{"id":2454,"date":"2016-11-14T10:00:38","date_gmt":"2016-11-14T01:00:38","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=2454"},"modified":"2017-05-01T13:04:02","modified_gmt":"2017-05-01T04:04:02","slug":"%e3%83%a1%e3%82%b9%e3%81%ab%e9%96%a2%e9%80%a3%e3%81%99%e3%82%8b3%e3%81%a4%e3%81%ae%e3%81%af%e3%81%9f%e3%82%89%e3%81%8d%e3%82%92%e6%8c%81%e3%81%a4%e9%81%ba%e4%bc%9d%e5%ad%90%e3%80%8cnrk%e3%80%8d","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=2454","title":{"rendered":"\u30e1\u30b9\u306b\u95a2\u9023\u3059\u308b3\u3064\u306e\u306f\u305f\u3089\u304d\u3092\u6301\u3064\u907a\u4f1d\u5b50\u300cNrk\u300d \u2013 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https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/10\/14813388_1302341826456252_653588033_o-1-\u306e\u30b3\u30d2\u309a\u30fc-2-1.jpeg 1524w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p class=\"p1\">\u7d30\u80de\u5897\u6b96\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308bKi67\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u514d\u75ab\u67d3\u8272\u3092\u884c\u3046\u3068\u3001\u7279\u306b\u30e9\u30d3\u30ea\u30f3\u30b9\u5c64\u306b\u98df\u3044\u8fbc\u3093\u3067\u3044\u308b\u90e8\u5206\u306e\u30b9\u30dd\u30f3\u30b8\u30aa\u30c8\u30ed\u30db\u30d6\u30e9\u30b9\u30c8\u7d30\u80de\u304c\u65fa\u76db\u306b\u5897\u6b96\u3057\u7d9a\u3051\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059(C)\u3002\u307e\u305f\u3001\u91ce\u751f\u578b\u306e\u80ce\u76e4\u5207\u7247\u306b\u5bfe\u3057\u3066in situ hybridization\u3067Nrk mRNA\u306e\u767a\u73fe\u3092\u3001\u514d\u75ab\u67d3\u8272\u3067Nrk\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u767a\u73fe\u3092\u8abf\u3079\u308b\u3068\u3001\u3044\u305a\u308c\u3082\u30b9\u30dd\u30f3\u30b8\u30aa\u30c8\u30ed\u30db\u30d6\u30e9\u30b9\u30c8\u306b\u7279\u7570\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3057\u305f(D)\u3002<\/p>\n<p class=\"p1\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-2483 aligncenter\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/10\/14813388_1302341826456252_653588033_o-1-\u306e\u30b3\u30d2\u309a\u30fc-1-300x196.jpeg\" alt=\"14813388_1302341826456252_653588033_o-1-%e3%81%ae%e3%82%b3%e3%83%92%e3%82%9a%e3%83%bc\" width=\"495\" height=\"323\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/10\/14813388_1302341826456252_653588033_o-1-\u306e\u30b3\u30d2\u309a\u30fc-1-300x196.jpeg 300w, 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class=\"p1\">\u3057\u305f\u304c\u3063\u3066\u3001Nrk\u306f\u30b9\u30dd\u30f3\u30b8\u30aa\u30c8\u30ed\u30db\u30d6\u30e9\u30b9\u30c8\u306b\u304a\u3044\u3066\u305d\u306e\u904e\u5897\u6b96\u3092\u6291\u5236\u3059\u308b\u50cd\u304d\u3092\u3082\u3064\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001Nrk\u304c\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u305d\u306e\u5897\u6b96\u3092\u6291\u3048\u308b\u306e\u304b\u3001\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u672a\u89e3\u660e\u3067\u3059\u3002<\/p>\n<h3>Nrk\u306f\u80ce\u4ed4\/\u80ce\u76e4\u304b\u3089\u6bcd\u4f53\u306b\u5411\u3051\u305f\u5206\u5a29\u8a98\u767a\u30b7\u30b0\u30ca\u30eb\u306e\u767a\u4fe1\u306b\u5fc5\u8981\u3067\u3042\u308b<\/h3>\n<p 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-2614\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/11\/\u56f33-300x180.jpg\" alt=\"%e5%9b%b33\" width=\"500\" height=\"300\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/11\/\u56f33-300x180.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/11\/\u56f33.jpg 692w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/p>\n<p>\u5148\u306b\u3001Nrk\u306e\u767a\u73fe\u306f\u8abf\u3079\u3089\u308c\u305f\u9650\u308a\u306e\u3059\u3079\u3066\u306e\u6210\u4f53\u7d44\u7e54\u3067\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u3068\u66f8\u304d\u307e\u3057\u305f\u304c\u3001\u598a\u5a20\u671f\u306b\u304a\u3051\u308b\u767a\u73fe\u306f\u8abf\u3079\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8abf\u3079\u3066\u307f\u308b\u3068\u3001Nrk\u306f\u975e\u598a\u5a20\u671f\u306e\u4e73\u817a\u3067\u306f\u767a\u73fe\u3057\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u598a\u5a20\u5f8c\u671f\u306e\u4e73\u817a\u3067\u767a\u73fe\u8a98\u5c0e\u3055\u308c\u3066\u304f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u598a\u5a20\u671f\u306b\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4f5c\u7528\u306b\u3088\u308a\u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u304c\u5897\u6b96\u3057\u3001\u51