{"id":13056,"date":"2020-04-22T08:00:33","date_gmt":"2020-04-21T23:00:33","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=13056"},"modified":"2020-05-13T13:21:40","modified_gmt":"2020-05-13T04:21:40","slug":"%e3%83%92%e3%83%88%e8%84%b3%e9%80%b2%e5%8c%96%e7%a0%94%e7%a9%b6%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e3%83%81%e3%83%b3%e3%83%91%e3%83%b3%e3%82%b8%e3%83%bcips%e7%b4%b0%e8%83%9e-%e3%80%8c%e3%83%92","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=13056","title":{"rendered":"\u30d2\u30c8\u8133\u9032\u5316\u7814\u7a76\u3068\u3057\u3066\u306e\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de &#8211; \u300c\u30d2\u30c8\u306e\u77e5\u6027\u300d\u306e\u89e3\u660e\u3092\u76ee\u6307\u3057\u3066\u3001\u8133\u306e\u5f62\u6210\u30d7\u30ed\u30bb\u30b9\u3092\u8ffd\u3046"},"content":{"rendered":"<h3>\u30d2\u30c8\u8133\u9032\u5316\u7814\u7a76\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc<\/h3>\n<p>\u30db\u30e2\u30fb\u30b5\u30d4\u30a8\u30f3\u30b9\uff08=\u8ce2\u3044\u30d2\u30c8\uff09\u3068\u3044\u3046\u540d\u79f0\u304c\u8868\u3059\u3088\u3046\u306b\u3001\u79c1\u305f\u3061\u30d2\u30c8\u3092\u4eba\u305f\u3089\u3057\u3081\u3066\u3044\u308b\u6700\u5927\u306e\u7279\u5fb4\u306f\u9ad8\u5ea6\u306a\u77e5\u6027\u306b\u3042\u308b\u3068\u3044\u3048\u307e\u3059\u3002\u4e8b\u5b9f\u3001\u79c1\u305f\u3061\u30d2\u30c8\u306e\u77e5\u6027\u306f\u3001\u53e4\u4eca\u6771\u897f\u3001\u5730\u7403\u4e0a\u306b\u751f\u606f\u3059\u308b\u3055\u307e\u3056\u307e\u306a\u751f\u7269\u3068\u306f\u4e00\u7dda\u3092\u753b\u3057\u3001\u9ad8\u5ea6\u306a\u6587\u660e\u3092\u7bc9\u304f\u306b\u81f3\u308a\u307e\u3057\u305f\u3002\u3067\u306f\u3001\u79c1\u305f\u3061\u30d2\u30c8\u306e\u77e5\u6027\u306f\u4e00\u4f53\u3069\u306e\u3088\u3046\u306b\u3057\u3066\u751f\u307f\u51fa\u3055\u308c\u305f\u306e\u3067\u3057\u3087\u3046\u304b\uff1f \u3053\u308c\u306f\u3001\u9577\u5e74\u306b\u308f\u305f\u308b\u751f\u7269\u5b66\u4e0a\u306e\u5927\u304d\u306a\u547d\u984c\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u304a\u305d\u3089\u304f\u8ab0\u3082\u304c\u4e00\u5ea6\u306f\u8003\u3048\u305f\u3053\u3068\u306e\u3042\u308b\u666e\u904d\u7684\u304b\u3064\u7d20\u6734\u306a\u7591\u554f\u3067\u3057\u3087\u3046\u3002<\/p>\n<p>\u30d2\u30c8\u306e\u77e5\u6027\u306e\u8d77\u6e90\u3092\u89e3\u304d\u660e\u304b\u305d\u3046\u3068\u3059\u308b\u3068\u304d\u3001\u9032\u5316\u7684\u306b\u30d2\u30c8\u306b\u6700\u3082\u8fd1\u7e01\u306a\u73fe\u751f\u52d5\u7269\u3067\u3042\u308a\u3001\u304a\u3088\u305d99\uff05\u306e\u30b2\u30ce\u30e0\u60c5\u5831\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306f\u3001\u6700\u9069\u306a\u6bd4\u8f03\u7814\u7a76\u5bfe\u8c61\u3068\u306a\u308a\u307e\u3059\u3002\u3068\u308a\u308f\u3051\u3001\u8133\u306e\u5f62\u6210\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u6bd4\u8f03\u7814\u7a76\u306f\u6975\u3081\u3066\u91cd\u8981\u3067\u3001\u300c\u3069\u3046\u3057\u3066\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u3067\u306f\u9055\u3046\u8133\u304c\u4f5c\u3089\u308c\u308b\u306e\u304b\u300d\u3068\u3044\u3046\u554f\u3044\u306b\u30d2\u30c8\u306e\u77e5\u6027\u306e\u9375\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_13057\" aria-describedby=\"caption-attachment-13057\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13057\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-7.jpg\" alt=\"\" width=\"600\" height=\"450\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-7.