u7528\u306b\u3088\u308b\u300c\u9593\u63a5\u7684\u300d\u306a\u52b9\u679c\u3092\u6392\u9664\u3059\u308b\u305f\u3081\u306bEpiLC\u306bPRDM14\u3092\u8a98\u5c0e\u7684\u306b\u767a\u73fe\u3055\u305b\u3001\u6562\u3048\u3066\u300c\u63a5\u7740\u300d\u57f9\u990a\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u300c\u3069\u3093\u306a\u7d30\u80de\u3078\u5909\u5316\u3059\u308b\u306e\u3060\u308d\u3046\uff1f\u300d\u3068\u30ef\u30af\u30ef\u30af\u3057\u306a\u304c\u3089\u9855\u5fae\u93e1\u3092\u8997\u3044\u3066\u307f\u308b\u3068\u3001\u504f\u5e73\u72b6\u306eEpiLC\u304c\u307f\u308b\u307f\u308bES\u7d30\u80de\u306e\u3088\u3046\u306a\u5f62\u614b\u306b\u5909\u5316\u3057\u3066\u3044\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u5de6\uff1aES\u7d30\u80de\u3001\u4e2d\u592e\uff1aES\u7d30\u80de\u304b\u3089\u5206\u5316\u8a98\u5c0e\u3057\u305fEpiLC \u3001\u53f3\uff1aEpiLC\u306bPRDM14\u3092\u767a\u73fe\u3057\u30662\u65e5\u5f8c<\/figcaption><\/figure>\n

\u9a5a\u304f\u3079\u304d\u3053\u3068\u306b\u3001ES\u7d30\u80de\u306e\u672a\u5206\u5316\u6027\u7dad\u6301\u306b\u5fc5\u8981\u306a\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3067\u3042\u308bLIF\u3059\u3089\u3053\u306e\u57f9\u990a\u7cfb\u306b\u306f\u5165\u3063\u3066\u3044\u307e\u305b\u3093\u3002ES\u7d30\u80de\u306fin vivo\u306e3.5\u65e5\u80da\u306e\u5185\u90e8\u7d30\u80de\u584a\u306b\u76f8\u5f53\u3059\u308b\u6027\u8cea\u3092\u6301\u3061\u3001\u4e00\u65b9\u3067EpiLC\u306f5.5\u65e5\u80da\u306e\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u306b\u8fd1\u3044\u6027\u8cea\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001PRDM14\u306f\u5358\u72ec\u3067\u7d30\u80de\u306e\u904b\u547d\u3092\u7d042\u65e5\u9593\u5dfb\u304d\u623b\u3059\u6d3b\u6027\u3092\u6301\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u3002\u30de\u30a6\u30b9\u80da\u3067\u306e\u767a\u73fe\u3084\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u8868\u73fe\u7cfb\u304b\u3089PRDM14\u306f\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u5206\u5316\u306b\u5fc5\u8981\u306a\u30de\u30b9\u30bf\u30fc\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3068\u8003\u3048\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u89e3\u6790\u7d50\u679c\u304b\u3089\u59cb\u539f\u751f\u6b96\u7d30\u80de\u306e\u5206\u5316\u3088\u308a\u3082\u3001\u3080\u3057\u308d\u591a\u80fd\u6027\u7d30\u80de\u306e\u6210\u7acb\u306b\u91cd\u8981\u306a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u751f\u7406\u7684\u521d\u671f\u5316\u3092\u5229\u7528\u3057\u305f\u9ad8\u54c1\u8ceaiPS\u7d30\u80de\u4f5c\u88fd\u306e\u53ef\u80fd\u6027<\/h3>\n

