{"id":13097,"date":"2020-04-28T08:00:03","date_gmt":"2020-04-27T23:00:03","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=13097"},"modified":"2020-05-13T13:19:27","modified_gmt":"2020-05-13T04:19:27","slug":"%e7%b4%b0%e8%83%9e%e3%81%af%e5%8a%9b%e5%88%ba%e6%bf%80%e3%82%92%e5%8f%97%e3%81%91%e3%82%8b%e3%81%a8%e7%b4%b0%e8%83%9e%e9%96%93%e3%81%ae%e6%8e%a5%e7%9d%80%e3%82%92%e5%bc%b7%e3%81%8f%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=13097","title":{"rendered":"\u7d30\u80de\u306f\u529b\u523a\u6fc0\u3092\u53d7\u3051\u308b\u3068\u7d30\u80de\u9593\u306e\u63a5\u7740\u3092\u5f37\u304f\u3059\u308b\uff1f &#8211; 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class=\"center\">\n<!--Ads1-->\n<\/div>\n<h3>\u529b\u306b\u5bfe\u3059\u308b\u7d30\u80de\u306e\u5fdc\u7b54<\/h3>\n<p>\u7d30\u80de\u304c\u529b\u306e\u523a\u6fc0\u3092\u53d7\u3051\u308b\u3068\u3069\u306e\u3088\u3046\u306b\u5909\u5316\u3059\u308b\u306e\u304b\uff1f \u3053\u306e\u7814\u7a76\u306f\u9577\u3044\u3042\u3044\u3060\u3001\u4e3b\u306b\u57f9\u990a\u7d30\u80de\u3092\u7528\u3044\u3066\u3001\u3055\u307e\u3056\u307e\u306a\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u5909\u5316\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u6709\u540d\u306a\u7814\u7a76\u306f2006\u5e74\u306eDischer\u3089\u306b\u3088\u3063\u3066\u5831\u544a\u3055\u308c\u305f\u3001\u57fa\u8cea\u306e\u786c\u3055\uff08\u5f3e\u6027\uff09\u306b\u3088\u3063\u3066\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306e\u5206\u5316\u65b9\u5411\u304c\u6c7a\u307e\u308b\u3068\u3044\u3046\u767a\u898b\u3067\u3059\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306f\u3001\u57f9\u990a\u7d30\u80de\u3067\u306f\u306a\u304f\u3001\u521d\u671f\u80da\u304c\u305d\u306e\u5f62\u3092\u4f5c\u308a\u4e0a\u3052\u308b\u904e\u7a0b\uff08\u5f62\u614b\u5f62\u6210\uff09\u306b\u304a\u3044\u3066\u3001\u7d30\u80de\u96c6\u56e3\u304c\u80da\u306e\u4e2d\u3067\u751f\u307e\u308c\u308b\u529b\u306b\u3069\u306e\u3088\u3046\u306b\u5fdc\u7b54\u3059\u308b\u304b\u8208\u5473\u3092\u3082\u3061\u3001\u3053\u306e\u4e00\u9023\u306e\u7814\u7a76\u3092\u884c\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u307e\u305a\u79c1\u305f\u3061\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u3067\u306f\u306a\u304f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u306b\u7740\u76ee\u3057\u307e\u3057\u305f\u3002\u30ea\u30f3\u9178\u5316\u53cd\u5fdc\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u5909\u5316\u3088\u308a\u65e9\u304f\u8d77\u3053\u308b\u305f\u3081\u3001\u7d30\u80de\u5916\u304b\u3089\u306e\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u8fc5\u901f\u306a\u7d30\u80de\u5fdc\u7b54\u3092\u89e3\u6790\u3067\u304d\u308b\u3068\u8003\u3048\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u305d\u306e\u7d30\u80de\u5fdc\u7b54\u306e\u5168\u4f53\u50cf\u3092\u63cf\u304d\u51fa\u3059\u305f\u3081\u306b\u3001\u300c\u30ea\u30f3\u9178\u5316\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u300d\u3068\u3044\u3046\u65b9\u6cd5\u3092\u7528\u3044\u307e\u3057\u305f\u3002\u3053\u306e\u305f\u3081\u306b\u3001\u7c73\u56fd\u30d7\u30ea\u30f3\u30b9\u30c8\u30f3\u5927\u5b66\u306eCristea\u6559\u6388\