{"id":2994,"date":"2017-03-02T10:00:56","date_gmt":"2017-03-02T01:00:56","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=2994"},"modified":"2017-08-15T18:22:04","modified_gmt":"2017-08-15T09:22:04","slug":"%e6%9c%9d%e3%81%a8%e5%a4%9c%e3%81%a7%e3%81%af%e8%a8%98%e6%86%b6%e5%8a%9b%e3%81%8c%e5%a4%89%e5%8c%96%e3%81%99%e3%82%8b-%e3%83%9e%e3%82%a6%e3%82%b9%e5%ae%9f%e9%a8%93%e3%81%a7%e8%a7%a3%e6%98%8e","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=2994","title":{"rendered":"\u671d\u3068\u591c\u3067\u306f\u8a18\u61b6\u529b\u304c\u5909\u5316\u3059\u308b? &#8211; 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3002\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig1-6.jpg\" alt=\"fig1\" width=\"500\" height=\"360\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig1-6.jpg 564w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig1-6-300x216.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-3003\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-5.jpg\" alt=\"fig2\" width=\"500\" height=\"406\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-5.jpg 400w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/12\/fig2-5-300x244.jpg 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" 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sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p>\u3053\u306e\u3088\u3046\u306bSCOP\u306f\u3001\u6d77\u99ac\u306e\u9577\u671f\u8a18\u61b6\u30b7\u30b9\u30c6\u30e0\u306e\u4e0a\u6d41\u306b\u4f4d\u7f6e\u3057\u3001\u8a18\u61b6\u306e\u56fa\u5b9a\u5316\u306b\u95a2\u308f\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bK-Ras\u3092\u62b1\u304d\u8fbc\u3080\u3053\u3068\u3067\u3001\u9577\u671f\u8a18\u61b6\u3092\u5f62\u6210\u3059\u308b\u305f\u3081\u306e\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u3092\u84c4\u3048\u307e\u3059\u3002\u4f53\u5185\u6642\u8a08\u304c\u9577\u671f\u8a18\u61b6\u306e\u52b9\u7387\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u306f\u3001SCOP \u304c\u95a2\u308f\u308b\u8a18\u61b6\u56fa\u5b9a\u5316\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u6a5f\u69cb\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002\u6d77\u99ac\u795e\u7d4c\u7d30\u80de\u306e\u819c\u30e9\u30d5\u30c8\u3068\u3044\u3046\u7d30\u80de\u819c\u5185\u306e\u30de\u30a4\u30af\u30ed\u30c9\u30e1\u30a4\u30f3\u306b\u304a\u3044\u3066\u3001\u6d77\u99ac\u6642\u8a08\u306e\u5236\u5fa1\u306b\u3088\u3063\u3066\u6d77\u99ac\u306eSCOP \u91cf\u304c\u6642\u523b\u5909\u5316\u3057\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u62b1\u304d\u8fbc\u3080 K-Ras \u306e\u91cf\u304c\u5909\u5316\u3057\u3001\u9577\u671f\u8a18\u61b6\u5f62\u6210\u306e\u30dd\u30c6\u30f3\u30b7\u30e3\u30eb\u3092\u4e00\u65e5\u306e\u6d3b\u52d5\u671f\u306e\u524d\u534a\u3060\u3051\u306b\u84c4\u3048\u307e\u3059\u3002\u540c\u3058\u5b66\u7fd2\u30b7\u30b0\u30ca\u30eb\u304c\u6d77\u99ac\u306b\u5230\u9054\u3057\u3066\u3082\u3001\u3053\u308c\u3092\u56fa\u5b9a\u5316\u3059\u308b\u904e\u7a0b\u3067\u50cd\u304f\u5206\u5b50\u306e\u91cf\u304c\u65e5\u5468\u5909\u52d5\u3057\u3066\u3044\u308b\u306e\u3067\u3001\u9577\u671f\u8a18\u61b6\u306b\u6642\u523b\u5909\u5316\u304c\u751f\u307f\u51fa\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<h3>\u304a\u308f\u308a\u306b<\/h3>\n<p>\u30d2\u30c8\u3067\u3082\u8a18\u61b6\u3057\u3084\u3059\u3055\u306b\u306f\u6642\u523b\u5909\u5316\u304c\u3042\u308a\u305d\u3046\u3060\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u767a\u898b\u3057\u305f\u4ed5\u7d44\u307f\u306b\u95a2\u308f\u308b\u3059\u3079\u3066\u306e\u5206\u5b50\u306f\u30d2\u30c8\u306b\u3082\u5b58\u5728\u3059\u308b\u306e\u3067\u3001\u3053\u306e\u4ed5\u7d44\u307f\u306f\u30d2\u30c8\u306b\u3082\u3042\u3066\u306f\u307e\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305f\u3060\u3057\u3001\u9577\u671f\u8a18\u61b6\u306e\u30d4\u30fc\u30af\u304c\u6d3b\u52d5\u671f\u306e\u524d\u534a\u3060\u3068\u3059\u308c\u3070\u3001\u591c\u884c\u6027\u306e\u30de\u30a6\u30b9\u306b\u5bfe\u3057\u3066\u663c\u884c\u6027\u306e\u30d2\u30c8\u3067\u306f\u3001\u9577\u671f\u8a18\u61b6\u306e\u5b66\u7fd2\u52b9\u679c\u306e\u30d4\u30fc\u30af\u306f\u663c\u306e\u524d\u534a\uff08\u5348\u524d\u4e2d\uff09\u306b\u3042\u305f\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u8a18\u61b6\u306e\u56fa\u5b9a\u5316\u306e\u6642\u523b\u5909\u5316\u3092\u5229\u7528\u3057\u3066\u3001\u3088\u308a\u52b9\u7387\u3088\u304f\u5b66\u7fd2\u52b9\u679c\u3092\u4e0a\u3052\u308b\u3053\u3068\u3082\u53ef\u80fd\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<p>K. Shimizu et al. (2016) Nature Communications 7, 12926<br \/>\nK. Shimizu et al. (2007) Cell 128, 1219-1229<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d2\u30c8\u3092\u542b\u3080\u3055\u307e\u3056\u307e\u306a\u52d5\u7269\u306f\u3001\u7761\u7720\u30fb\u899a\u9192\u3084\u30db\u30eb\u30e2\u30f3\u5206\u6ccc\u306a\u3069\u306e\u591a\u304f\u306e\u751f\u7406\u6a5f\u80fd\u304c\u3001\u4e00\u65e5\u306e\u3046\u3061\u306e\u6642\u523b\u306b\u3088\u3063\u3066\u5909\u5316\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5909\u5316\u306f\u3001\u4f53\u5185\u6642\u8a08\uff08\u6982\u65e5\u6642\u8a08\uff09\u304c\u53f8\u3063\u3066\u3044\u307e\u3059\u3002\u4f53\u5185\u6642\u8a08\u306f\u500b\u3005\u306e\u4f53\u5185\u3067\u3001\u7d0424 [&hellip;]<\/p>\n","protected":false},"author":74,"featured_media":3002,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[107,15,24],"class_list":["post-2994","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-107","tag-biology","tag-24","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/74"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2994"}],"version-history":[{"count":0,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2994\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/3002"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2994"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2994"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}