{"id":1478,"date":"2016-09-06T10:00:19","date_gmt":"2016-09-06T01:00:19","guid":{"rendered":"https:\/\/dev.academist-cf.com\/journal\/?p=1478"},"modified":"2018-07-09T17:11:50","modified_gmt":"2018-07-09T08:11:50","slug":"%e7%b3%96%e5%b0%bf%e7%97%85%e3%81%af%e3%81%aa%e3%81%9c%e7%99%ba%e7%97%87%e3%81%99%e3%82%8b%e3%81%ae%e3%81%8b%ef%bc%9f-%e3%83%9e%e3%82%a6%e3%82%b9%e3%82%92%e7%94%a8%e3%81%84%e3%81%9f%e6%96%b0","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=1478","title":{"rendered":"\u7cd6\u5c3f\u75c5\u306f\u306a\u305c\u767a\u75c7\u3059\u308b\u306e\u304b\uff1f &#8211; \u30de\u30a6\u30b9\u3092\u7528\u3044\u305f\u65b0\u305f\u306a\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u89e3\u660e"},"content":{"rendered":"<p>&nbsp;<\/p>\n<h3>\u7cd6\u5c3f\u75c5\u3068\u306f<\/h3>\n<p class=\"p1\"><span 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class=\"s1\">2\u578b\u7cd6\u5c3f\u75c5\u306e\u539f\u56e0 &#8211; \u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3068\u306f<\/span><\/h3>\n<p class=\"p1\"><span class=\"s1\">2<\/span><span 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cell\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u514d\u75ab\u7d30\u80de\u304c\u95a2\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u6162\u6027\u708e\u75c7\u3067\u306f\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3044\u3046\u6db2\u6027\u56e0\u5b50\u304c\u653e\u51fa\u3055\u308c\u307e\u3059\u3002\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306b\u306f\u3001\u5148\u306b\u8ff0\u3079\u305f\u30a4\u30f3\u30b9\u30ea\u30f3\u30b7\u30b0\u30ca\u30eb\u3092\u906e\u65ad\u3059\u308b\u4f5c\u7528\u304c\u3042\u308a\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u304c\u767a\u75c7\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u5404\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u81d3\u5668\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u6a19\u7684\u81d3\u5668\u306b\u3001\u3053\u308c\u3089\u306e\u514d\u75ab\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u30ea\u30af\u30eb\u30fc\u30c8\u3055\u308c\u3066\u3044\u304f\u304b\u306a\u3069\u306e\u6642\u7cfb\u5217\u3092\u8ffd\u3063\u305f\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3057\u3066\u306f\u3001\u4e0d\u660e\u306a\u70b9\u304c\u591a\u304f\u3042\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<h3><span 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class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1480\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig1-1.png\" alt=\"fig1\" width=\"500\" height=\"331\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig1-1.png 974w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig1-1-300x199.png 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig1-1-768x509.png 768w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-1480\" class=\"wp-caption-text\">\u8178\u5185\u7d30\u83cc\u53e2\u3001\u8178\u7ba1\u7c98\u819c\u3001\u8178\u5185\u514d\u75ab\u7cfb\u3067\u69cb\u6210\u3055\u308c\u308b \u8178\u5185\u74b0\u5883<\/figcaption><\/figure>\n<p class=\"p1\"><span