{"id":12088,"date":"2019-11-11T08:00:32","date_gmt":"2019-11-10T23:00:32","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=12088"},"modified":"2020-01-10T17:56:28","modified_gmt":"2020-01-10T08:56:28","slug":"%e3%83%91%e3%83%bc%e3%82%ad%e3%83%b3%e3%82%bd%e3%83%b3%e7%97%85%e3%81%af%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%81%a7%e4%ba%88%e9%98%b2%e3%81%a7%e3%81%8d%e3%82%8b%e3%81%8b%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=12088","title":{"rendered":"\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u4e88\u9632\u3067\u304d\u308b\u304b\uff1f &#8211; 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id=\"attachment_12083\" aria-describedby=\"caption-attachment-12083\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/003.jpg\" alt=\"\" width=\"600\" height=\"168\" class=\"size-full wp-image-12083\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/003.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/003-300x84.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12083\" class=\"wp-caption-text\">\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u51dd\u96c6\u304c\u795e\u7d4c\u56de\u8def\u3092\u4f1d\u67d3\u3057\u3001\u8133\u5185\u306b\u5e83\u304c\u308b<br 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id=\"attachment_12084\" aria-describedby=\"caption-attachment-12084\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/004.jpg\" alt=\"\" width=\"600\" height=\"284\" class=\"size-full wp-image-12084\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/004.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/004-300x142.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12084\" class=\"wp-caption-text\">\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306f\u795e\u7d4c\u6d3b\u52d5\u306b\u4f34\u3063\u3066\u3001\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de\u306b\u304f\u3063\u3064\u3044\u305f\u308a\u3001\u96e2\u308c\u305f\u308a\u3092\u7e70\u308a\u8fd4\u3057\u3066\u3044\u308b<br \/><\/figcaption><\/figure>\n<h3>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u539f\u56e0\u907a\u4f1d\u5b50PLA2G6\u304b\u3089\u3001\u30cf\u30a8\u3092\u4f7f\u3063\u3066\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u51dd\u96c6\u306e\u306a\u305e\u306b\u8feb\u308b<\/h3>\n<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u3046\u30615\uff5e10%\u304c\u907a\u4f1d\u6027\u3067\u3001\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u4ee5\u5916\u306b\u3044\u304f\u3064\u304b\u306e\u539f\u56e0\u907a\u4f1d\u5b50\u304c\u308f\u304b\u3063\u3066\u3044\u307e\u3059\u3002\u305d\u306e\u3046\u3061PLA2G6\u3068\u3044\u3046\u907a\u4f1d\u5b50\u306b\u5909\u7570\u304c\u3042\u308b\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u30ec\u30d3\u30fc\u5c0f\u4f53\u304c\u8133\u5185\u306b\u8457\u3057\u304f\u5f62\u6210\u3055\u308c\u308b\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u307e\u3059\u3002PLA2G6\u306f\u30ea\u30f3\u8102\u8cea\u306e\u758e\u6c34\u57fa\u3068\u3044\u3046\u90e8\u5206\u3092\u7de8\u96c6\u3059\u308b\u9175\u7d20\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_12085\" aria-describedby=\"caption-attachment-12085\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/005.jpg\" alt=\"\" width=\"600\" height=\"154\" class=\"size-full wp-image-12085\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/005.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/005-300x77.