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\"\"
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<\/div>\n

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\u3053\u3053\u3067\u306f\u7279\u306b\u305f\u3093\u3071\u304f\u8cea\u5206\u89e3\u9175\u7d20\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u306a\u305c\u304b\u3068\u3044\u3046\u3068\u3001\u7cbe\u5b50\u304c\u6210\u719f\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u7cbe\u5b50\u306e\u8868\u9762\u306e\u305f\u3093\u3071\u304f\u8cea\u304c\u9069\u5207\u306b\u5206\u89e3\u3055\u308c\u308b\u3053\u3068\u304c\u5fc5\u9808\u3060\u304b\u3089\u3067\u3059\u3002\u307e\u305f\u3001\u305f\u3093\u3071\u304f\u8cea\u5206\u89e3\u9175\u7d20\u306e\u306f\u305f\u3089\u304d\u3092\u6291\u3048\u308b\u963b\u5bb3\u5264\u304c\u898b\u3064\u304b\u308c\u3070\u3001\u7537\u6027\u907f\u598a\u85ac\u3078\u306e\u5fdc\u7528\u306b\u3082\u3064\u306a\u304c\u308a\u307e\u3059\u3002<\/p>\n

NELL2\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3067\u306f\u6570\u5341\u7a2e\u985e\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u305d\u306e\u4e2d\u306bOVCH2\u3068\u3044\u3046\u305f\u3093\u3071\u304f\u8cea\u5206\u89e3\u9175\u7d20\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002OVCH2\u306f\u7cbe\u5de3\u4e0a\u4f53\u3060\u3051\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u7279\u5225\u306a\u305f\u3093\u3071\u304f\u8cea\u5206\u89e3\u9175\u7d20\u3067\u3059\u3002\u305d\u3053\u3067OVCH2\u306e\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u305f\u3068\u3053\u308d\u3001\u7cbe\u5b50\u306e\u6210\u719f\u306b\u7570\u5e38\u3092\u304d\u305f\u3057\u3001\u3084\u306f\u308a\u96c4\u6027\u4e0d\u598a\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u7cbe\u5b50\u6210\u719f\u306b\u5fc5\u9808\u306a\u305f\u3093\u3071\u304f\u8ceaOVCH2\uff08\u7d2b\uff09\u3002\u30b9\u30a4\u30c3\u30c1\u5206\u5b50NELL2\u306b\u5fdc\u7b54\u3057\u3066\u3001\u7cbe\u5de3\u4e0a\u4f53\u3067\u6210\u719f\u6a5f\u69cb\u304c\u30aa\u30f3\u306b\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308b\u3002<\/figcaption><\/figure>\n

\u7cbe\u5b50\u8868\u9762\u306b\u306f\u3001\u7cbe\u5b50\u304c\u5375\u5b50\u3068\u51fa\u4f1a\u3046\u305f\u3081\u306b\u5fc5\u8981\u4e0d\u53ef\u6b20\u306aADAM3\u3068\u3044\u3046\u305f\u3093\u3071\u304f\u8cea\u304c\u3042\u308b\u306e\u3067\u3059\u304c\u3001OVCH2\u3092\u6b20\u640d\u3057\u305f\u7cbe\u5b50\u3067\u306f\u3001\u3053\u306e\u7cbe\u5b50\u8868\u9762\u306eADAM3\u306e\u5206\u89e3\u306b\u7570\u5e38\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3059\u306a\u308f\u3061\u3001\u7cbe\u5b50\u304c\u6210\u719f\u3059\u308b\u305f\u3081\u306b\u5fc5\u9808\u3068\u306a\u308b\u7cbe\u5b50\u8868\u9762\u305f\u3093\u3071\u304f\u8cea\u306e\u5206\u89e3\u306b\u3001\u5206\u89e3\u9175\u7d20OVCH2\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u7a81\u304d\u6b62\u3081\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u7cbe\u5b50\u6210\u719f\u904e\u7a0b\u306e\u7406\u89e3\u304b\u3089\u3088\u308a\u5e83\u3044\u751f\u547d\u73fe\u8c61\u306e\u89e3\u660e\u3078<\/h3>\n

