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\u5206\u5316\u3057\u305f\u72b6\u614b\u306e\u7d30\u80de\u3068\u672a\u5206\u5316\u72b6\u614b\u306e\u7d30\u80de\u306f\u3001\u7d30\u80de\u6838\u5185\u306b\u3042\u308bDNA\u306e\u30d1\u30c3\u30ad\u30f3\u30b0\u72b6\u614b\u304c\u9055\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u7b4b\u8089\u306e\u7d30\u80de\u3067\u306f\u3001\u7b4b\u8089\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u304c\u3069\u3093\u3069\u3093\u767a\u73fe\u3059\u308b\u4e00\u65b9\u3067\u3001\u4e0d\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u306f\u30ae\u30e5\u3063\u3068\u30d1\u30c3\u30ad\u30f3\u30b0\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7b4b\u8089\u7d30\u80de\u304b\u3089\u672a\u5206\u5316\u72b6\u614b\u306eiPS\u7d30\u80de\u3092\u4f5c\u308b\u3068\u3001\u30d1\u30c3\u30ad\u30f3\u30b0\u3055\u308c\u305f\u72b6\u614b\u304b\u3089\u30d1\u30c3\u30ad\u30f3\u30b0\u3055\u308c\u3066\u3044\u306a\u3044\u72b6\u614b\u306b\u306a\u308b\u305f\u3081\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u30c4\u30fc\u30eb\u304c\u907a\u4f1d\u5b50\u306b\u8fd1\u4ed8\u304d\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u3064\u307e\u308a\u3001ES\u7d30\u80de\u3084iPS\u7d30\u80de\u3067\u306f\u3001\u3044\u308d\u3044\u308d\u306a\u907a\u4f1d\u5b50\u3092\u7834\u58ca\u3057\u3084\u3059\u3044\u3068\u3044\u3046\u610f\u5473\u3067\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u3068\u306e\u76f8\u6027\u304c\u826f\u3044\u3068\u3044\u3046\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\u3053\u3046\u306a\u308c\u3070\u3082\u3046\u3001\u30a2\u30a4\u30c7\u30a2\u6b21\u7b2c\u3067\u306a\u3093\u3067\u3082\u3067\u304d\u3066\u3057\u307e\u3046\u3093\u3067\u3059\u3088\u306d\u3002<\/p>\n

\u30fc\u30a2\u30a4\u30c7\u30a2\u6b21\u7b2c\u3067\u306a\u3093\u3067\u3082\u3067\u304d\u308b\u3068\u3044\u3046\u306e\u306f\u3001\u8af8\u5203\u306e\u5263\u306b\u306a\u308a\u5f97\u307e\u3059\u3088\u306d\u3002<\/strong><\/p>\n

\u305d\u3046\u3067\u3059\u306d\u3002\u305f\u3068\u3048\u3070\u3001\u96e3\u75c5\u3092\u53d7\u7cbe\u5375\u306e\u72b6\u614b\u3067\u6cbb\u3059\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u3001\u75c5\u6c17\u81ea\u4f53\u3092\u6839\u7d76\u3067\u304d\u308b\u3053\u3068\u306b\u306a\u308b\u306e\u3067\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u4eba\u985e\u3092\u6551\u3044\u5f97\u308b\u6280\u8853\u3067\u3042\u308b\u3053\u3068\u306f\u9593\u9055\u3044\u3042\u308a\u307e\u305b\u3093\u3002\u5b89\u5168\u9762\u3084\u502b\u7406\u9762\u3092\u8003\u3048\u308b\u3068\u3001\u6b8b\u5ff5\u306a\u304c\u3089\u307e\u3060\u4f7f\u3048\u308b\u30ec\u30d9\u30eb\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u304c\u2026\u2026\u3002\u4e00\u65b9\u3067\u3001\u4e16\u754c\u4e2d\u306e\u30a2\u30b9\u30ea\u30fc\u30c8\u306e\u907a\u4f1d\u5b50\u3092\u8abf\u3079\u3042\u3052\u3066\u3001\u904b\u52d5\u80fd\u529b\u306b\u79c0\u3067\u305f\u30d2\u30c8\u3092\u4f5c\u308a\u307e\u3057\u3087\u3046\u3068\u306a\u308c\u3070\u3001SF\u306e\u4e16\u754c\u3067\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u300c\u30c7\u30b6\u30a4\u30ca\u30fc\u30fb\u30d9\u30a4\u30d3\u30fc\u300d\u304c\u3067\u304d\u306a\u3044\u3068\u306f\u9650\u308a\u307e\u305b\u3093\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u304c\u305d\u306e\u3088\u3046\u306a\u5074\u9762\u3092\u6301\u3064\u6280\u8853\u3067\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u306f\u3001\u8a8d\u8b58\u3057\u3066\u304a\u304f\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u30fc\u5b89\u5168\u306b\u4f7f\u3046\u305f\u3081\u306b\u306f\u3001\u3069\u308c\u304f\u3089\u3044\u306e\u5b9f\u9a13\u30c7\u30fc\u30bf\u304c\u84c4\u7a4d\u3055\u308c\u308c\u3070\u826f\u3044\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/strong><\/p>\n

