{"id":3319,"date":"2017-01-11T10:00:35","date_gmt":"2017-01-11T01:00:35","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=3319"},"modified":"2017-01-08T11:56:12","modified_gmt":"2017-01-08T02:56:12","slug":"%e3%80%8c%e7%97%9b%e3%81%bf%e3%80%8d%e3%82%92%e3%81%aa%e3%81%8f%e3%81%99%e3%81%93%e3%81%a8%e3%81%af%e3%81%a7%e3%81%8d%e3%82%8b%e3%81%ae%e3%81%8b%ef%bc%9f-%e7%96%bc%e7%97%9b%e9%96%a2%e9%80%a3","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=3319","title":{"rendered":"\u300c\u75db\u307f\u300d\u3092\u306a\u304f\u3059\u3053\u3068\u306f\u3067\u304d\u308b\u306e\u304b\uff1f &#8211; \u75bc\u75db\u95a2\u9023\u56e0\u5b50 &#8220;\u30cd\u30c8\u30ea\u30f34&#8221; 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loading=\"lazy\" decoding=\"async\" class=\"wp-image-3322 aligncenter\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-14.jpg\" width=\"500\" height=\"492\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-14.jpg 975w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-14-300x295.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-14-768x755.jpg 768w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p>\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u306e\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u3046\u3061\u3001Central cells\u3068\u3044\u3046\u30bf\u30a4\u30d7\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u7279\u7570\u7684\u306b\u30cd\u30c8\u30ea\u30f34\u304c\u767a\u73fe\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u30cd\u30c8\u30ea\u30f34\u306f\u3001\u7d30\u80de\u5916\u306b\u5206\u6ccc\u3055\u308c\u308b\u305f\u3093\u3071\u304f\u8cea\u3067\u3001\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u304b\u3089\u5206\u6ccc\u3055\u308c\u3066\u3001\u4ed6\u306e\u795e\u7d4c\u7d30\u80de\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u3067\u306f\u30cd\u30c8\u30ea\u30f34\u306f\u3001\u3069\u306e\u3088\u3046\u306a\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<p>\u3053\u306e\u7591\u554f\u306b\u7b54\u3048\u308b\u305f\u3081\u306b\u3001\u300c\u810a\u9ac4\u5f8c\u89d2\u306b\u304a\u3051\u308b\u30cd\u30c8\u30ea\u30f34\u304c\u306a\u304b\u3063\u305f\u3089\u3069\u3046\u306a\u308b\u304b\uff1f\u300d\u3068\u3044\u3046\u5b9f\u9a13\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u5177\u4f53\u7684\u306b\u306f\u3001\u30cd\u30c8\u30ea\u30f34\u907a\u4f1d\u5b50\u3092\u6b20\u640d\u3059\u308b\u30e9\u30c3\u30c8\u3092\u7528\u3044\u3066\u75db\u307f\u306e\u53cd\u5fdc\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u901a\u5e38\u306e\u30e9\u30c3\u30c8\u3067\u306f\u3001\u672b\u68a2\u795e\u7d4c\u3092\u969c\u5bb3\u3059\u308b\u3068\u3001\u666e\u901a\u3067\u306f\u75db\u307f\u3092\u5f15\u304d\u8d77\u3053\u3055\u306a\u3044\u523a\u6fc0\u306b\u3088\u3063\u3066\u75db\u307f\u3092\u751f\u3058\u308b\u75db\u899a\u904e\u654f\u3068\u3044\u308f\u308c\u308b\u75c7\u72b6\u304c\u8d77\u3053\u308a\u307e\u3059\u304c\u3001\u30cd\u30c8\u30ea\u30f34\u3092\u6b20\u640d\u3057\u305f\u30e9\u30c3\u30c8\u3067\u306f\u305d\u306e\u75c7\u72b6\u304c\u8d77\u3053\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u672b\u68a2\u795e\u7d4c\u304c\u969c\u5bb3\u3055\u308c\u75db\u899a\u904e\u654f\u306e\u75c7\u72b6\u304c\u3042\u308b\u30e9\u30c3\u30c8\u306b\u3001\u30cd\u30c8\u30ea\u30f34\u306e\u6a5f\u80fd\u3092\u6291\u5236\u3059\u308b\u6297\u4f53\u3084\u30cd\u30c8\u30ea\u30f34\u306e\u767a\u73fe\u3092\u6291\u3048\u308b\u6838\u9178\uff08siRNA\uff09\u3092\u6295\u4e0e\u3059\u308b\u3068\u3001\u6301\u7d9a