{"id":16579,"date":"2023-01-31T09:28:57","date_gmt":"2023-01-31T00:28:57","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=16579"},"modified":"2023-01-31T09:28:02","modified_gmt":"2023-01-31T00:28:02","slug":"%e3%83%8b%e3%83%9b%e3%83%b3%e3%82%b6%e3%83%abips%e7%b4%b0%e8%83%9e%e3%81%ae%e7%a5%9e%e7%b5%8c%e7%99%ba%e7%94%9f%e3%81%8b%e3%82%89%e8%a6%8b%e3%81%88%e3%81%a6%e3%81%8d%e3%81%9f%e3%80%81%e3%83%81","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=16579","title":{"rendered":"\u30cb\u30db\u30f3\u30b6\u30ebiPS\u7d30\u80de\u306e\u795e\u7d4c\u767a\u751f\u304b\u3089\u898b\u3048\u3066\u304d\u305f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3084\u30d2\u30c8\u3068\u306e\u6642\u9593\u7684\u306a\u9055\u3044"},"content":{"rendered":"<h3>\u767a\u751f\u306e\u7570\u6642\u6027\uff08\u30d8\u30c6\u30ed\u30af\u30ed\u30cb\u30fc\uff09:\u81d3\u5668\u30b5\u30a4\u30ba\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u6642\u9593\u306e\u5909\u5316<\/h3>\n<p>\u73fe\u5728\u3001\u5730\u7403\u4e0a\u306b500\u7a2e\u4ee5\u4e0a\u306e\u970a\u9577\u985e\u304c\u751f\u606f\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u4f53\u3084\u81d3\u5668\u306e\u30b5\u30a4\u30ba\u306f\u7a2e\u306b\u3088\u3063\u3066\u307e\u3061\u307e\u3061\u3067\u3059\u3002\u9032\u5316\u306e\u8996\u70b9\u304b\u3089\u81d3\u5668\u306e\u30b5\u30a4\u30ba\u306b\u6ce8\u76ee\u3057\u3066\u307f\u308b\u3068\u3001\u5927\u8133\u306e\u30b5\u30a4\u30ba\u306f\u30d2\u30c8\u306b\u5411\u304b\u3063\u3066\u9032\u5316\u304c\u9032\u3080\u306b\u3064\u308c\u3066\u62e1\u5927\u3057\u7d9a\u3051\u3066\u304d\u305f\u50be\u5411\u306b\u3042\u308a\u3001\u7d50\u679c\u3068\u3057\u3066\u30d2\u30c8\u306f\u970a\u9577\u985e\u3067\u6700\u5927\u30b5\u30a4\u30ba\u306e\u5927\u8133\u3092\u3082\u3064\u3053\u3068\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u3046\u3057\u305f\u81d3\u5668\u30b5\u30a4\u30ba\u3068\u3044\u3046\u300c\u7a7a\u9593\u7684\u306a\u5909\u5316\u300d\u3092\u5f15\u304d\u8d77\u3053\u3059\u305f\u3081\u306b\u306f\u3001\u81d3\u5668\u3092\u5f62\u6210\u3059\u308b\u767a\u751f\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u300c\u6642\u9593\u7684\u306a\u5909\u5316\u300d\u3092\u52a0\u3048\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u81d3\u5668\u30b5\u30a4\u30ba\u3092\u5927\u304d\u304f\u3057\u3088\u3046\u3068\u3057\u305f\u5834\u5408\u3001\u5897\u91cf\u5206\u306e\u30b5\u30a4\u30ba\u306b\u76f8\u5f53\u3059\u308b\u7d30\u80de\u306e\u6570\u3092\u5897\u3084\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u7d30\u80de\u306e\u6570\u3092\u5897\u3084\u3059\u305f\u3081\u306b\u306f\u3001\u7d30\u80de\u304c\u5897\u6b96\u3059\u308b\u671f\u9593\u3092\u5ef6\u3070\u3059\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u7d30\u80de\u5897\u6b96\u306e\u671f\u9593\u3092\u5ef6\u3070\u3059\u3068\u3001\u4ed8\u968f\u3057\u3066\u7d30\u80de\u306e\u5206\u5316\u3084\u79fb\u52d5\u3001\u6210\u719f\u3001\u7d44\u7e54\u69cb\u7bc9\u3068\u3044\u3063\u305f\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u3082\u8abf\u6574\u304c\u5fc5\u8981\u3067\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u970a\u9577\u985e\u306e\u9032\u5316\u306e\u904e\u7a0b\u3067\u3088\u308a\u5927\u304d\u306a\u8133\u7d44\u7e54\u3092\u69cb\u7bc9\u3059\u308b