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u8cea\u91cf\u5206\u6790\u8a08\u3068\u3044\u3046\u597d\u611f\u5ea6\u306b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u691c\u51fa\u3059\u308b\u6a5f\u5668\u3092\u7528\u3044\u3066\u3001\u691c\u51fa\u3057\u3046\u308b\u3059\u3079\u3066\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u30da\u30d7\u30c1\u30c9\u306e\u30ea\u30f3\u9178\u5316\u3092\u6349\u3048\u308b\u3053\u3068\u3092\u8a66\u307f\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u7814\u7a76\u6750\u6599\u306f\u5375\u306e\u76f4\u5f84\u304c1.2mm\u307b\u3069\u3067\u6bd4\u8f03\u7684\u5927\u304d\u304f\u3001\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b9a\u91cf\u7684\u89e3\u6790\u306e\u305f\u3081\u306b\u591a\u304f\u306e\u53d7\u7cbe\u5375\u304c\u96c6\u3081\u3089\u308c\u308b\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u3092\u3001\u521d\u671f\u80da\u306b\u529b\u3092\u8ca0\u8377\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u3001\u591a\u6570\u306e\u53d7\u7cbe\u5375\u306b\u5747\u4e00\u306b\u8ca0\u8377\u3067\u304d\u308b\u9060\u5fc3\u5206\u96e2\u6a5f\u3092\u7528\u3044\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_13098\" aria-describedby=\"caption-attachment-13098\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13098\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-9.jpg\" alt=\"\" width=\"600\" height=\"296\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-9.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-9-300x148.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13098\" class=\"wp-caption-text\">\u30a2\u30d5\u30ea\u30ab\u30c4\u30e1\u30ac\u30a8\u30eb\u80da\u3078\u306e\u529b\u306e\u8ca0\u8377<br \/>\u539f\u8178\u80da\u3092\u30a2\u30ac\u30ed\u30fc\u30b9\u306e\u4e0a\u306b\u4e26\u3079\u3001\u9060\u5fc3\u306b\u3088\u3063\u3066\u529b\u3092\u8ca0\u8377\u3057\u305f\u3002\u77ed\u6642\u9593\uff0810\u5206\u7a0b\u5ea6\uff09\u306e\u9060\u5fc3\u3067\u80da\u306f\u5909\u5f62\u3059\u308b\u304c\u3001\u9060\u5fc3\u505c\u6b62\u5f8c\u5143\u306e\u7403\u5f62\u306b\u623b\u308a\u6b63\u5e38\u306b\u767a\u751f\u3059\u308b\u3002\u3053\u306e\u80da\u3092\u8a66\u6599\u3068\u3057\u3066\u30ea\u30f3\u9178\u5316\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u3092\u884c\u3063\u305f\uff08\u4f5c\u56f3\u306f\u5c71\u68a8\u5927\u5b66\u68ee\u7530\u4ec1\u535a\u58eb\uff09\u3002<\/figcaption><\/figure>\n<h3>\u529b\u306b\u3088\u3063\u3066\u5f37\u304f\u306a\u308b\u7d44\u7e54<\/h3>\n<p>\u529b\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u72b6\u614b\u306e\u5909\u5316\u306b\u95a2\u3059\u308b\u81a8\u5927\u306a\u30c7\u30fc\u30bf\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u7d30\u80de-\u7d30\u80de\u9593\u63a5\u7740\u3084\u7d30\u80de-\u57fa\u8cea\u9593\u63a5\u7740\u306b\u95a2\u308f\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u308b\u9375\u30bf\u30f3\u30d1\u30af\u8cea\uff08ZO-1\u3084\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\uff09\u306b\u6a5f\u80fd\u7684\u306b\u95a2\u9023\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u304c\u3001\u529b\u523a\u6fc0\u306b\u3088\u3063\u3066\u8fc5\u901f\u306b\u30ea\u30f3\u9178\u5316\u3055\u308c\u3001\u305d\u308c\u3089\u306f