class=\"s2\">\u3053\u308c\u307e\u3067\u3001\u8178\u5185\u7d30\u83cc\u53e2\u304c\u5168\u8eab\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5831\u544a\u304c\u591a\u3044\u306a\u304b\u3001\u8178\u7ba1\u514d\u75ab\u7d30\u80de\u306e\u7cd6\u30fb\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u8abf\u7bc0\u306b\u95a2\u3057\u3066\u306f\u3001\u3042\u307e\u308a\u77e5\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u4e2d\u3067\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u30fb\u6a39\u72b6\u7d30\u80de\u3068\u3044\u3063\u305f\u5358\u6838\u8caa\u98df\u7d30\u80de\u306f\u3001\u8178\u7ba1\u5185\u306e\u6297\u539f\u3092\u53d6\u308a\u8fbc\u307f\u3001T\u7d30\u80de\u3078\u63d0\u793a\u3059\u308b\u5f79\u5272\u3092\u6709\u3057\u3066\u304a\u308a\u3001\u8178\u7ba1\u306e\u6162\u6027\u708e\u75c7\u30fb\u5168\u8eab\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3078\u306e\u5f71\u97ff\u30fb2\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u3068\u3044\u3063\u305f\u89b3\u70b9\u304b\u3089\u3001\u306a\u3093\u3089\u304b\u306e\u5f79\u5272\u3092\u62c5\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002\u5b9f\u969b\u3001\u8178\u7ba1\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u3001\u54fa\u4e73\u52d5\u7269\u306e\u8178\u7ba1\u306e\u4e2d\u3067\u6700\u3082\u591a\u3044\u767d\u8840\u7403\u306e\u4e00\u3064\u3067\u3042\u308a\u3001\u4f53\u5185\u306e\u4e2d\u3067\u306e\u5358\u6838\u8caa\u98df\u7d30\u80de\u7fa4\u3068\u3057\u3066\u306f\u6700\u5927\u3067\u3059\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">\u30de\u30a6\u30b9\u306b\u3001\u8102\u80aa\u5206\u306e\u3046\u3061\u7d0470\uff05\u306b\u98fd\u548c\u8102\u80aa\u9178\u3092\u542b\u3080\u300c\u9ad8\u8102\u80aa\u98df\u300d\u3092\u4e0e\u3048\u305f\u3068\u3053\u308d\u30014\u9031\u9593\u3067\u5927\u8178\u306e\u9577\u3055\u304c\u77ed\u7e2e\u3057\u3001\u30de\u30a6\u30b9\u306e\u76f2\u8178\u304c\u5c0f\u3055\u304f\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<figure id=\"attachment_1481\" aria-describedby=\"caption-attachment-1481\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1481\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig2-1024x895.jpg\" alt=\"\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u3067\u306f\u5927\u8178\u306e\u77ed\u7e2e\u3068\u3001\u76f2\u8178\u306e\u7e2e\u5c0f\u304c\u8a8d\u3081\u3089\u308c\u308b\" width=\"500\" height=\"437\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig2-1024x895.jpg 1024w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig2-300x262.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig2-768x671.jpg 768w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig2.jpg 1559w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-1481\" class=\"wp-caption-text\">\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u3067\u306f\u5927\u8178\u306e\u77ed\u7e2e\u3068\u3001\u76f2\u8178\u306e\u7e2e\u5c0f\u304c\u8a8d\u3081\u3089\u308c\u308b<\/figcaption><\/figure>\n<p class=\"p1\"><span class=\"s2\">\u5927\u8178\u306e\u9577\u3055\u306e\u77ed\u7e2e\u306f\u3001\u708e\u75c7\u306e\u7279\u5fb4\u3067\u3042\u308a\u3001\u76f2\u8178\u306e\u5927\u304d\u3055\u306e\u5909\u5316\u306f\u8178\u5185\u7d30\u83cc\u53e2\u306e\u5909\u5316\u3092\u7269\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u98fd\u548c\u8102\u80aa\u9178\u3092\u591a\u304f\u542b\u3080\u98df\u4e8b\u306b\u3088\u308a\u3001\u5927\u8178\u306b\u708e\u75c7\u304c\u8d77\u304d\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u540c\u3058\u98df\u4e8b\u3092\u4e0e\u3048\u3066\u3001\u3069\u306e\u304f\u3089\u3044\u306e\u671f\u9593\u3067\u4f53\u306e\u5404\u81d3\u5668\u3067\u708e\u75c7\u304c\u8d77\u304d\u308b\u304b\u3092\u3001\u5927\u8178\u3001\u5c0f\u8178\u3001\u5185\u81d3\u8102\u80aa\u7d44\u7e54\u3001\u809d\u81d3\u306e\u81d3\u5668\u5225\u306b\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u3053\u308c\u307e\u3067\