{"id":11942,"date":"2019-11-26T08:00:08","date_gmt":"2019-11-25T23:00:08","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=11942"},"modified":"2020-01-10T17:54:01","modified_gmt":"2020-01-10T08:54:01","slug":"%e5%8d%b5%e5%b7%a3%e7%9a%ae%e8%b3%aa%e3%81%ab%e7%9c%a0%e3%82%8b%e3%80%8c%e5%8e%9f%e5%a7%8b%e5%8d%b5%e8%83%9e%e3%80%8d%e3%81%af%e3%80%81%e5%8a%a0%e5%9c%a7%e4%b8%8b%e3%81%a7%e7%b4%b0%e8%83%9e%e6%a0%b8","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=11942","title":{"rendered":"\u5375\u5de3\u76ae\u8cea\u306b\u7720\u308b\u300c\u539f\u59cb\u5375\u80de\u300d\u306f\u3001\u52a0\u5727\u4e0b\u3067\u7d30\u80de\u6838\u3092\u56de\u8ee2\u3057\u9759\u6b62\u671f\u3092\u7dad\u6301\u3057\u3066\u3044\u308b"},"content":{"rendered":"<h3>\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u6761\u4ef6\u3068\u306f<\/h3>\n<p>\u751f\u6b96\u7d30\u80de\u306f\u6b21\u4e16\u4ee3\u306b\u907a\u4f1d\u60c5\u5831\u3092\u7e4b\u3050\u552f\u4e00\u306e\u7d30\u80de\u7cfb\u8b5c\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u751f\u904e\u7a0b\u3067\u3055\u307e\u3056\u307e\u306a\u6027\u8cea\u3001\u5f62\u614b\u306e\u5909\u5316\u3092\u4f34\u3044\u307e\u3059\u3002\u7279\u306b\u5375\u5b50\u306f\u500b\u4f53\u306e\u767a\u751f\u3092\u9042\u884c\u3059\u308b\u6a5f\u80fd\u3092\u62c5\u3046\u91cd\u8981\u306a\u7d30\u80de\u3067\u3059\u3002<\/p>\n<p>\u54fa\u4e73\u985e\u306e\u5375\u5b50\u306f\u51fa\u751f\u76f4\u5f8c\u306b\u539f\u59cb\u5375\u80de\u3068\u3057\u3066\u7dad\u6301\u3055\u308c\u308b\u3082\u306e\u3092\u751f\u6daf\u306b\u308f\u305f\u3063\u3066\u4f7f\u3044\u7d9a\u3051\u307e\u3059\u3002\u3059\u306a\u308f\u3061\u5375\u6bcd\u7d30\u80de\u306e\u6570\u306f\u51fa\u751f\u6642\u306b\u6c7a\u307e\u3063\u3066\u304a\u308a\u3001\u305d\u306e\u5f8c\u5897\u3048\u308b\u3053\u3068\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3057\u305f\u304c\u3063\u3066\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u3001\u6d3b\u6027\u5316\u306f\u751f\u6b96\u671f\u9593\u306e\u6c7a\u5b9a\u3068\u76f4\u7d50\u3059\u308b\u91cd\u8981\u306a\u6a5f\u69cb\u3067\u3059\u3002\u5b9f\u969b\u306b\u30d2\u30c8\u306b\u304a\u3051\u308b\u539f\u59cb\u5375\u80de\u306e\u67af\u6e07\u306f\u65e9\u671f\u9589\u7d4c\u3092\u5f15\u304d\u8d77\u3053\u3057\u3001\u793e\u4f1a\u7684\u306a\u554f\u984c\u3068\u306a\u3063\u3066\u3044\u308b\u4e0d\u598a\u306e\u5927\u304d\u306a\u8981\u56e0\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n<p>\u539f\u59cb\u5375\u80de\u306f\u5375\u5de3\u5185\u306e\u76ae\u8cea\u5074\u306b\u4f4d\u7f6e\u3057\u3001\u5468\u56f2\u3092\u4e00\u5c64\u306e\u6241\u5e73\u306a\u9846\u7c92\u819c\u7d30\u80de\u3068\u3044\u3046\u5375\u6bcd\u7d30\u80de\u3092\u652f\u6301\u3059\u308b\u7d30\u80de\u306b\u56f2\u307e\u308c\u305f\u72b6\u614b\u3067\u7dad\u6301\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u6d3b\u6027\u5316\u306b\u4f34\u3044\u6241\u5e73\u306a\u9846\u7c92\u819c\u7d30\u80de\u306f\u7acb\u65b9\u72b6\u3078\u3068\u5f62\u614b\u5909\u5316\u3057\u3001\u305d\u306e\u4f4d\u7f6e\u3082\u6b21\u7b2c\u306b\u9ac4