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/001-7-300x225.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13057\" class=\"wp-caption-text\">\u9032\u5316\u7684\u306b\u30d2\u30c8\u306b\u3082\u3063\u3068\u3082\u8fd1\u7e01\u306a\u73fe\u751f\u52d5\u7269\u3067\u3042\u308b\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306f\u3001\u30d2\u30c8\u77e5\u6027\u306e\u8d77\u6e90\u3092\u63a2\u308b\u6bd4\u8f03\u7814\u7a76\u5bfe\u8c61\u3068\u3057\u3066\u6700\u9069\u3067\u3042\u308b\u3002<\/figcaption><\/figure>\n<div class=\"center\">\n<!--Ads1-->\n<\/div>\n<p>\u3053\u306e\u8b0e\u3092\u89e3\u304f\u305f\u3081\u306b\u3001\u3053\u308c\u307e\u3067\u306b\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306e\u8133\u3084\u30b2\u30ce\u30e0\u306e\u6bd4\u8f03\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u3001\u8133\u3084\u30b2\u30ce\u30e0\u306e\u6bd4\u8f03\u3067\u306f\u300c\u9055\u3044\u304c\u4f55\u304b\u300d\u306f\u308f\u304b\u308a\u307e\u3059\u304c\u3001\u300c\u3069\u3046\u3057\u3066\u9055\u3046\u8133\u306b\u306a\u308b\u306e\u304b\u300d\u306f\u308f\u304b\u308a\u307e\u305b\u3093\u3002\u300c\u9055\u3046\u8133\u304c\u4f5c\u3089\u308c\u308b\u300d\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u304d\u660e\u304b\u3059\u305f\u3081\u306b\u306f\u3001\u5b8c\u6210\u3055\u308c\u305f\u8133\uff08\u30a2\u30a6\u30c8\u30d7\u30c3\u30c8\uff09\u306e\u6bd4\u8f03\u89e3\u6790\u3067\u306f\u306a\u304f\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306e\u8133\u304c\u5f62\u6210\u3055\u308c\u308b\u904e\u7a0b\u3067\u300c\u3044\u3064\u300d\u300c\u4f55\u304c\u300d\u9055\u3046\u306e\u304b\u3068\u3044\u3046\u300c\u30d7\u30ed\u30bb\u30b9\u300d\u306e\u89e3\u660e\u304c\u4e0d\u53ef\u6b20\u3067\u3059\u3002<\/p>\n<p>\u305d\u306e\u305f\u3081\u306b\u306f\u3001\u521d\u671f\u80da\u304b\u3089\u80ce\u751f\u671f\u3001\u80ce\u5150\u671f\u306b\u304b\u3051\u3066\u8133\u304c\u5f62\u6210\u3055\u308c\u308b\u30d7\u30ed\u30bb\u30b9\uff08\u521d\u671f\u795e\u7d4c\u767a\u751f\uff09\u306e\u89e3\u6790\u304c\u5fc5\u8981\u3067\u3059\u304c\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3084\u30d2\u30c8\u306e\u80da\u3084\u80ce\u5150\u306e\u8133\u795e\u7d4c\u767a\u751f\u3092\u7d99\u6642\u7684\u306b\u89e3\u6790\u3059\u308b\u3053\u3068\u306f\u502b\u7406\u7684\u306b\u8a8d\u3081\u3089\u308c\u305a\u3001\u307e\u305f\u6280\u8853\u7684\u306b\u3082\u4e0d\u53ef\u80fd\u3067\u3042\u308a\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306e\u8133\u5206\u5316\u306e\u30d7\u30ed\u30bb\u30b9\u3084\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<h3>\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306e\u4f5c\u88fd\u3068\u795e\u7d4c\u5e79\u7d30\u80de\u3078\u306e\u5206\u5316\u8a98\u5c0e<\/h3>\n<p>\u30d2\u30c8\u8133\u9032\u5316\u7814\u7a76\u306e\u300c\u30d7\u30ed\u30bb\u30b9\u554f\u984c\u300d\u3092\u89e3\u6c7a\u3059\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3068\u3057\u3066\u3001\u79c1\u305f\u3061\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306eiPS\u7d30\u80de\u3092\u4f5c\u88fd\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3078\u3068\u5206\u5316\u8a98\u5c0e\u3059\u308b\u57f9\u990a\u7cfb\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u306b\u3057\u307e\u3057\u305f\u3002iPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u5e79\u7d30\u80de\u306b\u81f3\u308b\u7d30\u80de