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class='footnote' id='fnref-12395-1'><a href='#fn-12395-1' rel='footnote'>1<\/a><\/sup>\u300d\u304c\u3001\u3053\u306e\u3088\u3046\u306a\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u6642\u9593\u306b\u3088\u308b\u5909\u52d5\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u4f53\u5185\u6642\u8a08\u3068\u306f\u3001\u79c1\u305f\u3061\u306e\u4f53\u306e\u4e2d\u306e\u307b\u307c\u3059\u3079\u3066\u306e\u7d30\u80de\u306b\u5b58\u5728\u3057\u3001\u500b\u3005\u306e\u7d30\u80de\u6d3b\u52d5\u30921\u65e5\u306e\u6642\u9593\u306b\u5fdc\u3058\u3066\u6700\u9069\u5316\u3059\u308b\u3057\u304f\u307f\u3067\u3059\u3002\u4e00\u65b9\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306e\u5927\u90e8\u5206\u306f\u30de\u30b9\u30c8\u7d30\u80de\u3068\u547c\u3070\u308c\u308b\u514d\u75ab\u7d30\u80de\u304c\u3001\u30b9\u30ae\u306a\u3069\u306e\u30a2\u30ec\u30eb\u30ae\u30fc\u7269\u8cea\uff08\u30a2\u30ec\u30eb\u30b2\u30f3\uff09\u306b\u53cd\u5fdc\u3057\u3066\u30d2\u30b9\u30bf\u30df\u30f3\u306a\u3069\u306e\u304f\u3057\u3083\u307f\u3084\u9f3b\u6c34\u3001\u54b3\u3001\u3058\u3093\u307e\u3057\u3093\u306a\u3069\u3092\u8a98\u767a\u3059\u308b\u5316\u5b66\u7269\u8cea\u3092\u653e\u51fa\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u306e\u4e2d\u3067\u306f\u305f\u3089\u3044\u3066\u3044\u308b\u6642\u8a08\u304c\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u5bfe\u3059\u308b\u611f\u53d7\u6027\uff08IgE\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u305f\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u5206\u5b50\u306e\u767a\u73fe\u30ec\u30d9\u30eb\uff09\u3092\u3001\u6d3b\u52d5\u671f\u306f\u4f11\u606f\u671f\u306b\u6bd4\u3079\u3066\u6291\u5236\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u3064\u3051\u307e\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u4f11\u606f\u671f\u306b\u30a2\u30ec\u30eb\u30b2\u30f3\u306b\u66dd\u9732\u3055\u308c\u308b\u3068\u30de\u30b9\u30c8\u7d30\u80de\u304c\u653e\u51fa\u3059\u308b\u30d2\u30b9\u30bf\u30df\u30f3\u91cf\u304c\u6d3b\u52d5\u671f\u3088\u308a\u9ad8\u304f\u306a\u308a\u3001\u304f\u3057\u3083\u307f\u3084\u9f3b\u6c34\u3001\u54b3\u3001\u3058\u3093\u307e\u3057\u3093\u306a\u3069\u306e\u53cd\u5fdc\u3082\u4f11\u606f\u671f\uff08\u30d2\u30c8\u3067\u306f\u591c\u9593\u3001\u591c\u884c\u6027\u306e\u30de\u30a6\u30b9\u3067\u306f\u65e5\u4e2d\uff09\u306b\u5f37\u304f\u306a\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>\u4e0d\u898f\u5247\u306a\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u3092\u5f37\u304f\u3059\u308b<\/h3>\n<p>\u4f53\u5185\u6642\u8a08\u306f\u3001\u4e0d\u7720\u3084\u30b9\u30c8\u30ec\u30b9\u3001\u904b\u52d5\u3001\u98df\u4e8b\u306e\u6642\u9593\u306b\u3088\u3063\u3066\u5f71\u97ff\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u591c\u98df\u306a\u3069\u4e0d\u898f\u5247\u306a\u6642\u9593\u5e2f\u3067\u306e\u98df\u4e8b\u6442\u53d6\u306f\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u3092\u4e71\u3057\u80a5\u6e80\u306a\u3069\u3092\u8a98\u767a\u3055\u305b\u3084\u3059\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u3068\u4f53\u5185\u6642\u8a08\u3068\u306e\u5bc6\u63a5\u306a\u95a2\u4fc2\u304b\u3089\u3001\u79c1\u305