\u7684\u304b\u3064\u5f37\u529b\u306a\u93ae\u75db\u52b9\u679c\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u308c\u3068\u306f\u9006\u306b\u3001\u30cd\u30c8\u30ea\u30f34\u3092\u810a\u9ac4\u5185\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001\u75db\u899a\u904e\u654f\u304c\u8d77\u3053\u308a\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u306e\u307f\u306a\u3089\u305a\u3001\u708e\u75c7\u306b\u3088\u308a\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u75bc\u75db\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u30e9\u30c3\u30c8\u306b\u304a\u3044\u3066\u3082\u3001\u540c\u69d8\u306e\u93ae\u75db\u52b9\u679c\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u30cd\u30c8\u30ea\u30f34\u306f\u75db\u307f\u306e\u767a\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u7269\u8cea\u3067\u3042\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u810a\u9ac4\u5f8c\u89d2\u306e\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u304b\u3089\u5206\u6ccc\u3055\u308c\u308b\u30cd\u30c8\u30ea\u30f34\u306f\u3001\u75db\u307f\u3092\u4f1d\u3048\u308b\u4e8c\u6b21\u75db\u899a\u795e\u7d4c\u306b\u767a\u73fe\u3059\u308bUnc5B\u53d7\u5bb9\u4f53\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u795e\u7d4c\u306b\u795e\u7d4c\u8208\u596e\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u4e0a\u56f3\u306e\u3088\u3046\u306b\u3001\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u3092\u767a\u75c7\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u30cd\u30c8\u30ea\u30f34\u306b\u3088\u3063\u3066\u75db\u307f\u304c\u5897\u5e45\u3055\u308c\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<h3>\u6cbb\u7642\u85ac\u306e\u958b\u767a\u3078<\/h3>\n<p>\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u3067\u3001\u65b0\u898f\u306e\u75bc\u75db\u95a2\u9023\u56e0\u5b50\u3067\u3042\u308bNetrin4\u304c\u810a\u9ac4\u4ecb\u5728\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\u3001\u75db\u307f\u3092\u60f9\u8d77\u3059\u308b\u5f79\u5272\u3092\u62c5\u3046\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u307e\u3057\u305f\u3002Netrin4\u3092\u6b20\u640d\u3057\u305f\u52d5\u7269\u306f\u3001\u795e\u7d4c\u969c\u5bb3\u6027\u75bc\u75db\u3084\u708e\u75c7\u6027\u75bc\u75db\u3092\u767a\u73fe\u305b\u305a\u3001\u8907\u6570\u306e\u30e9\u30c3\u30c8\u75bc\u75db\u75c5\u614b\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3001\u6297\u4f53\u3084\u6838\u9178\u3092\u7528\u3044\u3066Netrin4\u3092\u4e00\u904e\u6027\u306b\u963b\u5bb3\u3057\u3066\u3082\u3001\u6301\u7d9a\u7684\u3067\u5f37\u529b\u306a\u93ae\u75db\u52b9\u679c\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u4e00\u65b9\u3067\u3001\u4e2d\u67a2\u6027\u526f\u4f5c\u7528\u306a\u3069\u3092\u8a8d\u3081\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u306fNetrin4\u963b\u5bb3\u5264\u304c\u3001\u65e2\u5b58\u85ac\u3067\u306f\u6cbb\u7642\u3057\u304d\u308c\u306a\u3044\u591a\u304f\u306e\u6162\u6027\u75bc\u75db\u60a3\u8005\u3055\u3093\u306b\u304a\u3044\u3066\u3001\u9ad8\u3044\u6709\u52b9\u6027\u3068\u5b89\u5168\u6027\u3092\u4e21\u7acb\u3055\u305b\u305f\u753b\u671f\u7684\u306a\u75bc\u75db\u6cbb\u7642\u85ac\u306b\u306a\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ul>\n<li>Hayano, Y., Takasu, K., Koyama, Y., Ogawa, K., Minami, K., Asaki, T., Kitada, K., Kuwabara, S. and Yamashita, T. (2016) Dorsal horn interneuron-derived Netrin-4 contributes to spinal sensitization in chronic pain via Unc5B. J. Exp. 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