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u306e\u767a\u75c7\u306b\u5927\u304d\u304f\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u305f\u8102\u80aa\u7d44\u7e54\u3001\u809d\u81d3\u3088\u308a\u3082\u65e9\u304f\u5927\u8178\u3067\u708e\u75c7\u6027\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306e\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u3001\u5b9f\u969b\u306b\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6570\u3082\u5897\u52a0\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u3053\u3068\u306f\u3001\u3053\u308c\u307e\u3067\u8a00\u308f\u308c\u3066\u3044\u305f\u3053\u3068\u3068\u306f\u7570\u306a\u308a\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u3067\u306f\u5927\u8178\u3067\u6700\u3082\u65e9\u304f\u6162\u6027\u708e\u75c7\u304c\u8d77\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<h3><span class=\"s1\">\u708e\u75c7\u6027\u8178\u7ba1\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6570\u3092\u6e1b\u3089\u3059\u3068\u3069\u3046\u306a\u308b\u304b\uff1f<\/span><\/h3>\n<p class=\"p1\"><span class=\"s2\">\u5927\u8178\u306e\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u5897\u52a0\u304c\u30de\u30a6\u30b9\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u306e\u304b\uff1f\u3068\u3044\u3046\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u305d\u306e\u5897\u52a0\u3092\u6291\u3048\u3066\u5f71\u97ff\u3092\u898b\u308b\u3053\u3068\u304c\u5e38\u9053\u3067\u3059\u3002\u4e00\u822c\u306b\u3001\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6570\u3092\u5236\u5fa1\u3059\u308b\u306e\u306f\u300c<\/span><span class=\"s2\">\u30b1\u30e2\u30ab\u30a4\u30f3\u300d\u3068\u300c\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u300d\u3067\u3059\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">\u30b1\u30e2\u30ab\u30a4\u30f3\u3068\u306f\u3001\u708e\u75c7\u6027\u306e\u514d\u75ab\u7d30\u80de\uff08\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u542b\u3080\uff09\u3092\u708e\u75c7\u306e\u5834\u306b\u5f15\u304d\u5bc4\u305b\u308b\u6db2\u6027\u56e0\u5b50\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001\u3055\u307e\u3056\u307e\u306a\u7a2e\u985e\u304c\u3042\u308a\u307e\u3059\u3002\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u3068\u306f\u3001\u305d\u308c\u3089\u30b1\u30e2\u30ab\u30a4\u30f3\u304c\u7d50\u5408\u3059\u308b\u53d7\u5bb9\u4f53\u3067\u3001\u514d\u75ab\u7d30\u80de\u306e\u819c\u8868\u9762\u306b\u3042\u308a\u3001\u305d\u308c\u305e\u308c\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u306b\u547c\u5fdc\u3059\u308b\u7a2e\u985e\u306e\u53d7\u5bb9\u4f53\u304c\u5b58\u5728\u3057\u307e\u3059\u3002\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u5834\u5408\u3001\u5c40\u6240\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u7523\u751f\u306b\u547c\u5fdc\u3057\u3066\u3001\u9aa8\u9ac4\u304a\u3088\u3073\u672b\u68a2\u8840\u6db2\u4e2d\u306b\u3042\u308b\u305d\u306e\u30b1\u30e2\u30ab\u30a4\u30f3\u304c\u7d50\u5408\u3059\u308b\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u3092\u6301\u3064\u5358\u6838\u7403\u304c\u305d\u306e\u5c40\u6240\u306b\u79fb\u52d5\u3057\u3066\u3001\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">\u79c1\u305f\u3061\u306e\u691c\u8a0e\u306b\u3088\u308b\u3068\u3001\u30de\u30a6\u30b9\u5927\u8178\u3067\u306f\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308aCcl2\u3068\u3044\u3046\u30b1\u30e2\u30ab\u30a4\u30f3\u304c\u5927\u8178\u306e\u8178\u7ba1\u4e0a\u76ae\u304b\u3089\u5206\u6ccc\u3055\u308c\u3001