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id=\"attachment_12660\" aria-describedby=\"caption-attachment-12660\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12660\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/002-3.jpg\" alt=\"\" width=\"600\" height=\"440\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/002-3.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/002-3-300x220.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12660\" class=\"wp-caption-text\">\u30ca\u30a4\u30fc\u30d6\u578b\u3068\u30d7\u30e9\u30a4\u30e0\u578b\u306e\u5206\u5316\u591a\u80fd\u6027\u306e\u9055\u3044<\/figcaption><\/figure>\n<p>\u4f8b\u3092\u6319\u3052\u308b\u3068\u3001\u30ca\u30a4\u30fc\u30d6\u578b\u306e\u7d30\u80de\u306f\u30c9\u30fc\u30e0\u72b6\u306e\u30b3\u30ed\u30cb\u30fc\u3092\u5f62\u6210\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001\u30d7\u30e9\u30a4\u30e0\u578b\u3067\u306f\u6241\u5e73\u306a\u30b3\u30ed\u30cb\u30fc\u3092\u4f5c\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u30ca\u30a4\u30fc\u30d6\u578b\u306e\u672a\u5206\u5316\u72b6\u614b\u306fLIF\u30b7\u30b0\u30ca\u30eb\u306b\u3088\u3063\u3066\u7dad\u6301\u3055\u308c\u307e\u3059\u304c\u3001\u30d7\u30e9\u30a4\u30e0\u578b\u3067\u306f\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b502\uff08FGF2\uff09\u30b7\u30b0\u30ca\u30eb\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002\u4ed6\u306b\u3082\u3001\u96cc\u6027\u30b2\u30ce\u30e0\uff08XX\uff09\u3092\u3082\u3064\u5834\u5408\u3001\u30ca\u30a4\u30fc\u30d6\u578b\u3067\u306f\u4e21\u65b9\u306eX\u67d3\u8272\u4f53\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u4e00\u65b9\u3001\u30d7\u30e9\u30a4\u30e0\u578b\u3067\u306f\u4f53\u7d30\u80de\u3068\u540c\u3058\u304f\u7247\u65b9\u304c\u4e0d\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3001\u306a\u3069\u306e\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u901a\u5e38\u3001\u30de\u30a6\u30b9\u306eiPS\u7d30\u80de\u306f\u30ca\u30a4\u30fc\u30d6\u578b\u3001\u30d2\u30c8\u3084\u970a\u9577\u985e\u306eiPS\u7d30\u80de\u306f\u30d7\u30e9\u30a4\u30e0\u578b\u306e\u7279\u5fb4\u3092\u793a\u3057\u307e\u3059\u3002\u30de\u30a6\u30b9\u3067\u306f\u57f9\u990a\u6761\u4ef6\u3092\u5207\u308a\u66ff\u3048\u308b\u3060\u3051\u3067\u30ca\u30a4\u30fc\u30d6\u578b\u3068\u30d7\u30e9\u30a4\u30e0\u578b\u3092\u5bb9\u6613\u306b\u8ee2\u63db\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u304c\u3001\u30d2\u30c8\u306e\u30ca\u30a4\u30fc\u30d6\u578b\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306f\u975e\u5e38\u306b\u56f0\u96e3\u3067\u3001\u8907\u6570\u306e\u907a\u4f1d\u5b50\u5c0e\u5165\u3068\u85ac\u5264\u51e6\u7406\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u5fc5\u8981\u3067\u3059\u3002\u30d2\u30c8iPS\u7d30\u80de\u3092\u30de\u30a6\u30b9iPS\u7d30\u80de\uff08\u30ca\u30a4\u30fc\u30d6\u578b\uff09\u7528\u306e2i\/LIF\u57f9\u5730\u3067\u57f9\u990a\u3057\u305f\u5834\u5408\u3001\u521d\u671f\u795e\u7d4c\u4e0a\u76ae\u7d30\u80de\u306e\u3088\u3046\u306a\u6027\u8cea\u3092\u3082\u3063\u305f\u7d30\u80de\u306b\u5909\u5316\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002<\/p>\n<p>\u3067\u306f\u30012i\/LIF\u57f9\u5730\u3067\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3057\u305f\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e2iL\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u7d30\u80de\u306f\u3001\u4e00\u4f53\u3069\u306e\u3088\u3046\u306a\u6027\u8cea\u3092\u3082\u3063\