{"id":12356,"date":"2020-01-15T08:00:31","date_gmt":"2020-01-14T23:00:31","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=12356"},"modified":"2020-01-19T21:32:47","modified_gmt":"2020-01-19T12:32:47","slug":"%e4%b8%8d%e8%89%af%e3%83%9f%e3%83%88%e3%82%b3%e3%83%b3%e3%83%89%e3%83%aa%e3%82%a2%e3%82%92%e5%88%86%e8%a7%a3%e3%81%99%e3%82%8b%e3%83%9e%e3%82%a4%e3%83%88%e3%83%95%e3%82%a1%e3%82%b8%e3%83%bc","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=12356","title":{"rendered":"\u4e0d\u826f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5206\u89e3\u3059\u308b&#8221;\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc&#8221; \u306e\u5236\u5fa1\u56e0\u5b50\u3092\u767a\u898b\uff01 &#8211; 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id=\"attachment_12358\" aria-describedby=\"caption-attachment-12358\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12358\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/001-7.jpg\" alt=\"\" width=\"600\" height=\"344\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/001-7.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/001-7-300x172.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12358\" class=\"wp-caption-text\">\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u8a73\u7d30\u306a\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0<br 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&#8211; CRISPR\u30e9\u30a4\u30d6\u30e9\u30ea\u306b\u3088\u308b\u9806\u907a\u4f1d\u5b66\u30b9\u30af\u30ea\u30fc\u30cb\u30b0<\/h3>\n<p>\u30b8\u30a7\u30ce\u30bf\u30a4\u30d7\uff08\u907a\u4f1d\u5b50\u578b\uff09\u3068\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\uff08\u8868\u73fe\u578b\uff09\u306e\u95a2\u9023\u3092\u898b\u308b\u7814\u7a76\u306b\u304a\u3044\u3066\u3001\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u304b\u3089\u30b8\u30a7\u30ce\u30bf\u30a4\u30d7\u3092\u8abf\u3079\u308b\u7814\u7a76\u3092\u9806\u907a\u4f1d\u5b66\u7814\u7a76\u3068\u3044\u3044\u307e\u3059\u3002\u53cd\u5bfe\u306b\u3001\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u3092\u8abf\u3079\u308b\u3088\u3046\u306a\u7814\u7a76\u3092\u9006\u907a\u4f1d\u5b66\u7814\u7a76\u3068\u3044\u3044\u307e\u3059\u3002<\/p>\n<p>\u9806\u907a\u4f1d\u5b66\u7814\u7a76\u3092\u884c\u3046\u3046\u3048\u3067\u6709\u529b\u306a\u30c4\u30fc\u30eb\u306e\u3072\u3068\u3064\u3068\u3057\u3066\u3001CRISPR\u30e9\u30a4\u30d6\u30e9\u30ea\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u3072\u3068\u3064\u306e\u907a\u4f1d\u5b50\u306b\u5bfe\u3057\u30664\uff5e10\u500b\u306egRNA\u304c\u8a2d\u8a08\u3055\u308c\u3001\u5408\u8a088\uff5e20\u4e07\u500b\u306egRNA\u304c\u30d7\u30fc\u30eb\u3055\u308c\u305f\u30ec\u30f3\u30c1\u30a6\u30a4\u30eb\u30b9\u30d9\u30fc\u30b9\u306e\u30e9\u30a4\u30d6\u30e9\u30ea\u3067\u3059\u3002\u3053\u306e\u30a6\u30a4\u30eb\u30b9\u30e9\u30a4\u30d6\u30e9\u30ea\u3092\u30e9\u30fc\u30b8\u30b9\u30b1\u30fc\u30eb\u3067\u7d30\u80de\u306b\u611f\u67d3\u3055\u305b\u308b\u3053\u3068\u3067\u3001\u305d\u308c\u305e\u308c\u7570\u306a\u308b\u907a\u4f1d\u5b50\u304c\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u3055\u308c\u305f\u30d8\u30c6\u30ed\u306a\u7d30\u80de\u96c6\u56e3\u3092\u6e96\u5099\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e\u7d30\u80de\u96c6\u56e3\u306b\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u8a98\u5c0e\u3057\u3001\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u4ea2\u9032\u3057\u3066\u3044\u308b\u7d30\u80de\u96c6\u56e3\uff08High\uff09\u3068\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u7d30\u80de\u96c6\u56e3\uff08Low\uff09\u3092FACS\uff08fluorescence