\u306a\u305c\u3001\u8133\u306b\u30b7\u30ef\u304c\u3067\u304d\u308b\u4ed5\u7d44\u307f\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u306a\u3044\u306e\u304b\uff1f<\/h3>\n
\u3053\u306e\u3088\u3046\u306b\u3001\u8133\u306e\u30b7\u30ef\u306f\u91cd\u8981\u306a\u50cd\u304d\u3092\u6301\u3064\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30b7\u30ef\u304c\u8133\u8868\u9762\u306b\u3067\u304d\u3042\u304c\u308b\u4ed5\u7d44\u307f\u3084\u3001\u6ed1\u8133\u75c7\u3084\u591a\u5c0f\u8133\u56de\u75c7\u306a\u3069\u3067\u30b7\u30ef\u306b\u7570\u5e38\u304c\u751f\u3058\u308b\u4ed5\u7d44\u307f\u306f\u3001\u307e\u3060\u9a5a\u304f\u307b\u3069\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n
\u300c\u304c\u3093\u3092\u8d77\u3053\u3059\u907a\u4f1d\u5b50\u3092\u767a\u898b\u300d\u306a\u3069\u306e\u898b\u51fa\u3057\u3092\u65b0\u805e\u3067\u898b\u308b\u3053\u3068\u3082\u3042\u308b\u304b\u3068\u601d\u3044\u307e\u3059\u3002\u304c\u3093\u306e\u4ed5\u7d44\u307f\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u539f\u56e0\u3068\u306a\u308b\u907a\u4f1d\u5b50\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u306a\u306e\u3067\u3059\u3002\u540c\u3058\u3088\u3046\u306b\u3001\u8133\u306b\u30b7\u30ef\u304c\u3067\u304d\u308b\u4ed5\u7d44\u307f\u3092\u89e3\u304d\u660e\u304b\u3059\u305f\u3081\u306b\u306f\u3001\u8133\u306b\u30b7\u30ef\u3092\u3064\u304f\u308b\u907a\u4f1d\u5b50\u3092\u898b\u3064\u3051\u308b\u3053\u3068\u304c\u91cd\u8981\u306b\u306a\u3063\u3066\u304d\u307e\u3059\u3002<\/p>\n
\u305f\u3068\u3048\u3070\u3001\u6ce8\u76ee\u3059\u308b\u907a\u4f1d\u5b50X\u3092\u4eba\u70ba\u7684\u306b\u50cd\u304b\u306a\u304f\u3057\u305f\u5834\u5408\u306b\u30b7\u30ef\u304c\u306a\u304f\u306a\u308c\u3070\u3001\u907a\u4f1d\u5b50X\u306f\u8133\u306e\u30b7\u30ef\u3092\u3064\u304f\u308b\u305f\u3081\u306b\u5fc5\u8981\u306a\u907a\u4f1d\u5b50\u3067\u3042\u308b\u3068\u8a00\u3048\u307e\u3059\u3002\u9006\u306b\u3001\u907a\u4f1d\u5b50X\u3092\u4eba\u70ba\u7684\u306b\u5897\u3084\u3057\u305f\u5834\u5408\u306b\u30b7\u30ef\u304c\u5897\u3048\u308c\u3070\u3001\u305d\u306e\u907a\u4f1d\u5b50X\u306f\u30b7\u30ef\u3092\u65b0\u305f\u306b\u4f5c\u308b\u80fd\u529b\u3092\u6301\u3064\u907a\u4f1d\u5b50\u3068\u8a00\u3048\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u6ce8\u76ee\u3059\u308b\u907a\u4f1d\u5b50\u3092\u4eba\u70ba\u7684\u306b\u5897\u3084\u3057\u305f\u308a\u6e1b\u3089\u3057\u305f\u308a\u3059\u308b\u6280\u8853\u304c\u3001\u8eab\u4f53\u306e\u4ed5\u7d44\u307f\u3092\u89e3\u660e\u3059\u308b\u305f\u3081\u306b\u306f\u5fc5\u8981\u3067\u3059\u3002\u533b\u5b66\u3084\u751f\u7269\u5b66\u306e\u7814\u7a76\u306b\u30de\u30a6\u30b9\u304c\u591a\u304f\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u30de\u30a6\u30b9\u3067\u306f\u3053\u306e\u6280\u8853\u304c\u4f7f\u7528\u53ef\u80fd\u3067\u3042\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n