\u5206\u5316\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u8a73\u7d30\u306b\u89e3\u6790\u3059\u308c\u3070\u3001\u521d\u671f\u795e\u7d4c\u767a\u751f\u306b\u4f34\u3046\u6bb5\u968e\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3084\u7d30\u80de\u7279\u6027\u306e\u5909\u9077\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u7d30\u80de\u57f9\u990a\u30ec\u30d9\u30eb\u3067\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u306e\u521d\u671f\u795e\u7d4c\u767a\u751f\u3092\u6bd4\u8f03\u3067\u304d\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_13058\" aria-describedby=\"caption-attachment-13058\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13058\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002-4.jpg\" alt=\"\" width=\"600\" height=\"449\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002-4.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/002-4-300x225.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13058\" class=\"wp-caption-text\">\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u3067\u300c\u3069\u3046\u3057\u3066\u9055\u3046\u8133\u306b\u306a\u308b\u306e\u304b\u300d\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u300c\u3044\u3064\u3001\u4f55\u304c\u9055\u3046\u306e\u304b\u300d\u306e\u89e3\u660e\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001iPS\u7d30\u80de\u6280\u8853\u304c\u5f79\u306b\u7acb\u3064\u3002<\/figcaption><\/figure>\n<p>\u307e\u305a\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306e\u4f5c\u88fd\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u65e5\u672c\u56fd\u5185\u306e\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u60c5\u5831\u306f\u300c\u5927\u578b\u985e\u4eba\u733f\u60c5\u5831\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff08GAIN\uff09\u300d\u306b\u96c6\u7d04\u3055\u308c\u3066\u304a\u308a\u3001\u7814\u7a76\u7528\u306e\u8a66\u6599\u5229\u7528\u3082\u53ef\u80fd\u3067\u3059\u3002\u305d\u3053\u3067\u3001\u4eac\u90fd\u5927\u5b66\u970a\u9577\u985e\u7814\u7a76\u6240\uff08\u897f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u300139\u6b73\u3001\u30e1\u30b9\uff09\u3001\u540c\u91ce\u751f\u52d5\u7269\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u718a\u672c\u30b5\u30f3\u30af\u30c1\u30e5\u30a2\u30ea\uff08\u4e9c\u7a2e\u9593\u96d1\u7a2e\u300124\u6b73\u3001\u30aa\u30b9\uff09\u3001\u52d5\u7269\u5712\uff08\u6771\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u300139\u6b73\u3001\u30e1\u30b9\uff09\u306e\u6210\u4f53\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc3\u500b\u4f53\u306b\u3064\u3044\u3066\u3001\u76ae\u819a\u304b\u3089\u57f9\u990a\u3057\u305f\u7dda\u7dad\u82bd\u7d30\u80de\u3092\u4f7f\u7528\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u30d2\u30c8\u306eiPS\u7d30\u80de\u3092\u4f5c\u88fd\u3059\u308b\u65b9\u6cd5\u3092\u53c2\u8003\u306b\u3001\u521d\u671f\u5316\u56e0\u5b50\u306e\u30bb\u30c3\u30c8\u3092\u7d30\u80de\u306b\u907a\u4f1d\u5b50\u5c0e\u5165\u3057\u305f\u3068\u3053\u308d\u3001\u304a\u3088\u305d1\u30f6\u6708\u5f8c\u306b\u306f\u30d2\u30c8iPS\u7d30\u80de\u3068\u985e\u4f3c\u3057\u305f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306e\u30b3\u30ed\u30cb\u30fc\u304c\u73fe\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306f\u30d2\u30c8iPS\u7d30\u80de\u3068\u540c\u3058\u57f9\u990a\u6761\u4ef6\u3067\u81ea\u5df1\u8907\u88fd\u3057\u3001\u591a\u80fd\u6027\u5e79\u7d30\u80de\u306