{"id":11209,"date":"2019-06-24T08:00:29","date_gmt":"2019-06-23T23:00:29","guid":{"rendered":"https:\/\/academist-cf.com\/journal\/?p=11209"},"modified":"2020-11-14T13:58:02","modified_gmt":"2020-11-14T04:58:02","slug":"%e9%ab%98%e9%bd%a2%e8%80%85%e3%81%ae%e4%bd%93%e3%81%8c%e9%9c%87%e3%81%88%e3%82%8b%e5%8e%9f%e5%9b%a0%e3%81%a8%e3%81%af%ef%bc%9f-%e3%80%8c%e6%9c%ac%e6%85%8b%e6%80%a7%e6%8c%af%e6%88%a6%e3%80%8d","status":"publish","type":"post","link":"https:\/\/academist-cf.com\/journal\/?p=11209","title":{"rendered":"\u9ad8\u9f62\u8005\u306e\u4f53\u304c\u9707\u3048\u308b\u539f\u56e0\u3068\u306f\uff1f – \u300c\u672c\u614b\u6027\u632f\u6226\u300d\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u30de\u30a6\u30b9\u306e\u8133\u304b\u3089\u63a2\u308b"},"content":{"rendered":"

\u672c\u614b\u6027\u632f\u6226\u3068\u306f\uff1f<\/h3>\n

\u4eca\u3001\u65e5\u672c\u306f\u672a\u66fd\u6709\u306e\u9ad8\u9f62\u5316\u793e\u4f1a\u3067\u3059\u3002\u9023\u65e5\u306e\u3088\u3046\u306b\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u3088\u308b\u3055\u307e\u3056\u307e\u306a\u554f\u984c\u304c\u30de\u30b9\u30e1\u30c7\u30a3\u30a2\u306b\u3088\u3063\u3066\u5831\u9053\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4eba\u306f\u6b73\u3092\u53d6\u308b\u3068\u7d30\u304b\u3044\u52d5\u304d\u304c\u4e0d\u5f97\u610f\u306b\u306a\u308a\u307e\u3059\u3002\u3068\u304f\u306b\u624b\u5148\u306e\u9707\u3048\u306f\u8001\u5316\u3068\u5171\u306b\u9855\u8457\u306b\u898b\u3089\u308c\u308b\u73fe\u8c61\u3067\u3001\u533b\u5b66\u7684\u306b\u306f\u300c\u672c\u614b\u6027\u632f\u6226\uff08\u307b\u3093\u305f\u3044\u305b\u3044\u3057\u3093\u305b\u3093\uff09\u300d\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u9707\u3048\u4ee5\u5916\u306b\u75c7\u72b6\u304c\u898b\u3089\u308c\u305a\u3001\u539f\u56e0\u304c\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u75c5\u6c17\u3092\u672c\u614b\u6027\u632f\u6226\u3068\u3044\u3044\u300165\u6b73\u4ee5\u4e0a\u3067\u306f\u7d0414%\u3068\u975e\u5e38\u306b\u591a\u304f\u306e\u9ad8\u9f62\u8005\u306b\u898b\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3053\u306e\u9707\u3048\u306f\u610f\u8b58\u3067\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3067\u304d\u306a\u3044\u7570\u5e38\u306a\u52d5\u304d\u3067\u3042\u308b\u305f\u3081\u3001\u7d30\u304b\u3044\u4f5c\u696d\u3092\u3059\u308b\u969b\u306b\u306f\u652f\u969c\u3092\u6765\u3059\u3053\u3068\u3068\u306a\u308a\u3001\u9ad8\u9f62\u8005\u304c\u50cd\u304d\u7d9a\u3051\u308b\u3046\u3048\u3067\u5927\u304d\u306a\u969c\u5bb3\u3068\u306a\u308a\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306b\u65e5\u5e38\u7684\u306b\u3082\u3088\u304f\u898b\u3089\u308c\u308b\u75c5\u6c17\u3067\u3042\u308a\u306a\u304c\u3089\u3001\u306a\u305c\u632f\u6226\u304c\u767a\u75c7\u3059\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u306f\u3053\u308c\u307e\u3067\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\n\n<\/div>\n