\u306b\u306f\u3001\u767a\u751f\u671f\u9593\u306e\u5ef6\u4f38\u304c\u4e0d\u53ef\u6b20\u3067\u3042\u308a\u3001\u7d30\u80de\u904b\u547d\u6c7a\u5b9a\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u304a\u3044\u3066\u3082\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u5909\u66f4\u304c\u8d77\u3053\u3063\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u767a\u751f\u306b\u751f\u3058\u305f\u7a2e\u9593\u306e\u6642\u9593\u7684\u306a\u9055\u3044\u306e\u3053\u3068\u3092\u300c\u767a\u751f\u306e\u7570\u6642\u6027\uff08\u30d8\u30c6\u30ed\u30af\u30ed\u30cb\u30fc\uff09\u300d\u3068\u3044\u3044\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_16583\" aria-describedby=\"caption-attachment-16583\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-16583 size-full\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2023\/01\/fig.1-e1674802347334.jpg\" alt=\"\" width=\"600\" height=\"433\" \/><figcaption id=\"caption-attachment-16583\" class=\"wp-caption-text\">\u54fa\u4e73\u52d5\u7269\u306e\u8133\u30b5\u30a4\u30ba\u306e\u5927\u578b\u5316\u3068\u3044\u3046\u300c\u7a7a\u9593\u7684\u306a\u5909\u5316\u300d\u3092\u3082\u305f\u3089\u3059\u4e00\u56e0\u3068\u3057\u3066\u3001\u8133\u306e\u767a\u751f\u306b\u8cbb\u3084\u3055\u308c\u308b\u300c\u6642\u9593\u7684\u306a\u5909\u5316\u300d\u304c\u8003\u3048\u3089\u308c\u308b\u3002<\/figcaption><\/figure>\n<p>\u79c1\u305f\u3061\u306f\u3053\u308c\u307e\u3067\u306b\u970a\u9577\u985e\u306eiPS\u7d30\u80de\u3092\u4f5c\u88fd\u3057\u3001\u795e\u7d4c\u767a\u751f\u306e\u5206\u5316\u8a98\u5c0e\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u304c\u958b\u767a\u3057\u305f\u795e\u7d4c\u767a\u751f\u306e\u5206\u5316\u8a98\u5c0e\u6cd5\uff08\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\uff09\u306f\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3001\u30d2\u30c8\u306eiPS\u7d30\u80de\u306b\u9069\u7528\u3067\u304d\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u3001\u3055\u307e\u3056\u307e\u306a\u970a\u9577\u985e\u306eiPS\u7d30\u80de\u304b\u3089\u540c\u3058\u65b9\u6cd5\u3067\u795e\u7d4c\u767a\u751f\u306e\u5206\u5316\u8a98\u5c0e\u3092\u5b9f\u65bd\u3057\u3001\u305d\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u6bd4\u8f03\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u7a2e\u3054\u3068\u306e\u795e\u7d4c\u767a\u751f\u306e\u7279\u5fb4\u3068\u7570\u6642\u6027\u3092\u89e3\u660e\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u3084\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3088\u308a\u3082\u8133\u30b5\u30a4\u30ba\u304c\u5c0f\u3055\u304f\u3001\u598a\u5a20\u671f\u9593\u3082\u77ed\u3044\uff08\uff1d\u767a\u751f\u304c\u65e9\u304f\u5b8c\u4e86\u3059\u308b\uff09\u30cb\u30db\u30f3\u30b6\u30eb\u306b\u7740\u76ee\u3057\u3001iPS\u7d30\u80de\u306e\u795e\u7d4c\u767a\u751f\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u7d30\u80de\u904b\u547d\u8ee2\u63db\u306e\u89e3\u6790\u3092\u8a66\u307f\u307e\u3057\u305f\u3002<\/p>\n<h3>\u30cb\u30db\u30f3\u30b6\u30eb\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3088\u308a\u3082\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4f5c\u308a\u51fa\u3059\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u65e9\u3044<\/h3>\n<p>\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