f\u3061\u306f\u3001\u4e0d\u898f\u5247\u306a\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u306f\u3001\u80a5\u6e80\u3060\u3051\u3067\u306a\u304f\u30a2\u30ec\u30eb\u30ae\u30fc\u306b\u3082\u5f71\u97ff\u3059\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3001\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u3053\u3067\u3001\u3053\u306e\u4eee\u8aac\u3092\u78ba\u304b\u3081\u308b\u305f\u3081\u306b\u3001\u30de\u30a6\u30b9\u3092\u4ee5\u4e0b\u306e3\u7fa4\u306b\u5206\u3051\u3066\u5b9f\u9a13\u3092\u884c\u306a\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>1) \u990c\u309224\u6642\u9593\u81ea\u7531\u306b\u4e0e\u3048\u308b\uff08\u30de\u30a6\u30b9\u306f\u591c\u884c\u6027\u306a\u306e\u3067\u4e3b\u306b\u591c\u9593\u306b\u990c\u3092\u6442\u53d6\u3059\u308b\uff09\u3002<br \/>\n2) \u990c\u3092\u6d3b\u52d5\u671f\uff08\u591c\u884c\u6027\u30de\u30a6\u30b9\u3067\u306f\u591c\u9593\uff09\u306e4\u6642\u9593\u3060\u3051\u4e0e\u3048\u308b\u3002<br \/>\n3) \u990c\u3092\u4f11\u606f\u671f\uff08\u591c\u884c\u6027\u30de\u30a6\u30b9\u3067\u306f\u65e5\u4e2d\uff09\u306e4\u6642\u9593\u3060\u3051\u4e0e\u3048\u308b\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u98df\u4e8b\u6761\u4ef6\u3067\u30de\u30a6\u30b9\u30922\u9031\u9593\u98fc\u80b2\u3057\u305f\u3042\u3068\u3001\u30d2\u30c8\u306b\u304a\u3051\u308b\u3058\u3093\u307e\u3057\u3093\u53cd\u5fdc\u306e\u30e2\u30c7\u30eb\uff08PCA\u53cd\u5fdc\uff09\u3092\u3001\u305d\u308c\u305e\u308c\u306e\u7fa4\u3067\u3001\u65e5\u4e2d\uff08\u5348\u524d10\u6642\uff1a\u30de\u30a6\u30b9\u306e\u4f11\u606f\u671f\uff09\u3068\u591c\u9593\uff08\u5348\u5f8c10\u6642\uff1a\u30de\u30a6\u30b9\u306e\u6d3b\u52d5\u671f\uff09\u306b\u8d77\u3053\u3057\u3066\u307f\u307e\u3057\u305f\u3002\u306a\u304a\u3001\u30de\u30a6\u30b9\u304c\u6442\u53d6\u3057\u305f\u990c\u306e\u91cf\u306f3\u7fa4\u9593\u3067\u307b\u3068\u3093\u3069\u5909\u308f\u3089\u305a\u4f53\u91cd\u5909\u5316\u30823\u7fa4\u9593\u3067\u307b\u307c\u540c\u3058\u3067\u3057\u305f\u3002<\/p>\n<p>PCA\u53cd\u5fdc\u306e\u5f37\u3055\u306f\u30011) \u30682) \u306e\u7fa4\u3067\u306f\u3001\u4f11\u606f\u671f\u306b\u5f37\u304f\u6d3b\u52d5\u671f\u306b\u5f31\u3044\u53cd\u5fdc\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u4ee5\u524d\u306b\u79c1\u305f\u3061\u304c\u898b\u51fa\u3057\u305f\u7d50\u679c\u3068\u540c\u3058\u3067\u3059\u3002\u4e00\u65b9\u3001\u8208\u5473\u6df1\u3044\u3053\u3068\u306b3) \u306e\u7fa4\u3067\u306f\u3001\u4f11\u606f\u671f\u3082\u6d3b\u52d5\u671f\u3082\u5f37\u3044\u53cd\u5fdc\u304c\u898b\u3089\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u306e\u4f53\u5185\u6642\u8a08\u306e\u30ea\u30ba\u30e0\u3092\u8abf\u3079\u308b\u3068\u30013) \u306e\u7fa4\u3067\u306f1) 2) \u306e\u7fa4\u304c\u793a\u3059\u672c\u6765\u898b\u3089\u308c\u308b\uff08\u6b63\u5e38\u306a\uff09\u30ea\u30ba\u30e0\u3068\u306f\u7570\u306a\u308b\u30ea\u30ba\u30e0\u304c\u523b\u307e\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_12392\" aria-describedby=\"caption-attachment-12392\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12392\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/001.jpg\" alt=\"\" width=\"600\" height=\"419\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/001.