\u30de\u30a6\u30b9\u306e\u9707\u3048\u3068\u30af\u30e9\u30b9II ARF\u30bf\u30f3\u30d1\u30af\u8cea<\/h3>\n

\u4eca\u56de\u6211\u3005\u306fARF\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u30de\u30a6\u30b9\u3092\u4f5c\u88fd\u3057\u307e\u3057\u305f\u3002ARF\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306f6\u7a2e\u985e\u3042\u308a\u3001\u819c\u306e\u8f38\u9001\u306b\u95a2\u4e0e\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30af\u30e9\u30b9II\u306b\u5206\u985e\u3055\u308c\u308bARF4\u3068ARF5\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u50cd\u304d\u306f\u3088\u304f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u305d\u3053\u3067\u3053\u308c\u3089\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u3044\u30de\u30a6\u30b9\uff08\u6b63\u78ba\u306b\u306fARF4+\/-<\/sup>\/ARF5-\/-<\/sup>\u30de\u30a6\u30b9\uff09\u3092\u4f5c\u88fd\u3057\u305f\u3068\u3053\u308d\u3001\u5bdd\u3066\u3044\u308b\u3068\u304d\u3084\u6b62\u307e\u3063\u3066\u3044\u308b\u3068\u304d\u4ee5\u5916\u306f\u5e38\u306b\u4f53\u3092\u9707\u308f\u305b\u3066\u3044\u308b\u30de\u30a6\u30b9\u304c\u7523\u307e\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u30af\u30e9\u30b9II ARF\u907a\u4f1d\u5b50\u3092\u6b20\u5931\u3055\u305b\u305f\u30de\u30a6\u30b9\u306f\u632f\u6226\u3092\u793a\u3059<\/br>\uff08\u5de6\uff09\u6b63\u5e38\u306a\u30de\u30a6\u30b9\uff08\u53f3\uff09\u30af\u30e9\u30b9II ARF\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9<\/figcaption><\/figure>\n

\u4f53\u304c\u9707\u3048\u308b\u539f\u56e0\u3068\u3057\u3066\u3001\u4eba\u306e\u75c5\u6c17\u3067\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u672c\u614b\u6027\u632f\u6226\u304c\u3088\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u5b89\u9759\u6642\u306b\u624b\u304c\u9707\u3048\u308b\u306e\u306b\u5bfe\u3057\u3066\u3001\u672c\u614b\u6027\u632f\u6226\u3067\u306f\u52d5\u4f5c\u3092\u3057\u305f\u3068\u304d\u306b\u624b\u304c\u9707\u3048\u308b\u306a\u3069\u306e\u9055\u3044\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\"\"
\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3068\u672c\u614b\u6027\u632f\u6226\u306e\u9055\u3044<\/figcaption><\/figure>\n

\u6211\u3005\u306f\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3084\u672c\u614b\u6027\u632f\u6226\u306b\u52b9\u304f\u85ac\u3092\u3044\u308d\u3044\u308d\u8a66\u3057\u305f\u3068\u3053\u308d\u3001\u3069\u3046\u3084\u3089\u3053\u306e\u30de\u30a6\u30b9\u306e\u9707\u3048\u306f\u672c\u614b\u6027\u632f\u6226\u306e\u9707\u3048\u306b\u8fd1\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u3044\u3046\u7d50\u8ad6\u306b\u81f3\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u3055\u3089\u306b\u6211\u3005\u306f\u3001\u3053\u306e\u30de\u30a6\u30b9\u306e\u8133\u5185\u3092\u304f\u307e\u306a\u304f\u8abf\u3079\u3066\u307f\u307e\u3057\u305f\u3002\u306a\u304b\u306a\u304b\u7570\u5e38\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u304c\u3001\u300c\u5c0f\u8133\u306e\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u300d\u306b\u7570\u5e38\u304c\u3042\u308b\u3053\u3068\u304c\u5f90\u3005\u306b\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u5c0f\u8133\u306e\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u91cd\u8981\u306a\u50cd\u304d<\/h3>\n