\u3068\u3053\u308d\u304c\u3001\u30de\u30a6\u30b9\u306b\u306f\u554f\u984c\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u30d2\u30c8\u306e\u8133\u306b\u6bd4\u3079\u3066\u30de\u30a6\u30b9\u306e\u8133\u306f\u767a\u9054\u304c\u60aa\u304f\u3001\u5927\u8133\u306b\u306f\u30b7\u30ef\u304c\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u30de\u30a6\u30b9\u3092\u4f7f\u3063\u3066\u30b7\u30ef\u304c\u3067\u304d\u308b\u4ed5\u7d44\u307f\u3092\u7814\u7a76\u3059\u308b\u3053\u3068\u306f\u96e3\u3057\u304f\u306a\u308a\u307e\u3059\u3002\u3067\u306f\u3001\u30de\u30a6\u30b9\u4ee5\u5916\u306e\u52d5\u7269\u306f\u3069\u3046\u3067\u3057\u3087\u3046\u304b\uff1f\u3000\u30de\u30a6\u30b9\u4ee5\u5916\u306e\u52d5\u7269\u3067\u8133\u306b\u30b7\u30ef\u3092\u6301\u3064\u52d5\u7269\u306f\u3044\u308d\u3044\u308d\u3044\u308b\u306e\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u52d5\u7269\u3067\u306f\u3001\u907a\u4f1d\u5b50\u3092\u4eba\u70ba\u7684\u306b\u5897\u3084\u3057\u305f\u308a\u6e1b\u3089\u3057\u305f\u308a\u64cd\u4f5c\u3059\u308b\u6280\u8853\u304c\u6574\u5099\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u3053\u308c\u304c\u3001\u30b7\u30ef\u304c\u3067\u304d\u308b\u4ed5\u7d44\u307f\u3084\u30b7\u30ef\u306b\u7570\u5e38\u304c\u3042\u308b\u75c5\u6c17\u306e\u4ed5\u7d44\u307f\u304c\u3042\u307e\u308a\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u7406\u7531\u3067\u3059\u3002<\/p>\n
\u30d5\u30a7\u30ec\u30c3\u30c8\u3092\u5229\u7528\u3057\u3066\u3001\u30b7\u30ef\u5f62\u6210\u306e\u4ed5\u7d44\u307f\u306b\u8feb\u308b<\/h3>\n
\u79c1\u305f\u3061\u306f\u3001i\uff09\u8133\u306b\u30b7\u30ef\u304c\u3042\u308b\u52d5\u7269\u3067\u3001ii\uff09\u4eba\u70ba\u7684\u306b\u907a\u4f1d\u5b50\u3092\u64cd\u4f5c\u3067\u304d\u308b\u3001\u3068\u3044\u3046\u4e8c\u3064\u306e\u6761\u4ef6\u304c\u6e80\u305f\u3055\u308c\u308c\u3070\u3001\u8133\u306e\u30b7\u30ef\u306b\u95a2\u3059\u308b\u7814\u7a76\u3092\u9032\u3081\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u79c1\u305f\u3061\u304c\u7740\u76ee\u3057\u305f\u52d5\u7269\u304c\u3001\u30d5\u30a7\u30ec\u30c3\u30c8\u3067\u3059[1]\u3002\u30d5\u30a7\u30ec\u30c3\u30c8\u306f\u3001\u30a4\u30bf\u30c1\u79d1\u306e\u52d5\u7269\u3067\u30de\u30a6\u30b9\u306b\u6bd4\u3079\u3066\u8133\u304c\u767a\u9054\u3057\u3066\u304a\u308a\u3001\u5927\u8133\u306b\u306f\u30b7\u30ef\u3082\u898b\u3089\u308c\u307e\u3059\u3002\u6b27\u7c73\u3092\u4e2d\u5fc3\u3068\u3057\u3066\u7814\u7a76\u306b\u3082\u4f7f\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u304b\u3089\u3001\u7814\u7a76\u306e\u57fa\u790e\u3068\u306a\u308b\u30c7\u30fc\u30bf\u3082\u305d\u308d\u3063\u3066\u3044\u307e\u3057\u305f\u3002\u3068\u3053\u308d\u304c\u30d5\u30a7\u30ec\u30c3\u30c8\u306b\u306fii\uff09\u306e\u4eba\u70ba\u7684\u306b\u907a\u4f1d\u5b50\u3092\u64cd\u4f5c\u3059\u308b\u826f\u3044\u6280\u8853\u304c\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u79c1\u305f\u3061\u306f\u3053\u306e\u6280\u8853\u958b\u767a\u304b\u3089\u59cb\u3081\u307e\u3057\u305f\u3002\u8a66\u884c\u932f\u8aa4\u306e\u7d50\u679c\u3001\u30de\u30a6\u30b9\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u305f\u300c\u5b50\u5bae\u5185\u30a8\u30ec\u30af\u30c8\u30ed\u30dd\u30ec\u30fc\u30b7\u30e7\u30f3\u6cd5\u300d\u3068\u3044\u3046\u65b9\u6cd5\u3092\u30d5\u30a7\u30ec\u30c3\u30c8\u7528\u306b\u6539\u5909\u3059\u308b\u3053\u3068\u3067\u3001\u30d5\u30a7\u30ec\u30c3\u30c8\u306e\u5927\u8133\u3067\u306e\u907a\u4f1d\u5b50\u306e\u4eba\u70ba\u7684\u64cd\u4f5c\u304c\u3067\u304d\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f [2, 3]\u3002<\/p>\n 