\u3046\u30fc\u3093\u3001\u305d\u308c\u306f\u306a\u304b\u306a\u304b\u96e3\u3057\u3044\u3093\u3067\u3059\u3088\u306d\u3002\u307e\u305a\u3001CRISPR-Cas9\u306b\u306f\u5207\u65ad\u3057\u305f\u3044\u90e8\u4f4d\u3068\u4f3c\u305f\u90e8\u4f4d\u3092\u8aa4\u3063\u3066\u5207\u65ad\u3057\u3066\u3057\u307e\u3046\u30aa\u30d5\u30bf\u30fc\u30b2\u30c3\u30c8\u52b9\u679c\u3068\u3044\u3046\u3082\u306e\u304c\u3042\u308b\u306e\u3067\u3001\u305d\u306e\u3088\u3046\u306a\u985e\u4f3c\u306e\u914d\u5217\u306b\u95a2\u3057\u3066\u306f\u3001\u4f53\u7cfb\u7684\u306b\u8abf\u3079\u308b\u5fc5\u8981\u304c\u3042\u308b\u3088\u3046\u306b\u601d\u3044\u307e\u3059\u3002<\/p>\n

\u305f\u3060\u3001\u7db2\u7f85\u7684\u306b\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3057\u3066\u3082\u3001\u3084\u306f\u308a\u8ab2\u984c\u306f\u6b8b\u308a\u307e\u3059\u3002\u3068\u3044\u3046\u306e\u3082\u3001\u79c1\u305f\u3061\u306e\u4f53\u3092\u69cb\u6210\u3059\u308b\u7d30\u80de\u5185\u306eDNA\u306f\u3001\u523a\u6fc0\u3092\u53d7\u3051\u3066\u65e5\u3005\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u3057\u305f\u3068\u306f\u3044\u3048\u3001\u305d\u308c\u304c\u81ea\u7136\u306b\u8d77\u304d\u305f\u5909\u5316\u306a\u306e\u304b\u3001\u30b2\u30ce\u30e0\u7de8\u96c6\u306b\u3088\u308b\u5909\u5316\u306a\u306e\u304b\u306f\u3001\u7d71\u8a08\u7684\u306a\u6709\u610f\u5dee\u3092\u898b\u308b\u3057\u304b\u306a\u304f\u3001\u8a00\u3044\u5207\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u3093\u3067\u3059\u3088\u3002\u5b9f\u9a13\u30c7\u30fc\u30bf\u3092\u84c4\u7a4d\u3057\u3066\u3044\u304f\u3068\u540c\u6642\u306b\u3001\u305d\u306e\u8fba\u308a\u306e\u66d6\u6627\u3055\u3092\u3069\u306e\u3088\u3046\u306b\u89e3\u91c8\u3059\u308b\u306e\u304b\u3001\u8003\u3048\u3066\u3044\u304b\u306a\u304f\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u306d\u3002<\/p>\n

\u30fc\u65e5\u672c\u306e\u30b2\u30ce\u30e0\u7de8\u96c6\u306f\u3001\u4e16\u754c\u7684\u306b\u898b\u3066\u3069\u306e\u3088\u3046\u306a\u4f4d\u7f6e\u306b\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002<\/strong><\/p>\n