\u5c0f\u8133\u306f\u3001\u30b9\u30e0\u30fc\u30ba\u306a\u904b\u52d5\u3092\u5b9f\u73fe\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u305d\u3057\u3066\u3001\u5c0f\u8133\u76ae\u8cea\u304b\u3089\u552f\u4e00\u5916\u306b\u4fe1\u53f7\u3092\u9001\u308a\u51fa\u3059\u795e\u7d4c\u7d30\u80de\u3067\u3042\u308b\u300c\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u300d\u304c\u305d\u306e\u4e2d\u5fc3\u7684\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u56de\u4f5c\u88fd\u3057\u305f\u30de\u30a6\u30b9\u306e\u8133\u306e\u6d3b\u52d5\u3092\u8a73\u7d30\u306b\u8abf\u3079\u305f\u3068\u3053\u308d\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u304c\u767a\u751f\u3059\u308b\u96fb\u6c17\u4fe1\u53f7\uff08\u3053\u306e\u4fe1\u53f7\u3092\u300c\u6d3b\u52d5\u96fb\u4f4d\u300d\u3068\u3044\u3044\u307e\u3059\uff09\u304c\u5f31\u307e\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u5c0f\u8133\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u96fb\u6c17\u4fe1\u53f7\uff08\u6d3b\u52d5\u96fb\u4f4d\uff09<\/br>\uff08\u4e0a\uff09\u6b63\u5e38\u306a\u30de\u30a6\u30b9\uff08\u4e0b\uff09\u30af\u30e9\u30b9II ARF\u30ce\u30c3\u30af\u30a2\u30a6\u30c8\u30de\u30a6\u30b9\uff08\u632f\u6226\u30de\u30a6\u30b9\uff09<\/figcaption><\/figure>\n

\u795e\u7d4c\u7d30\u80de\u306b\u306f\u3001\u8ef8\u7d22\u3068\u3044\u3046\u795e\u7d4c\u7d30\u80de\u306e\u7d30\u80de\u4f53\u304b\u3089\u9577\u304f\u4f38\u3073\u308b\u4e00\u672c\u306e\u7a81\u8d77\u304c\u3042\u308a\u3001\u6b21\u306e\u795e\u7d4c\u7d30\u80de\u306b\u4fe1\u53f7\u3092\u4f1d\u3048\u308b\u50cd\u304d\u3092\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\"\"
\u795e\u7d4c\u7d30\u80de\u306e\u8ef8\u7d22\u3068\u96fb\u6c17\u4fe1\u53f7<\/figcaption><\/figure>\n

\u6211\u3005\u306e\u89e3\u6790\u306e\u7d50\u679c\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u8ef8\u7d22\u306e\u6839\u672c\uff08\u8ef8\u7d22\u8d77\u59cb\u90e8\uff09\u306b\u304a\u3044\u3066\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30eb\uff08\u7d30\u80de\u5916\u304b\u3089\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u3092\u53d6\u308a\u8fbc\u3080\u30bf\u30f3\u30d1\u30af\u8cea\uff09\u306e\u3072\u3068\u3064\u3067\u3042\u308b\u300cNav1.6\u300d\u304c\u5931\u308f\u308c\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30eb\u306e\u6d88\u5931\u304c\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u96fb\u6c17\u4fe1\u53f7\u304c\u5f31\u307e\u3063\u3066\u3044\u308b\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\"\"
\u632f\u6226\u30de\u30a6\u30b9\u3067\u306f\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u8ef8\u7d22\u8d77\u59cb\u90e8\u306b\u3042\u308b\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30ebNav1.6\u304c\u5931\u308f\u308c\u308b<\/figcaption><\/figure>\n

\u4e00\u65b9\u3001\u30a6\u30a4\u30eb\u30b9\u3092\u907a\u4f1d\u5b50\u306e\u904b\u3073\u5c4b\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u306e\u632f\u6226\u30de\u30a6\u30b9\u306e\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u307f\u3067\u518d\u3073\u30af\u30e9\u30b9II ARF\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u4f5c\u3089\u305b\u305f\u3068\u3053\u308d\u3001\u30de\u30a6\u30b9\u306e\u9707\u3048\u304c\u5c11\u306a\u304f\u306a\u308a\u3001\u75c7\u72b6\u304c\u6539\u5584\u3057\u307e\u3057\u305f\u3002<\/p>\n

\u672c\u614b\u6027\u632f\u6226\u306e\u767a\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0<\/h3>\n