\u8907\u96d1\u306a\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u3092\u5f62\u6210\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_13099\" aria-describedby=\"caption-attachment-13099\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13099\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002.jpeg\" alt=\"\" width=\"600\" height=\"502\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002.jpeg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002-300x251.jpeg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13099\" class=\"wp-caption-text\">\u30d7\u30ed\u30c6\u30aa\u30fc\u30e0\u89e3\u6790\u304b\u3089\u63cf\u304b\u308c\u305f\u30ea\u30f3\u9178\u5316\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u56f3<br \/>ZO-1\uff08\u5de6\u77e2\u5370\uff09\u304a\u3088\u3073\u30a4\u30f3\u30c6\u30b0\u30ea\u30f3\u306e\u5236\u5fa1\u30bf\u30f3\u30d1\u30af\u8ceaTalin (Tln)\uff08\u53f3\u77e2\u5370\uff09\u306b\u6a5f\u80fd\u7684\u306b\u95a2\u9023\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u7fa4\u306e\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\u69cb\u9020\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002\u30de\u30b9\u76ee\u306f\u5de6\u304b\u3089\u9060\u5fc3\u505c\u6b62\u5f8c10\u5206\u300130\u5206\u300160\u5206\u306e\u5404\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30ea\u30f3\u9178\u5316\u72b6\u614b\u3092\u793a\u3057\u3001\u8272\u304c\u6fc3\u3044\u307b\u3069\u30ea\u30f3\u9178\u5316\u304c\u4ea2\u9032\u3057\u305f\u3053\u3068\u3092\u793a\u3059\u3002\uff08Hashimoto et al., Cell Syst., 2019\u3092\u6539\u5909\uff09<\/figcaption><\/figure>\n<p>\u307e\u305f\u3001\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\uff08\u5bc6\u7740\u7d50\u5408\uff09\u3068\u3044\u3046\u7d30\u80de\u3068\u7d30\u80de\u306e\u3042\u3044\u3060\u3092\u30b7\u30fc\u30eb\u3057\u3001\u4f53\u6db2\u3084\u5206\u5b50\u306e\u79fb\u52d5\u3092\u9632\u3050\u69cb\u9020\u3092\u3064\u304f\u308b\u305f\u3081\u306b\u5fc5\u9808\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bZO-1\u3068\u3044\u3046\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u3001\u30ea\u30f3\u9178\u5316\u306b\u4f34\u3063\u3066\u7d30\u80de\u8cea\u304b\u3089\u7d30\u80de\u819c\u306b\u79fb\u52d5\u3057\u3001\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u69cb\u9020\u306b\u96c6\u7a4d\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u7d50\u679c\u304b\u3089\u3001\u529b\u523a\u6fc0\u3092\u53d7\u3051\u305f\u521d\u671f\u80da\u7d30\u80de\u306f\u7d30\u80de-\u7d30\u80de\u9593\u63a5\u7740\u3092\u5f37\u5316\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_13100\" aria-describedby=\"caption-attachment-13100\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13100\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-4.jpg\" alt=\"\" width=\"600\" height=\"338\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-4.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-4-300x169.