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[4]\u3002\u73fe\u5728\u3001Tbr2\u306e\u50cd\u304d\u3092\u6291\u5236\u3057\u305f\u30d5\u30a7\u30ec\u30c3\u30c8\u3092\u7528\u3044\u3066\u3001\u30b7\u30ef\u304c\u3067\u304d\u308b\u305f\u3081\u306e\u4ed5\u7d44\u307f\u3092\u8a73\u7d30\u306b\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n 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\u79c1\u305f\u3061\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u7814\u7a76\u3092\u4e00\u7dd2\u306b\u3059\u308b\u5927\u5b66\u9662\u751f\u3084\u7814\u7a76\u54e1\u306e\u4ef2\u9593\u3092\u63a2\u3057\u3066\u3044\u307e\u3059\u3002\u3082\u3057\u8208\u5473\u306e\u3042\u308b\u4eba\u304c\u3044\u3089\u3063\u3057\u3083\u308c\u3070\u6c17\u8efd\u306b\u79c1\u307e\u3067\u3054\u9023\u7d61\u304f\u3060\u3055\u3044\u3002\u306a\u304a\u7814\u7a76\u5ba4\u306e\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a>\u3082\u3057\u304f\u306f\u79c1\u306eFacebook<\/a>\u304b\u3089\u7814\u7a76\u5ba4\u306e\u69d8\u5b50\u306f\u3054\u89a7\u9802\u3051\u307e\u3059\u306e\u3067\u3001\u8208\u5473\u304c\u3042\u308c\u3070\u305c\u3072\uff01<\/p>\n \u53c2\u8003\u6587\u732e<\/strong><\/p>\n 1. Kawasaki H, Crowley JC, Livesey FJ, et al. Molecular organization of the ferret visual thalamus. J Neurosci. 2004;24:9962-70. \u8133\u3068\u30b7\u30ef\u306e\u95a2\u4fc2\u6027 \u30d2\u30c8\u306e\u8133\u306e\u8868\u9762\u304c\u30b7\u30ef\u3060\u3089\u3051\u3067\u3042\u308b\u3053\u3068\u306f\u3001\u305f\u3076\u3093\u307b\u3068\u3093\u3069\u306e\u4eba\u304c\u3054\u5b58\u3058\u304b\u3068\u601d\u3044\u307e\u3059\u3002\u307e\u305f\u300c\u8ce2\u3044\u3072\u3068\u306f\u8133\u306b\u30b7\u30ef\u304c\u591a\u3044\u306e\uff1f\u300d\u3068\u805e\u304b\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3088\u3046\u306b\u3001\u8133\u306e\u30b7\u30ef\u306b\u8208\u5473\u304c\u3042\u308b\u4eba\u306f\u591a\u3044\u306e\u3067\u306f\u306a\u3044 […]<\/p>\n","protected":false},"author":27,"featured_media":7364,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[15,157],"class_list":["post-1361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-biology","tag-157","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/27"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1361"}],"version-history":[{"count":4,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1361\/revisions"}],"predecessor-version":[{"id":10118,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/1361\/revisions\/10118"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/7364"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2016\/09\/001-2.jpg\")
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\u304a\u308f\u308a\u306b<\/h3>\n
\n2. Kawasaki H, Iwai L, Tanno K. Rapid and efficient genetic manipulation of gyrencephalic carnivores using in utero electroporation. Mol Brain. 2012;5:24.
\n3. Kawasaki H, Toda T, Tanno K. In vivo genetic manipulation of cortical progenitors in gyrencephalic carnivores using in utero electroporation. Biol Open. 2013;2:95-100.
\n4. Toda T, Shinmyo Y, Dinh Duong TA, et al. An essential role of SVZ progenitors in cortical folding in gyrencephalic mammals. Sci Rep. 2016;6:29578.
\n5. Masuda K, Toda T, Shinmyo Y, et al. Pathophysiological analyses of cortical malformation using gyrencephalic mammals. Sci Rep. 2015;5:15370.<\/p>\n","protected":false},"excerpt":{"rendered":"