{"id":14897,"date":"2020-11-27T08:00:23","date_gmt":"2020-11-26T23:00:23","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=14897"},"modified":"2020-12-02T12:19:47","modified_gmt":"2020-12-02T03:19:47","slug":"%e8%84%b3%e5%86%85%e3%81%ae%e6%ad%bb%e7%b4%b0%e8%83%9e%e3%82%92%e6%8e%83%e9%99%a4%e3%81%99%e3%82%8b%e6%96%b0%e3%81%9f%e3%81%aa%e3%83%a1%e3%82%ab%e3%83%8b%e3%82%ba%e3%83%a0%e3%81%a8%e3%81%af%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=14897","title":{"rendered":"\u8133\u5185\u306e\u6b7b\u7d30\u80de\u3092\u6383\u9664\u3059\u308b\u65b0\u305f\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u306f\uff1f &#8211; 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id=\"attachment_14893\" aria-describedby=\"caption-attachment-14893\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-14893\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/003-4.jpg\" alt=\"\" width=\"600\" height=\"235\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/003-4.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/003-4-300x118.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-14893\" 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src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/004-2.jpg\" alt=\"\" width=\"600\" height=\"332\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/004-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/004-2-300x166.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-14894\" class=\"wp-caption-text\">\u81ea\u7136\u6b7b\u3057\u305f\u7d30\u80de\uff08\u9752\uff09\u306f\u3001\u91ce\u751f\u578b\u30de\u30a6\u30b9\uff08\u56f3\u5de6\uff09\u3067\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\uff08\u8d64\uff09\u306b\u53d6\u308a\u56f2\u307e\u308c\u3066\u3044\u305f\u304c\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6a5f\u80fd\u4f4e\u4e0b\u304c\u8d77\u3053\u308bIRF8\u6b20\u640d\u30de\u30a6\u30b9\uff08\u56f3\u53f3\uff09\u3067\u306f\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\uff08\u7dd1\uff09\u306b\u53d6\u308a\u56f2\u307e\u308c\u3066\u3044\u305f\u3002<\/figcaption><\/figure>\n<h3>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u3055\u3089\u306a\u308b\u7406\u89e3\u3092\u76ee\u6307\u3057\u3066<\/h3>\n<p>\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u8caa\u98df\u80fd\u529b\u306e\u6709\u7121\u3084\u305d\u306e\u610f\u7fa9\u3001\u3055\u3089\u306b\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u8caa\u98df\u80fd\u529b\u3068\u306e\u76f8\u9055\u70b9\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u8b0e\u304c\u591a\u3044\u72b6\u614b\u3067\u3057\u305f\u3002\u672c\u7814\u7a76\u304b\u3089\u3001\u901a\u5e38\u6642\u304b\u3089\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u8caa\u98df\u80fd\u529b\u3092\u5099\u3048\u3066\u3044\u308b\u3053\u3068\u3001\u307e\u305f\u3001\u305d\u306e\u8caa\u98df\u80fd\u529b\u306f\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u304c\u6a5f\u80fd\u4f4e\u4e0b\u3092\u8d77\u3053\u3057\u305f\u3068\u304d\u306b\u767a\u63ee\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_14895\" aria-describedby=\"caption-attachment-14895\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-14895\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/005.jpg\" alt=\"\" width=\"600\" height=\"271\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/005.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/11\/005-300x136.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-14895\" class=\"wp-caption-text\">\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u4e0d\u5728\u307e\u305f\u306f\u6a5f\u80fd\u4e0d\u5168\u306e\u3068\u304d\u306b\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306f\u8caa\u98df\u6a5f\u80fd\u3092\u767a\u63ee\u3059\u308b\u3002<\/figcaption><\/figure>\n<p>\u4eca\u5f8c\u3001\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u3068\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u4e21\u7d30\u80de\u304c\u6301\u3064\u8caa\u98df\u4f5c\u7528\u3092\u76f8\u4e92\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u52a0\u9f62\u3084\u795e\u7d4c\u640d\u50b7\u6642\u306e\u8133\u5185\u304b\u3089\u7570\u7269\u3084\u6b7b\u7d30\u80de\u3092\u52b9\u7387\u7684\u306b\u9664\u53bb\u3057\u3001\u8133\u5185\u74b0\u5883\u3092\u6574\u3048\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u671f\u5f85\u3055\u308c\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u306b\u306f\u3001\u300c\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u304c\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u6a5f\u80fd\u4f4e\u4e0b\u3092\u3001\u3069\u306e\u3088\u3046\u306b\u8a8d\u8b58\u3057\u8caa\u98df\u6a5f\u80fd\u3092\u767a\u52d5\u3059\u308b\u306e\u304b\uff1f\u300d\u3068\u3044\u3046\u7591\u554f\u3092\u307e\u305a\u89e3\u6c7a\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u3068\u8003\u3048\u3001\u73fe\u5728\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><b>\u53c2\u8003\u6587\u732e<\/b><br \/>\n\u30fbKonishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, Udagawa N, Jung S, Ozato K, Tamura T, Tsuda M, Yamanaka K, Ogi T, Sato K, Kiyama H. &#8220;Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction&#8221; <em>EMBO J<\/em>, e104464, 2020. <a href=\"https:\/\/doi.org\/10.15252\/embj.2020104464\" onclick=\"ga('send', 'event', '14897', 'https:\/\/doi.org\/10.15252\/embj.2020104464', 'ref1');\">https:\/\/doi.org\/10.15252\/embj.2020104464<\/a><br \/>\n\u30fbKonishi H, Kobayashi M, Kunisawa T, Imai K, Sayo A, Malissen B, Crocker PR, Sato K, Kiyama H. &#8220;Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes&#8221; <em>Glia<\/em>, 65(12):1927-1943, 2017. <a href=\"https:\/\/doi.org\/10.1002\/glia.23204\" onclick=\"ga('send', 'event', '14897', 'https:\/\/doi.org\/10.1002\/glia.23204', 'ref2');\">https:\/\/doi.org\/10.1002\/glia.23204<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u8133\u5185\u306e\u6b7b\u7d30\u80de\u306f\u3069\u306e\u3088\u3046\u306b\u6383\u9664\u3055\u308c\u308b\u304b\uff1f \u79c1\u305f\u3061\u306e\u8133\u5185\u3067\u306f\u5065\u5eb7\u306a\u72b6\u614b\u3067\u3082\u6bce\u65e5\u5c11\u3057\u305a\u3064\u7d30\u80de\u304c\u6b7b\u3093\u3067\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u8133\u6897\u585e\u3084\u810a\u9ac4\u640d\u50b7\u306a\u3069\u306e\u795e\u7d4c\u640d\u50b7\u6642\u306b\u306f\u975e\u5e38\u306b\u591a\u304f\u306e\u7d30\u80de\u304c\u6b7b\u306b\u307e\u3059\u3002\u6b7b\u7d30\u80de\u306e\u84c4\u7a4d\u306f\u708e\u75c7\u306a\u3069\u3055\u307e\u3056 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