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-4-240x135.jpg 240w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13100\" class=\"wp-caption-text\">\u529b\u523a\u6fc0\u306b\u3088\u308b\u7d30\u80de\u5909\u5316<br \/>\u529b\u306b\u3088\u308a\u7d30\u80de\u306f\u5909\u5f62\u3057\u3001\u305d\u306e\u7d50\u679c\u3001ZO-1\u306f\u7d30\u80de\u8cea\u304b\u3089\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306b\u96c6\u7a4d\u3059\u308b\u3088\u3046\u306b\u306a\u308a\u3001\u7d30\u80de-\u7d30\u80de\u9593\u63a5\u7740\u304c\u5f37\u5316\u3055\u308c\u308b\uff08\u4e0a\u6bb5\uff1a\u7d30\u80de\u3092\u6c34\u5e73\u306b\u898b\u305f\u6a21\u5f0f\u56f3\uff09\u3002GFP\u3067\u6a19\u8b58\u3057\u305fZO-1\u306f\u7d30\u80de\u8cea\u306b\u51dd\u96c6\u4f53\u3068\u3057\u3066\u5b58\u5728\u3059\u308b\u304c\u3001\u529b\u523a\u6fc0\u306b\u3088\u3063\u3066\u7d30\u80de\u819c\u306b\u96c6\u307e\u308b\uff08\u4e0b\u6bb5\uff1a\u7d30\u80de\u3092\u4e0a\u304b\u3089\u898b\u305f\u86cd\u5149\u9855\u5fae\u93e1\u50cf\uff09\u3002<\/figcaption><\/figure>\n<p>\u3053\u306e\u73fe\u8c61\u306f\u3001\u4e0a\u76ae\u7d30\u80de\u304c\u6027\u8cea\u3092\u5909\u3048\u904b\u52d5\u80fd\u3092\u7372\u5f97\u3059\u308bEMT\u3068\u547c\u3070\u308c\u308b\u73fe\u8c61\u3068\u9006\u306e\u73fe\u8c61\u3067\u3001MET\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001F-\u30a2\u30af\u30c1\u30f3\u304c\u7d30\u80de\u8868\u5c64\u306b\u96c6\u307e\u308a\u3001\u7d44\u7e54\u306e\u5f3e\u6027\u3082\u9ad8\u304f\u306a\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u3046\u3044\u3063\u305f\u5fdc\u7b54\u306f\u3001\u7d44\u7e54\u304c\u529b\u306b\u3088\u3063\u3066\u30d0\u30e9\u30d0\u30e9\u306b\u306a\u308b\u306e\u3092\u9632\u304e\u3001\u7d71\u5408\u6027\u3092\u4fdd\u3063\u3066\u767a\u751f\u3092\u6b63\u5e38\u306b\u9032\u3081\u308b\u305f\u3081\u306e\u30d5\u30a3\u30fc\u30c9\u30d0\u30c3\u30af\u6a5f\u69cb\u3067\u3042\u308a\u3001\u5b9f\u306b\u7406\u306b\u304b\u306a\u3063\u305f\u5de7\u5999\u306a\u751f\u7269\u306e\u3057\u304f\u307f\u3067\u3042\u308b\u3068\u89e3\u91c8\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001EMT\u306f\u30ac\u30f3\u306e\u6d78\u6f64\u30fb\u8ee2\u79fb\u306e\u4e3b\u8981\u306a\u539f\u56e0\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001EMT-MET \u306e\u30b9\u30a4\u30c3\u30c1\u30f3\u30b0\u6a5f\u69cb\u306e\u89e3\u660e\u306f\u304c\u3093\u7814\u7a76\u306b\u3082\u8ca2\u732e\u3059\u308b\u3053\u3068\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n<h3>\u529b\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u3042\u308b\u304b\uff1f<\/h3>\n<p>\u3067\u306f\u3001\u7d30\u80de\u306f\u3069\u306e\u3088\u3046\u306b\u529b\u3092\u611f\u77e5\u3057\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u79c1\u305f\u3061\u306e\u6700\u8fd1\u306e\u7814\u7a76\u3067\u3001FGF\u3068\u547c\u3070\u308c\u308b\u7d30\u80de\u5897\u6b96\u56e0\u5b50\u306e\u53d7\u5bb9\u4f53\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u901a\u5e38FGF\u53d7\u5bb9\u4f53\u306f\u305d\u306e\u30ea\u30ac\u30f3\u30c9\u3067\u3042\u308bFGF\u304c\u7d50\u5408\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u30ea\u30f3\u9178\u5316\u9175\u7d20\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001\u3053\u306e\u529b\u3078\u306e\u5fdc\u7b54\u6a5f\u69cb\u306b\u306fFGF\u306f\u5fc5\u8981\u306a\u3044\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u529b\u306b\u3088\u308b\u7d30\u80de-\u7d30\u80de\u9593\u63a5\u7740\u306e\u5f37\u5316\u306f\u9060\