{"id":2996,"date":"2016-12-21T10:00:04","date_gmt":"2016-12-21T01:00:04","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=2996"},"modified":"2017-05-01T13:03:31","modified_gmt":"2017-05-01T04:03:31","slug":"%e3%81%8c%e3%82%93%e9%81%ba%e4%bc%9d%e5%ad%90%e3%80%8cgrwd1%e3%80%8d%e3%81%ae%e7%99%ba%e8%a6%8b-%e6%96%b0%e3%81%9f%e3%81%aa%e6%8a%97%e3%81%8c%e3%82%93%e5%89%a4%e3%81%ae%e9%96%8b%e7%99%ba%e3%82%92","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=2996","title":{"rendered":"\u304c\u3093\u907a\u4f1d\u5b50\u300cGRWD1\u300d\u306e\u767a\u898b – \u65b0\u305f\u306a\u6297\u304c\u3093\u5264\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066"},"content":{"rendered":"

 <\/p>\n

\u300c\u304c\u3093\u300d\u3068\u306f\uff1f<\/h3>\n

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\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u7570\u5e38\u304c\u751f\u3058\u308b\u7406\u7531<\/h3>\n

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\u65b0\u305f\u306a\u304c\u3093\u907a\u4f1d\u5b50\u306e\u767a\u898b<\/h3>\n

\u4eca\u56de\u79c1\u305f\u3061\u306f\u3001\u304c\u3093\u907a\u4f1d\u5b50\uff08\u7d30\u80de\u306e\u304c\u3093\u5316\u3092\u4fc3\u9032\u3059\u308b\u907a\u4f1d\u5b50\uff09GRWD1\u3092\u65b0\u305f\u306b\u767a\u898b\u3057\u307e\u3057\u305f\uff08Kayama et al., EMBO reports, e201642444\uff09\u3002GRWD1\u907a\u4f1d\u5b50\u304c\u4f5c\u308a\u51fa\u3059\u30bf\u30f3\u30d1\u30af\u8ceaGRWD1\u306f\u3001RPL11\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u306e\u7d50\u5408\u3092\u4ecb\u3057\u3066p53\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u3092\u6e1b\u5c11\u3055\u305b\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u3092\u4fc3\u9032\u3055\u305b\u307e\u3059\u3002<\/p>\n

\"fig1\"
\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u306e\u6982\u7565\u56f3\uff1ap53\u30bf\u30f3\u30d1\u30af\u8cea\u306f\u7d30\u80de\u5897\u6b96\u306e\u30d6\u30ec\u30fc\u30ad\u306a\u306e\u3067\u3001\u6b63\u5e38\u306b\u5897\u3048\u3066\u3044\u308b\u7d30\u80de\u4e2d\u3067\u306f\u3001MDM2\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u50cd\u304d\u3067\u5206\u89e3\u3055\u308c\u3066\u3044\u308b\uff08\u5de6\u4e0a\uff09\u3002\u7d30\u80de\u304c\u3001\u7570\u5e38\u306a\u5897\u6b96\u523a\u6fc0\u3084DNA\u30c0\u30e1\u30fc\u30b8\u306a\u3069\u306e\u30b9\u30c8\u30ec\u30b9\u306b\u6652\u3055\u308c\u305f\u5834\u5408\u3001RPL11\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304cMDM2\u306b\u7d50\u5408\u3057\u305d\u306e\u6a5f\u80fd\u3092\u6291\u3048\u308b\u3002\u305d\u306e\u7d50\u679cp53\u91cf\u304c\u5897\u52a0\u3057\u3001\u7d30\u80de\u306e\u5897\u6b96\u3092\u6b62\u3081\u3066\u7570\u5e38\u3092\u4fee\u5fa9\u3057\u305f\u308a\u3001\u4fee\u5fa9\u3057\u304d\u308c\u306a\u3044\u5834\u5408\u306f\u7d30\u80de\u3092\u81ea\u6bba\u3055\u305b\u3001\u304c\u3093\u5316\u3092\u9632\u3044\u3067\u3044\u308b\uff08\u53f3\u4e0a\uff09\u3002GRWD1\u30bf\u30f3\u30d1\u30af\u8cea\u91cf\u304c\u5897\u52a0\u3057\u305f\u5834\u5408\u3001\u305d\u306eGRWD1\u304cRPL11\u306b\u7d50\u5408\u3057\u50cd\u304d\u3092\u90aa\u9b54\u3057\u3066\u3057\u307e\u3046\u3002\u305d\u306e\u7d50\u679c\u3001\u7d30\u80de\u306e\u304c\u3093\u5316\u304c\u4fc3\u9032\u3055\u308c\u308b\uff08\u4e0b\uff09\u3002<\/figcaption><\/figure>\n

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\"fig2\"
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