Ccr2\u3068\u3044\u3046\u30b1\u30e2\u30ab\u30a4\u30f3\u53d7\u5bb9\u4f53\u3092\u6301\u3064\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u96c6\u307e\u3063\u3066\u304f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306eCcr2\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9(M-Ccr2KO)\u3068\u8178\u7ba1\u4e0a\u76ae\u3067Ccl2\u3092\u6b20\u640d\u3055\u305b\u305f\u30de\u30a6\u30b9(Vil-Ccl2KO)\u3092\u4f5c\u88fd\u3057\u3001\u9ad8\u8102\u80aa\u98df\u3092\u98df\u3079\u3055\u305b\u3066\u5f71\u97ff\u3092\u691c\u8a0e\u3057\u307e\u3057\u305f\u3002\u3069\u3061\u3089\u306e\u30de\u30a6\u30b9\u3082\u4e88\u60f3\u901a\u308a\u3001\u9ad8\u8102\u80aa\u98df\u3092\u98df\u3079\u3055\u305b\u3066\u3082\u5927\u8178\u306e\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306f\u5897\u52a0\u305b\u305a\u3001\u76ee\u7684\u306e\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3067\u304d\u305f\u3053\u3068\u3092\u78ba\u8a8d\u3057\u307e\u3057\u305f\u3002\u4e21\u30de\u30a6\u30b9\u3068\u3082\u5bfe\u7167\u7fa4\u306e\u30de\u30a6\u30b9\u3068\u540c\u69d8\u306b\u80a5\u6e80\u3092\u5448\u3057\u305f\u306b\u3082 \u95a2\u308f\u3089\u305a\u3001\u30d6\u30c9\u30a6\u7cd6\u8ca0\u8377\u306b\u3088\u308b\u8840\u7cd6\u306e\u4e0a\u6607\u306f\u6291\u3048\u3089\u308c\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u306e\u52b9\u304d\u3082\u826f\u304f\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<figure id=\"attachment_1482\" aria-describedby=\"caption-attachment-1482\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1482\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig3-1024x679.jpg\" alt=\"\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u7279\u7570\u7684Cc\/2 \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308b\u8840\u7d71\u4e0a\u6607\u304c30%\u7a0b\u5ea6\u6291\u5236\u3055\u308c\u305f\" width=\"500\" height=\"331\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig3-1024x679.jpg 1024w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig3-300x199.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig3-768x509.jpg 768w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig3.jpg 1740w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-1482\" class=\"wp-caption-text\">\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u7279\u7570\u7684Cc\/2 \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308b\u8840\u7d71\u4e0a\u6607\u304c30%\u7a0b\u5ea6\u6291\u5236\u3055\u308c\u305f<\/figcaption><\/figure>\n<p class=\"p1\"><span class=\"s2\">\u3055\u3089\u306b\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001Vil-Ccl2KO\u3067\u306f\u3001\u5927\u8178\u3060\u3051\u3067\u306f\u306a\u304f\u8102\u80aa\u7d44\u7e54\u3067\u3082\u8102\u80aa\u7d30\u80de\u304c\u80a5\u5927\u5316\u3057\u3066\u3044\u308b\u306b\u3082\u95a2\u308f\u3089\u305a\u3001\u6162\u6027\u708e\u75c7\u304c\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/span><\/p>\n<figure id=\"attachment_1483\" aria-describedby=\"caption-attachment-1483\" style=\"width: 500px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1483\" src=\"https:\/\/dev.academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig4.jpg\" alt=\"\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u7279\u7570\u7684Cc\/2 \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u304c\u6291\u3048\u3089\u308c\u305f\" width=\"500\" height=\"905\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig4.jpg 454w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/08\/fig4-166x300.jpg 