\u4eca\u56de\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u307e\u305a\u7cbe\u5de3\u304b\u3089\u30eb\u30df\u30af\u30e9\u30a4\u30f3\u56e0\u5b50NELL2\u304c\u5206\u6ccc\u3055\u308c\u3001\u6b21\u306b\u7cbe\u5de3\u4e0a\u4f53\u306eROS1\u304c\u3053\u308c\u3092\u30ad\u30e3\u30c3\u30c1\u3057\u3066\u7cbe\u5b50\u6210\u719f\u6a5f\u69cb\u3092\u8d77\u52d5\u3057\u3001\u305d\u306e\u7d50\u679c\u767a\u73fe\u3057\u3066\u304f\u308bOVCH2\u304c\u7cbe\u5b50\u8868\u9762\u306eADAM3\u306b\u50cd\u304d\u304b\u3051\u3066\u7cbe\u5b50\u3092\u6210\u719f\u3055\u305b\u308b\u3001\u3068\u3044\u3046\u30b9\u30ad\u30fc\u30e0\u304c\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u8b0e\u306e\u591a\u304b\u3063\u305f\u7cbe\u5de3\u4e0a\u4f53\u306b\u3088\u308b\u7cbe\u5b50\u6210\u719f\u6a5f\u69cb\u306e\u5168\u4f53\u50cf\u304c\u3001\u3088\u3046\u3084\u304f\u5206\u5b50\u30ec\u30d9\u30eb\u3067\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u672c\u7814\u7a76\u306b\u3088\u308a\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u7cbe\u5b50\u6210\u719f\u306e\u30e1\u30ab\u30cb\u30ba\u30e0<\/figcaption><\/figure>\n

\u3053\u308c\u306b\u3088\u3063\u3066\u4e0d\u598a\u75c7\u306e\u8a3a\u65ad\u3084\u75c5\u56e0\u89e3\u660e\u306b\u3001\u7cbe\u5b50\u306e\u6210\u719f\u3068\u3044\u3046\u300c\u8cea\u300d\u306e\u89b3\u70b9\u304c\u65b0\u305f\u306b\u52a0\u308f\u308a\u307e\u3057\u305f\u3057\u3001OVCH2\u3092\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3057\u305f\u7537\u6027\u907f\u598a\u85ac\u958b\u767a\u3078\u306e\u5fdc\u7528\u3082\u671f\u5f85\u3055\u308c\u307e\u3059\u3002NELL2-ROS1-OVCH2\u3068\u9375\u3068\u306a\u308b\u305f\u3093\u3071\u304f\u8cea\u306e\u3064\u306a\u304c\u308a\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u306e\u3067\u3001\u4eca\u5f8c\u306f\u3053\u308c\u3089\u3092\u8d77\u70b9\u3068\u3057\u305f\u751f\u6b96\u7814\u7a76\u306e\u3055\u3089\u306a\u308b\u9032\u5c55\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u7ba1\u3092\u4ecb\u3057\u305f\u60c5\u5831\u4f1d\u9054\u6a5f\u69cb\u3067\u3042\u308b\u300c\u30eb\u30df\u30af\u30e9\u30a4\u30f3\u300d\u306f\u3001\u751f\u6b96\u306b\u9650\u3089\u305a\u3055\u307e\u3056\u307e\u306a\u751f\u547d\u73fe\u8c61\u3092\u5236\u5fa1\u3059\u308b\u6a5f\u69cb\u3068\u3057\u3066\u306f\u305f\u3089\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u4eca\u56de\u79c1\u305f\u3061\u304c\u30eb\u30df\u30af\u30e9\u30a4\u30f3\u6a5f\u69cb\u3092\u660e\u3089\u304b\u306b\u3057\u305f\u3053\u3068\u3067\u3001\u3088\u308a\u5e83\u3044\u751f\u547d\u73fe\u8c61\u306e\u57fa\u672c\u7684\u7406\u89e3\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u3092\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/b><\/p>\n

    \n
  • Kiyozumi D, Noda T, Yamaguchi R, Tobita T, Matsumura T, Shimada K, Kodani M, Kohda T, Fujihara Y, Ozawa M, Yu Z, Miklossy G, Bohren KM, Horie M, Okabe M, Matzuk MM, Ikawa M. NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science<\/em>. 2020 Jun 5; 368(6495): 1132-1135. doi: 10.1126\/science.aay5134.<\/li>\n
  • Lord T, Oatley JM. Testicular-borne factors affect sperm fertility. Science<\/em>. 2020 Jun 5; 368(6495): 1053-1054. doi: 10.1126\/science.abc2732.<\/li>\n
  • Moniem KA, Glover TD, Lubicz-Nawrocki CW. Effects of duct ligation and orchidectomy on histochemical reactions in the hamster epididymis. J Reprod Fertil<\/em>. 1978 Sep; 54(1): 173-176. doi: 10.1530\/jrf.0.0540173.<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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