fa\u7523\u5f8c\u306e\u6388\u4e73\u306b\u5099\u3048\u3066\u4e73\u817a\u304c\u767a\u9054\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e73\u817a\u304c\u5341\u5206\u306b\u767a\u9054\u3057\u305f\u5f8c\u3001\u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u306f\u305d\u306e\u5897\u6b96\u3092\u505c\u6b62\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u3002\u79c1\u305f\u3061\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u598a\u5a20\u5f8c\u671f\u306e\u4e73\u817a\u306b\u304a\u3044\u3066Nrk\u306e\u767a\u73fe\u304c\u8a98\u5c0e\u3055\u308c\u3066\u4e73\u817a\u4e0a\u76ae\u7d30\u80de\u306e\u904e\u5897\u6b96\u3092\u6b62\u3081\u308b\u305f\u3081\u306b\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u3001\u305d\u3057\u3066\u305d\u306e\u7834\u7dbb\u304c\u4e73\u304c\u3093\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u4eca\u5f8c\u3001\u305d\u306e\u7d30\u80de\u5897\u6b96\u6291\u5236\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u304c\u3001\u30d2\u30c8\u4e73\u304c\u3093\u306e\u767a\u75c7\u6a5f\u69cb\u3092\u7406\u89e3\u3059\u308b\u3046\u3048\u3067\u3082\u5927\u5909\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<h3>\u304a\u308f\u308a\u306b<\/h3>\n<p>\u4ee5\u4e0a\u306b\u3088\u308a\u3001X\u67d3\u8272\u4f53\u4e0a\u306e\u907a\u4f1d\u5b50Nrk\u304c\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u300c\u80ce\u76e4\u306b\u304a\u3051\u308b\u7d30\u80de\u5897\u6b96\u306e\u5236\u5fa1\u300d\u300c\u5206\u5a29\u8a98\u767a\u300d\u300c\u4e73\u304c\u3093\u306e\u6291\u5236\u300d\u3068\u3044\u3046\u3001\u3044\u305a\u308c\u3082\u30e1\u30b9\u306b\u95a2\u9023\u3059\u308b\uff13\u3064\u306e\u6a5f\u80fd\u306b\u4e0d\u53ef\u6b20\u306a\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001Nrk\u304c\u3069\u306e\u3088\u3046\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3067\u3053\u308c\u3089\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u306e\u304b\u306f\u307e\u3060\u4e0d\u660e\u3067\u3059\u3002\u3053\u308c\u3089\u3092\u4e00\u3064\u3072\u3068\u3064\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u304f\u3053\u3068\u3067\u3001\u3053\u306e\u8208\u5473\u6df1\u3044\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u3088\u308a\u6df1\u304f\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u3072\u3044\u3066\u306f\u305d\u308c\u304c\u79c1\u305f\u3061\u30d2\u30c8\u3092\u542b\u3080\u54fa\u4e73\u52d5\u7269\u306e\u3088\u308a\u9ad8\u5ea6\u306a\u7406\u89e3\u306b\u3064\u306a\u304c\u308b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p class=\"p1\"><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ol class=\"ol1\">\n<li class=\"li5\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21715335\">Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor.<\/a> Denda K, Nakao-Wakabayashi K, Okamoto N, Kitamura N, Ryu JY, Tagawa Y, Ichisaka T, Yamanaka S, Komada M. <i>J. Biol. Chem.<\/i> 286, 28802-28810 (2011)<\/li>\n<li class=\"li5\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27634343\">Deficiency of X-linked protein kinase Nrk during pregnancy triggers breast tumor in mice.<\/a>Yanagawa T, Denda K, Inatani T, Fukushima T, Tanaka T, Kumaki N, Inagaki Y, Komada M. <i>Am. J. Pathol.<\/i> 186, 2751-2760 (2016)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u306f\u3058\u3081\u306b \u54fa\u4e73\u52d5\u7269\u306e\u6027\u67d3\u8272\u4f53\u306b\u306fX\u67d3\u8272\u4f53\u3068Y\u67d3\u8272\u4f53\u304c\u3042\u308a\u3001\u30aa\u30b9\u306f\u305d\u308c\u305e\u308c\u30921\u672c\u305a\u3064\u3001\u30e1\u30b9\u306fX\u67d3\u8272\u4f53\u30922\u672c\u3082\u3063\u3066\u3044\u307e\u3059\u3002Nrk\uff08Nik-related kinase\uff09\u306f\u3001X\u67d3\u8272\u4f53\u306b\u30b3\u30fc\u30c9\u3055 [&hellip;]<\/p>\n","protected":false},"author":52,"featured_media":2614,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[17,15,85],"class_list":["post-2454","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-17","tag-biology","tag-85","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2454","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/52"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2454"}],"version-history":[{"count":0,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/2454\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/2614"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2454"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2454"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2454"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}