u3067\u306f\u3001\u795e\u7d4c\u767a\u751f\u3092\u4fc3\u3059\u5316\u5408\u7269\u3092\u52a0\u3048\u305f\u57f9\u5730\u4e2d\u306biPS\u7d30\u80de\u3092\u6d6e\u904a\u3055\u305b\u30017\u65e5\u9593\u57f9\u990a\u3059\u308b\u3053\u3068\u3067\u5206\u5316\u3092\u8a98\u5c0e\u3057\u307e\u3059\u3002\u3053\u306e\u6d6e\u904a\u57f9\u990a\u306b\u3088\u3063\u3066\u795e\u7d4c\u5e79\u7d30\u80de\u306b\u307e\u3067\u5206\u5316\u3057\u305f\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u306f\u3001\u305d\u306e\u5f8c\u3055\u3089\u306b\u63a5\u7740\u57f9\u990a\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u3068\u5206\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_16584\" aria-describedby=\"caption-attachment-16584\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16584\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2023\/01\/fig.2-e1674802537384.jpg\" alt=\"\" width=\"600\" height=\"398\" \/><figcaption id=\"caption-attachment-16584\" class=\"wp-caption-text\">\u672c\u7814\u7a76\u3067\u306f\u3001iPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u5e79\u7d30\u80de\u30927\u65e5\u9593\u306e\u6d6e\u904a\u57f9\u990a\u3067\u8a98\u5c0e\u3059\u308b\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u57f9\u990a\u3068\u3001\u30b9\u30d5\u30a7\u30a2\u306e\u63a5\u7740\u57f9\u990a\u306b\u3088\u308b\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u8a98\u5c0e\u3092\u884c\u3063\u305f\u3002<\/figcaption><\/figure>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u306b\u5148\u3093\u3058\u3066\u3001\u79c1\u305f\u3061\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306eiPS\u7d30\u80de\u3067\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u3092\u884c\u3044\u3001\u7d30\u80de\u904b\u547d\u8ee2\u63db\u306e\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u306f\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u57f9\u990a1\u65e5\u76ee\u304b\u30893\u65e5\u76ee\u306e\u9593\u306b\u591a\u80fd\u6027\u304b\u3089\u795e\u7d4c\u7cfb\u3078\u3068\u7d30\u80de\u904b\u547d\u304c\u5207\u308a\u66ff\u308f\u308a\u3001\u57f9\u990a3\u65e5\u76ee\u304b\u30895\u65e5\u76ee\u306e\u9593\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4f5c\u308a\u51fa\u3059\u80fd\u529b\u3092\u5f97\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u305d\u308c\u3067\u306f\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u767a\u751f\u3092\u8a98\u5c0e\u3057\u305f\u5834\u5408\u306e\u7d30\u80de\u904b\u547d\u8ee2\u63db\u306e\u30bf\u30a4\u30e0\u30b9\u30b1\u30b8\u30e5\u30fc\u30eb\u306f\u3069\u3046\u306a\u3063\u3066\u3044\u308b\u3067\u3057\u3087\u3046\u304b\u3002<\/p>\n<p>\u5b50\u4f9b\u3068\u6210\u4f53\u306e\u30cb\u30db\u30f3\u30b6\u30eb\u306e\u76ae\u819a\u7d30\u80de\u304b\u3089\u4f5c\u88fd\u3057\u305fiPS\u7d30\u80de\u3092\u4f7f\u3044\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4f5c\u308a\u51fa\u3059\u30bf\u30a4\u30df\u30f3\u30b0\u306b\u6ce8\u76ee\u3057\u305f\u3068\u3053\u308d\u3001\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u57f9\u990a1\u65e5\u76ee\u3067\u306f\u307b\u3068\u3093\u3069\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4f5c\u308a\u307e\u305b\u3093\u304c\u3001\u57f9\u990a3\u65e5\u76ee\u306b\u306a\u308b\u30685\u65e5\u76ee\u4ee5\u964d\