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/001-300x210.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12392\" class=\"wp-caption-text\">\u4f11\u606f\u671f\u3060\u3051\u98df\u4e8b\u3092\u6442\u53d6\u3059\u308b\u74b0\u5883\u3067\u98fc\u80b2\u3055\u308c\u305f\u30de\u30a6\u30b9\u3067\u306f\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u5e38\u306b\u5f37\u304f\u306a\u308b\u3002\u4e0a\u306e\u5199\u771f\u306f<br \/>1) \u990c\u309224\u6642\u9593\u81ea\u7531\u306b\u4e0e\u3048\u308b\uff08\u30de\u30a6\u30b9\u306f\u591c\u884c\u6027\u306a\u306e\u3067\u4e3b\u306b\u591c\u9593\u306b\u990c\u3092\u6442\u53d6\u3059\u308b\uff09(AD)<br \/>2) \u990c\u3092\u6d3b\u52d5\u671f\uff08\u591c\u884c\u6027\u30de\u30a6\u30b9\u3067\u306f\u591c\u9593\uff09\u306e4\u6642\u9593\u3060\u3051\u4e0e\u3048\u308b(EN)<br \/>3) \u990c\u3092\u4f11\u606f\u671f\uff08\u591c\u884c\u6027\u30de\u30a6\u30b9\u3067\u306f\u65e5\u4e2d\uff09\u306e4\u6642\u9593\u3060\u3051\u4e0e\u3048\u308b(ED)<br \/>\u306e3\u7fa4\u306e\u30de\u30a6\u30b9\u306ePCA\uff08Passive Cutaneous Anaphylactic\uff09\u53cd\u5fdc\u3092\u6bd4\u8f03\u3057\u305f\u3082\u306e\u3002PCA\u53cd\u5fdc\u3068\u306f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3057\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u5f37\u3044\u304b\u3069\u3046\u304b\u3092\u8868\u3059\u53cd\u5fdc\u3002\u5199\u771f\u306e\u9752\u3044\u6591\u70b9\u304cPCA\u53cd\u5fdc\u306e\u5f37\u3055\u3092\u793a\u3057\u3001\u6591\u70b9\u304c\u306f\u3063\u304d\u308a\u3068\u5927\u304d\u3044\u307b\u3069\u30de\u30b9\u30c8\u7d30\u80de\u304c\u6d3b\u6027\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308b\uff08\u767d\u3044\u6591\u70b9\u306f\u3001\u53cd\u5fdc\u3092\u5b9a\u91cf\u5316\u3059\u308b\u305f\u3081\u306b\u5f37\u8abf\u3057\u305f\u3082\u306e\uff09\u30021) 2) \u306e\u30de\u30a6\u30b9\uff08\u5199\u771f\u4e0a\uff09\u3067\u306f\u3001PCA\u53cd\u5fdc\u3092\u884c\u3046\u6642\u9593\u306b\u3088\u3063\u3066\u9752\u3044\u6591\u70b9\u306e\u5927\u304d\u3055\u304c\u5909\u5316\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308b\uff08\u5404\u6642\u9593\u5e2f\u306bPCA\u53cd\u5fdc\u3092\u884c\u3063\u305f\u30de\u30a6\u30b9\u304c5\u5339\u305a\u3064\u3044\u308b\uff09\u3002\u5348\u524d10\u6642\u306f\u6591\u70b9\u304c\u5927\u304d\u304f\u3001\u30de\u30b9\u30c8\u7d30\u80de\u304c\u6d3b\u767a\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u5f37\u3044\u3053\u3068\u3092\u793a\u3059\u3002\u4e00\u65b9\u3001\u5348\u5f8c10\u6642\u3067\u306f\u6591\u70b9\u306f\u5c0f\u3055\u304f\u306a\u308a\u3001\u30de\u30b9\u30c8\u7d30\u80de\u304c\u304a\u3068\u306a\u3057\u304f\u306a\u308a\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u304c\u5f31\u304f\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u30893) 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id=\"attachment_12393\" aria-describedby=\"caption-attachment-12393\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12393\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002.jpg\" alt=\"\" width=\"600\" height=\"446\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-300x223.