u5fc3\u3070\u304b\u308a\u3067\u306a\u304f\u3001\u5727\u7e2e\u3001\u4f38\u5f35\u306b\u3088\u3063\u3066\u3082\u8d77\u3053\u308b\u3053\u3068\u304b\u3089\u3001\u304a\u305d\u3089\u304f\u529b\u306b\u3088\u3063\u3066\u7d30\u80de\u304c\u5909\u5f62\u3059\u308b\u3053\u3068\u304c\u3001FGF\u53d7\u5bb9\u4f53\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002\u5b9f\u969b\u306b\u3001\u539f\u8178\u5f62\u6210\u3068\u3044\u3046\u80da\u7d44\u7e54\u304c\u5927\u304d\u304f\u52d5\u304d\u518d\u7de8\u6210\u3055\u308c\u308b\u904b\u52d5\u3067\u306f\u3001\u80da\u306e\u8868\u9762\u3092\u8986\u3046\u5916\u80da\u8449\u7d30\u80de\u304c\u5927\u304d\u304f\u4f38\u5c55\u3057\u3066\u3044\u308b\u3001\u3064\u307e\u308a\u529b\u3092\u53d7\u3051\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3059\u3002<\/p>\n<p>FGF\u53d7\u5bb9\u4f53\u304c\u6d3b\u6027\u5316\u3057\u305f\u7d50\u679c\u3001Erk\u3068\u3044\u3046\u7d30\u80de\u5185\u56e0\u5b50\u304c\u30ea\u30f3\u9178\u5316\u3055\u308c\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u7d30\u80de\u8cea\u304b\u3089\u6838\u5185\u306b\u79fb\u884c\u3057\u307e\u3059\u3002\u305d\u306e\u5f8c\u3001\u3069\u306e\u3088\u3046\u306a\u7d4c\u8def\u3092\u305f\u3069\u3063\u3066ZO-1\u304c\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306b\u96c6\u7a4d\u3059\u308b\u306e\u304b\u306f\u307e\u3060\u308f\u304b\u3063\u3066\u304a\u3089\u305a\u3001\u305d\u308c\u3092\u89e3\u660e\u3059\u308b\u3053\u3068\u304c\u79c1\u305f\u3061\u306e\u73fe\u5728\u306e\u8ab2\u984c\u3067\u3059\u3002\u3044\u305a\u308c\u306b\u3057\u3066\u3082\u3001\u529b\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306f\u65e2\u5b58\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3092\u5229\u7528\u3057\u3066\u3001\u7d30\u80de\u306e\u5909\u5316\u3092\u5f15\u304d\u8d77\u3053\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_13101\" aria-describedby=\"caption-attachment-13101\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13101\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-3.jpg\" alt=\"\" width=\"600\" height=\"476\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-3.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-3-300x238.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13101\" class=\"wp-caption-text\">\u529b\u306b\u3088\u3063\u3066\u6d3b\u6027\u5316\u3055\u308c\u308b\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u3068\u305d\u306e\u610f\u7fa9<br \/>\u529b\u306fFGF\u53d7\u5bb9\u4f53\u3001Erk2\u3092\u6d3b\u6027\u5316\u3057\u3001\u305d\u306e\u5f8cZO-1\u306f\u30bf\u30a4\u30c8\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306b\u96c6\u7a4d\u3059\u308b\u3002\u7d30\u80de\u63a5\u7740\u5206\u5b50\u30ab\u30c9\u30d8\u30ea\u30f3\u3082\u540c\u69d8\u306e\u6319\u52d5\u3092\u793a\u3057\u3001\u30a2\u30c9\u30d8\u30ec\u30f3\u30b9\u30b8\u30e3\u30f3\u30af\u30b7\u30e7\u30f3\u306b\u96c6\u7a4d\u3059\u308b\u3002\u30a2\u30af\u30c1\u30f3\u3082\u8868\u5c64\u306b\u96c6\u307e\u308b\u7d50\u679c\u3001\u7d44\u7e54\u306e\u7d71\u5408\u6027\u3001\u9811\u5f37\u6027\u304c\u9ad8\u307e\u308b\u3000\uff08\u56f3\u306f\u57fa\u790e\u751f\u7269\u5b66\u7814\u7a76\u6240\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3088\u308a\u