b\u7279\u5fb4\u7684\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3084\u4e09\u80da\u8449\u3078\u306e\u5206\u5316\u80fd\u529b\u3092\u793a\u3059\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306b\u3001\u5f97\u3089\u308c\u305f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u5e79\u7d30\u80de\u3078\u306e\u9078\u629e\u7684\u306a\u5206\u5316\u8a98\u5c0e\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u65b9\u6cd5\u3068\u3057\u3066\u306f\u3001\u4ee5\u524d\u306b\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u3092\u4f7f\u3063\u3066\u958b\u767a\u3057\u305f\u57f9\u990a\u6cd5\uff08\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\uff09\u3092\u9069\u7528\u3057\u3001\u795e\u7d4c\u7cfb\u306e\u767a\u751f\u3092\u4fc3\u3059\u5316\u5408\u7269\u3092\u7528\u3044\u305f\u6d6e\u904a\u57f9\u990a\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306e7\u65e5\u9593\u306e\u6d6e\u904a\u57f9\u990a\u306b\u3088\u3063\u3066\u795e\u7d4c\u5e79\u7d30\u80de\u306e\u96c6\u5408\u584a\uff08\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\uff09\u304c\u5f62\u6210\u3055\u308c\u3001\u3053\u306e\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u3092\u63a5\u7740\u57f9\u990a\u3059\u308b\u3053\u3068\u3067\u30cb\u30e5\u30fc\u30ed\u30f3\u3084\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u3078\u3068\u5206\u5316\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_13059\" aria-describedby=\"caption-attachment-13059\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13059\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-3.jpg\" alt=\"\" width=\"600\" height=\"438\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-3.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/003-3-300x219.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13059\" class=\"wp-caption-text\">\u4f5c\u88fd\u3057\u305f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306eiPS\u7d30\u80de\u306f\u3001\u30d2\u30c8iPS\u7d30\u80de\u3068\u540c\u69d8\u306e\u6027\u8cea\u3092\u793a\u3057\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3078\u3068\u5206\u5316\u8a98\u5c0e\u3059\u308b\u3053\u3068\u3082\u53ef\u80fd\u3067\u3042\u308b\u3002<\/figcaption><\/figure>\n<h3>\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u304b\u3089\u8a98\u5c0e\u3055\u308c\u308b\u6bb5\u968e\u7684\u306a\u521d\u671f\u795e\u7d4c\u767a\u751f<\/h3>\n<p>\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u306e\u7d50\u679c\u3092\u8e0f\u307e\u3048\u3001iPS\u7d30\u80de\u304b\u3089\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u304c\u3067\u304d\u308b\u307e\u3067\u306e7\u65e5\u9593\u306e\u5206\u5316\u8a98\u5c0e\u30d7\u30ed\u30bb\u30b9\u306b\u6ce8\u76ee\u3057\u3001\u57f9\u990a1\u30013\u30015\u30017\u65e5\u76ee\u306e\u7d30\u80de\u904b\u547d\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u5206\u5316\u8a98\u5c0e\u524d\u306eiPS\u7d30\u80de\u304a\u3088\u3073\u5404\u57f9\u990a\u65e5\u6570\u306e\u5206\u5316\u8a98\u5c0e\u7d30\u80de\u3092\u56de\u53ce\u3057\u3001RNA\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u306b\u3088\u3063\u3066\u7db2\u7f85\u7684\u306b\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u89e3\u6790\u3057\u305f\u3068\u3053\u308d\u3001\u57f9\u990a1\u65e5\u76ee\u304b\u30893\u65e5\u76ee\u306b\u304b\u3051\u3066\u300c\u591a\u80fd\u6027\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u6d88\u5931\u300d\u3068\u300c\u521d\u671f\u