\u4eca\u56de\u79c1\u305f\u3061\u306e\u7814\u7a76\u306b\u3088\u308a\u3001PRDM14\u304c\u4f53\u7d30\u80de\u3078\u306e\u5206\u5316\u6e96\u5099\u3092\u59cb\u3081\u305f\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u3092\u518d\u3073\u591a\u80fd\u6027\u7d30\u80de\u3078\u5dfb\u304d\u623b\u3059\u50cd\u304d\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002\u4eca\u56de\u306e\u5b9f\u9a13\u306f\u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u89e3\u6790\u3067\u3059\u304c\u3001\u540c\u69d8\u306e\u73fe\u8c61\u306f\u30d2\u30c8\u3067\u3082\u8d77\u304d\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30d2\u30c8\u306eiPS\u7d30\u80de\u306f\u30c9\u30ca\u30fc\u7d30\u80de\u306e\u30a8\u30d4\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u5b8c\u5168\u306b\u6d88\u53bb\u3067\u304d\u306a\u3044\u305f\u3081\u3001\u5206\u5316\u3057\u3065\u3089\u304b\u3063\u305f\u308a\u3001\u307e\u305f\u5206\u5316\u306e\u65b9\u5411\u6027\u306b\u504f\u308a\u304c\u3042\u308b\u3053\u3068\u304c\u554f\u984c\u3068\u306a\u3063\u3066\u304a\u308a\u307e\u3059\u3002PRDM14\u306b\u306fOCT4\u3001SOX2\u3001KLF\u306b\u306f\u306a\u3044DNA\u306e\u8131\u30e1\u30c1\u30eb\u5316\u8a98\u5c0e\u6d3b\u6027\u3068\u3044\u3046\u30e6\u30cb\u30fc\u30af\u306a\u6a5f\u80fd\u304c\u3042\u308b\u305f\u3081\u3001PRDM14\u3092\u5229\u7528\u3057\u3066iPS\u7d30\u80de\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u3067\u3001\u3088\u308a\u54c1\u8cea\u306e\u9ad8\u3044iPS\u7d30\u80de\u306e\u6a39\u7acb\u306b\u3064\u306a\u304c\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

    \n
  • Seki, Y., Hayashi, K., Itoh, K., Mizugaki, M., Saitou, M., and Matsui, Y. (2005). Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Developmental biology 278, 440-458.<\/li>\n
  • Yamaji, M., Seki, Y., Kurimoto, K., Yabuta, Y., Yuasa, M., Shigeta, M., Yamanaka, K., Ohinata, Y., and Saitou, M. (2008). Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nature genetics 40, 1016-1022.<\/li>\n
  • Okashita, N., Suwa Y., Nishimura O., Sakashita N., Kadota M., Nagamatsu G., Kawaguchi M., Kashida H., Nakajima A., Tachibana M., Seki Y. (2016). PRDM14 drives OCT3\/4 recruitment via active demethylation in the transition from primed to na\u00efve pluripotency., Stem Cell Reports 7 (6), 1072-1086<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

      \u751f\u547d\u306e\u9023\u7d9a\u6027\u3092\u62c5\u3046\u552f\u4e00\u306e\u7d30\u80de\u3001\u751f\u6b96\u7d30\u80de \u79c1\u305f\u3061\u306e\u751f\u306f\u305f\u3063\u305f\u3072\u3068\u3064\u306e\u5375\u306b\u3072\u3068\u3064\u306e\u7cbe\u5b50\u304c\u53d7\u7cbe\u3057\u305f\u77ac\u9593\u306b\u59cb\u307e\u308a\u307e\u3059\u304c\u3001\u4e0d\u53ef\u9006\u7684\u306a\u6642\u9593\u7d4c\u904e\u306b\u3088\u308a\u6052\u5e38\u6027\u3092\u4fdd\u3064\u3053\u3068\u304c\u56f0\u96e3\u3068\u306a\u3063\u305f\u500b\u4f53\u306f\u6700\u7d42\u7684\u306b\u306f\u5fc5\u305a […]<\/p>\n","protected":false},"author":86,"featured_media":3414,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[51,52,15,54,85],"class_list":["post-3406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-ips","tag-52","tag-biology","tag-54","tag-85","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3406","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/86"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3406"}],"version-history":[{"count":0,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3406\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/3414"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3406"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3406"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3406"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}