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12393\" class=\"wp-caption-text\">\u30a4\u30e9\u30b9\u30c8\u30ec\u30fc\u30b7\u30e7\u30f3\uff1a\u5c71\u68a8\u5927\u5b66\u30a2\u30c9\u30df\u30c3\u30b7\u30e7\u30f3\u30bb\u30f3\u30bf\u30fc\u3000\u9234\u6728\u5f8b\u5b50<\/figcaption><\/figure>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u300c\u98df\u4e8b\u6442\u53d6\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u300d\u3068\u3044\u3046\u60a3\u8005\u306e\u65e5\u5e38\u751f\u6d3b\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u306e\u6539\u5584\u3084\u6cbb\u7642\u85ac\u306e\u6e1b\u91cf\u3001\u767a\u4f5c\u306e\u4e88\u9632\u3092\u76ee\u6307\u3059\u3068\u3044\u3046\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u7642\u306b\u304a\u3051\u308b\u65b0\u3057\u3044\u30a2\u30a4\u30c7\u30a2\u3092\u63d0\u793a\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u4f55\u6642\u306b\u98df\u4e8b\u3092\u53d6\u308b\u304b\u3068\u3044\u3046\u3053\u3068\u304c\u30a2\u30ec\u30eb\u30ae\u30fc\u53cd\u5fdc\u306b\u5f71\u97ff\u3059\u308b\u3068\u3044\u3046\u300c\u98df\u4e8b\u300d\u306e\u60f3\u5b9a\u5916\u306e\u6a5f\u80fd\u3082\u63d0\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306f\u3001\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3092\u898b\u76f4\u3059\u3060\u3051\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u75c7\u72b6\u304c\u7de9\u548c\u3067\u304d\u308b\u60a3\u8005\u304c\u5168\u4f53\u306e2\u5272\u7a0b\u5ea6\u306f\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u81e8\u5e8a\u7684\u306a\u7d4c\u9a13\u304b\u3089\u63a8\u6e2c\u3057\u3066\u3044\u307e\u3059\u3002\u73fe\u5728\u3001\u60a3\u8005\u3055\u3093\u306e\u65e5\u5e38\u751f\u6d3b\u60c5\u5831\u3092\u81e8\u5e8a\u306b\u6d3b\u304b\u3059\u8a66\u307f\u306f\u3001\u201cApple Watch\u201d\u306b\u4ee3\u8868\u3055\u308c\u308b\u5065\u5eb7\u30c7\u30d0\u30a4\u30b9\u3084\u30d3\u30c3\u30b0\u30c7\u30fc\u30bf\u3068\u76f8\u6027\u304c\u826f\u304f\u3001\u5c06\u6765\u767a\u5c55\u304c\u671f\u5f85\u3055\u308c\u308b\u533b\u7642\u5206\u91ce\u306e\u3072\u3068\u3064\u3067\u3059\u3002\u79c1\u305f\u3061\u306f\u3001\u81ea\u6cbb\u4f53\u3084\u4f01\u696d\u3068\u5354\u529b\u3057\u3066\u3001\u98df\u4e8b\u306e\u30bf\u30a4\u30df\u30f3\u30b0\u3068\u30a2\u30ec\u30eb\u30ae\u30fc\uff08\u82b1\u7c89\u75c7\u306a\u3069\uff09\u75c7\u72b6\u3068\u306e\u95a2\u4fc2\u3092\u3001\u30b9\u30de\u30d5\u30a9\u30a2\u30d7\u30ea\u306a\u3069\u3092\u7528\u3044\u3066\u89e3\u6790\u3059\u308b\u7814\u7a76\u3092\u8a08\u753b\u4e2d\u3067\u3059\u3002\u4eca\u5f8c\u3053\u306e\u3088\u3046\u306a\u7814\u7a76\u3092\u66f4\u306b\u9032\u3081\u308b\u3053\u3068\u3067\u30a2\u30ec\u30eb\u30ae\u30fc\u8a3a\u7642\u306e\u65b0\u3057\u3044\u5927\u304d\u306a\u9032\u6b69\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\nNakamura Y, Ishimaru K, Nakao A.&#8221;Time-restricted feeding in rest phase alters IgE\/mast cell-mediated allergic reaction in mice.&#8221; <em>Allergology International<\/em>. 2019 Oct 14. pii: S1323-8930(19)30160-1. <a href=\"https:\/\/doi.org\/10.1016\/j.alit.2019.09.004\">https:\/\/doi.org\/10.1016\/j.alit.2019.09.004<\/a><\/p>\n<p><strong>\u88dc\u8db3<\/strong><br \/>\n<span class='footnote' id='fn-12395-1'><a href='#fnref-12395-1'>1<\/a>.<\/span> 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