\u8cea\u5074\u3078\u3068\u79fb\u52d5\u3057\u307e\u3059\u3002\u3053\u306e\u969b\u306b\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u306b\u5fc5\u9808\u306e\u8ee2\u5199\u56e0\u5b50\u3067\u3042\u308bFOXO3a\u304c\u6838\u5185\u304b\u3089\u6838\u5916\u3078\u3068\u79fb\u884c\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u9846\u7c92\u819c\u7d30\u80de\u306e\u5f62\u614b\u3068FOXO3a\u306e\u5c40\u5728\u304c\u539f\u59cb\u5375\u80de\u306e\u9759\u6b62\u72b6\u614b\u3068\u6d3b\u6027\u5316\u3092\u5206\u3051\u308b\u6307\u6a19\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u306b\u306f\u5375\u6bcd\u7d30\u80de\u3068\u9846\u7c92\u819c\u7d30\u80de\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304a\u3088\u3073\u5375\u5de3\u76ae\u8cea\u306e\u74b0\u5883\u8981\u7d20\u304c\u91cd\u8981\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u305d\u306e\u8a73\u7d30\u306f\u4e0d\u660e\u306e\u307e\u307e\u3067\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_11943\" aria-describedby=\"caption-attachment-11943\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11943\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image1.jpg\" alt=\"\" width=\"800\" height=\"371\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image1.jpg 800w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image1-300x139.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image1-768x356.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-11943\" class=\"wp-caption-text\">\u30de\u30a6\u30b9\u5375\u6bcd\u7d30\u80de\u306e\u767a\u751f\uff08\u4e0a\uff09\u3068\u3001\u30de\u30a6\u30b9\u539f\u59cb\u5375\u80de\u306e\u7279\u5fb4\uff08\u4e0b\uff09<\/figcaption><\/figure>\n<div class=\"center\">\n<!--Ads1-->\n<\/div>\n<h3>\u539f\u59cb\u5375\u80de\u3092\u5236\u5fa1\u3059\u308b\u306e\u306f\u3001\u7d30\u80de\u5916\u57fa\u8cea<\/h3>\n<p>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u80ce\u751f\u671f\u306e\u5375\u539f\u7d30\u80de\u3068\u5f62\u6210\u76f4\u5f8c\u306e\u539f\u59cb\u5375\u80de\u4e2d\u306e\u5375\u6bcd\u7d30\u80de\u3068\u306e\u6bd4\u8f03\u304b\u3089\u3001\u539f\u59cb\u5375\u80de\u5f62\u6210\u904e\u7a0b\u306b\u304a\u3044\u3066\u7d30\u80de\u5916\u57fa\u8cea\u304c\u5927\u304d\u304f\u767a\u9054\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u3001\u51fa\u751f\u5f8c\u306e\u5375\u5de3\u306b\u304a\u3044\u3066\u30b9\u30c8\u30ec\u30b9\u30d5\u30a1\u30a4\u30d0\u30fc\u3067\u3042\u308bF-actin\u306e\u67d3\u8272\u3092\u304a\u3053\u306a\u3063\u305f\u3068\u3053\u308d\u3001\u76ae\u8cea\u306e\u6700\u5916\u5c64\u90e8\u5206\u3067\u30d4\u30fc\u30af\u3068\u306a\u308b\u30b7\u30b0\u30ca\u30eb\u304c\u691c\u51fa\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u30d4\u30fc\u30af\u306f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u9175\u7d20\u6db2\uff08CTK : collagenase, trypsin, KSR\uff09\u3067\u5375\u5de3\u3092\u51e6\u7406\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u6d88\u5931\u3059\u308b\u305f\u3081\u3001\u7d30\u80de\u9593\u304a\u3088\u3073\u7d30\u80de\u5916\u57fa\u8cea\u306b\u3088\u308b\u5c40\u6240\u7684\u306a\u7279\u5fb4\uff08\u5fae\u5c0f\u74b0\u5883\uff09\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u6b21\u306b\u3053\u306e\u5fae\u5c0f\u74b0\u5883\u3068\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u3001\u6d3b\u6027\u5316\u3068\u306e\u95a2\u4fc2\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u305f\u3081\u3001CTK\u51e6\u7406\u3092\u884c\u3063\u305f\u5375\u5de3\u3092FOXO3a\u306e\u514d\u75ab\u67d3\u8272\u3067\u89e3\u6790\u3057\u307e\u3057\u305f\u3002FOXO3a\u306f\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u306b\u5fc5\u9808\u306e\u56e0\u5b50\u3067\u3042\u308a\u3001\u5375\u6bcd\u7d30\u80de\u306e\u6838\u5185\u306b\u5b58\u5728\u3057\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u6d3b\u6027\u5316\u306b\u4f34\u3044\u6838\u304b\u3089\u7d30\u80de\u8cea\u3078\u3068\u5c40\u5728\u3092\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u514d\u75ab\u67d3\u8272\u306e\u7d50\u679c\u3001CTK\u51e6\u7406\u306b\u3088\u3063\u3066FOXO3a\u306e\u6838\u5916\u79fb\u884c\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306fCTK\u51e6\u7406\u306b\u3088\u3063\u3066\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u3053\u3067\u3001CTK\u51e6\u7406\u3092\u3057\u305f\u5375\u5de3\u306e\u57f9\u990a\u3092\u884c\u3044\u3001\u5375\u80de\u306e\u6210\u719f\u904e\u7a0b\u306e\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679cCTK\u51e6\u7406\u3092\u884c\u3046\u3068\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u304c\u4fc3\u9032\u3055\u308c\u6210\u9577\u3057\u305f\u5375\u5b50\u306e\u6570\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u7d30\u80de\u9593\u304a\u3088\u3073\u7d30\u80de\u5916\u57fa\u8cea\u306b\u3088\u308b\u5375\u5de3\u5185\u76ae\u8cea\u306e\u5fae\u5c0f\u74b0\u5883\u304c\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u3001\u6d3b\u6027\u5316\u306b\u76f4\u63a5\u304b\u304b\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_11944\" aria-describedby=\"caption-attachment-11944\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11944\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image2.jpg\" alt=\"\" width=\"800\" height=\"409\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image2.jpg 800w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image2-300x153.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image2-768x393.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-11944\" class=\"wp-caption-text\">\u5de6\uff09\u30de\u30a6\u30b9\u65b0\u751f\u5150\uff087\u65e5\uff09\u5375\u5de3\u5207\u7247\u306e\u514d\u75ab\u67d3\u8272\u50cf\uff08\u8d64\uff1aMVH\uff3b\u751f\u6b96\u7d30\u80de\u30de\u30fc\u30ab\u30fc\uff3d\u3001\u7dd1 : Foxo3a\uff3b\u8ee2\u5199\u56e0\u5b50\uff3d\u3001\u9752 : DAPI\uff3b\u6838\uff3d\uff09\u3002CTK\u51e6\u7406\u306b\u3088\u3063\u3066\u539f\u59cb\u5375\u80de\u306b\u304a\u3051\u308bFoxo3a\u306e\u5c40\u5728\u304c\u6838\u5185\u304b\u3089\u7d30\u80de\u8cea\u3078\u3068\u79fb\u884c\u3057\u3066\u3044\u308b\uff08\u77e2\u5370\uff09\u3002<br \/>\u53f3\uff09\u30de\u30a6\u30b9\u65b0\u751f\u5150\uff083\u65e5\uff09\u5375\u5de3\u3092\u4f53\u5916\u57f9\u990a\u3057\u306614\u65e5\u76ee\u306e\u7d44\u7e54\u50cf\uff08Stella-CFP : Stella\u306e\u767a\u73fe\u5236\u5fa1\u4e0b\u306bCFP\u3092\u767a\u73fe\u3059\u308bTg\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u304a\u308a\u3001\u5375\u6bcd\u7d30\u80de\u304cCFP\u3067\u30de\u30fc\u30af\u3055\u308c\u308b\uff09\u3002CTK\u51e6\u7406\u306b\u3088\u308a\u5375\u6bcd\u7d30\u80de\u306e\u6210\u719f\u304c\u4fc3\u9032\u3055\u308c\u3066\u3044\u308b\u3002<\/figcaption><\/figure>\n<h3>\u539f\u59cb\u5375\u80de\u306f\u5727\u529b\u306b\u3088\u3063\u3066\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b<\/h3>\n<p>\u30b9\u30c8\u30ec\u30b9\u30d5\u30a1\u30a4\u30d0\u30fc\u3067\u3042\u308bF-actin\u306f\u7269\u7406\u7684\u306a\u5727\u529b\u72b6\u614b\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u4f11\u6b62\u671f\u306e\u539f\u59cb\u5375\u80de\u306b\u304a\u3051\u308b\u9846\u7c92\u819c\u7d30\u80de\u306e\u5f62\u614b\u306f\u6241\u5e73\u3067\u3059\u3002\u7d30\u80de\u306e\u5f62\u72b6\u3068\u3057\u3066\u6241\u5e73\u306a\u3082\u306e\u306e\u65b9\u304c\u7acb\u65b9\u72b6\u306e\u3082\u306e\u3088\u308a\u3082\u5185\u90e8\u306b\u5f37\u304f\u5727\u529b\u3092\u304b\u3051\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u3053\u3068\u304b\u3089\u5375\u5de3\u5185\u76ae\u8cea\u3067\u306f\u7269\u7406\u7684\u306a\u5727\u529b\u304c\u5468\u56f2\u306b\u6bd4\u3079\u3066\u5f37\u304f\u304b\u304b\u3063\u3066\u3044\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u63a8\u6e2c\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u3053\u3067\u3001\u751f\u4f53\u5916\u3067\u4eba\u70ba\u7684\u306b\u5727\u529b\u3092\u4f5c\u7528\u3055\u305b\u308b\u3053\u3068\u306e\u3067\u304d\u308b\u30c1\u30e3\u30f3\u30d0\u30fc\u3092\u7528\u3044\u3066\u57f9\u990a\u5b9f\u9a13\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u4eba\u70ba\u7684\u5727\u529b\u306b\u3088\u3063\u3066CTK\u51e6\u7406\u306b\u3088\u308b\u7d30\u80de\u5916\u57fa\u8cea\u306e\u6d88\u5316\u6761\u4ef6\u4e0b\u306b\u304a\u3044\u3066\u3082\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u3092\u6291\u5236\u3067\u304d\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u3053\u3068\u306f\u7d30\u80de\u5916\u57fa\u8cea\u306b\u3088\u308b\u5727\u529b\u72b6\u614b\u304c\u539f\u59cb\u5375\u80de\u306e\u9759\u6b62\u671f\u7dad\u6301\u306b\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<h3>\u539f\u59cb\u5375\u80de\u3067\u306f\u6838\u304c\u56de\u8ee2\u3057\u3066\u3044\u305f<\/h3>\n<p>\u4e00\u65b9\u3067\u3001\u52a0\u5727\u51e6\u7406\u306b\u3068\u3082\u306a\u3046\u5375\u6bcd\u7d30\u80de\u306e\u4f53\u7a4d\u3092\u6e2c\u5b9a\u3059\u308b\u305f\u3081\u306b\u751f\u4f53\u5375\u5de3\u3092\u3082\u3061\u3044\u3066\u539f\u59cb\u5375\u80de\u306e\u7acb\u4f53\u753b\u50cf\u306e\u64ae\u5f71\u3092\u884c\u3063\u305f\u3068\u3053\u308d\u3001\u4e88\u671f\u305b\u306c\u3053\u3068\u306b\u901a\u5e38\u72b6\u614b\u306e\u539f\u59cb\u5375\u80de\u4e