\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5\u3067\u306f\u3001\u8133\u306e\u9ed2\u8cea\u3068\u3044\u3046\u90e8\u5206\u306b\u3042\u308b\u30c9\u30fc\u30d1\u30df\u30f3\u5206\u6ccc\u795e\u7d4c\u7d30\u80de\u304c\u5931\u308f\u308c\u308b\u3053\u3068\u304c\u767a\u75c7\u306e\u539f\u56e0\u3067\u3059\u304c\u3001\u672c\u614b\u6027\u632f\u6226\u306e\u539f\u56e0\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n

\u4eca\u56de\u306e\u6211\u3005\u306e\u7814\u7a76\u7d50\u679c\u304b\u3089\u3001\u672c\u614b\u6027\u632f\u6226\u306e\u4f53\u306e\u9707\u3048\u306f\u3001\u5c0f\u8133\u306e\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u306e\u8ef8\u7d22\u8d77\u59cb\u90e8\u3067\u30ca\u30c8\u30ea\u30a6\u30e0\u30a4\u30aa\u30f3\u30c1\u30e3\u30f3\u30cd\u30eb\u306eNav1.6\u304c\u5931\u308f\u308c\u3001\u30d7\u30eb\u30ad\u30f3\u30a8\u7d30\u80de\u304c\u5c0f\u8133\u76ae\u8cea\u304b\u3089\u5916\u306b\u9001\u308b\u96fb\u6c17\u4fe1\u53f7\u304c\u5f31\u307e\u308b\u3053\u3068\u3067\u8d77\u3053\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u4eca\u5f8c\u306f\u3001\u8001\u5316\u3067\u306a\u305cNav1.6\u306e\u6a5f\u80fd\u304c\u5931\u308f\u308c\u308b\u306e\u304b\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u3053\u3068\u3067\u3001\u672c\u614b\u6027\u632f\u6226\u306e\u75c7\u72b6\u306e\u6839\u672c\u7684\u306a\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3092\u8a66\u307f\u3088\u3046\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/strong>
\nNobutake Hosoi, Koji Shibasaki, Mayu Hosono, Ayumu Konno, Yo Shinoda, Hiroshi Kiyonari, Kenichi Inoue, Shin-ichi Muramatsu, Yasuki Ishizaki, Hirokazu Hirai, Teiichi Furuichi, Tetsushi Sadakata, \u201cDeletion of class II ARFs in mice causes tremor by the Nav1.6 loss in cerebellar Purkinje cell axon initial segments\u201d Journal of Neuroscience<\/em>. 2019, 2002-18; DOI: https:\/\/doi.org\/10.1523\/JNEUROSCI.2002-18.2019<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u672c\u614b\u6027\u632f\u6226\u3068\u306f\uff1f \u4eca\u3001\u65e5\u672c\u306f\u672a\u66fd\u6709\u306e\u9ad8\u9f62\u5316\u793e\u4f1a\u3067\u3059\u3002\u9023\u65e5\u306e\u3088\u3046\u306b\u9ad8\u9f62\u5316\u793e\u4f1a\u306b\u3088\u308b\u3055\u307e\u3056\u307e\u306a\u554f\u984c\u304c\u30de\u30b9\u30e1\u30c7\u30a3\u30a2\u306b\u3088\u3063\u3066\u5831\u9053\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u4eba\u306f\u6b73\u3092\u53d6\u308b\u3068\u7d30\u304b\u3044\u52d5\u304d\u304c\u4e0d\u5f97\u610f\u306b\u306a\u308a\u307e\u3059\u3002\u3068\u304f\u306b\u624b\u5148\u306e\u9707\u3048\u306f\u8001 […]<\/p>\n","protected":false},"author":408,"featured_media":11202,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[3],"tags":[22,40,24],"class_list":["post-11209","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-outcome","tag-22","tag-40","tag-24","has_thumb"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/11209","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/users\/408"}],"replies":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=11209"}],"version-history":[{"count":7,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/11209\/revisions"}],"predecessor-version":[{"id":14862,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/posts\/11209\/revisions\/14862"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=\/wp\/v2\/media\/11202"}],"wp:attachment":[{"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=11209"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=11209"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/academist-cf.com\/journal\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=11209"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}