166w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><figcaption id=\"caption-attachment-1483\" class=\"wp-caption-text\">\u8178\u7ba1\u4e0a\u76ae\u7d30\u80de\u7279\u7570\u7684Cc\/2 \u6b20\u640d\u30de\u30a6\u30b9\u3067\u306f\u8102\u80aa\u7d44\u7e54\u306b\u304a\u3051\u308b\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306e\u6d78\u6f64\u304c\u6291\u3048\u3089\u308c\u305f<\/figcaption><\/figure>\n<p class=\"p1\"><span class=\"s2\">\u4ee5\u4e0a\u306e\u3053\u3068\u306f\u3001\u5927\u8178\u306e\u6162\u6027\u708e\u75c7\u3001\u3059\u306a\u308f\u3061\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3092\u5236\u5fa1\u3059\u308c\u3070\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u4f5c\u7528\u306b\u91cd\u8981\u306a\u672b\u68a2\u306e\u81d3\u5668\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u611f\u53d7\u6027\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u308b\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/span><\/p>\n<h3><span class=\"s1\">\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u304c\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u30e1\u30ab\u30cb\u30ba\u30e0<\/span><\/h3>\n<p class=\"p1\"><span class=\"s2\">\u305d\u308c\u3067\u306f\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308b\u5927\u8178\u306e\u708e\u75c7\u6027\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u3088\u308b\u6162\u6027\u708e\u75c7\u304c\u3069\u306e\u3088\u3046\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u8d77\u3053\u3057\u3001\u7cd6\u5c3f\u75c5\u306b\u3064\u306a\u304c\u308b\u306e\u3067\u3057\u3087\u3046\u304b\u3002\u5927\u304d\u304f\u4e8c\u3064\u306e\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">\u3072\u3068\u3064\u306f\u3001\u5927\u8178\u306e\u8178\u7ba1\u30d0\u30ea\u30a2\u30fc\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3067\u3059\u3002\u524d\u8ff0\u3057\u305f\u3088\u3046\u306b\u3001\u8178\u7ba1\u8154\u306b\u306f\u98df\u7269\u6297\u539f\u3001\u8178\u5185\u7d30\u83cc\u3092\u306f\u3058\u3081\u3068\u3057\u305f\u3055\u307e\u3056\u307e\u306a\u751f\u4f53\u5916\u306e\u7570\u7269\u304c\u5b58\u5728\u3057\u3001\u305d\u308c\u3089\u304c\u3001\u5faa\u74b0\u8840\u4e2d\u306b\u5165\u3089\u306a\u3044\u3088\u3046\u306b\u9632\u5fa1\u3059\u308b\u9694\u305f\u308a\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u305d\u308c\u304c\u8178\u7ba1\u30d0\u30ea\u30a2\u30fc\u6a5f\u80fd\u3067\u3059\u3002\u8178\u7ba1\u30d0\u30ea\u30a2\u6a5f\u80fd\u306f\u3001\u305d\u308c\u306b\u95a2\u308f\u308b\u7279\u6b8a\u306a\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u4fc2\u3057\u3066\u304a\u308a\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u3067\u306e\u5927\u8178\u3067\u306f\u305d\u306e\u3046\u3061\u306e\u4e00\u3064Claudin1\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u4f4e\u4e0b\u3057\u3001\u8178\u7ba1\u8154\u304b\u3089\u7269\u8cea\u304c\u5faa\u74b0\u8840\u4e2d\u306b\u6f0f\u308c\u3084\u3059\u3044\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u7279\u5fb4\u7684\u306a\u306e\u306f\u3001\u7d30\u83cc\u69cb\u6210\u6210\u5206\u306e\u4e00\u3064\u3067\u3042\u308a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3068\u3082\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u308blipopolysaccharide(LPS)\u306e\u9580\u8108\u4e2d\u306e\u6fc3\u5ea6\u304c\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u3057\u305f\u5bfe\u7167\u7fa4\u30de\u30a6\u30b9\u3067\u306f\u666e\u901a\u98df\u7fa4\u306b\u6bd4\u3079\u6709\u610f\u306b\u5897\u52a0\u3057\u3001\u4f5c\u88fd\u3057\u305f\u3075\u305f\u3064\u306e\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3067\u306f\u3001\u6b63\u5e38\u5316\u3057\u3066\u3044\u305f\u3053\u3068\u3067\u3059\u3002<\/span><\/p>\n<p