activated cell sorting\uff1a\u86cd\u5149\u6d3b\u6027\u5316\u30bb\u30eb\u30bd\u30fc\u30c6\u30a3\u30f3\u30b0\uff09\u3067\u56de\u53ce\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u30b2\u30ce\u30e0DNA\u3092\u62bd\u51fa\u3057\u3001\u30c7\u30a3\u30fc\u30d7\u30b7\u30fc\u30af\u30a8\u30f3\u30b9\u3067\u96c6\u56e3\u306b\u542b\u307e\u308c\u308bgRNA\u306e\u5dee\u3092\u89e3\u6790\u3059\u308b\u3053\u3068\u3067\u3001\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306b\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\u3092\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_12388\" aria-describedby=\"caption-attachment-12388\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12388\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-1.jpg\" alt=\"\" width=\"600\" height=\"469\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-1.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-1-300x235.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12388\" class=\"wp-caption-text\">CRISPR\u30e9\u30a4\u30d6\u30e9\u30ea\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u6982\u8981<\/figcaption><\/figure>\n<p>\u4eca\u56de\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3067\u306f\u3001\u307e\u305a\u65e2\u77e5\u306e\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u907a\u4f1d\u5b50\u304c\u6570\u591a\u304f\u30d2\u30c3\u30c8\u3057\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u6a5f\u80fd\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u5c0f\u80de\u306e\u7d50\u5408\u3084\u30a8\u30f3\u30c9\u30bd\u30fc\u30e0\u306e\u6210\u719f\u306b\u5fc5\u9808\u3067\u3042\u308bHOPS\u3084ESCRT\u306e\u69cb\u6210\u56e0\u5b50\u304c\u6570\u591a\u304f\u30d2\u30c3\u30c8\u3057\u3001\u3053\u308c\u3089\u306e\u91cd\u8981\u6027\u304c\u518d\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u65b0\u898f\u306e\u56e0\u5b50\u3068\u3057\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u306b\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3067\u306fLC3\u30ec\u30bb\u30d7\u30bf\u30fc\u3068\u3057\u3066OPTN\u3068NDP52\u304c\u5fc5\u9808\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4eca\u56de\u7528\u3044\u305f\u30de\u30a6\u30b9\u306e\u7b4b\u82bd\u7d30\u80de\u3067\u306fTax1BP1\u304c\u5fc5\u9808\u3067\u3057\u305f\u3002\u307e\u305f\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u304b\u3089ATP\u3092\u7d30\u80de\u8cea\u3078\u904b\u642c\u3059\u308b\u300cANT\uff08\u30a2\u30c7\u30cb\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u4ea4\u63db\u8f38\u9001\u4f53\uff09\u300d\u3068\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u306b\u3042\u308b\u30b7\u30e3\u30da\u30ed\u30f3\u30bf\u30f3\u30d1\u30af\u300cTIM22\u8907\u5408\u4f53\u300d\u304c\u3001PINK1\u306e\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5916\u819c\u3078\u306e\u79fb\u884c\u306b\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_12386\" aria-describedby=\"caption-attachment-12386\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12386\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-2.jpg\" alt=\"\" width=\"600\" height=\"452\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-2.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2020\/01\/002-2-300x226.