\u30b2\u30ce\u30e0\u7de8\u96c6\u3092\u884c\u3046\u969b\u306b\u306f\u3001\u7279\u5b9a\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u30cf\u30b5\u30df\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u7b2c\u4e00\u4e16\u4ee3\u306eZFN\u3001\u7b2c\u4e8c\u4e16\u4ee3\u306eTALEN\u3001\u305d\u3057\u3066Cas9\u306e\u7279\u8a31\u306f\u3059\u3079\u3066\u6d77\u5916\u306b\u3042\u308a\u307e\u3059\u3002\u6d77\u5916\u306b\u6291\u3048\u3089\u308c\u3066\u3044\u308b\u3068\u306a\u308b\u3068\u3001\u5546\u696d\u5229\u7528\u306e\u969b\u306b\u306f\u9ad8\u3044\u4f7f\u7528\u6599\u3092\u6255\u308f\u306a\u304f\u3066\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u305d\u308c\u306f\u4f55\u3068\u304b\u907f\u3051\u305f\u3044\u3068\u3044\u3046\u3053\u3068\u3067\u3001\u73fe\u5728Cas9\u306b\u4ee3\u308f\u308b\u30cf\u30b5\u30df\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u767a\u898b\u3059\u308b\u305f\u3081\u306b\u3001\u5185\u95a3\u5e9c\u3084\u7d4c\u6e08\u7523\u696d\u7701\u304c\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u7acb\u3066\u3066\u304a\u308a\u3001\u56fd\u3092\u6319\u3052\u305f\u7814\u7a76\u958b\u767a\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4e00\u65b9\u3067\u3001CRISPR-Cas9\u304c\u3042\u307e\u308a\u306b\u3082\u4f7f\u3044\u3084\u3059\u3044\u305f\u3081\u3001\u4e16\u306e\u4e2d\u304cCRISPR-Cas9\u3067\u52d5\u3044\u3066\u3044\u308b\u306e\u3082\u73fe\u5b9f\u3067\u3059\u3002\u6700\u8fd1\u3067\u306f\u3001\u304c\u3093\u306e\u767a\u75c7\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u3092\u63a2\u7d22\u3057\u3088\u3046\u3068\u3044\u3046\u6d41\u308c\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001\u305d\u3053\u3067CRISPR-Cas9\u3092\u4f7f\u308f\u306a\u3044\u624b\u306f\u306a\u3044\u3093\u3067\u3059\u3088\u306d\u3002\u3053\u306e\u30c4\u30fc\u30eb\u306f\u672c\u5f53\u306b\u7279\u6b8a\u3067\u30012012\u5e74\u306e\u590f\u306b\u8ad6\u6587\u304c\u51fa\u3066\u3001\u3088\u3057\u3053\u308c\u306f\u4f7f\u3048\u308b\u305e\uff01\u3000\u3068\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u305f\u3061\u304c\u4f7f\u3063\u3066\u30012013\u5e74\u306e\u306f\u3058\u3081\u306b\u8ad6\u6587\u304c\u4e00\u6c17\u306b\u51fa\u307e\u3057\u305f\u3002\u305d\u308c\u304b\u3089\u308f\u305a\u304b3\u5e74\u534a\u306e\u3042\u3044\u3060\u306b\u3001\u3053\u308c\u3060\u3051\u306e\u5e83\u304c\u308a\u3092\u898b\u305b\u3066\u3001\u6bce\u9031\u306e\u3088\u3046\u306b\u65b0\u3057\u3044\u8ad6\u6587\u304c\u51fa\u308b\u6280\u8853\u3063\u3066\u3001\u3053\u308c\u307e\u3067\u306e\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3067\u306f\u304a\u305d\u3089\u304f\u306a\u3044\u3068\u601d\u3046\u3093\u3067\u3059\u3002<\/p>\n

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\u30fcCRISPR-Cas9\u306b\u4ee3\u308f\u308b\u65e5\u672c\u521d\u306e\u30c4\u30fc\u30eb\u3092\u958b\u767a\u3059\u308b\u3068\u540c\u6642\u306b\u3001\u65e2\u5b58\u306e\u30c4\u30fc\u30eb\u3092\u7528\u3044\u305f\u6280\u8853\u958b\u767a\u3092\u9032\u3081\u3066\u3044\u304f\u5fc5\u8981\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u306d\u3002\u6700\u5f8c\u306b\u3001\u5c71\u672c\u5148\u751f\u304c\u30b2\u30ce\u30e0\u7de8\u96c6\u3067\u5b9f\u73fe\u3057\u305f\u3044\u3053\u3068\u304c\u3042\u308c\u3070\u6559\u3048\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n

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  \u751f\u547d\u306e\u8a2d\u8a08\u56f3\u3068\u8a00\u308f\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3092\u4eba\u70ba\u7684\u306b\u64cd\u4f5c\u3067\u304d\u308b\u300c\u30b2\u30ce\u30e0\u7de8\u96c6\u6280\u8853\u300d\u304c\u6ce8\u76ee\u3092\u6d74\u3073\u3066\u3044\u308b\u3002\u3053\u306e\u6280\u8853\u3092\u3046\u307e\u304f\u6d3b\u7528\u3067\u304d\u308c\u3070\u3001\u98df\u6599\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u3001\u533b\u7642\u5206\u91ce\u306a\u3069\u306b\u304a\u3051\u308b\u554f\u984c\u3092\u4e00\u6c17\u306b\u89e3\u6c7a\u3067\u304d\u308b\u304b\u3082\u3057 […]<\/p>\n","protected":false},"author":2,"featured_media":3166,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[16,15],"class_list":["post-3091","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-16","tag-biology","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3091","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3091"}],"version-history":[{"count":1,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3091\/revisions"}],"predecessor-version":[{"id":16227,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/3091\/revisions\/16227"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/3166"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3091"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3091"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3091"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}