306e\u795e\u7d4c\u767a\u751f\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u300d\u304c\u8d77\u3053\u308a\u3001\u57f9\u990a5\u30017\u65e5\u76ee\u306b\u306a\u308b\u3068\u300c\u653e\u5c04\u72b6\u30b0\u30ea\u30a2\u7d30\u80de\uff08\u8133\u306e\u795e\u7d4c\u5e79\u7d30\u80de\uff09\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u300d\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u57f9\u990a1\u30013\u65e5\u76ee\u306e\u6642\u70b9\u3067\u306f\u307e\u3060\u30cb\u30e5\u30fc\u30ed\u30f3\u3078\u306e\u5206\u5316\u80fd\u529b\u306f\u3042\u308a\u307e\u305b\u3093\u304c\u3001\u57f9\u990a5\u30017\u65e5\u76ee\u306b\u306a\u308b\u3068\u30cb\u30e5\u30fc\u30ed\u30f3\u5206\u5316\u80fd\u304c\u7372\u5f97\u3055\u308c\u308b\u3053\u3068\u3082\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u57f9\u990a1\u65e5\u76ee\u304b\u30893\u65e5\u76ee\u306e\u3042\u3044\u3060\u306b\u7d30\u80de\u904b\u547d\u304c\u591a\u80fd\u6027\u304b\u3089\u795e\u7d4c\u7cfb\u3078\u3068\u5207\u308a\u66ff\u308f\u308a\u3001\u57f9\u990a3\u65e5\u76ee\u304b\u30895\u65e5\u76ee\u306e\u3042\u3044\u3060\u306b\u30cb\u30e5\u30fc\u30ed\u30f3\u5206\u5316\u80fd\u3092\u7372\u5f97\u3059\u308b\u3053\u3068\u304c\u898b\u3048\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u751f\u4f53\u5185\u306e\u521d\u671f\u795e\u7d4c\u767a\u751f\u3067\u306f\u3001\u591a\u80fd\u6027\u3092\u3082\u3064\u5f8c\u671f\u306e\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\u304b\u3089\u6700\u521d\u306e\u795e\u7d4c\u7cfb\u306e\u7d30\u80de\u3067\u3042\u308b\u795e\u7d4c\u4e0a\u76ae\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u3001\u795e\u7d4c\u677f\uff08\u306e\u3061\u306e\u795e\u7d4c\u7ba1\uff09\u3092\u5f62\u6210\u3057\u307e\u3059\u3002\u795e\u7d4c\u7ba1\u306e\u524d\u90e8\u304b\u3089\u8133\u304c\u5f62\u6210\u3055\u308c\u59cb\u3081\u308b\u3068\u3001\u795e\u7d4c\u4e0a\u76ae\u7d30\u80de\u306e\u5f62\u614b\u304c\u5909\u308f\u308a\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u5206\u5316\u80fd\u3092\u3082\u3064\u653e\u5c04\u72b6\u30b0\u30ea\u30a2\u7d30\u80de\u3078\u3068\u8ee2\u63db\u3057\u307e\u3059\u3002\u540c\u69d8\u306b\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u306e\u30c0\u30a4\u30ec\u30af\u30c8\u30fb\u30cb\u30e5\u30fc\u30ed\u30b9\u30d5\u30a7\u30a2\u5f62\u6210\u57f9\u990a\u3067\u306f\u3001\u57f9\u990a\u65e5\u6570\u306b\u5fdc\u3058\u3066\u7d30\u80de\u72b6\u614b\u304c\u5f8c\u671f\u524d\u90e8\u30a8\u30d4\u30d6\u30e9\u30b9\u30c8\uff081\u65e5\u76ee\uff09\u3001\u795e\u7d4c\u4e0a\u76ae\u7d30\u80de\uff083\u65e5\u76ee\uff09\u3001\u653e\u5c04\u72b6\u30b0\u30ea\u30a2\u7d30\u80de\uff085\u30017\u65e5\u76ee\uff09\u3068\u6bb5\u968e\u7684\u306a\u521d\u671f\u795e\u7d4c\u767a\u751f\u3092\u7d4c\u904e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<figure id=\"attachment_13060\" aria-describedby=\"caption-attachment-13060\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-13060\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-2.jpg\" alt=\"\" width=\"600\" height=\"450\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/04\/004-2-300x225.