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12386\" class=\"wp-caption-text\">CRISPR\u30e9\u30a4\u30d6\u30e9\u30ea\u306b\u3088\u308b\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u306e\u7d50\u679c<\/figcaption><\/figure>\n<h3>\u30a2\u30c7\u30cb\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u4ea4\u63db\u8f38\u9001\u4f53\uff08ANT\uff09\u306fTIM23\u3092\u4ecb\u3057\u3066\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5236\u5fa1\u3059\u308b<\/h3>\n<p>ANT\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306eATP\u3068\u7d30\u80de\u8cea\u306eADP\u3092\u4ea4\u63db\u3059\u308b\u3053\u3068\u3067ATP\u3092\u7d30\u80de\u8cea\u3078\u904b\u642c\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u4eca\u56de\u767a\u898b\u3057\u305fANT\u306e\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u5236\u5fa1\u306f\u3053\u306e\u306f\u305f\u3089\u304d\u3068\u306f\u72ec\u7acb\u3057\u305f\u3082\u306e\u3067\u3057\u305f\u3002ANT\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u5185\u819c\u306e\u30bf\u30f3\u30d1\u30af\u8f38\u9001\u4f53\u3067\u3042\u308bTIM23\u8907\u5408\u4f53\u306eTIM44\u3068\u7d50\u5408\u3059\u308b\u3053\u3068\u3067TIM23\u306e\u8f38\u9001\u6a5f\u80fd\u306b\u95a2\u4e0e\u3057\u3001\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u901a\u5e38\u72b6\u614b\u3067\u306f\u3001PINK1\u306fTIM23\u306b\u90e8\u5206\u7684\u306b\u53d6\u308a\u8fbc\u307e\u308c\u3001PARL\u306b\u3088\u308a\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u304c\u5207\u65ad\u3055\u308c\u308b\u3053\u3068\u3067\u7d30\u80de\u8cea\u3078\u653e\u51fa\u3055\u308c\u3001\u30d7\u30ed\u30c6\u30a2\u30be\u30fc\u30e0\u3067\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u9006\u306b\u3001\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u969c\u5bb3\u6642\u306fTIM23\u306e\u30b2\u30fc\u30c8\u304c\u9589\u9396\u3057PINK1\u304c\u30a2\u30af\u30bb\u30b9\u3067\u304d\u306a\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u304c\u4fdd\u6301\u3055\u308c\u3001PINK1\u306f\u30d7\u30ed\u30c6\u30a2\u30be\u30fc\u30e0\u3067\u5206\u89e3\u3055\u308c\u305a\u306bTIM22\u306e\u30b7\u30e3\u30da\u30ed\u30f3\u6a5f\u80fd\u306e\u4e0b\u3067\u5916\u819c\u306b\u84c4\u7a4d\u3057\u307e\u3059\u3002<\/p>\n<p>ANT\u306f\u3053\u306eTIM23\u306e\u30b2\u30fc\u30c8\u9589\u9396\u306b\u91cd\u8981\u3067\u3001ANT\u306e\u6b20\u640d\u3084\u4e00\u90e8\u306e\u75be\u60a3\u907a\u4f1d\u5b50\u5909\u7570\u3067\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u969c\u5bb3\u6642\u306eTIM23\u306e\u30b2\u30fc\u30c8\u9589\u9396\u304c\u4e0d\u5341\u5206\u3068\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066PINK1\u306e\u819c\u8cab\u901a\u30c9\u30e1\u30a4\u30f3\u304c\u5207\u65ad\u3055\u308c\u3001\u30d7\u30ed\u30c6\u30a2\u30be\u30fc\u30e0\u3067\u306e\u5206\u89e3\u304c\u751f\u3058\u308b\u305f\u3081\u3001PINK1\u306e\u84c4\u7a4d\u304c\u4f4e\u4e0b\u3057\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u8a98\u5c0e\u304c\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_12360\" aria-describedby=\"caption-attachment-12360\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-12360\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/003-8.jpg\" alt=\"\" width=\"600\" height=\"346\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/003-8.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/12\/003-8-300x173.