u3068\u905c\u8272\u306a\u3044\u30ec\u30d9\u30eb\u3067\u30cb\u30e5\u30fc\u30ed\u30f3\u3092\u4f5c\u308a\u51fa\u3059\u3088\u3046\u306b\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3088\u308a\u3082\u65e9\u3044\u57f9\u990a1\u65e5\u76ee\u304b\u30893\u65e5\u76ee\u306e\u9593\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u80fd\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_16587\" aria-describedby=\"caption-attachment-16587\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16587\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2023\/01\/fig.3-e1674802727412.jpg\" alt=\"\" width=\"600\" height=\"489\" \/><figcaption id=\"caption-attachment-16587\" class=\"wp-caption-text\">\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u304c\u89b3\u5bdf\u3055\u308c\u308b\u306e\u306f\u57f9\u990a5\u65e5\u76ee\u4ee5\u964d\u3060\u304c\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u306f\u57f9\u990a3\u65e5\u76ee\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002<\/figcaption><\/figure>\n<p>\u305d\u3053\u3067\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u30bf\u30a4\u30df\u30f3\u30b0\u306e\u7570\u6642\u6027\u306b\u7740\u76ee\u3057\u3001\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u3079\u3066\u307f\u305f\u3068\u3053\u308d\u3001\u610f\u5916\u306a\u3053\u3068\u306b\u795e\u7d4c\u767a\u751f\u306e\u9032\u884c\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306f\u6982\u306d\u985e\u4f3c\u3057\u3066\u304a\u308a\u3001\u5927\u304d\u306a\u9055\u3044\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<h3>\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\/\u30d2\u30c8\u3067\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306e\u9055\u3046\u907a\u4f1d\u5b50<\/h3>\n<p>\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u3067\u3001\u795e\u7d4c\u767a\u751f\u3092\u5236\u5fa1\u3059\u308b\u4e3b\u8981\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5927\u304d\u306a\u9055\u3044\u306f\u898b\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u5c11\u6570\u306a\u304c\u3089\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u304c\u9055\u3046\u907a\u4f1d\u5b50\u3082\u898b\u4ed8\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_16588\" aria-describedby=\"caption-attachment-16588\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16588\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2023\/01\/fig.4-e1674802783896.jpg\" alt=\"\" width=\"600\" height=\"527\" \/><figcaption id=\"caption-attachment-16588\" class=\"wp-caption-text\">\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u795e\u7d4c\u767a\u751f\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306f\u4f3c\u3066\u3044\u305f\u304c\u3001\u9055\u3063\u305f\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3059\u907a\u4f1d\u5b50\u3082\u898b\u4ed8\u304b\u3063\u305f\u3002<\/figcaption><\/figure>\n<p>\u305d\u306e\u3072\u3068\u3064\u304c\u3001\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u5206\u89e3\u9175\u7d20\u306eCYP26A1\u3067\u3059\u3002\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u306f\u795e\u7d4c\u767a\u751f\u3092\u8a98\u5c0e\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u306e\u3072\u3068\u3064\u3067\u3001CYP26A1\u306f\u305d\u306