u3066\u3044\u308b\u306e\u3067\u3057\u3087\u3046\u304b\uff1f<\/p>\n<h3>2iL\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u7d30\u80de\u306f\u3001\u591a\u5206\u5316\u80fd\u30fb\u816b\u760d\u5f62\u6210\u80fd\u30fb\u795e\u7d4c\u5824\u7d30\u80de\u69d8\u306e\u6027\u8cea\u3092\u3082\u3064<\/h3>\n<p>\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e2iL\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u7d30\u80de\u306f\u3001\u30ca\u30a4\u30fc\u30d6\u578b\u306e\u30de\u30a6\u30b9iPS\u7d30\u80de\u3068\u540c\u3058\u3088\u3046\u306a\u611f\u899a\u3067\u57f9\u990a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3001\u6b63\u5e38\u306a\u67d3\u8272\u4f53\u3092\u7dad\u6301\u3057\u3066\u9577\u671f\u9593\u5897\u6b96\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u80da\u69d8\u4f53\u5f62\u6210\u306b\u3088\u308b\u5206\u5316\u57f9\u990a\u306b\u3088\u3063\u3066\u4e09\u80da\u8449\uff08\u5916\u80da\u8449\u3001\u4e2d\u80da\u8449\u3001\u5185\u80da\u8449\uff09\u306e\u7d30\u80de\u306b\u5206\u5316\u3057\u3001\u514d\u75ab\u4e0d\u5168\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3059\u308b\u3068\u4e09\u80da\u8449\u6027\u306e\u816b\u760d\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/p>\n<p>\u3068\u3053\u308d\u304c\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u89e3\u6790\u3057\u3066\u307f\u308b\u3068\u3001\u3053\u306e\u7d30\u80de\u306f\u591a\u80fd\u6027\u5e79\u7d30\u80de\u306e\u6297\u539f\u3067\u3042\u308bNANOG\u3084\u7d30\u80de\u819c\u8868\u9762\u7cd6\u9396\uff08SSEA1\u3001TRA-1-81\u306a\u3069\uff09\u304c\u9670\u6027\u3067\u3042\u308b\u3068\u540c\u6642\u306b\u3001\u795e\u7d4c\u5e79\u7d30\u80de\u3084\u795e\u7d4c\u5824\u7d30\u80de\u306e\u6297\u539f\u3067\u3042\u308bNESTIN\u304c\u967d\u6027\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u8a73\u3057\u304f\u89e3\u6790\u3059\u308b\u3068\u3001\u591a\u80fd\u6027\u95a2\u9023\u907a\u4f1d\u5b50\uff08NODAL\u3001REX1\u306a\u3069\uff09\u306e\u767a\u73fe\u304c\u3042\u307e\u308a\u898b\u3089\u308c\u306a\u3044\u3053\u3068\u3001X\u67d3\u8272\u4f53\u306e\u4e0d\u6d3b\u6027\u5316\u3092\u5f15\u304d\u8d77\u3053\u3059XIST\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001\u521d\u671f\u5316\u56e0\u5b50\u3068\u3057\u3066\u5c0e\u5165\u3057\u305f\u907a\u4f1d\u5b50\u3067\u306f\u3001OCT3\/4\u306e\u5916\u6765\u907a\u4f1d\u5b50\u304c\u30b2\u30ce\u30e0\u306b\u633f\u5165\u3055\u308c\u3066\u304a\u308a\u3001\u5185\u5728\u6027\u907a\u4f1d\u5b50\u306e\u4ee3\u308f\u308a\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_12661\" aria-describedby=\"caption-attachment-12661\" style=\"width: 599px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12661\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/003-3.jpg\" alt=\"\" width=\"599\" height=\"442\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/003-3.jpg 599w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/02\/003-3-300x221.jpg 300w\" sizes=\"auto, (max-width: 599px) 100vw, 599px\" \/><figcaption id=\"caption-attachment-12661\" 