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-13060\" class=\"wp-caption-text\">\u4eca\u56de\u306e\u7814\u7a76\u3067\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u304b\u3089\u6bb5\u968e\u7684\u306a\u521d\u671f\u795e\u7d4c\u767a\u751f\u3092\u8a98\u5c0e\u3067\u304d\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u30d2\u30c8\u3084\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u3068\u306e\u6bd4\u8f03\u89e3\u6790\u3092\u884c\u3046\u57fa\u76e4\u304c\u6574\u3063\u305f\u3002<\/figcaption><\/figure>\n<h3>\u300c\u30d2\u30c8\u3089\u3057\u3055\u300d\u3092\u53f8\u308b\u907a\u4f1d\u5b50\u306e\u7279\u5b9a\u3092\u76ee\u6307\u3057\u3066<\/h3>\n<p>\u4eca\u56de\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fciPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u5e79\u7d30\u80de\u3078\u306e\u5206\u5316\u8a98\u5c0e\u30d7\u30ed\u30bb\u30b9\u3092\u7cbe\u67fb\u3059\u308b\u3053\u3068\u3067\u3001\u6bb5\u968e\u7684\u306a\u521d\u671f\u795e\u7d4c\u767a\u751f\u306e\u9032\u884c\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u80da\u3084\u80ce\u5150\u306a\u3069\u306e\u751f\u4f53\u8a66\u6599\u3092\u4f7f\u3046\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3067\u306f\u3001iPS\u7d30\u80de\u306e\u5206\u5316\u8a98\u5c0e\u7cfb\u306f\u521d\u671f\u795e\u7d4c\u767a\u751f\u3092\u89e3\u6790\u3059\u308b\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6975\u3081\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u3044\u3048\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u672c\u7814\u7a76\u3067\u4f7f\u7528\u3057\u305f\u5206\u5316\u8a98\u5c0e\u6cd5\u306f\u3001\u4ee5\u524d\u306b\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u304b\u3089\u795e\u7d4c\u5e79\u7d30\u80de\u3092\u8a98\u5c0e\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u3057\u305f\u624b\u6cd5\u3067\u3042\u308a\u3001\u540c\u3058\u65b9\u6cd5\u3067\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3001\u30d2\u30c8\u306eiPS\u7d30\u80de\u306e\u5206\u5316\u8a98\u5c0e\u3092\u884c\u3046\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u30cb\u30db\u30f3\u30b6\u30eb\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3001\u30d2\u30c8\u306e\u5206\u5316\u8a98\u5c0e\u30d7\u30ed\u30bb\u30b9\u3092\u89e3\u6790\u3059\u308b\u305f\u3081\u306e\u57fa\u76e4\u304c\u3059\u3067\u306b\u6574\u3063\u3066\u304a\u308a\u3001\u4eca\u5f8c\u306f\u3053\u306e3\u7a2e\u9593\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u6bd4\u8f03\u306b\u3088\u3063\u3066\u3001\u30d2\u30c8\u306e\u521d\u671f\u795e\u7d4c\u767a\u751f\u306f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3084\u30cb\u30db\u30f3\u30b6\u30eb\u3068\u300c\u3044\u3064\u300d\u300c\u4f55\u304c\u300d\u9055\u3046\u306e\u304b\u3092\u89e3\u304d\u660e\u304b\u3057\u3066\u3044\u304f\u4e88\u5b9a\u3067\u3059\u3002\u3055\u3089\u306b\u3001\u30d2\u30c8\u306e\u521d\u671f\u795e\u7d4c\u767a\u751f\u306b\u56fa\u6709\u306e\u907a\u4f1d\u5b50\u3092\u7279\u5b9a\u3057\u3001\u3069\u306e\u3088\u3046\u306a\u6a5f\u80fd\u3092\u3082\u3063\u3066\u3044\u308b\u306e\u304b\u3092\u89e3\u660e\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u3046\u3057\u305f\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u521d\u671f\u795e\u7d4c\u767a\u751f\u306e\u7814\u7a76\u306b\u9650\u308a\u307e\u305b\u3093\u3002\u4eca\u56de\u3001\u9ad8\u5ea6\u306a\u77e5\u6027\u3092\u53f8\u308b\u8133\u306e\u767a\u751f\u306b\u6ce8\u76ee\u3057\u3066\u7814\u7a76\u3092\u884c\u3044\u307e\u3057\u305f\u304c\u3001\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u3068\u30d2\u30c8\u3067\u306f\u8eab\u4f53\u69cb\u9020\u3068\u6a5f\u80fd\u306b\u3055\u307e\u3056\u307e\u306a\u9055\u3044\u304c\u307f\u3089\u308c\u307e\u3059\u3002iPS\u7d30\u80de\u3092\u7279\u5b9a\u306e\u7d30\u80de