e\u30ec\u30c1\u30ce\u30a4\u30f3\u9178\u3092\u5206\u89e3\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u767a\u751f\u306e\u958b\u59cb\u3092\u6291\u3048\u307e\u3059\u3002\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u306b\u304a\u3051\u308bCYP26A1\u306e\u767a\u73fe\u30d4\u30fc\u30af\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u6700\u3082\u65e9\u304f\uff08\u57f9\u990a1\u65e5\u76ee\uff09\u3001\u6b21\u3044\u3067\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\uff083\u65e5\u76ee\uff09\u3001\u30d2\u30c8\uff083-4\u65e5\u76ee\uff09\u3068\u306a\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001CYP26A1\u3068\u3044\u3046\u795e\u7d4c\u767a\u751f\u306e\u30d6\u30ec\u30fc\u30ad\u304c\u5916\u308c\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u304c\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3001\u30d2\u30c8\u306e\u9806\u306b\u9045\u304f\u306a\u3063\u3066\u3044\u308b\u3088\u3046\u306b\u898b\u3048\u307e\u3059\u3002\u307e\u305f\u3001\u591a\u80fd\u6027\u304b\u3089\u795e\u7d4c\u7cfb\u3078\u306e\u904b\u547d\u6c7a\u5b9a\u306b\u95a2\u308f\u308b\u5225\u306e\u907a\u4f1d\u5b50\u306b\u3001NPTX1\u304c\u3042\u308a\u307e\u3059\u3002NPTX1\u306f\u30d2\u30c8\u3068\u30de\u30a6\u30b9\u3067\u6a5f\u80fd\u304c\u9055\u3044\u3001\u30d2\u30c8\u3067\u306f\u795e\u7d4c\u767a\u751f\u958b\u59cb\u6642\u306b\u4e00\u904e\u7684\u306b\u767a\u73fe\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3067\u795e\u7d4c\u767a\u751f\u306e\u30b9\u30a4\u30c3\u30c1\u3092\u5165\u308c\u307e\u3059\u304c\u3001\u30de\u30a6\u30b9\u3067\u306f\u3053\u3046\u3057\u305f\u4e00\u904e\u7684\u306a\u767a\u73fe\u4e0a\u6607\u3084\u795e\u7d4c\u767a\u751f\u306e\u30b9\u30a4\u30c3\u30c1\u6a5f\u80fd\u306f\u306a\u304f\u3001\u3082\u3063\u3068\u5f8c\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u6210\u719f\u3059\u308b\u6bb5\u968e\u306b\u306a\u3063\u3066\u304b\u3089\u6a5f\u80fd\u3057\u307e\u3059\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001NPTX1\u306e\u767a\u73fe\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u306f\u30d2\u30c8\u3068\u540c\u3058\u304f\u5206\u5316\u521d\u671f\uff08\u57f9\u990a3\u65e5\u76ee\uff09\u306b\u4e00\u904e\u7684\u306b\u4e0a\u6607\u3057\u307e\u3059\u304c\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u306f\u3053\u3046\u3057\u305f\u4e00\u904e\u7684\u306a\u5909\u52d5\u306f\u8d77\u3053\u3089\u305a\u306b\u3001\u30de\u30a6\u30b9\u3068\u540c\u69d8\u306e\u767a\u73fe\u4e0a\u6607\u3057\u7d9a\u3051\u308b\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u9055\u3044\u306f\u3001\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u306e\u9593\u3060\u3051\u3067\u306f\u306a\u304f\u3001\u305d\u306e\u5f8c\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u80fd\u3092\u691c\u8a3c\u3059\u308b\u305f\u3081\u306e\u63a5\u7740\u57f9\u990a\u306b\u304a\u3044\u3066\u3082\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u3067\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30eb\u306b\u3001NOTCH\u30b7\u30b0\u30ca\u30eb\u304c\u3042\u308a\u307e\u3059\u3002NOTCH\u30b7\u30b0\u30ca\u30eb\u306e\u95a2\u9023\u907a\u4f1d\u5b50\uff08DLL1\u3001HES5\uff09\u306e\u767a\u73fe\u3092\u898b\u3066\u307f\u308b\u3068\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u3082