2d\u306e\u5375\u6bcd\u7d30\u80de\u3067\u306f\u6838\u304c\u56de\u8ee2\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u6838\u306e\u56de\u8ee2\u306fCTK\u51e6\u7406\u306b\u3088\u3063\u3066\u505c\u6b62\u3059\u308b\u3082\u306e\u306e\u3001CTK\u51e6\u7406\u3092\u52a0\u5727\u6761\u4ef6\u4e0b\u306b\u304a\u3044\u3066\u884c\u3046\u3068\u7dad\u6301\u3055\u308c\u308b\u3053\u3068\u304b\u3089\u539f\u59cb\u5375\u80de\u4e2d\u306e\u5375\u6bcd\u7d30\u80de\u306e\u6838\u56de\u8ee2\u306f\u5727\u529b\u306b\u3088\u308b\u3082\u306e\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u3053\u306e\u5375\u6bcd\u7d30\u80de\u306e\u6838\u56de\u8ee2\u904b\u52d5\u306f\u30c0\u30a4\u30cb\u30f3\u3068\u3088\u3070\u308c\u308b\u30e2\u30fc\u30bf\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u963b\u5bb3\u5264\uff08Ciliobrevin D : CD\uff09\u3092\u4f5c\u7528\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u505c\u6b62\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u305f\u3081\u3001\u30c0\u30a4\u30cb\u30f3\u4f9d\u5b58\u7684\u306a\u904b\u52d5\u3068\u8003\u3048\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p>\u305d\u3053\u3067\u3001\u6838\u306e\u56de\u8ee2\u904b\u52d5\u3068\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u3001\u6d3b\u6027\u5316\u3068\u306e\u95a2\u4fc2\u3092\u8abf\u3079\u308b\u305f\u3081\u306b\u5375\u5de3\u306bCD\u3092\u4f5c\u7528\u3055\u305b\u3001FOXO3a\u306e\u5c40\u5728\u3092\u89e3\u6790\u3057\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001CD\u51e6\u7406\u306b\u3088\u3063\u3066FOXO3a\u306e\u6838\u5916\u79fb\u884c\u304c\u4fc3\u9032\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u57f9\u990a\u5b9f\u9a13\u306e\u7d50\u679c\u304b\u3089CD\u51e6\u7406\u306b\u3088\u3063\u3066\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u304c\u4fc3\u9032\u3055\u308c\u6210\u9577\u3057\u305f\u5375\u80de\u306e\u6570\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u3088\u3046\u306a\u539f\u59cb\u5375\u80de\u6d3b\u6027\u5316\u306e\u7d50\u679c\u306fCTK\u51e6\u7406\u306e\u969b\u3068\u540c\u69d8\u306e\u3082\u306e\u3067\u3042\u308a\u3001\u5375\u5de3\u5185\u306e\u5fae\u5c0f\u74b0\u5883\u306b\u3088\u308b\u5727\u529b\u4ed8\u52a0\u3001\u5375\u6bcd\u7d30\u80de\u306e\u6838\u56de\u8ee2\u3001\u539f\u59cb\u5375\u80de\u306e\u9759\u6b62\u671f\u7dad\u6301\u3068\u3044\u3063\u305f\u4e00\u9023\u306e\u30ab\u30b9\u30b1\u30fc\u30c9\u3092\u793a\u5506\u3059\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<figure id=\"attachment_11945\" aria-describedby=\"caption-attachment-11945\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11945\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image3.jpg\" alt=\"\" width=\"800\" height=\"458\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image3.jpg 800w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image3-300x172.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image3-768x440.