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12085\" class=\"wp-caption-text\">PLA2G6\u306b\u5909\u7570\u304c\u5165\u308b\u3068\u3001\u751f\u4f53\u819c\u3092\u69cb\u6210\u3059\u308b\u30ea\u30f3\u8102\u8cea\u306e\u758e\u6c34\u57fa\u304c\u77ed\u304f\u306a\u308b<\/figcaption><\/figure>\n<p>\u79c1\u305f\u3061\u306f\u3001PLA2G6\u306e\u5909\u7570\u3067\u8133\u5185\u306b\u3069\u306e\u3088\u3046\u306a\u3053\u3068\u304c\u8d77\u3053\u308b\u304b\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u304c\u51dd\u96c6\u3059\u308b\u4ed5\u7d44\u307f\u304c\u308f\u304b\u308b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u7528\u3044\u305f\u306e\u306f\u30ad\u30a4\u30ed\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3001\u3069\u3053\u306b\u3067\u3082\u3044\u308b\u5c0f\u3055\u306a\u30cf\u30a8\u3067\u3059\u3002\u8aad\u8005\u306e\u306a\u304b\u306b\u306f\u3001\u9ad8\u6821\u306e\u751f\u7269\u5b66\u306e\u6388\u696d\u3067\u3001\u8d64\u773c\u3068\u767d\u773c\u306e\u907a\u4f1d\u306e\u5b9f\u9a13\u3067\u4f7f\u3063\u305f\u65b9\u3082\u3044\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u79c1\u305f\u3061\u306f\u672c\u90a6\u3067\u521d\u3081\u3066\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u3092\u4f7f\u3063\u3066\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u7814\u7a76\u3092\u59cb\u3081\u307e\u3057\u305f\u3002\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306f\u5c0f\u3055\u304f\u3066\u5bff\u547d\u304c\u77ed\u304f\u3001\u7814\u7a76\u306b\u6642\u9593\u3068\u30b3\u30b9\u30c8\u304c\u304b\u304b\u3089\u306a\u3044\u3068\u3044\u3046\u30e1\u30ea\u30c3\u30c8\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u4f55\u3088\u308a\u30b7\u30e7\u30a6\u30b8\u30e7\u30a6\u30d0\u30a8\u306f\u3001\u4eba\u306e\u75c5\u6c17\u306e\u907a\u4f1d\u5b50\u3068\u76f8\u540c\u306a\u907a\u4f1d\u5b50\u3092\u5c11\u306a\u304f\u3068\u308275%\u4ee5\u4e0a\u6301\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u7279\u5fb4\u304c\u3042\u308a\u3001\u4eba\u3068\u540c\u3058\u304f\u52a0\u9f62\u306b\u3088\u308b\u4f53\u306e\u5909\u5316\u3082\u8d77\u3053\u308a\u307e\u3059\u3002\u3088\u3063\u3066\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u4eba\u3068\u540c\u3058\u5909\u7570\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u306e\u3088\u3046\u306a\u30cf\u30a8\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u7814\u7a76\u306e\u8a73\u7d30\u306f\u3001\u79c1\u305f\u3061\u306e<a 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id=\"attachment_12086\" aria-describedby=\"caption-attachment-12086\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/006.jpg\" alt=\"\" width=\"600\" height=\"277\" class=\"size-full wp-image-12086\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/006.jpg 600w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/11\/006-300x139.jpg 300w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-12086\" class=\"wp-caption-text\">\u30b7\u30ca\u30d7\u30b9\u5c0f\u80de\u819c\u304c\u5c0f\u3055\u304f\u306a\u308b\u3068\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u304c\u5916\u308c\u3084\u3059\u304f\u306a\u308a\u3001\u51dd\u96c6\u30ea\u30b9\u30af\u304c\u9ad8\u307e\u308b\u3002\u77ed\u304f\u306a\u3063\u305f\u758e\u6c34\u57fa\u3092\u5143\u306b\u623b\u3059\u305f\u3081\u306b\u30ea\u30ce\u30fc\u30eb\u9178\u3092\u6442\u53d6\u3059\u308b\u3068\u3001\u03b1\u30b7\u30cc\u30af\u30ec\u30a4\u30f3\u306e\u51dd\u96c6\u5316\u304c\u6291\u3048\u3089\u308c\u305f\u3002<br 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href=\"https:\/\/www.juntendo.ac.jp\/graduate\/laboratory\/labo\/parkinsons_disease\/k4.html\">\u9806\u5929\u5802\u5927\u5b66\u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1 \u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u75c5\u614b\u89e3\u660e\u7814\u7a76\u8b1b\u5ea7 \u7814\u7a76\u7d39\u4ecb\u30db\u30fc\u30e0\u30da\u30fc\u30b8<\/a><\/li>\n<li>Mori A, Hatano T, Inoshita T, Shiba-Fukushima K, Koinuma T, Meng H, Kubo S-i, Spratt S, Cui C, Yamashita C, Miki Y, Yamamoto K, Hirabayashi T, Murakami M, Takahashi Y, Shindou H, Nonaka T, Hasegawa M, Okuzumi A, <u>Imai Y<\/u>, Hattori N: Parkinson\u2019s disease-associated iPLA2-VIA\/PLA2G6 regulates neuronal functions and \u03b1-synuclein stability through membrane remodeling. <em><strong>Proc Natl Acad Sci U S A.<\/strong><\/em> 116: 20689-20699 (2019)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u306f\uff1f 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