class=\"p1\"><span class=\"s2\">\u3082\u3046\u3072\u3068\u3064\u306f\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u306b\u3088\u308a\u5927\u8178\u306e\u30a4\u30f3\u30d5\u30e9\u30de\u30be\u30fc\u30e0\u306e\u6d3b\u6027\u5316\u304c\u8d77\u3053\u308b\u3053\u3068\u3067\u3059\u3002\u8fd1\u5e74\u3001\u9ad8\u8102\u80aa\u98df\u306b\u3088\u308b\u6162\u6027\u708e\u75c7\u306e\u8a98\u5c0e\u6a5f\u5e8f\u306b\u304a\u3044\u3066\u3001\u708e\u75c7\u8a98\u5c0e\u30b7\u30b0\u30ca\u30eb\u3092\u611f\u77e5\u3057\u708e\u75c7\u306e\u30b7\u30b0\u30ca\u30eb\u3092\u4f1d\u9054\u3059\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u30a2\u30c0\u30d7\u30bf\u30fc\u86cb\u767d\u3068\u3057\u3066\u30a4\u30f3\u30d5\u30e9\u30de\u30be\u30fc\u30e0\u304c\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u8a8d\u8b58\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u9ad8\u8102\u80aa\u98df\u8ca0\u83774\u9031\u306e\u5927\u8178\u306b\u304a\u3044\u3066inflammasome\u306e\u6d3b\u6027\u5316\u3092\u793a\u5506\u3059\u308bspeckled pattern\u3092\u5448\u3059\u308bASC\u6d3b\u6027\u7d30\u80de\u306e\u6709\u610f\u306a\u5897\u52a0\u3092\u8a8d\u3081\u307e\u3057\u305f\u304c\u3001<i>M-Ccr2KO<\/i>\u3068<i>Vil-Ccl2KO<\/i>\u30de\u30a6\u30b9\u5927\u8178\u306b\u304a\u3044\u3066\u306f\u3001\u305d\u308c\u3089\u304c\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u30a4\u30f3\u30d5\u30e9\u30de\u30be\u30fc\u30e0\u306b\u5236\u5fa1\u3055\u308c\u308b\u4ee3\u8868\u7684\u306a\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3068\u3057\u3066IL1\u03b2\u3068IL18\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001<i>M-Ccr2KO<\/i>\u3001<i>Vil-Ccl2KO<\/i>\u5927\u8178\u3067\u306f\u3001\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3068\u6bd4\u8f03\u3057\u3066\u305d\u308c\u3089\u306e\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u304a\u308a\u3001\u305d\u308c\u306b\u4f34\u3044\u9580\u8108\u5185IL-18\u6fc3\u5ea6\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3001\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u6539\u5584\u306e\u4e00\u56e0\u306b\u306a\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u306e\u7d50\u679c\u304b\u3089\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u5927\u8178\u306b\u304a\u3044\u3066\u306f\u3001inflammasome\u306e\u6d3b\u6027\u5316\u304c\u5927\u8178\u306e\u8178\u7ba1\u4e0a\u76ae<i>Ccl2-<\/i>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8<i>Ccr2<\/i>\u7d4c\u8def\u306b\u5236\u5fa1\u3092\u53d7\u3051\u308b\u4e8b\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/span><\/p>\n<h3><span class=\"s1\">\u4eca\u5f8c\u306e\u5c55\u671b<\/span><\/h3>\n<p class=\"p1\"><span class=\"s2\">\u672c\u7814\u7a76\u306e\u7d50\u679c\u304b\u3089\u3001\u9ad8\u8102\u80aa\u98df\u8ca0\u8377\u8a98\u5c0e\u6027\u306e\u80a5\u6e80\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u8178\u7ba1\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u304c\u8102\u80aa\u7d44\u7e54\u306e\u6162\u6027\u708e\u75c7\u3092\u201d\u30ea\u30e2\u30fc\u30c8\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u201d\u3057\u3001\u5168\u8eab\u306e\u30a4\u30f3\u30b9\u30ea\u30f3\u62b5\u6297\u6027\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/span><\/p>\n<p class=\"p1\"><span 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