\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u3082\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u57f9\u990a3\u65e5\u76ee\u3067\u306f\u4f4e\u304f\u30015\u65e5\u76ee\u306b\u306a\u3063\u3066\u4e0a\u6607\u3057\u307e\u3059\u3002\u3068\u3053\u308d\u304c\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u306f\u57f9\u990a3\u65e5\u76ee\u306e\u7d30\u80de\u3067\u3042\u3063\u3066\u3082\u3001\u63a5\u7740\u57f9\u990a\u306b\u79fb\u3057\u305f\u5f8c\u306b\u306f\u57f9\u990a5\u65e5\u76ee\u306e\u7d30\u80de\u3068\u540c\u7b49\u306b\u307e\u3067\u767a\u73fe\u304c\u4e0a\u6607\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u540c\u3058\u73fe\u8c61\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u306f\u8a8d\u3081\u3089\u308c\u305a\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3067\u306fNOTCH\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u65e9\u671f\u304b\u3064\u81ea\u767a\u7684\u306b\u8d77\u3053\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<h3>\u970a\u9577\u985e\u306e\u795e\u7d4c\u767a\u751f\u9032\u5316\u306e\u30d7\u30ed\u30b0\u30e9\u30e0\u89e3\u660e\u306b\u5411\u3051\u3066<\/h3>\n<p>\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3001\u30d2\u30c8\u306e\u8133\u306f\u30b5\u30a4\u30ba\u304c\u5927\u304d\u304f\u9055\u3044\u307e\u3059\u306e\u3067\u3001\u5206\u5316\u8a98\u5c0e\u57f9\u990a\u3067\u3082\u4f55\u304b\u3057\u3089\u306e\u9055\u3044\u304c\u8868\u308c\u308b\u3053\u3068\u306f\u4e88\u60f3\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u7d50\u679c\u3092\u898b\u3066\u9a5a\u3044\u305f\u3053\u3068\u304c2\u3064\u3042\u308a\u307e\u3059\u3002\u3072\u3068\u3064\u306f\u3001\u795e\u7d4c\u767a\u751f\u306b\u91cd\u8981\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306b\u5927\u304d\u306a\u9055\u3044\u304c\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3053\u3068\u3067\u3001\u767a\u751f\u306e\u57fa\u76e4\u3068\u306a\u308b\u30d7\u30ed\u30b0\u30e9\u30e0\u81ea\u4f53\u306f\u7a2e\u3092\u8d85\u3048\u3066\u5f37\u56fa\u306b\u4fdd\u5b58\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u4f3a\u3048\u307e\u3059\u3002\u3082\u3046\u3072\u3068\u3064\u306f\u3001\u308f\u305a\u304b7\u65e5\u3068\u3044\u3046\u77ed\u671f\u9593\u306e\u5206\u5316\u8a98\u5c0e\u57f9\u990a\u3067\u3042\u3063\u3066\u3059\u3089\u30cb\u30e5\u30fc\u30ed\u30f3\u7523\u751f\u306b\u9055\u3044\u304c\u898b\u3089\u308c\u305f\u3053\u3068\u3067\u3001\u7570\u6642\u6027\u3068\u3044\u3046\u30d7\u30ed\u30b0\u30e9\u30e0\u3082\u307e\u305f\u305d\u308c\u305e\u308c\u306e\u7a2e\u306e\u30b2\u30ce\u30e0\u306b\u5f37\u56fa\u306b\u7d44\u307f\u8fbc\u307e\u308c\u3066\u3044\u308b\u3068\u63a8\u5bdf\u3055\u308c\u307e\u3059\u3002\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306e\u7570\u306a\u308b\u907a\u4f1d\u5b50\u306f\u3001\u795e\u7d4c\u767a\u751f\u306b\u91cd\u8981\u306a\u7a2e\u5171\u901a\u306e\u30b7\u30b0\u30ca\u30eb\u306e\u8abf\u7bc0\u56e0\u5b50\u3067\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u30e1\u30a4\u30f3\u30d7\u30ed\u30b0\u30e9\u30e0\u3092\u8abf\u7bc0\u3059\u308b\u30b5\u30d6\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u9055\u3044\u304c\u795e\u7d4c\u767a\u751f\u306e\u7a2e\u5dee\u3092\u751f\u307f\u51fa\u3057\u3066\u3044\u308b\u5b9f\u4f53\