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-11945\" class=\"wp-caption-text\">\u5de6\uff09\u30de\u30a6\u30b9\u65b0\u751f\u5150\uff087\u65e5\uff09\u5375\u5de3\u306e\u6838\u67d3\u8272\uff08Hoechist 33342\uff09\u306b\u3088\u308b\u30bf\u30a4\u30e0\u30e9\u30d7\u30b9\u30a4\u30e1\u30fc\u30b8\u30f3\u30b0\u306e\u9023\u7d9a\u5199\u771f\u3002\u539f\u59cb\u5375\u80de\u4e2d\u306e\u5375\u6bcd\u7d30\u80de\u306e\u6838\u304c\u56de\u8ee2\u3057\u3066\u3044\u308b\u3002<br \/>\u53f3\uff09\u539f\u59cb\u5375\u80de\u4e2d\u306e\u5375\u6bcd\u7d30\u80de\u306e\u6838\u56de\u8ee2\u306b\u3064\u3044\u3066\u306e\u307e\u3068\u3081<\/figcaption><\/figure>\n<h3>\u751f\u4f53\u5916\u3067\u539f\u59cb\u5375\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u6210\u529f<\/h3>\n<p>\u3053\u308c\u307e\u3067\u306b\u80ce\u5150\u671f\u5375\u5de3\u304a\u3088\u3073\u591a\u80fd\u6027\u5e79\u7d30\u80de\u7531\u6765\u306e\u59cb\u539f\u751f\u6b96\u7d30\u80de\u69d8\u7d30\u80de\u3068\u80ce\u5150\u671f\u5375\u5de3\u4f53\u7d30\u80de\u306b\u3088\u308b\u518d\u69cb\u6210\u5375\u5de3\u306e\u57f9\u990a\u304b\u3089\u53d7\u7cbe\u53ef\u80fd\u306a\u6210\u719f\u3057\u305f\u5375\u5b50\u3092\u8a98\u5c0e\u3059\u308b\u4f53\u5916\u57f9\u990a\u7cfb\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u5f93\u6765\u306e\u57f9\u990a\u6761\u4ef6\u3067\u306f\u539f\u59cb\u5375\u80de\u306f\u8a98\u5c0e\u3055\u308c\u3066\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u6210\u679c\u3068\u3057\u3066\u751f\u4f53\u5185\u3067\u306f\u5727\u529b\u304c\u95a2\u308f\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u3001\u4f53\u5916\u57f9\u990a\u3068\u306e\u5dee\u7570\u3067\u306f\u306a\u3044\u304b\u3068\u8003\u3048\u307e\u3057\u305f\u3002\u305d\u3057\u3066\u751f\u4f53\u5185\u306b\u304a\u3051\u308b\u5375\u5de3\u76ae\u8cea\u306e\u74b0\u5883\u3092\u6a21\u3057\u305f\u52a0\u5727\u57f9\u990a\u306b\u3088\u3063\u3066\u751f\u4f53\u5916\u3067\u539f\u59cb\u5375\u80de\u3092\u8a98\u5c0e\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<figure id=\"attachment_11946\" aria-describedby=\"caption-attachment-11946\" style=\"width: 800px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-11946\" src=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image4.jpg\" alt=\"\" width=\"800\" height=\"367\" srcset=\"https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image4.jpg 800w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image4-300x138.jpg 300w, https:\/\/academist-cf.com\/journal\/wp-content\/uploads\/2019\/10\/image4-768x352.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><figcaption id=\"caption-attachment-11946\" class=\"wp-caption-text\">\u5de6\uff09\u30de\u30a6\u30b9\u80ce\u5150\u5375\u5de3\uff08\u80ce\u751f12.5\u65e5\uff09\u57f9\u990a\u5f8c21\u306b\u304a\u3051\u308b\u7d44\u7e54\u306e\u514d\u75ab\u67d3\u8272\u50cf\uff08\u7dd1\uff1aMVH\uff3b\u751f\u6b96\u7d30\u80de\u30de\u30fc\u30ab\u30fc\uff3d\u3001\u8d64 : Foxo3a\uff3b\u8ee2\u5199\u56e0\u5b50\uff3d\u3001\u9752 : DAPI\uff3b\u6838\uff3d\uff09\u3002\u52a0\u5727\u57f9\u990a\u4e0b\u3067\u306f\u70b9\u7dda\u3067\u793a\u3055\u305b\u308b\u3088\u3046\u306a\u5c0f\u3055\u306a\u5375\u6bcd\u7d30\u80de\u304c\u8a98\u5c0e\u3055\u308c\u3001\u9ad8\u500d\u7387\u50cf\u304b\u3089Foxo3a\u304c\u6838\u5185\u306b\u5b58\u5728\u3059\u308b\u539f\u59cb\u5375\u80de\u3067\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3067\u304d\u308b\u3002<br \/>\u53f3\uff09\u4f53\u5916\u57f9\u990a\u306b\u304a\u3051\u308b\u52a0\u5727\u306e\u52b9\u679c\u306e\u6982\u5ff5\u56f3\u3002\u4f53\u5916\u57f9\u990a\u3067\u306f\u6416\u52d5\u3055\u308c\u306a\u3044\u539f\u59cb\u5375\u80de\u304c\u52a0\u5727\u57f9\u990a\u3067\u306f\u8a98\u5c0e\u3055\u308c\u3066\u304f\u308b\u3002<\/figcaption><\/figure>\n<h3>\u5c06\u6765\u7684\u306a\u751f\u6b96\u88dc\u52a9\u533b\u7642\u3078\u306e\u5fdc\u7528\u3078\u3064\u306a\u3052\u308b<\/h3>\n<p>\u672c\u7814\u7a76\u306e\u6210\u679c\u306b\u3088\u308a\u3001\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u306e\u5236\u5fa1\u306b\u5727\u529b\u304c\u95a2\u308f\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u52a0\u5727\u57f9\u990a\u306b\u3088\u3063\u3066\u3053\u308c\u307e\u3067\u751f\u4f53\u5916\u3067\u306f\u8a98\u5c0e\u3067\u304d\u306a\u304b\u3063\u305f\u539f\u59cb\u5375\u80de\u306e\u8a98\u5c0e\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eca\u5f8c\u306f\u6e1b\u5727\u306b\u3088\u308b\u539f\u59cb\u5375\u80de\u306e\u6d3b\u6027\u5316\u5236\u5fa1\u3084\u3001\u751f\u4f53\u5916\u3067\u306e\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u3068\u3044\u3063\u305f\u5c06\u6765\u7684\u306a\u751f\u6b96\u88dc\u52a9\u533b\u7642\u3078\u306e\u5fdc\u7528\u3078\u3068\u3064\u306a\u3052\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u7d30\u80de\u6838\u306e\u56de\u8ee2\u306f50\u5e74\u4ee5\u4e0a\u524d\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u308b\u3082\u306e\u306e\u3001\u305d\u306e\u751f\u7269\u5b66\u7684\u610f\u7fa9\u306f\u307b\u3068\u3093\u3069\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u6838\u306e\u56de\u8ee2\u304c\u3082\u305f\u3089\u3059\u751f\u547d\u73fe\u8c61\u3068\u3044\u3046\u672a\u77e5\u306e\u9818\u57df\u306b\u3082\u6311\u6226\u3057\u3066\u3044\u304d\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u53c2\u8003\u6587\u732e<\/strong><br \/>\nNagamatsu G, Shimamoto S, Hamazaki N, Nishimura Y, Hayashi K., Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes., Sci Adv. 2019 Jun 26;5(6):eaav9960.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u539f\u59cb\u5375\u80de\u306e\u7dad\u6301\u306b\u91cd\u8981\u306a\u6761\u4ef6\u3068\u306f \u751f\u6b96\u7d30\u80de\u306f\u6b21\u4e16\u4ee3\u306b\u907a\u4f1d\u60c5\u5831\u3092\u7e4b\u3050\u552f\u4e00\u306e\u7d30\u80de\u7cfb\u8b5c\u3067\u3042\u308a\u3001\u305d\u306e\u767a\u751f\u904e\u7a0b\u3067\u3055\u307e\u3056\u307e\u306a\u6027\u8cea\u3001\u5f62\u614b\u306e\u5909\u5316\u3092\u4f34\u3044\u307e\u3059\u3002\u7279\u306b\u5375\u5b50\u306f\u500b\u4f53\u306e\u767a\u751f\u3092\u9042\u884c\u3059\u308b\u6a5f\u80fd\u3092\u62c5\u3046\u91cd\u8981\u306a\u7d30\u80de\u3067\u3059\u3002 \u54fa\u4e73 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