\u306b\u5206\u5316\u8a98\u5c0e\u3059\u308b\u5b9f\u9a13\u7cfb\u3092\u5229\u7528\u3059\u308c\u3070\u3001\u3055\u307e\u3056\u307e\u306a\u7d30\u80de\u30fb\u7d44\u7e54\u306e\u5206\u5316\u30d7\u30ed\u30bb\u30b9\u306b\u304a\u3051\u308b\u7a2e\u5dee\u3084\u30d2\u30c8\u7279\u7570\u6027\u3092\u660e\u3089\u304b\u306b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>iPS\u7d30\u80de\u3092\u30c4\u30fc\u30eb\u306b\u30d2\u30c8\u9032\u5316\u306e\u8b0e\u306b\u8feb\u308b\u300c\u5e79\u7d30\u80de\u4eba\u985e\u5b66\u300d\u304c\u9686\u8208\u3059\u308b\u3053\u3068\u3067\u3001\u300c\u30d2\u30c8\u304c\u30d2\u30c8\u3067\u3042\u308b\u300d\u3053\u3068\u3092\u88cf\u4ed8\u3051\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u63a2\u7d22\u7814\u7a76\u304c\u6d3b\u767a\u306b\u306a\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\n\u30fbRyunosuke Kitajima, Risako Nakai, Takuya Imamura, Tomonori Kameda, Daiki Kozuka, Hirohisa Hirai, Haruka Ito, Hiroo Imai, Masanori Imamura (2020). Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. <em>Stem Cell Research<\/em>, 44: 101749.<br \/>\n\u30fb<a href=\"https:\/\/academist-cf.com\/journal\/?p=12658\">\u4eca\u6751\u516c\u7d00\u3001\u4ef2\u4e95\u7406\u6c99\u5b50 \u300e\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u7d30\u80de\u3092\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0 &#8211; iPS\u7d30\u80de\u88fd\u4f5c\u306e\u526f\u7523\u7269\u304c\u793a\u3059\u795e\u7d4c\u5824\u7d30\u80de\u69d8\u306e\u7279\u6027\u300f\uff08academist journal\u30012020\u5e742\u670820\u65e5\uff09<\/a><br \/>\n\u30fb<a href=\"https:\/\/academist-cf.com\/journal\/?p=8841\">\u4eca\u6751\u516c\u7d00\u3001\u4ef2\u4e95\u7406\u6c99\u5b50 \u300e\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u306e\u4f5c\u88fd\u306b\u6210\u529f\uff01-\u300c\u970a\u9577\u985e\u5b66\u300d\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u300f\uff08academist journal\u30012018\u5e7410\u670823\u65e5\uff09<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30d2\u30c8\u8133\u9032\u5316\u7814\u7a76\u3068\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc \u30db\u30e2\u30fb\u30b5\u30d4\u30a8\u30f3\u30b9\uff08=\u8ce2\u3044\u30d2\u30c8\uff09\u3068\u3044\u3046\u540d\u79f0\u304c\u8868\u3059\u3088\u3046\u306b\u3001\u79c1\u305f\u3061\u30d2\u30c8\u3092\u4eba\u305f\u3089\u3057\u3081\u3066\u3044\u308b\u6700\u5927\u306e\u7279\u5fb4\u306f\u9ad8\u5ea6\u306a\u77e5\u6027\u306b\u3042\u308b\u3068\u3044\u3048\u307e\u3059\u3002\u4e8b\u5b9f\u3001\u79c1\u305f\u3061\u30d2\u30c8\u306e\u77e5\u6027\u306f\u3001\u53e4\u4eca\u6771\u897f\u3001\u5730\u7403\u4e0a\u306b\u751f\u606f [&hellip;]<\/p>\n","protected":false},"author":341,"featured_media":13057,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[51,111,40,85,76],"class_list":["post-13056","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-ips","tag-111","tag-40","tag-85","tag-76","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/13056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/341"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13056"}],"version-history":[{"count":9,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/13056\/revisions"}],"predecessor-version":[{"id":13270,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/13056\/revisions\/13270"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/13057"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}