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>\u73fe\u5728\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306e\u795e\u7d4c\u767a\u751f\u306e\u9055\u3044\u306b\u3064\u3044\u3066\u3082\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6bd4\u8f03\u89e3\u6790\u3092\u884c\u3063\u3066\u3044\u308b\u3068\u3053\u308d\u3067\u3059\u3002\u307e\u305f\u3001\u4eca\u56de\u306e\u6210\u679c\u3068\u307b\u307c\u540c\u3058\u30bf\u30a4\u30df\u30f3\u30b0\u3067\u767a\u8868\u3057\u305f\u5225\u306e\u8ad6\u6587\u3067\u306f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306eiPS\u7d30\u80de\u3067\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u30a8\u30d4\u30b2\u30ce\u30e0\u3092\u7db2\u7f85\u7684\u306b\u6bd4\u8f03\u3057\u3001\u30b2\u30ce\u30e0\u306b\u633f\u5165\u3055\u308c\u305f\u30ec\u30c8\u30ed\u30a6\u30a4\u30eb\u30b9\u306e\u9055\u3044\u304c\u4e21\u7a2e\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u9055\u3044\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u4ed6\u306b\u3082\u79c1\u305f\u3061\u306f\u3055\u307e\u3056\u307e\u306a\u970a\u9577\u985e\u3067iPS\u7d30\u80de\u3092\u4f5c\u88fd\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u3066\u304a\u308a\u307e\u3059\u306e\u3067\u3001\u970a\u9577\u985e\u306e\u795e\u7d4c\u767a\u751f\u9032\u5316\u306e\u89e3\u660e\u304c\u4eca\u5f8c\u5927\u304d\u304f\u9032\u5c55\u3059\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u6210\u679c\u3067\u306f\u3001\u5149\u6804\u306a\u3053\u3068\u306b\u79c1\u305f\u3061\u306e\u5b9f\u9a13\u30c7\u30fc\u30bf\u304c\u63b2\u8f09\u30b8\u30e3\u30fc\u30ca\u30eb\u306e\u8868\u7d19\u3092\u98fe\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_16589\" aria-describedby=\"caption-attachment-16589\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-16589\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2023\/01\/fig.5-e1674802847680.jpg\" alt=\"\" width=\"600\" height=\"493\" \/><figcaption id=\"caption-attachment-16589\" class=\"wp-caption-text\">\u4ef2\u4e95\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u304b\u3089\u9078\u629c\u3057\u305f\u30cb\u30db\u30f3\u30b6\u30ebiPS\u7d30\u80de\u7531\u6765\u306e\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5199\u771f\u306e\u3072\u3068\u3064\u3002<\/figcaption><\/figure>\n<p>\u7b46\u8005\u306e\u4e00\u4eba\u3067\u3042\u308b\u4ef2\u4e95\u306f\u30cb\u30e5\u30fc\u30ed\u30f3\u304c\u3068\u3066\u3082\u597d\u304d\u3067\u3001\u5206\u5316\u8a98\u5c0e\u306e\u5ea6\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u5199\u771f\u3092\u4f55\u5341\u679a\u3068\u64ae\u5f71\u3057\u3066\u304a\u308a\u3001\u30c7\u30a3\u30b9\u30ab\u30c3\u30b7\u30e7\u30f3\u3067\u306f\u5927\u91cf\u306e\u7d30\u80de\u30c7\u30fc\u30bf\u3092\u898b\u308b\u306e\u304c\u5e38\u3067\u3057\u305f\u3002\u4eca\u56de\u3001\u305d\u306e\u4ef2\u4e95\u30b3\u30ec\u30af\u30b7\u30e7\u30f3\u306e\u4e00\u7aef\u3092\u30b8\u30e3\u30fc\u30ca\u30eb\u8868\u7d19\u3068\u3044\u3046\u5f62\u3067\u4e16\u306b\u516c\u8868\u3067\u304d\u3001\u5927\u5909\u5b09\u3057\u304f\u601d\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u3053\u306e\u8ad6\u6587\u3092\u6295\u7a3f\u3057\u305f\u3068\u304d\u3001\u4ef2\u4e95\u306f\u535a\u58eb\u53f7\u3092\u6240\u5f97\u3057\u3066\u65e2\u306b\u7b46\u8005\uff08\u4eca\u6751\uff09