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12360\" class=\"wp-caption-text\">\u30a2\u30c7\u30cb\u30f3\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u4ea4\u63db\u8f38\u9001\u4f53\uff08ANT\uff09\u306b\u3088\u308bTIM44-TIM23\u3092\u4ecb\u3057\u305fPINK1\u5236\u5fa1\u30e1\u30ab\u30cb\u30ba\u30e0<\/figcaption><\/figure>\n<p>\u3053\u308c\u307e\u3067\u306b\u3001ANT1\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u306b\u3088\u308b\u30df\u30aa\u30d1\u30c1\u30fc\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4e00\u90e8\u306e\u907a\u4f1d\u5b50\u7570\u5e38\u3067\u306fADP\/ATP\u4ea4\u63db\u8f38\u9001\u80fd\u306f\u969c\u5bb3\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u6a5f\u80fd\u7684\u539f\u56e0\u304c\u4e0d\u660e\u3067\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u4ea4\u63db\u8f38\u9001\u80fd\u304c\u6b63\u5e38\u306a\u5909\u7570\u3067\u306f\u3001\u4eca\u56de\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306e\u8a98\u5c0e\u304c\u969c\u5bb3\u3055\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u4eca\u307e\u3067\u6a5f\u80fd\u7684\u539f\u56e0\u304c\u4e0d\u660e\u3067\u3042\u3063\u305f\u30df\u30aa\u30d1\u30c1\u30fc\u306f\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u4e0d\u5168\u3068\u305d\u308c\u306b\u3088\u308b\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u4f4e\u4e0b\u304c\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<h3>\u4eca\u5f8c\u306e\u767a\u5c55<\/h3>\n<p>\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u306e\u4f4e\u4e0b\u306f\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3084\u5fc3\u4e0d\u5168\u3001\u7cd6\u5c3f\u75c5\u306a\u3069\u306e\u5e45\u5e83\u3044\u75be\u60a3\u3068\u95a2\u9023\u3057\u3001\u307e\u305f\u8001\u5316\u306b\u3082\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u306f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u6a5f\u80fd\u3092\u6b63\u5e38\u306b\u7dad\u6301\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u3084\u8001\u5316\u306b\u304a\u3044\u3066\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u5831\u544a\u304c\u591a\u304f\u3042\u308a\u307e\u3059\u3002\u305d\u306e\u305f\u3081\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u4ea2\u9032\u3055\u305b\u308b\u3053\u3068\u3067\u75c5\u614b\u306e\u9032\u884c\u3084\u3001\u8001\u5316\u3092\u6291\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u3092\u6d3b\u6027\u5316\u3055\u305b\u308b\u65b9\u6cd5\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u4eca\u5f8c\u306f\u672c\u7814\u7a76\u304b\u3089\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u8a73\u7d30\u306a\u30e1\u30ab\u30cb\u30ba\u30e0\u3082\u53c2\u8003\u306b\u3057\u3066\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u6d3b\u6027\u5316\u306e\u65b0\u305f\u306a\u65b9\u6cd5\u3092\u958b\u767a\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\nHoshino A, Wang WJ, Wada S, McDermott-Roe C, Evans CS, Gosis B, Morley MP, Rathi KS, Li J, Li K, Yang S, McManus MJ, Bowman C, Potluri P, Levin M, Damrauer S, Wallace DC, Holzbaur ELF, Arany Z. \u201cThe ADP\/ATP translocase drives mitophagy independent of nucleotide exchange.\u201d <em>Nature<\/em> <strong>575<\/strong>, 375-379 (2019)<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-1667-4\">doi: 10.1038\/s41586-019-1667-4.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0d\u826f\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u3092\u5206\u89e3\u3059\u308b\u300c\u30de\u30a4\u30c8\u30d5\u30a1\u30b8\u30fc\u300d 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