8ee2\u8f09\uff09\u3002<\/figcaption><\/figure>\n<p>\u79c1\u305f\u3061\u306f\u3053\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7cfb\u304c\u30de\u30a6\u30b9\u306b\u3082\u5b58\u5728\u3059\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u8a3c\u660e\u3059\u308b\u305f\u3081\u306e\u7814\u7a76\u3082\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u3082\u3057\u5b58\u5728\u3059\u308c\u3070\u3001\u521d\u671f\u80da\u7d30\u80de\u306e\u529b\u3078\u306e\u5fdc\u7b54\u6a5f\u69cb\u306f\u54fa\u4e73\u52d5\u7269\u306b\u307e\u3067\u4fdd\u5b58\u3055\u308c\u3001\u751f\u7269\u9032\u5316\u306b\u3068\u3063\u3066\u3082\u975e\u5e38\u306b\u91cd\u8981\u306a\u6a5f\u69cb\u3067\u3042\u308b\u3068\u3044\u3048\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n<h3>\u529b\u3092\u6e2c\u308b\u3001\u64cd\u308b<\/h3>\n<p>\u907a\u4f1d\u5b50\u3084\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5b9a\u91cf\u6280\u8853\u306f\u9032\u6b69\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u529b\u306f\u76ee\u306b\u898b\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u3068\u304f\u306b\u751f\u304d\u305f\u751f\u7269\u306e\u306a\u304b\u3067\u529b\u3092\u5b9a\u91cf\u3059\u308b\u3053\u3068\u306f\u81f3\u96e3\u306e\u6280\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u529b\u306b\u3088\u3063\u3066\u7d30\u80de\u304c\u5909\u5f62\u3057\u3001\u305d\u306e\u7d50\u679c\u8d77\u3053\u308b\u5206\u5b50\u69cb\u9020\u5909\u5316\u3092\u3001\u86cd\u5149\u306e\u5909\u5316\u304b\u3089\u6349\u3048\u308b\u30d7\u30ed\u30fc\u30d6\u3084\u7d30\u80de\u5185\u306b\u5fae\u5c0f\u306a\u30d3\u30fc\u30ba\u3092\u5165\u308c\u3066\u305d\u306e\u6d41\u52d5\u6027\u304b\u3089\u529b\u3092\u63a8\u5b9a\u3059\u308b\u65b9\u6cd5\u306a\u3069\u3001\u3055\u307e\u3056\u307e\u306a\u6e2c\u5b9a\u6280\u8853\u306b\u52a0\u3048\u3066\u3001\u30ac\u30e9\u30b9\u30cb\u30fc\u30c9\u30eb\u3084\u78c1\u6c17\u30d3\u30fc\u30ba\u3092\u4f7f\u3063\u3066\u7d30\u80de\u306b\u5c40\u6240\u7684\u306a\u529b\u523a\u6fc0\u3092\u4e0e\u3048\u308b\u306a\u3069\u306e\u64cd\u4f5c\u6280\u8853\u3082\u958b\u767a\u3055\u308c\u3064\u3064\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u4eca\u5f8c\u591a\u7d30\u80de\u304b\u3089\u306a\u308b\u751f\u7269\u306e\u8907\u96d1\u306a\u767a\u751f\u904e\u7a0b\u306b\u304a\u3051\u308b\u529b\u306e\u610f\u7fa9\u306e\u5168\u8c8c\u89e3\u660e\u306b\u306f\u3001\u975e\u4fb5\u8972\u3067\u529b\u3092\u6e2c\u5b9a\u3059\u308b\u6280\u8853\u3084\u7d30\u80de\u30fb\u7d44\u7e54\u3092\u64cd\u4f5c\u3057\u3066\u6442\u52d5\u3092\u4e0e\u3048\u308b\u6280\u8853\u306e\u958b\u767a\u304c\u9375\u306b\u306a\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><\/p>\n<ul>\n<li>Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell 126, 677-689. 2006<\/li>\n<li>Hashimoto Y, Kinoshita N, Greco TM, Federspiel JD, Jean Beltran PM., Ueno N*, Cristea IM*. Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos. Cell Syst. 8, 226-241, 2019 *\u5171\u8cac\u4efb\u8457\u8005<\/li>\n<li>Kinoshita N, Hashimoto Y, Yasue N, Suzuki M, Cristea IM, Ueno N. Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR\/Erk2 Signaling Pathway during Embryogenesis. 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