\u306e\u30e9\u30dc\u3092\u5352\u696d\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u67fb\u8aad\u5f8c\u306e\u518d\u6295\u7a3f\u306b\u5411\u3051\u305f\u5bfe\u5fdc\u3092\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u983b\u7e41\u306b\u8b70\u8ad6\u3057\u3064\u3064\u3001\u4f11\u65e5\u306b\u306f\u51fa\u623b\u3063\u3066\u8ffd\u52a0\u5b9f\u9a13\u306b\u53d6\u308a\u7d44\u3093\u3060\u308a\u3057\u3066\u3044\u307e\u3057\u305f\u3002\u8ad6\u6587\u306b\u306f1\u3064\u3072\u3068\u3064\u4ed8\u968f\u3057\u305f\u601d\u3044\u51fa\u304c\u3042\u308b\u3082\u306e\u3067\u3059\u304c\u3001\u4eca\u56de\u306e\u8ad6\u6587\u3067\u307e\u305f\u3072\u3068\u3064\u3001\u3055\u307e\u3056\u307e\u306a\u601d\u3044\u51fa\u304c\u8a70\u307e\u3063\u305f\u30a2\u30eb\u30d0\u30e0\u304c\u5897\u3048\u307e\u3057\u305f\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<p>\u30fbRisako Nakai, Yusuke Hamazaki, Haruka Ito, Masanori Imamura (2022). Early neurogenic properties of iPSC-derived neurosphere formation in Japanese macaque monkeys. Differentiation, 128: 33-42.<br \/>\n\u30fb\u4eca\u6751\u516c\u7d00\u3001\u4ef2\u4e95\u7406\u6c99\u5b50 \u300c\u30d2\u30c8\u8133\u9032\u5316\u7814\u7a76\u3068\u3057\u3066\u306e\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de \u2013 \u300c\u30d2\u30c8\u306e\u77e5\u6027\u300d\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3001\u8133\u306e\u5f62\u6210\u30d7\u30ed\u30bb\u30b9\u3092\u8ffd\u3046\u300d\uff08academist journal\u30012020\u5e744\u670822\u65e5\uff09.<br \/>\n\u30fb\u4eca\u6751\u516c\u7d00\u3001\u4ef2\u4e95\u7406\u6c99\u5b50 \u300e\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u306e\u4f5c\u88fd\u306b\u6210\u529f\uff01-\u300c\u970a\u9577\u985e\u5b66\u300d\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u300f\uff08academist journal\u30012018\u5e7410\u670823\u65e5\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u767a\u751f\u306e\u7570\u6642\u6027\uff08\u30d8\u30c6\u30ed\u30af\u30ed\u30cb\u30fc\uff09:\u81d3\u5668\u30b5\u30a4\u30ba\u306e\u9055\u3044\u3092\u751f\u307f\u51fa\u3059\u6642\u9593\u306e\u5909\u5316 \u73fe\u5728\u3001\u5730\u7403\u4e0a\u306b500\u7a2e\u4ee5\u4e0a\u306e\u970a\u9577\u985e\u304c\u751f\u606f\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u4f53\u3084\u81d3\u5668\u306e\u30b5\u30a4\u30ba\u306f\u7a2e\u306b\u3088\u3063\u3066\u307e\u3061\u307e\u3061\u3067\u3059\u3002\u9032\u5316\u306e\u8996\u70b9\u304b\u3089\u81d3\u5668\u306e\u30b5\u30a4\u30ba\u306b\u6ce8\u76ee\u3057 [&hellip;]<\/p>\n","protected":false},"author":341,"featured_media":16591,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[51,24,76],"class_list":["post-16579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-ips","tag-24","tag-76","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/16579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/341"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16579"}],"version-history":[{"count":14,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/16579\/revisions"}],"predecessor-version":[{"id":16601,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/16579\/revisions\/16601"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/16591"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}