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class=\"wp-caption-text\">\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc2iL\u30b3\u30ed\u30cb\u30fc\u5f62\u6210\u7d30\u80de\u306f\u795e\u7d4c\u5824\u7d30\u80de\u306b\u4f3c\u305f\u907a\u4f1d\u5b50\u767a\u73fe\u30fb\u7d30\u80de\u7279\u6027\u3092\u3082\u3064\u3002<\/figcaption><\/figure>\n<h3>\u7d50\u8a9e\uff1a\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u6a5f\u69cb\u306e\u89e3\u660e\u306b\u5411\u3051\u3066<\/h3>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u30012i\/LIF\u57f9\u5730\u3067\u30c1\u30f3\u30d1\u30f3\u30b8\u30fc\u306e\u7d30\u80de\u3092\u30ea\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3059\u308b\u3068\u3001\u591a\u5206\u5316\u80fd\u3068\u816b\u760d\u5f62\u6210\u80fd\u3092\u3082\u3064\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u308b\u3082\u306e\u306e\u3001\u3053\u306e\u7d30\u80de\u306f\u591a\u80fd\u6027\u5e79\u7d30\u80de\u3067\u306f\u306a\u304f\u3001\u795e\u7d4c\u5824\u7d30\u80de\u69d8\u306e\u7279\u5fb4\u3092\u4f75\u305b\u3082\u3064\u7d30\u80de\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u3053\u306e\u7d30\u80de\u306f\u3001\u672b\u68a2\u30cb\u30e5\u30fc\u30ed\u30f3\u7814\u7a76\u306e\u30c4\u30fc\u30eb\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u3067\u306f\u3001\u306a\u305c\u795e\u7d4c\u5824\u7d30\u80de\u306e\u7279\u6027\u3092\u3082\u3064\u306e\u3067\u3057\u3087\u3046\u304b\uff1f 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Yu-Ching Lin, Risako Nakai, Hirohisa Hirai, Daiki Kozuka, Seiya Katayama, Shin-ichiro Nakamura, Sawako Okada, Ryunosuke Kitajima, Hiroo Imai, Hideyuki Okano, Masanori Imamura (2020). Reprogramming of chimpanzee fibroblasts into a multipotent cancerous but not fully pluripotent state by transducing iPSC factors in 2i\/LIF culture. <em>Differentiation<\/em>, 112: 67-76.<\/li>\n<li><a href=\"https:\/\/academist-cf.com\/journal\/?p=8841\">\u4eca\u6751\u516c\u7d00\u3001\u4ef2\u4e95\u7406\u6c99\u5b50\u300e\u30cb\u30db\u30f3\u30b6\u30eb\u306eiPS\u7d30\u80de\u306e\u4f5c\u88fd\u306b\u6210\u529f\uff01-\u300c\u970a\u9577\u985e\u5b66\u300d\u306e\u65b0\u305f\u306a\u53ef\u80fd\u6027\u300f\uff08academist journal\u30012018\u5e7410\u670823\u65e5\uff09<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u51fa\u767a\u70b9\uff1a\u30d2\u30c8\u306e\u7279\u6027\u3092\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u306f\u4f55\u304c\u5fc5\u8981\u3060\u308d\u3046\u304b\uff1f \u7b46\u8005\uff08\u4eca\u6751\uff09\u304c\u535a\u58eb\u53f7\u3092\u53d6\u5f97\u3057\u3066\u6570\u5e74\u304c\u7d4c\u3063\u305f\u3053\u308d\u3067\u3059\u3002\u305d\u308c\u307e\u3067\u30de\u30a6\u30b9\u3092\u6271\u3063\u305f\u57fa\u790e\u533b\u5b66\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3067\u304d\u307e\u3057\u305f\u304c\u3001\u65b0\u305f\u306b\u30b3\u30e2\u30f3\u30de\u30fc\u30e2\u30bb\u30c3\u30c8\u3068\u3044\u3046\u5c0f\u578b [&hellip;]<\/p>\n","protected":false},"author":341,"featured_media":12659,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[51,111,40,54,76],"class_list":["post-12658","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-ips","tag-111","tag-40","tag-54","tag-76","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/12658","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/341"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12658"}],"version-history":[{"count":12,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/12658\/revisions"}],"predecessor-version":[{"id":17357,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/12658\/revisions\/17357"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/12659"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12658"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12658"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12658"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}